Grounding 3D Object Affordance with Language Instructions, Visual Observations and Interactions

Grounding 3D object affordance is a task that locates objects in 3D space where they can be manipulated, which links perception and action for embodied intelligence. For example, for an intelligent robot, it is necessary to accurately ground the affordance of an object and grasp it according to human instructions. In this paper, we introduce a novel task that grounds 3D object affordance based on language instructions, visual observations and interactions, which is inspired by cognitive science. We collect an Affordance Grounding dataset with Points, Images and Language instructions (AGPIL) to support the proposed task. In the 3D physical world, due to observation orientation, object rotation, or spatial occlusion, we can only get a partial observation of the object. So this dataset includes affordance estimations of objects from full-view, partial-view, and rotation-view perspectives. To accomplish this task, we propose LMAffordance3D, the first multi-modal, language-guided 3D affordance grounding network, which applies a vision-language model to fuse 2D and 3D spatial features with semantic features. Comprehensive experiments on AGPIL demonstrate the effectiveness and superiority of our method on this task, even in unseen experimental settings. Our project is available at https://sites.google.com/view/lmaffordance3d.

Improving Complex Reasoning with Dynamic Prompt Corruption: A soft prompt Optimization Approach

Prompt-tuning (PT) for large language models (LLMs) can facilitate the performance on various conventional NLP tasks with significantly fewer trainable parameters. However, our investigation reveals that PT provides limited improvement and may even degrade the primitive performance of LLMs on complex reasoning tasks. Such a phenomenon suggests that soft prompts can positively impact certain instances while negatively affecting others, particularly during the later phases of reasoning. To address these challenges, We first identify an information accumulation within the soft prompts. Through detailed analysis, we demonstrate that this phenomenon is often accompanied by erroneous information flow patterns in the deeper layers of the model, which ultimately lead to incorrect reasoning outcomes. we propose a novel method called \textbf{D}ynamic \textbf{P}rompt \textbf{C}orruption (DPC) to take better advantage of soft prompts in complex reasoning tasks, which dynamically adjusts the influence of soft prompts based on their impact on the reasoning process. Specifically, DPC consists of two stages: Dynamic Trigger and Dynamic Corruption. First, Dynamic Trigger measures the impact of soft prompts, identifying whether beneficial or detrimental. Then, Dynamic Corruption mitigates the negative effects of soft prompts by selectively masking key tokens that interfere with the reasoning process. We validate the proposed approach through extensive experiments on various LLMs and reasoning tasks, including GSM8K, MATH, and AQuA. Experimental results demonstrate that DPC can consistently enhance the performance of PT, achieving 4\%-8\% accuracy gains compared to vanilla prompt tuning, highlighting the effectiveness of our approach and its potential to enhance complex reasoning in LLMs.

Don't Take Things Out of Context: Attention Intervention for Enhancing Chain-of-Thought Reasoning in Large Language Models

Few-shot Chain-of-Thought (CoT) significantly enhances the reasoning capabilities of large language models (LLMs), functioning as a whole to guide these models in generating reasoning steps toward final answers. However, we observe that isolated segments, words, or tokens within CoT demonstrations can unexpectedly disrupt the generation process of LLMs. The model may overly concentrate on certain local information present in the demonstration, introducing irrelevant noise into the reasoning process and potentially leading to incorrect answers. In this paper, we investigate the underlying mechanism of CoT through dynamically tracing and manipulating the inner workings of LLMs at each output step, which demonstrates that tokens exhibiting specific attention characteristics are more likely to induce the model to take things out of context; these tokens directly attend to the hidden states tied with prediction, without substantial integration of non-local information. Building upon these insights, we propose a Few-shot Attention Intervention method (FAI) that dynamically analyzes the attention patterns of demonstrations to accurately identify these tokens and subsequently make targeted adjustments to the attention weights to effectively suppress their distracting effect on LLMs. Comprehensive experiments across multiple benchmarks demonstrate consistent improvements over baseline methods, with a remarkable 5.91% improvement on the AQuA dataset, further highlighting the effectiveness of FAI.

A Generalist Cross-Domain Molecular Learning Framework for Structure-Based Drug Discovery

Structure-based drug discovery (SBDD) is a systematic scientific process that develops new drugs by leveraging the detailed physical structure of the target protein. Recent advancements in pre-trained models for biomolecules have demonstrated remarkable success across various biochemical applications, including drug discovery and protein engineering. However, in most approaches, the pre-trained models primarily focus on the characteristics of either small molecules or proteins, without delving into their binding interactions which are essential cross-domain relationships pivotal to SBDD. To fill this gap, we propose a general-purpose foundation model named BIT (an abbreviation for Biomolecular Interaction Transformer), which is capable of encoding a range of biochemical entities, including small molecules, proteins, and protein-ligand complexes, as well as various data formats, encompassing both 2D and 3D structures. Specifically, we introduce Mixture-of-Domain-Experts (MoDE) to handle the biomolecules from diverse biochemical domains and Mixture-of-Structure-Experts (MoSE) to capture positional dependencies in the molecular structures. The proposed mixture-of-experts approach enables BIT to achieve both deep fusion and domain-specific encoding, effectively capturing fine-grained molecular interactions within protein-ligand complexes. Then, we perform cross-domain pre-training on the shared Transformer backbone via several unified self-supervised denoising tasks. Experimental results on various benchmarks demonstrate that BIT achieves exceptional performance in downstream tasks, including binding affinity prediction, structure-based virtual screening, and molecular property prediction.

Advancing vision-language models in front-end development via data synthesis

Modern front-end (FE) development, especially when leveraging the unique features of frameworks like React and Vue, presents distinctive challenges. These include managing modular architectures, ensuring synchronization between data and visual outputs for declarative rendering, and adapting reusable components to various scenarios. Such complexities make it particularly difficult for state-of-the-art large vision-language models (VLMs) to generate accurate and functional code directly from design images. To address these challenges, we propose a reflective agentic workflow that synthesizes high-quality image-text data to capture the diverse characteristics of FE development. This workflow automates the extraction of self-contained\footnote{A \textbf{self-contained} code snippet is one that encapsulates all necessary logic, styling, and dependencies, ensuring it functions independently without requiring external imports or context.} code snippets from real-world projects, renders the corresponding visual outputs, and generates detailed descriptions that link design elements to functional code. To further expand the scope and utility of the synthesis, we introduce three data synthesis strategies: Evolution-based synthesis, which enables scalable and diverse dataset expansion; Waterfall-Model-based synthesis, which generates logically coherent code derived from system requirements; and Additive Development synthesis, which iteratively increases the complexity of human-authored components. We build a large vision-language model, Flame, trained on the synthesized datasets and demonstrate its effectiveness in generating React code via the $\text{pass}@k$ metric. Our results suggest that a code VLM trained to interpret images before code generation may achieve better performance.

No Parameters, No Problem: 3D Gaussian Splatting without Camera Intrinsics and Extrinsics

While 3D Gaussian Splatting (3DGS) has made significant progress in scene reconstruction and novel view synthesis, it still heavily relies on accurately pre-computed camera intrinsics and extrinsics, such as focal length and camera poses. In order to mitigate this dependency, the previous efforts have focused on optimizing 3DGS without the need for camera poses, yet camera intrinsics remain necessary. To further loose the requirement, we propose a joint optimization method to train 3DGS from an image collection without requiring either camera intrinsics or extrinsics. To achieve this goal, we introduce several key improvements during the joint training of 3DGS. We theoretically derive the gradient of the camera intrinsics, allowing the camera intrinsics to be optimized simultaneously during training. Moreover, we integrate global track information and select the Gaussian kernels associated with each track, which will be trained and automatically rescaled to an infinitesimally small size, closely approximating surface points, and focusing on enforcing multi-view consistency and minimizing reprojection errors, while the remaining kernels continue to serve their original roles. This hybrid training strategy nicely unifies the camera parameters estimation and 3DGS training. Extensive evaluations demonstrate that the proposed method achieves state-of-the-art (SOTA) performance on both public and synthetic datasets.

PTZ-Calib: Robust Pan-Tilt-Zoom Camera Calibration

In this paper, we present PTZ-Calib, a robust two-stage PTZ camera calibration method, that efficiently and accurately estimates camera parameters for arbitrary viewpoints. Our method includes an offline and an online stage. In the offline stage, we first uniformly select a set of reference images that sufficiently overlap to encompass a complete 360{\deg} view. We then utilize the novel PTZ-IBA (PTZ Incremental Bundle Adjustment) algorithm to automatically calibrate the cameras within a local coordinate system. Additionally, for practical application, we can further optimize camera parameters and align them with the geographic coordinate system using extra global reference 3D information. In the online stage, we formulate the calibration of any new viewpoints as a relocalization problem. Our approach balances the accuracy and computational efficiency to meet real-world demands. Extensive evaluations demonstrate our robustness and superior performance over state-of-the-art methods on various real and synthetic datasets. Datasets and source code can be accessed online at https://github.com/gjgjh/PTZ-Calib

CoL3D: Collaborative Learning of Single-view Depth and Camera Intrinsics for Metric 3D Shape Recovery

Recovering the metric 3D shape from a single image is particularly relevant for robotics and embodied intelligence applications, where accurate spatial understanding is crucial for navigation and interaction with environments. Usually, the mainstream approaches achieve it through monocular depth estimation. However, without camera intrinsics, the 3D metric shape can not be recovered from depth alone. In this study, we theoretically demonstrate that depth serves as a 3D prior constraint for estimating camera intrinsics and uncover the reciprocal relations between these two elements. Motivated by this, we propose a collaborative learning framework for jointly estimating depth and camera intrinsics, named CoL3D, to learn metric 3D shapes from single images. Specifically, CoL3D adopts a unified network and performs collaborative optimization at three levels: depth, camera intrinsics, and 3D point clouds. For camera intrinsics, we design a canonical incidence field mechanism as a prior that enables the model to learn the residual incident field for enhanced calibration. Additionally, we incorporate a shape similarity measurement loss in the point cloud space, which improves the quality of 3D shapes essential for robotic applications. As a result, when training and testing on a single dataset with in-domain settings, CoL3D delivers outstanding performance in both depth estimation and camera calibration across several indoor and outdoor benchmark datasets, which leads to remarkable 3D shape quality for the perception capabilities of robots.

GENERator: A Long-Context Generative Genomic Foundation Model

Advancements in DNA sequencing technologies have significantly improved our ability to decode genomic sequences. However, the prediction and interpretation of these sequences remain challenging due to the intricate nature of genetic material. Large language models (LLMs) have introduced new opportunities for biological sequence analysis. Recent developments in genomic language models have underscored the potential of LLMs in deciphering DNA sequences. Nonetheless, existing models often face limitations in robustness and application scope, primarily due to constraints in model structure and training data scale. To address these limitations, we present GENERator, a generative genomic foundation model featuring a context length of 98k base pairs (bp) and 1.2B parameters. Trained on an expansive dataset comprising 386B bp of eukaryotic DNA, the GENERator demonstrates state-of-the-art performance across both established and newly proposed benchmarks. The model adheres to the central dogma of molecular biology, accurately generating protein-coding sequences that translate into proteins structurally analogous to known families. It also shows significant promise in sequence optimization, particularly through the prompt-responsive generation of promoter sequences with specific activity profiles. These capabilities position the GENERator as a pivotal tool for genomic research and biotechnological advancement, enhancing our ability to interpret and predict complex biological systems and enabling precise genomic interventions.

Not Every Patch is Needed: Towards a More Efficient and Effective Backbone for Video-based Person Re-identification

This paper proposes a new effective and efficient plug-and-play backbone for video-based person re-identification (ReID). Conventional video-based ReID methods typically use CNN or transformer backbones to extract deep features for every position in every sampled video frame. Here, we argue that this exhaustive feature extraction could be unnecessary, since we find that different frames in a ReID video often exhibit small differences and contain many similar regions due to the relatively slight movements of human beings. Inspired by this, a more selective, efficient paradigm is explored in this paper. Specifically, we introduce a patch selection mechanism to reduce computational cost by choosing only the crucial and non-repetitive patches for feature extraction. Additionally, we present a novel network structure that generates and utilizes pseudo frame global context to address the issue of incomplete views resulting from sparse inputs. By incorporating these new designs, our backbone can achieve both high performance and low computational cost. Extensive experiments on multiple datasets show that our approach reduces the computational cost by 74\% compared to ViT-B and 28\% compared to ResNet50, while the accuracy is on par with ViT-B and outperforms ResNet50 significantly.