Department of Biomedical Engineering, School of Basic Medical Sciences, Central South University, 172 Tongzipo Road, Changsha, 410013, China
Abstract:This study explores the application of machine learning-based genetic linguistics for identifying heavy metal response genes in rice (Oryza sativa). By integrating convolutional neural networks and random forest algorithms, we developed a hybrid model capable of extracting and learning meaningful features from gene sequences, such as k-mer frequencies and physicochemical properties. The model was trained and tested on datasets of genes, achieving high predictive performance (precision: 0.89, F1-score: 0.82). RNA-seq and qRT-PCR experiments conducted on rice leaves which exposed to Hg0, revealed differential expression of genes associated with heavy metal responses, which validated the model's predictions. Co-expression network analysis identified 103 related genes, and a literature review indicated that these genes are highly likely to be involved in heavy metal-related biological processes. By integrating and comparing the analysis results with those of differentially expressed genes (DEGs), the validity of the new machine learning method was further demonstrated. This study highlights the efficacy of combining machine learning with genetic linguistics for large-scale gene prediction. It demonstrates a cost-effective and efficient approach for uncovering molecular mechanisms underlying heavy metal responses, with potential applications in developing stress-tolerant crop varieties.
Abstract:Rapid advancement of diffusion models has catalyzed remarkable progress in the field of image generation. However, prevalent models such as Flux, SD3.5 and Midjourney, still grapple with issues like model bias, limited text rendering capabilities, and insufficient understanding of Chinese cultural nuances. To address these limitations, we present Seedream 2.0, a native Chinese-English bilingual image generation foundation model that excels across diverse dimensions, which adeptly manages text prompt in both Chinese and English, supporting bilingual image generation and text rendering. We develop a powerful data system that facilitates knowledge integration, and a caption system that balances the accuracy and richness for image description. Particularly, Seedream is integrated with a self-developed bilingual large language model as a text encoder, allowing it to learn native knowledge directly from massive data. This enable it to generate high-fidelity images with accurate cultural nuances and aesthetic expressions described in either Chinese or English. Beside, Glyph-Aligned ByT5 is applied for flexible character-level text rendering, while a Scaled ROPE generalizes well to untrained resolutions. Multi-phase post-training optimizations, including SFT and RLHF iterations, further improve the overall capability. Through extensive experimentation, we demonstrate that Seedream 2.0 achieves state-of-the-art performance across multiple aspects, including prompt-following, aesthetics, text rendering, and structural correctness. Furthermore, Seedream 2.0 has been optimized through multiple RLHF iterations to closely align its output with human preferences, as revealed by its outstanding ELO score. In addition, it can be readily adapted to an instruction-based image editing model, such as SeedEdit, with strong editing capability that balances instruction-following and image consistency.
Abstract:Recent advancements in large language models (LLMs) have enabled LLM-based agents to successfully tackle interactive planning tasks. However, despite their successes, existing approaches often suffer from planning hallucinations and require retraining for each new agent. To address these challenges, we propose the Meta Plan Optimization (MPO) framework, which enhances agent planning capabilities by directly incorporating explicit guidance. Unlike previous methods that rely on complex knowledge, which either require significant human effort or lack quality assurance, MPO leverages high-level general guidance through meta plans to assist agent planning and enables continuous optimization of the meta plans based on feedback from the agent's task execution. Our experiments conducted on two representative tasks demonstrate that MPO significantly outperforms existing baselines. Moreover, our analysis indicates that MPO provides a plug-and-play solution that enhances both task completion efficiency and generalization capabilities in previous unseen scenarios.
Abstract:In this paper, we propose a novel garment-centric outpainting (GCO) framework based on the latent diffusion model (LDM) for fine-grained controllable apparel showcase image generation. The proposed framework aims at customizing a fashion model wearing a given garment via text prompts and facial images. Different from existing methods, our framework takes a garment image segmented from a dressed mannequin or a person as the input, eliminating the need for learning cloth deformation and ensuring faithful preservation of garment details. The proposed framework consists of two stages. In the first stage, we introduce a garment-adaptive pose prediction model that generates diverse poses given the garment. Then, in the next stage, we generate apparel showcase images, conditioned on the garment and the predicted poses, along with specified text prompts and facial images. Notably, a multi-scale appearance customization module (MS-ACM) is designed to allow both overall and fine-grained text-based control over the generated model's appearance. Moreover, we leverage a lightweight feature fusion operation without introducing any extra encoders or modules to integrate multiple conditions, which is more efficient. Extensive experiments validate the superior performance of our framework compared to state-of-the-art methods.
Abstract:Recent advances in Large Language Models (LLMs) have highlighted the challenge of handling long-context tasks, where models need to reason over extensive input contexts to aggregate target information. While Chain-of-Thought (CoT) prompting has shown promise for multi-step reasoning, its effectiveness for long-context scenarios remains underexplored. Through systematic investigation across diverse tasks, we demonstrate that CoT's benefits generalize across most long-context scenarios and amplify with increasing context length. Motivated by this critical observation, we propose LongRePS, a process-supervised framework that teaches models to generate high-quality reasoning paths for enhanced long-context performance. Our framework incorporates a self-sampling mechanism to bootstrap reasoning paths and a novel quality assessment protocol specifically designed for long-context scenarios. Experimental results on various long-context benchmarks demonstrate the effectiveness of our approach, achieving significant improvements over outcome supervision baselines on both in-domain tasks (+13.6/+3.8 points for LLaMA/Qwen on MuSiQue) and cross-domain generalization (+9.3/+8.1 points on average across diverse QA tasks). Our code, data and trained models are made public to facilitate future research.
Abstract:Large language models (LLMs) with extended context windows enable tasks requiring extensive information integration but are limited by the scarcity of high-quality, diverse datasets for long-context instruction tuning. Existing data synthesis methods focus narrowly on objectives like fact retrieval and summarization, restricting their generalizability to complex, real-world tasks. WildLong extracts meta-information from real user queries, models co-occurrence relationships via graph-based methods, and employs adaptive generation to produce scalable data. It extends beyond single-document tasks to support multi-document reasoning, such as cross-document comparison and aggregation. Our models, finetuned on 150K instruction-response pairs synthesized using WildLong, surpasses existing open-source long-context-optimized models across benchmarks while maintaining strong performance on short-context tasks without incorporating supplementary short-context data. By generating a more diverse and realistic long-context instruction dataset, WildLong enhances LLMs' ability to generalize to complex, real-world reasoning over long contexts, establishing a new paradigm for long-context data synthesis.
Abstract:As a data-driven approach, offline MARL learns superior policies solely from offline datasets, ideal for domains rich in historical data but with high interaction costs and risks. However, most existing methods are task-specific, requiring retraining for new tasks, leading to redundancy and inefficiency. To address this issue, in this paper, we propose a task-efficient multi-task offline MARL algorithm, Skill-Discovery Conservative Q-Learning (SD-CQL). Unlike existing offline skill-discovery methods, SD-CQL discovers skills by reconstructing the next observation. It then evaluates fixed and variable actions separately and employs behavior-regularized conservative Q-learning to execute the optimal action for each skill. This approach eliminates the need for local-global alignment and enables strong multi-task generalization from limited small-scale source tasks. Substantial experiments on StarCraftII demonstrates the superior generalization performance and task-efficiency of SD-CQL. It achieves the best performance on $\textbf{10}$ out of $14$ task sets, with up to $\textbf{65%}$ improvement on individual task sets, and is within $4\%$ of the best baseline on the remaining four.
Abstract:Existing cross-modal retrieval methods typically rely on large-scale vision-language pair data. This makes it challenging to efficiently develop a cross-modal retrieval model for under-resourced languages of interest. Therefore, Cross-lingual Cross-modal Retrieval (CCR), which aims to align vision and the low-resource language (the target language) without using any human-labeled target-language data, has gained increasing attention. As a general parameter-efficient way, a common solution is to utilize adapter modules to transfer the vision-language alignment ability of Vision-Language Pretraining (VLP) models from a source language to a target language. However, these adapters are usually static once learned, making it difficult to adapt to target-language captions with varied expressions. To alleviate it, we propose Dynamic Adapter with Semantics Disentangling (DASD), whose parameters are dynamically generated conditioned on the characteristics of the input captions. Considering that the semantics and expression styles of the input caption largely influence how to encode it, we propose a semantic disentangling module to extract the semantic-related and semantic-agnostic features from the input, ensuring that generated adapters are well-suited to the characteristics of input caption. Extensive experiments on two image-text datasets and one video-text dataset demonstrate the effectiveness of our model for cross-lingual cross-modal retrieval, as well as its good compatibility with various VLP models.
Abstract:Robot task planning is an important problem for autonomous robots in long-horizon challenging tasks. As large pre-trained models have demonstrated superior planning ability, recent research investigates utilizing large models to achieve autonomous planning for robots in diverse tasks. However, since the large models are pre-trained with Internet data and lack the knowledge of real task scenes, large models as planners may make unsafe decisions that hurt the robots and the surrounding environments. To solve this challenge, we propose a novel Safe Planner framework, which empowers safety awareness in large pre-trained models to accomplish safe and executable planning. In this framework, we develop a safety prediction module to guide the high-level large model planner, and this safety module trained in a simulator can be effectively transferred to real-world tasks. The proposed Safe Planner framework is evaluated on both simulated environments and real robots. The experiment results demonstrate that Safe Planner not only achieves state-of-the-art task success rates, but also substantially improves safety during task execution. The experiment videos are shown in https://sites.google.com/view/safeplanner .
Abstract:Offline-to-Online Reinforcement Learning has emerged as a powerful paradigm, leveraging offline data for initialization and online fine-tuning to enhance both sample efficiency and performance. However, most existing research has focused on single-agent settings, with limited exploration of the multi-agent extension, i.e., Offline-to-Online Multi-Agent Reinforcement Learning (O2O MARL). In O2O MARL, two critical challenges become more prominent as the number of agents increases: (i) the risk of unlearning pre-trained Q-values due to distributional shifts during the transition from offline-to-online phases, and (ii) the difficulty of efficient exploration in the large joint state-action space. To tackle these challenges, we propose a novel O2O MARL framework called Offline Value Function Memory with Sequential Exploration (OVMSE). First, we introduce the Offline Value Function Memory (OVM) mechanism to compute target Q-values, preserving knowledge gained during offline training, ensuring smoother transitions, and enabling efficient fine-tuning. Second, we propose a decentralized Sequential Exploration (SE) strategy tailored for O2O MARL, which effectively utilizes the pre-trained offline policy for exploration, thereby significantly reducing the joint state-action space to be explored. Extensive experiments on the StarCraft Multi-Agent Challenge (SMAC) demonstrate that OVMSE significantly outperforms existing baselines, achieving superior sample efficiency and overall performance.