Classification of Mild Cognitive Impairment Based on Dynamic Functional Connectivity Using Spatio-Temporal Transformer

Dynamic functional connectivity (dFC) using resting-state functional magnetic resonance imaging (rs-fMRI) is an advanced technique for capturing the dynamic changes of neural activities, and can be very useful in the studies of brain diseases such as Alzheimer's disease (AD). Yet, existing studies have not fully leveraged the sequential information embedded within dFC that can potentially provide valuable information when identifying brain conditions. In this paper, we propose a novel framework that jointly learns the embedding of both spatial and temporal information within dFC based on the transformer architecture. Specifically, we first construct dFC networks from rs-fMRI data through a sliding window strategy. Then, we simultaneously employ a temporal block and a spatial block to capture higher-order representations of dynamic spatio-temporal dependencies, via mapping them into an efficient fused feature representation. To further enhance the robustness of these feature representations by reducing the dependency on labeled data, we also introduce a contrastive learning strategy to manipulate different brain states. Experimental results on 345 subjects with 570 scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) demonstrate the superiority of our proposed method for MCI (Mild Cognitive Impairment, the prodromal stage of AD) prediction, highlighting its potential for early identification of AD.

Brain-Adapter: Enhancing Neurological Disorder Analysis with Adapter-Tuning Multimodal Large Language Models

Understanding brain disorders is crucial for accurate clinical diagnosis and treatment. Recent advances in Multimodal Large Language Models (MLLMs) offer a promising approach to interpreting medical images with the support of text descriptions. However, previous research has primarily focused on 2D medical images, leaving richer spatial information of 3D images under-explored, and single-modality-based methods are limited by overlooking the critical clinical information contained in other modalities. To address this issue, this paper proposes Brain-Adapter, a novel approach that incorporates an extra bottleneck layer to learn new knowledge and instill it into the original pre-trained knowledge. The major idea is to incorporate a lightweight bottleneck layer to train fewer parameters while capturing essential information and utilize a Contrastive Language-Image Pre-training (CLIP) strategy to align multimodal data within a unified representation space. Extensive experiments demonstrated the effectiveness of our approach in integrating multimodal data to significantly improve the diagnosis accuracy without high computational costs, highlighting the potential to enhance real-world diagnostic workflows.

The Devil is in Temporal Token: High Quality Video Reasoning Segmentation

Existing methods for Video Reasoning Segmentation rely heavily on a single special token to represent the object in the keyframe or the entire video, inadequately capturing spatial complexity and inter-frame motion. To overcome these challenges, we propose VRS-HQ, an end-to-end video reasoning segmentation approach that leverages Multimodal Large Language Models (MLLMs) to inject rich spatiotemporal features into hierarchical tokens.Our key innovations include a Temporal Dynamic Aggregation (TDA) and a Token-driven Keyframe Selection (TKS). Specifically, we design frame-level <SEG> and temporal-level <TAK> tokens that utilize MLLM's autoregressive learning to effectively capture both local and global information. Subsequently, we apply a similarity-based weighted fusion and frame selection strategy, then utilize SAM2 to perform keyframe segmentation and propagation. To enhance keyframe localization accuracy, the TKS filters keyframes based on SAM2's occlusion scores during inference. VRS-HQ achieves state-of-the-art performance on ReVOS, surpassing VISA by 5.9%/12.5%/9.1% in J&F scores across the three subsets. These results highlight the strong temporal reasoning and segmentation capabilities of our method. Code and model weights will be released at VRS-HQ.

Learning Motion and Temporal Cues for Unsupervised Video Object Segmentation

In this paper, we address the challenges in unsupervised video object segmentation (UVOS) by proposing an efficient algorithm, termed MTNet, which concurrently exploits motion and temporal cues. Unlike previous methods that focus solely on integrating appearance with motion or on modeling temporal relations, our method combines both aspects by integrating them within a unified framework. MTNet is devised by effectively merging appearance and motion features during the feature extraction process within encoders, promoting a more complementary representation. To capture the intricate long-range contextual dynamics and information embedded within videos, a temporal transformer module is introduced, facilitating efficacious inter-frame interactions throughout a video clip. Furthermore, we employ a cascade of decoders all feature levels across all feature levels to optimally exploit the derived features, aiming to generate increasingly precise segmentation masks. As a result, MTNet provides a strong and compact framework that explores both temporal and cross-modality knowledge to robustly localize and track the primary object accurately in various challenging scenarios efficiently. Extensive experiments across diverse benchmarks conclusively show that our method not only attains state-of-the-art performance in unsupervised video object segmentation but also delivers competitive results in video salient object detection. These findings highlight the method's robust versatility and its adeptness in adapting to a range of segmentation tasks. Source code is available on https://github.com/hy0523/MTNet.

AVS-Mamba: Exploring Temporal and Multi-modal Mamba for Audio-Visual Segmentation

The essence of audio-visual segmentation (AVS) lies in locating and delineating sound-emitting objects within a video stream. While Transformer-based methods have shown promise, their handling of long-range dependencies struggles due to quadratic computational costs, presenting a bottleneck in complex scenarios. To overcome this limitation and facilitate complex multi-modal comprehension with linear complexity, we introduce AVS-Mamba, a selective state space model to address the AVS task. Our framework incorporates two key components for video understanding and cross-modal learning: Temporal Mamba Block for sequential video processing and Vision-to-Audio Fusion Block for advanced audio-vision integration. Building on this, we develop the Multi-scale Temporal Encoder, aimed at enhancing the learning of visual features across scales, facilitating the perception of intra- and inter-frame information. To perform multi-modal fusion, we propose the Modality Aggregation Decoder, leveraging the Vision-to-Audio Fusion Block to integrate visual features into audio features across both frame and temporal levels. Further, we adopt the Contextual Integration Pyramid to perform audio-to-vision spatial-temporal context collaboration. Through these innovative contributions, our approach achieves new state-of-the-art results on the AVSBench-object and AVSBench-semantic datasets. Our source code and model weights are available at AVS-Mamba.

3UR-LLM: An End-to-End Multimodal Large Language Model for 3D Scene Understanding

Multi-modal Large Language Models (MLLMs) exhibit impressive capabilities in 2D tasks, yet encounter challenges in discerning the spatial positions, interrelations, and causal logic in scenes when transitioning from 2D to 3D representations. We find that the limitations mainly lie in: i) the high annotation cost restricting the scale-up of volumes of 3D scene data, and ii) the lack of a straightforward and effective way to perceive 3D information which results in prolonged training durations and complicates the streamlined framework. To this end, we develop pipeline based on open-source 2D MLLMs and LLMs to generate high-quality 3D-text pairs and construct 3DS-160K , to enhance the pre-training process. Leveraging this high-quality pre-training data, we introduce the 3UR-LLM model, an end-to-end 3D MLLM designed for precise interpretation of 3D scenes, showcasing exceptional capability in navigating the complexities of the physical world. 3UR-LLM directly receives 3D point cloud as input and project 3D features fused with text instructions into a manageable set of tokens. Considering the computation burden derived from these hybrid tokens, we design a 3D compressor module to cohesively compress the 3D spatial cues and textual narrative. 3UR-LLM achieves promising performance with respect to the previous SOTAs, for instance, 3UR-LLM exceeds its counterparts by 7.1\% CIDEr on ScanQA, while utilizing fewer training resources. The code and model weights for 3UR-LLM and the 3DS-160K benchmark are available at 3UR-LLM.

Evaluating Human Perception of Novel View Synthesis: Subjective Quality Assessment of Gaussian Splatting and NeRF in Dynamic Scenes

Gaussian Splatting (GS) and Neural Radiance Fields (NeRF) are two groundbreaking technologies that have revolutionized the field of Novel View Synthesis (NVS), enabling immersive photorealistic rendering and user experiences by synthesizing multiple viewpoints from a set of images of sparse views. The potential applications of NVS, such as high-quality virtual and augmented reality, detailed 3D modeling, and realistic medical organ imaging, underscore the importance of quality assessment of NVS methods from the perspective of human perception. Although some previous studies have explored subjective quality assessments for NVS technology, they still face several challenges, especially in NVS methods selection, scenario coverage, and evaluation methodology. To address these challenges, we conducted two subjective experiments for the quality assessment of NVS technologies containing both GS-based and NeRF-based methods, focusing on dynamic and real-world scenes. This study covers 360{\deg}, front-facing, and single-viewpoint videos while providing a richer and greater number of real scenes. Meanwhile, it's the first time to explore the impact of NVS methods in dynamic scenes with moving objects. The two types of subjective experiments help to fully comprehend the influences of different viewing paths from a human perception perspective and pave the way for future development of full-reference and no-reference quality metrics. In addition, we established a comprehensive benchmark of various state-of-the-art objective metrics on the proposed database, highlighting that existing methods still struggle to accurately capture subjective quality. The results give us some insights into the limitations of existing NVS methods and may promote the development of new NVS methods.

Large Language Models for Bioinformatics

With the rapid advancements in large language model (LLM) technology and the emergence of bioinformatics-specific language models (BioLMs), there is a growing need for a comprehensive analysis of the current landscape, computational characteristics, and diverse applications. This survey aims to address this need by providing a thorough review of BioLMs, focusing on their evolution, classification, and distinguishing features, alongside a detailed examination of training methodologies, datasets, and evaluation frameworks. We explore the wide-ranging applications of BioLMs in critical areas such as disease diagnosis, drug discovery, and vaccine development, highlighting their impact and transformative potential in bioinformatics. We identify key challenges and limitations inherent in BioLMs, including data privacy and security concerns, interpretability issues, biases in training data and model outputs, and domain adaptation complexities. Finally, we highlight emerging trends and future directions, offering valuable insights to guide researchers and clinicians toward advancing BioLMs for increasingly sophisticated biological and clinical applications.

From Dense to Sparse: Event Response for Enhanced Residential Load Forecasting

Residential load forecasting (RLF) is crucial for resource scheduling in power systems. Most existing methods utilize all given load records (dense data) to indiscriminately extract the dependencies between historical and future time series. However, there exist important regular patterns residing in the event-related associations among different appliances (sparse knowledge), which have yet been ignored. In this paper, we propose an Event-Response Knowledge Guided approach (ERKG) for RLF by incorporating the estimation of electricity usage events for different appliances, mining event-related sparse knowledge from the load series. With ERKG, the event-response estimation enables portraying the electricity consumption behaviors of residents, revealing regular variations in appliance operational states. To be specific, ERKG consists of knowledge extraction and guidance: i) a forecasting model is designed for the electricity usage events by estimating appliance operational states, aiming to extract the event-related sparse knowledge; ii) a novel knowledge-guided mechanism is established by fusing such state estimates of the appliance events into the RLF model, which can give particular focuses on the patterns of users' electricity consumption behaviors. Notably, ERKG can flexibly serve as a plug-in module to boost the capability of existing forecasting models by leveraging event response. In numerical experiments, extensive comparisons and ablation studies have verified the effectiveness of our ERKG, e.g., over 8% MAE can be reduced on the tested state-of-the-art forecasting models.

SAT-LDM: Provably Generalizable Image Watermarking for Latent Diffusion Models with Self-Augmented Training

The proliferation of AI-generated images necessitates effective watermarking to protect intellectual property and identify fake content. While existing training-based watermarking methods show promise, they often struggle with generalization across diverse prompts and tend to produce noticeable artifacts. To this end, we introduce a provably generalizable image watermarking method for Latent Diffusion Models with Self-Augmented Training (SAT-LDM), which aligns the training and testing phases by a free generation distribution to bolster the watermarking module's generalization capabilities. We theoretically consolidate our method by proving that the free generation distribution contributes to its tight generalization bound without the need to collect new data. Extensive experimental results show that SAT-LDM achieves robust watermarking while significantly improving the quality of watermarked images across diverse prompts. Furthermore, we conduct experimental analyses to demonstrate the strong generalization abilities of SAT-LDM. We hope our method offers a practical and convenient solution for securing high-fidelity AI-generated content.