Enhancing Community Vision Screening -- AI Driven Retinal Photography for Early Disease Detection and Patient Trust

Community vision screening plays a crucial role in identifying individuals with vision loss and preventing avoidable blindness, particularly in rural communities where access to eye care services is limited. Currently, there is a pressing need for a simple and efficient process to screen and refer individuals with significant eye disease-related vision loss to tertiary eye care centers for further care. An ideal solution should seamlessly and readily integrate with existing workflows, providing comprehensive initial screening results to service providers, thereby enabling precise patient referrals for timely treatment. This paper introduces the Enhancing Community Vision Screening (ECVS) solution, which addresses the aforementioned concerns with a novel and feasible solution based on simple, non-invasive retinal photography for the detection of pathology-based visual impairment. Our study employs four distinct deep learning models: RETinal photo Quality Assessment (RETQA), Pathology Visual Impairment detection (PVI), Eye Disease Diagnosis (EDD) and Visualization of Lesion Regions of the eye (VLR). We conducted experiments on over 10 datasets, totaling more than 80,000 fundus photos collected from various sources. The models integrated into ECVS achieved impressive AUC scores of 0.98 for RETQA, 0.95 for PVI, and 0.90 for EDD, along with a DICE coefficient of 0.48 for VLR. These results underscore the promising capabilities of ECVS as a straightforward and scalable method for community-based vision screening.

From Generalist to Specialist: Adapting Vision Language Models via Task-Specific Visual Instruction Tuning

Large vision language models (VLMs) combine large language models with vision encoders, demonstrating promise across various tasks. However, they often underperform in task-specific applications due to domain gaps between pre-training and fine-tuning. We introduce VITask, a novel framework that enhances task-specific adaptability of VLMs by integrating task-specific models (TSMs). VITask employs three key strategies: exemplar prompting (EP), response distribution alignment (RDA), and contrastive response tuning (CRT) to improve the task-specific performance of VLMs by adjusting their response distributions. EP allows TSM features to guide VLMs, while RDA enables VLMs to adapt without TSMs during inference by learning from exemplar-prompted models. CRT further optimizes the ranking of correct image-response pairs, thereby reducing the risk of generating undesired responses. Experiments on 12 medical diagnosis datasets across 9 imaging modalities show that VITask outperforms both vanilla instruction-tuned VLMs and TSMs, showcasing its ability to integrate complementary features from both models effectively. Additionally, VITask offers practical advantages such as flexible TSM integration and robustness to incomplete instructions, making it a versatile and efficient solution for task-specific VLM tuning. Our code are available at https://github.com/baiyang4/VITask.

Length Desensitization in Directed Preference Optimization

Direct Preference Optimization (DPO) is widely utilized in the Reinforcement Learning from Human Feedback (RLHF) phase to align Large Language Models (LLMs) with human preferences, thereby enhancing both their harmlessness and efficacy. However, it has been observed that DPO tends to over-optimize for verbosity, which can detrimentally affect both performance and user experience. In this paper, we conduct an in-depth theoretical analysis of DPO's optimization objective and reveal a strong correlation between its implicit reward and data length. This correlation misguides the optimization direction, resulting in length sensitivity during the DPO training and leading to verbosity. To address this issue, we propose a length-desensitization improvement method for DPO, termed LD-DPO. The proposed method aims to desensitize DPO to data length by decoupling explicit length preference, which is relatively insignificant, from the other implicit preferences, thereby enabling more effective learning of the intrinsic preferences. We utilized two settings (Base and Instruct) of Llama2-13B, Llama3-8B, and Qwen2-7B for experimental validation on various benchmarks including MT-Bench and AlpacaEval 2. The experimental results indicate that LD-DPO consistently outperforms DPO and other baseline methods, achieving more concise responses with a 10-40\% reduction in length compared to DPO. We conducted in-depth experimental analyses to demonstrate that LD-DPO can indeed achieve length desensitization and align the model more closely with human-real preferences.

UrFound: Towards Universal Retinal Foundation Models via Knowledge-Guided Masked Modeling

Retinal foundation models aim to learn generalizable representations from diverse retinal images, facilitating label-efficient model adaptation across various ophthalmic tasks. Despite their success, current retinal foundation models are generally restricted to a single imaging modality, such as Color Fundus Photography (CFP) or Optical Coherence Tomography (OCT), limiting their versatility. Moreover, these models may struggle to fully leverage expert annotations and overlook the valuable domain knowledge essential for domain-specific representation learning. To overcome these limitations, we introduce UrFound, a retinal foundation model designed to learn universal representations from both multimodal retinal images and domain knowledge. UrFound is equipped with a modality-agnostic image encoder and accepts either CFP or OCT images as inputs. To integrate domain knowledge into representation learning, we encode expert annotation in text supervision and propose a knowledge-guided masked modeling strategy for model pre-training. It involves reconstructing randomly masked patches of retinal images while predicting masked text tokens conditioned on the corresponding retinal image. This approach aligns multimodal images and textual expert annotations within a unified latent space, facilitating generalizable and domain-specific representation learning. Experimental results demonstrate that UrFound exhibits strong generalization ability and data efficiency when adapting to various tasks in retinal image analysis. By training on ~180k retinal images, UrFound significantly outperforms the state-of-the-art retinal foundation model trained on up to 1.6 million unlabelled images across 8 public retinal datasets. Our code and data are available at https://github.com/yukkai/UrFound.

Video Watermarking: Safeguarding Your Video from (Unauthorized) Annotations by Video-based LLMs

The advent of video-based Large Language Models (LLMs) has significantly enhanced video understanding. However, it has also raised some safety concerns regarding data protection, as videos can be more easily annotated, even without authorization. This paper introduces Video Watermarking, a novel technique to protect videos from unauthorized annotations by such video-based LLMs, especially concerning the video content and description, in response to specific queries. By imperceptibly embedding watermarks into key video frames with multi-modal flow-based losses, our method preserves the viewing experience while preventing misuse by video-based LLMs. Extensive experiments show that Video Watermarking significantly reduces the comprehensibility of videos with various video-based LLMs, demonstrating both stealth and robustness. In essence, our method provides a solution for securing video content, ensuring its integrity and confidentiality in the face of evolving video-based LLMs technologies.

Adversarial Robustness for Visual Grounding of Multimodal Large Language Models

Multi-modal Large Language Models (MLLMs) have recently achieved enhanced performance across various vision-language tasks including visual grounding capabilities. However, the adversarial robustness of visual grounding remains unexplored in MLLMs. To fill this gap, we use referring expression comprehension (REC) as an example task in visual grounding and propose three adversarial attack paradigms as follows. Firstly, untargeted adversarial attacks induce MLLMs to generate incorrect bounding boxes for each object. Besides, exclusive targeted adversarial attacks cause all generated outputs to the same target bounding box. In addition, permuted targeted adversarial attacks aim to permute all bounding boxes among different objects within a single image. Extensive experiments demonstrate that the proposed methods can successfully attack visual grounding capabilities of MLLMs. Our methods not only provide a new perspective for designing novel attacks but also serve as a strong baseline for improving the adversarial robustness for visual grounding of MLLMs.

Special Characters Attack: Toward Scalable Training Data Extraction From Large Language Models

Large language models (LLMs) have achieved remarkable performance on a wide range of tasks. However, recent studies have shown that LLMs can memorize training data and simple repeated tokens can trick the model to leak the data. In this paper, we take a step further and show that certain special characters or their combinations with English letters are stronger memory triggers, leading to more severe data leakage. The intuition is that, since LLMs are trained with massive data that contains a substantial amount of special characters (e.g. structural symbols {, } of JSON files, and @, # in emails and online posts), the model may memorize the co-occurrence between these special characters and the raw texts. This motivates us to propose a simple but effective Special Characters Attack (SCA) to induce training data leakage. Our experiments verify the high effectiveness of SCA against state-of-the-art LLMs: they can leak diverse training data, such as code corpus, web pages, and personally identifiable information, and sometimes generate non-stop outputs as a byproduct. We further show that the composition of the training data corpus can be revealed by inspecting the leaked data -- one crucial piece of information for pre-training high-performance LLMs. Our work can help understand the sensitivity of LLMs to special characters and identify potential areas for improvement.

Semi-supervised Text-based Person Search

Text-based person search (TBPS) aims to retrieve images of a specific person from a large image gallery based on a natural language description. Existing methods rely on massive annotated image-text data to achieve satisfactory performance in fully-supervised learning. It poses a significant challenge in practice, as acquiring person images from surveillance videos is relatively easy, while obtaining annotated texts is challenging. The paper undertakes a pioneering initiative to explore TBPS under the semi-supervised setting, where only a limited number of person images are annotated with textual descriptions while the majority of images lack annotations. We present a two-stage basic solution based on generation-then-retrieval for semi-supervised TBPS. The generation stage enriches annotated data by applying an image captioning model to generate pseudo-texts for unannotated images. Later, the retrieval stage performs fully-supervised retrieval learning using the augmented data. Significantly, considering the noise interference of the pseudo-texts on retrieval learning, we propose a noise-robust retrieval framework that enhances the ability of the retrieval model to handle noisy data. The framework integrates two key strategies: Hybrid Patch-Channel Masking (PC-Mask) to refine the model architecture, and Noise-Guided Progressive Training (NP-Train) to enhance the training process. PC-Mask performs masking on the input data at both the patch-level and the channel-level to prevent overfitting noisy supervision. NP-Train introduces a progressive training schedule based on the noise level of pseudo-texts to facilitate noise-robust learning. Extensive experiments on multiple TBPS benchmarks show that the proposed framework achieves promising performance under the semi-supervised setting.

Energy-Latency Manipulation of Multi-modal Large Language Models via Verbose Samples

Despite the exceptional performance of multi-modal large language models (MLLMs), their deployment requires substantial computational resources. Once malicious users induce high energy consumption and latency time (energy-latency cost), it will exhaust computational resources and harm availability of service. In this paper, we investigate this vulnerability for MLLMs, particularly image-based and video-based ones, and aim to induce high energy-latency cost during inference by crafting an imperceptible perturbation. We find that high energy-latency cost can be manipulated by maximizing the length of generated sequences, which motivates us to propose verbose samples, including verbose images and videos. Concretely, two modality non-specific losses are proposed, including a loss to delay end-of-sequence (EOS) token and an uncertainty loss to increase the uncertainty over each generated token. In addition, improving diversity is important to encourage longer responses by increasing the complexity, which inspires the following modality specific loss. For verbose images, a token diversity loss is proposed to promote diverse hidden states. For verbose videos, a frame feature diversity loss is proposed to increase the feature diversity among frames. To balance these losses, we propose a temporal weight adjustment algorithm. Experiments demonstrate that our verbose samples can largely extend the length of generated sequences.

MedRG: Medical Report Grounding with Multi-modal Large Language Model

Medical Report Grounding is pivotal in identifying the most relevant regions in medical images based on a given phrase query, a critical aspect in medical image analysis and radiological diagnosis. However, prevailing visual grounding approaches necessitate the manual extraction of key phrases from medical reports, imposing substantial burdens on both system efficiency and physicians. In this paper, we introduce a novel framework, Medical Report Grounding (MedRG), an end-to-end solution for utilizing a multi-modal Large Language Model to predict key phrase by incorporating a unique token, BOX, into the vocabulary to serve as an embedding for unlocking detection capabilities. Subsequently, the vision encoder-decoder jointly decodes the hidden embedding and the input medical image, generating the corresponding grounding box. The experimental results validate the effectiveness of MedRG, surpassing the performance of the existing state-of-the-art medical phrase grounding methods. This study represents a pioneering exploration of the medical report grounding task, marking the first-ever endeavor in this domain.