PathFinder: A Multi-Modal Multi-Agent System for Medical Diagnostic Decision-Making Applied to Histopathology

Diagnosing diseases through histopathology whole slide images (WSIs) is fundamental in modern pathology but is challenged by the gigapixel scale and complexity of WSIs. Trained histopathologists overcome this challenge by navigating the WSI, looking for relevant patches, taking notes, and compiling them to produce a final holistic diagnostic. Traditional AI approaches, such as multiple instance learning and transformer-based models, fail short of such a holistic, iterative, multi-scale diagnostic procedure, limiting their adoption in the real-world. We introduce PathFinder, a multi-modal, multi-agent framework that emulates the decision-making process of expert pathologists. PathFinder integrates four AI agents, the Triage Agent, Navigation Agent, Description Agent, and Diagnosis Agent, that collaboratively navigate WSIs, gather evidence, and provide comprehensive diagnoses with natural language explanations. The Triage Agent classifies the WSI as benign or risky; if risky, the Navigation and Description Agents iteratively focus on significant regions, generating importance maps and descriptive insights of sampled patches. Finally, the Diagnosis Agent synthesizes the findings to determine the patient's diagnostic classification. Our Experiments show that PathFinder outperforms state-of-the-art methods in skin melanoma diagnosis by 8% while offering inherent explainability through natural language descriptions of diagnostically relevant patches. Qualitative analysis by pathologists shows that the Description Agent's outputs are of high quality and comparable to GPT-4o. PathFinder is also the first AI-based system to surpass the average performance of pathologists in this challenging melanoma classification task by 9%, setting a new record for efficient, accurate, and interpretable AI-assisted diagnostics in pathology. Data, code and models available at https://pathfinder-dx.github.io/

REALEDIT: Reddit Edits As a Large-scale Empirical Dataset for Image Transformations

Existing image editing models struggle to meet real-world demands. Despite excelling in academic benchmarks, they have yet to be widely adopted for real user needs. Datasets that power these models use artificial edits, lacking the scale and ecological validity necessary to address the true diversity of user requests. We introduce REALEDIT, a large-scale image editing dataset with authentic user requests and human-made edits sourced from Reddit. REALEDIT includes a test set of 9300 examples to evaluate models on real user requests. Our results show that existing models fall short on these tasks, highlighting the need for realistic training data. To address this, we introduce 48K training examples and train our REALEDIT model, achieving substantial gains - outperforming competitors by up to 165 Elo points in human judgment and 92 percent relative improvement on the automated VIEScore metric. We deploy our model on Reddit, testing it on new requests, and receive positive feedback. Beyond image editing, we explore REALEDIT's potential in detecting edited images by partnering with a deepfake detection non-profit. Finetuning their model on REALEDIT data improves its F1-score by 14 percentage points, underscoring the dataset's value for broad applications.

SAM2Act: Integrating Visual Foundation Model with A Memory Architecture for Robotic Manipulation

Robotic manipulation systems operating in diverse, dynamic environments must exhibit three critical abilities: multitask interaction, generalization to unseen scenarios, and spatial memory. While significant progress has been made in robotic manipulation, existing approaches often fall short in generalization to complex environmental variations and addressing memory-dependent tasks. To bridge this gap, we introduce SAM2Act, a multi-view robotic transformer-based policy that leverages multi-resolution upsampling with visual representations from large-scale foundation model. SAM2Act achieves a state-of-the-art average success rate of 86.8% across 18 tasks in the RLBench benchmark, and demonstrates robust generalization on The Colosseum benchmark, with only a 4.3% performance gap under diverse environmental perturbations. Building on this foundation, we propose SAM2Act+, a memory-based architecture inspired by SAM2, which incorporates a memory bank, an encoder, and an attention mechanism to enhance spatial memory. To address the need for evaluating memory-dependent tasks, we introduce MemoryBench, a novel benchmark designed to assess spatial memory and action recall in robotic manipulation. SAM2Act+ achieves competitive performance on MemoryBench, significantly outperforming existing approaches and pushing the boundaries of memory-enabled robotic systems. Project page: https://sam2act.github.io/

MedicalNarratives: Connecting Medical Vision and Language with Localized Narratives

We propose MedicalNarratives, a dataset curated from medical pedagogical videos similar in nature to data collected in Think-Aloud studies and inspired by Localized Narratives, which collects grounded image-text data by curating instructors' speech and mouse cursor movements synchronized in time. MedicalNarratives enables pretraining of both semantic and dense objectives, alleviating the need to train medical semantic and dense tasks disparately due to the lack of reasonably sized datasets. Our dataset contains 4.7M image-text pairs from videos and articles, with 1M samples containing dense annotations in the form of traces and bounding boxes. To evaluate the utility of MedicalNarratives, we train GenMedClip based on the CLIP architecture using our dataset spanning 12 medical domains and demonstrate that it outperforms previous state-of-the-art models on a newly constructed medical imaging benchmark that comprehensively evaluates performance across all modalities. Data, demo, code and models available at https://medical-narratives.github.io

The One RING: a Robotic Indoor Navigation Generalist

Modern robots vary significantly in shape, size, and sensor configurations used to perceive and interact with their environments. However, most navigation policies are embodiment-specific; a policy learned using one robot's configuration does not typically gracefully generalize to another. Even small changes in the body size or camera viewpoint may cause failures. With the recent surge in custom hardware developments, it is necessary to learn a single policy that can be transferred to other embodiments, eliminating the need to (re)train for each specific robot. In this paper, we introduce RING (Robotic Indoor Navigation Generalist), an embodiment-agnostic policy, trained solely in simulation with diverse randomly initialized embodiments at scale. Specifically, we augment the AI2-THOR simulator with the ability to instantiate robot embodiments with controllable configurations, varying across body size, rotation pivot point, and camera configurations. In the visual object-goal navigation task, RING achieves robust performance on real unseen robot platforms (Stretch RE-1, LoCoBot, Unitree's Go1), achieving an average of 72.1% and 78.9% success rate across 5 embodiments in simulation and 4 robot platforms in the real world. (project website: https://one-ring-policy.allen.ai/)

Generate Any Scene: Evaluating and Improving Text-to-Vision Generation with Scene Graph Programming

DALL-E and Sora have gained attention by producing implausible images, such as "astronauts riding a horse in space." Despite the proliferation of text-to-vision models that have inundated the internet with synthetic visuals, from images to 3D assets, current benchmarks predominantly evaluate these models on real-world scenes paired with captions. We introduce Generate Any Scene, a framework that systematically enumerates scene graphs representing a vast array of visual scenes, spanning realistic to imaginative compositions. Generate Any Scene leverages 'scene graph programming', a method for dynamically constructing scene graphs of varying complexity from a structured taxonomy of visual elements. This taxonomy includes numerous objects, attributes, and relations, enabling the synthesis of an almost infinite variety of scene graphs. Using these structured representations, Generate Any Scene translates each scene graph into a caption, enabling scalable evaluation of text-to-vision models through standard metrics. We conduct extensive evaluations across multiple text-to-image, text-to-video, and text-to-3D models, presenting key findings on model performance. We find that DiT-backbone text-to-image models align more closely with input captions than UNet-backbone models. Text-to-video models struggle with balancing dynamics and consistency, while both text-to-video and text-to-3D models show notable gaps in human preference alignment. We demonstrate the effectiveness of Generate Any Scene by conducting three practical applications leveraging captions generated by Generate Any Scene: 1) a self-improving framework where models iteratively enhance their performance using generated data, 2) a distillation process to transfer specific strengths from proprietary models to open-source counterparts, and 3) improvements in content moderation by identifying and generating challenging synthetic data.

TACO: Learning Multi-modal Action Models with Synthetic Chains-of-Thought-and-Action

While open-source multi-modal language models perform well on simple question answering tasks, they often fail on complex questions that require multiple capabilities, such as fine-grained recognition, visual grounding, and reasoning, and that demand multi-step solutions. We present TACO, a family of multi-modal large action models designed to improve performance on such complex, multi-step, and multi-modal tasks. During inference, TACO produces chains-of-thought-and-action (CoTA), executes intermediate steps by invoking external tools such as OCR, depth estimation and calculator, then integrates both the thoughts and action outputs to produce coherent responses. To train TACO, we create a large dataset of over 1M synthetic CoTA traces generated with GPT-4o and Python programs. We then experiment with various data filtering and mixing techniques and obtain a final subset of 293K high-quality CoTA examples. This dataset enables TACO to learn complex reasoning and action paths, surpassing existing models trained on instruction tuning data with only direct answers. Our model TACO outperforms the instruction-tuned baseline across 8 benchmarks, achieving a 3.6% improvement on average, with gains of up to 15% in MMVet tasks involving OCR, mathematical reasoning, and spatial reasoning. Training on high-quality CoTA traces sets a new standard for complex multi-modal reasoning, highlighting the need for structured, multi-step instruction tuning in advancing open-source mutli-modal models' capabilities.

SAT: Spatial Aptitude Training for Multimodal Language Models

Spatial perception is a fundamental component of intelligence. While many studies highlight that large multimodal language models (MLMs) struggle to reason about space, they only test for static spatial reasoning, such as categorizing the relative positions of objects. Meanwhile, real-world deployment requires dynamic capabilities like perspective-taking and egocentric action recognition. As a roadmap to improving spatial intelligence, we introduce SAT, Spatial Aptitude Training, which goes beyond static relative object position questions to the more dynamic tasks. SAT contains 218K question-answer pairs for 22K synthetic scenes across a training and testing set. Generated using a photo-realistic physics engine, our dataset can be arbitrarily scaled and easily extended to new actions, scenes, and 3D assets. We find that even MLMs that perform relatively well on static questions struggle to accurately answer dynamic spatial questions. Further, we show that SAT instruction-tuning data improves not only dynamic spatial reasoning on SAT, but also zero-shot performance on existing real-image spatial benchmarks: $23\%$ on CVBench, $8\%$ on the harder BLINK benchmark, and $18\%$ on VSR. When instruction-tuned on SAT, our 13B model matches larger proprietary MLMs like GPT4-V and Gemini-3-1.0 in spatial reasoning. Our data/code is available at http://arijitray1993.github.io/SAT/ .

ProVision: Programmatically Scaling Vision-centric Instruction Data for Multimodal Language Models

With the rise of multimodal applications, instruction data has become critical for training multimodal language models capable of understanding complex image-based queries. Existing practices rely on powerful but costly large language models (LLMs) or multimodal language models (MLMs) to produce instruction data. These are often prone to hallucinations, licensing issues and the generation process is often hard to scale and interpret. In this work, we present a programmatic approach that employs scene graphs as symbolic representations of images and human-written programs to systematically synthesize vision-centric instruction data. Our approach ensures the interpretability and controllability of the data generation process and scales efficiently while maintaining factual accuracy. By implementing a suite of 24 single-image, 14 multi-image instruction generators, and a scene graph generation pipeline, we build a scalable, cost-effective system: ProVision which produces diverse question-answer pairs concerning objects, attributes, relations, depth, etc., for any given image. Applied to Visual Genome and DataComp datasets, we generate over 10 million instruction data points, ProVision-10M, and leverage them in both pretraining and instruction tuning stages of MLMs. When adopted in the instruction tuning stage, our single-image instruction data yields up to a 7% improvement on the 2D split and 8% on the 3D split of CVBench, along with a 3% increase in performance on QBench2, RealWorldQA, and MMMU. Our multi-image instruction data leads to an 8% improvement on Mantis-Eval. Incorporation of our data in both pre-training and fine-tuning stages of xGen-MM-4B leads to an averaged improvement of 1.6% across 11 benchmarks.

NVILA: Efficient Frontier Visual Language Models

Visual language models (VLMs) have made significant advances in accuracy in recent years. However, their efficiency has received much less attention. This paper introduces NVILA, a family of open VLMs designed to optimize both efficiency and accuracy. Building on top of VILA, we improve its model architecture by first scaling up the spatial and temporal resolutions, and then compressing visual tokens. This "scale-then-compress" approach enables NVILA to efficiently process high-resolution images and long videos. We also conduct a systematic investigation to enhance the efficiency of NVILA throughout its entire lifecycle, from training and fine-tuning to deployment. NVILA matches or surpasses the accuracy of many leading open and proprietary VLMs across a wide range of image and video benchmarks. At the same time, it reduces training costs by 4.5X, fine-tuning memory usage by 3.4X, pre-filling latency by 1.6-2.2X, and decoding latency by 1.2-2.8X. We will soon make our code and models available to facilitate reproducibility.