From Generalist to Specialist: A Survey of Large Language Models for Chemistry

Large Language Models (LLMs) have significantly transformed our daily life and established a new paradigm in natural language processing (NLP). However, the predominant pretraining of LLMs on extensive web-based texts remains insufficient for advanced scientific discovery, particularly in chemistry. The scarcity of specialized chemistry data, coupled with the complexity of multi-modal data such as 2D graph, 3D structure and spectrum, present distinct challenges. Although several studies have reviewed Pretrained Language Models (PLMs) in chemistry, there is a conspicuous absence of a systematic survey specifically focused on chemistry-oriented LLMs. In this paper, we outline methodologies for incorporating domain-specific chemistry knowledge and multi-modal information into LLMs, we also conceptualize chemistry LLMs as agents using chemistry tools and investigate their potential to accelerate scientific research. Additionally, we conclude the existing benchmarks to evaluate chemistry ability of LLMs. Finally, we critically examine the current challenges and identify promising directions for future research. Through this comprehensive survey, we aim to assist researchers in staying at the forefront of developments in chemistry LLMs and to inspire innovative applications in the field.

AdaEAGLE: Optimizing Speculative Decoding via Explicit Modeling of Adaptive Draft Structures

Speculative Decoding (SD) is a popular lossless technique for accelerating the inference of Large Language Models (LLMs). We show that the decoding speed of SD frameworks with static draft structures can be significantly improved by incorporating context-aware adaptive draft structures. However, current studies on adaptive draft structures are limited by their performance, modeling approaches, and applicability. In this paper, we introduce AdaEAGLE, the first SD framework that explicitly models adaptive draft structures. AdaEAGLE leverages the Lightweight Draft Length Predictor (LDLP) module to explicitly predict the optimal number of draft tokens during inference to guide the draft model. It achieves comparable speedup results without manual thresholds and allows for deeper, more specialized optimizations. Moreover, together with threshold-based strategies, AdaEAGLE achieves a $1.62\times$ speedup over the vanilla AR decoding and outperforms fixed-length SotA baseline while maintaining output quality.

Neural Directed Speech Enhancement with Dual Microphone Array in High Noise Scenario

In multi-speaker scenarios, leveraging spatial features is essential for enhancing target speech. While with limited microphone arrays, developing a compact multi-channel speech enhancement system remains challenging, especially in extremely low signal-to-noise ratio (SNR) conditions. To tackle this issue, we propose a triple-steering spatial selection method, a flexible framework that uses three steering vectors to guide enhancement and determine the enhancement range. Specifically, we introduce a causal-directed U-Net (CDUNet) model, which takes raw multi-channel speech and the desired enhancement width as inputs. This enables dynamic adjustment of steering vectors based on the target direction and fine-tuning of the enhancement region according to the angular separation between the target and interference signals. Our model with only a dual microphone array, excels in both speech quality and downstream task performance. It operates in real-time with minimal parameters, making it ideal for low-latency, on-device streaming applications.

Why Do Speech Language Models Fail to Generate Semantically Coherent Outputs? A Modality Evolving Perspective

Although text-based large language models exhibit human-level writing ability and remarkable intelligence, speech language models (SLMs) still struggle to generate semantically coherent outputs. There are several potential reasons for this performance degradation: (A) speech tokens mainly provide phonetic information rather than semantic information, (B) the length of speech sequences is much longer than that of text sequences, and (C) paralinguistic information, such as prosody, introduces additional complexity and variability. In this paper, we explore the influence of three key factors separately by transiting the modality from text to speech in an evolving manner. Our findings reveal that the impact of the three factors varies. Factor A has a relatively minor impact, factor B influences syntactical and semantic modeling more obviously, and factor C exerts the most significant impact, particularly in the basic lexical modeling. Based on these findings, we provide insights into the unique challenges of training SLMs and highlight pathways to develop more effective end-to-end SLMs.

SLAM-Omni: Timbre-Controllable Voice Interaction System with Single-Stage Training

Recent advancements highlight the potential of end-to-end real-time spoken dialogue systems, showcasing their low latency and high quality. In this paper, we introduce SLAM-Omni, a timbre-controllable, end-to-end voice interaction system with single-stage training. SLAM-Omni achieves zero-shot timbre control by modeling spoken language with semantic tokens and decoupling speaker information to a vocoder. By predicting grouped speech semantic tokens at each step, our method significantly reduces the sequence length of audio tokens, accelerating both training and inference. Additionally, we propose historical text prompting to compress dialogue history, facilitating efficient multi-round interactions. Comprehensive evaluations reveal that SLAM-Omni outperforms prior models of similar scale, requiring only 15 hours of training on 4 GPUs with limited data. Notably, it is the first spoken dialogue system to achieve competitive performance with a single-stage training approach, eliminating the need for pre-training on TTS or ASR tasks. Further experiments validate its multilingual and multi-turn dialogue capabilities on larger datasets.

Streaming Keyword Spotting Boosted by Cross-layer Discrimination Consistency

Connectionist Temporal Classification (CTC), a non-autoregressive training criterion, is widely used in online keyword spotting (KWS). However, existing CTC-based KWS decoding strategies either rely on Automatic Speech Recognition (ASR), which performs suboptimally due to its broad search over the acoustic space without keyword-specific optimization, or on KWS-specific decoding graphs, which are complex to implement and maintain. In this work, we propose a streaming decoding algorithm enhanced by Cross-layer Discrimination Consistency (CDC), tailored for CTC-based KWS. Specifically, we introduce a streamlined yet effective decoding algorithm capable of detecting the start of the keyword at any arbitrary position. Furthermore, we leverage discrimination consistency information across layers to better differentiate between positive and false alarm samples. Our experiments on both clean and noisy Hey Snips datasets show that the proposed streaming decoding strategy outperforms ASR-based and graph-based KWS baselines. The CDC-boosted decoding further improves performance, yielding an average absolute recall improvement of 6.8% and a 46.3% relative reduction in the miss rate compared to the graph-based KWS baseline, with a very low false alarm rate of 0.05 per hour.

NTC-KWS: Noise-aware CTC for Robust Keyword Spotting

In recent years, there has been a growing interest in designing small-footprint yet effective Connectionist Temporal Classification based keyword spotting (CTC-KWS) systems. They are typically deployed on low-resource computing platforms, where limitations on model size and computational capacity create bottlenecks under complicated acoustic scenarios. Such constraints often result in overfitting and confusion between keywords and background noise, leading to high false alarms. To address these issues, we propose a noise-aware CTC-based KWS (NTC-KWS) framework designed to enhance model robustness in noisy environments, particularly under extremely low signal-to-noise ratios. Our approach introduces two additional noise-modeling wildcard arcs into the training and decoding processes based on weighted finite state transducer (WFST) graphs: self-loop arcs to address noise insertion errors and bypass arcs to handle masking and interference caused by excessive noise. Experiments on clean and noisy Hey Snips show that NTC-KWS outperforms state-of-the-art (SOTA) end-to-end systems and CTC-KWS baselines across various acoustic conditions, with particularly strong performance in low SNR scenarios.

VQTalker: Towards Multilingual Talking Avatars through Facial Motion Tokenization

We present VQTalker, a Vector Quantization-based framework for multilingual talking head generation that addresses the challenges of lip synchronization and natural motion across diverse languages. Our approach is grounded in the phonetic principle that human speech comprises a finite set of distinct sound units (phonemes) and corresponding visual articulations (visemes), which often share commonalities across languages. We introduce a facial motion tokenizer based on Group Residual Finite Scalar Quantization (GRFSQ), which creates a discretized representation of facial features. This method enables comprehensive capture of facial movements while improving generalization to multiple languages, even with limited training data. Building on this quantized representation, we implement a coarse-to-fine motion generation process that progressively refines facial animations. Extensive experiments demonstrate that VQTalker achieves state-of-the-art performance in both video-driven and speech-driven scenarios, particularly in multilingual settings. Notably, our method achieves high-quality results at a resolution of 512*512 pixels while maintaining a lower bitrate of approximately 11 kbps. Our work opens new possibilities for cross-lingual talking face generation. Synthetic results can be viewed at https://x-lance.github.io/VQTalker.

Reducing Tool Hallucination via Reliability Alignment

Large Language Models (LLMs) have extended their capabilities beyond language generation to interact with external systems through tool calling, offering powerful potential for real-world applications. However, the phenomenon of tool hallucinations, which occur when models improperly select or misuse tools, presents critical challenges that can lead to flawed task execution and increased operational costs. This paper investigates the concept of reliable tool calling and highlights the necessity of addressing tool hallucinations. We systematically categorize tool hallucinations into two main types: tool selection hallucination and tool usage hallucination. To mitigate these issues, we propose a reliability-focused alignment framework that enhances the model's ability to accurately assess tool relevance and usage. By proposing a suite of evaluation metrics and evaluating on StableToolBench, we further demonstrate the effectiveness of our framework in mitigating tool hallucination and improving the overall system reliability of LLM tool calling.

Compressing KV Cache for Long-Context LLM Inference with Inter-Layer Attention Similarity

The increasing context window size in Large Language Models (LLMs), such as the GPT and LLaMA series, has improved their ability to tackle complex, long-text tasks, but at the cost of inference efficiency, particularly regarding memory and computational complexity. Existing methods, including selective token retention and window-based attention, improve efficiency but risk discarding important tokens needed for future text generation. In this paper, we propose an approach that enhances LLM efficiency without token loss by reducing the memory and computational load of less important tokens, rather than discarding them.We address two challenges: 1) investigating the distribution of important tokens in the context, discovering recent tokens are more important than distant tokens in context, and 2) optimizing resources for distant tokens by sharing attention scores across layers. The experiments show that our method saves $35\%$ KV cache without compromising the performance.