Rethinking the Uncertainty: A Critical Review and Analysis in the Era of Large Language Models

In recent years, Large Language Models (LLMs) have become fundamental to a broad spectrum of artificial intelligence applications. As the use of LLMs expands, precisely estimating the uncertainty in their predictions has become crucial. Current methods often struggle to accurately identify, measure, and address the true uncertainty, with many focusing primarily on estimating model confidence. This discrepancy is largely due to an incomplete understanding of where, when, and how uncertainties are injected into models. This paper introduces a comprehensive framework specifically designed to identify and understand the types and sources of uncertainty, aligned with the unique characteristics of LLMs. Our framework enhances the understanding of the diverse landscape of uncertainties by systematically categorizing and defining each type, establishing a solid foundation for developing targeted methods that can precisely quantify these uncertainties. We also provide a detailed introduction to key related concepts and examine the limitations of current methods in mission-critical and safety-sensitive applications. The paper concludes with a perspective on future directions aimed at enhancing the reliability and practical adoption of these methods in real-world scenarios.

MMedAgent: Learning to Use Medical Tools with Multi-modal Agent

Multi-Modal Large Language Models (MLLMs), despite being successful, exhibit limited generality and often fall short when compared to specialized models. Recently, LLM-based agents have been developed to address these challenges by selecting appropriate specialized models as tools based on user inputs. However, such advancements have not been extensively explored within the medical domain. To bridge this gap, this paper introduces the first agent explicitly designed for the medical field, named \textbf{M}ulti-modal \textbf{Med}ical \textbf{Agent} (MMedAgent). We curate an instruction-tuning dataset comprising six medical tools solving seven tasks, enabling the agent to choose the most suitable tools for a given task. Comprehensive experiments demonstrate that MMedAgent achieves superior performance across a variety of medical tasks compared to state-of-the-art open-source methods and even the closed-source model, GPT-4o. Furthermore, MMedAgent exhibits efficiency in updating and integrating new medical tools.

ToolBeHonest: A Multi-level Hallucination Diagnostic Benchmark for Tool-Augmented Large Language Models

Tool-augmented large language models (LLMs) are rapidly being integrated into real-world applications. Due to the lack of benchmarks, the community still needs to fully understand the hallucination issues within these models. To address this challenge, we introduce a comprehensive diagnostic benchmark, ToolBH. Specifically, we assess the LLM's hallucinations through two perspectives: depth and breadth. In terms of depth, we propose a multi-level diagnostic process, including (1) solvability detection, (2) solution planning, and (3) missing-tool analysis. For breadth, we consider three scenarios based on the characteristics of the toolset: missing necessary tools, potential tools, and limited functionality tools. Furthermore, we developed seven tasks and collected 700 evaluation samples through multiple rounds of manual annotation. The results show the significant challenges presented by the ToolBH benchmark. The current advanced models Gemini-1.5-Pro and GPT-4o only achieve a total score of 45.3 and 37.0, respectively, on a scale of 100. In this benchmark, larger model parameters do not guarantee better performance; the training data and response strategies also play a crucial role in tool-enhanced LLM scenarios. Our diagnostic analysis indicates that the primary reason for model errors lies in assessing task solvability. Additionally, open-weight models suffer from performance drops with verbose replies, whereas proprietary models excel with longer reasoning.

Holistic Evaluation for Interleaved Text-and-Image Generation

Interleaved text-and-image generation has been an intriguing research direction, where the models are required to generate both images and text pieces in an arbitrary order. Despite the emerging advancements in interleaved generation, the progress in its evaluation still significantly lags behind. Existing evaluation benchmarks do not support arbitrarily interleaved images and text for both inputs and outputs, and they only cover a limited number of domains and use cases. Also, current works predominantly use similarity-based metrics which fall short in assessing the quality in open-ended scenarios. To this end, we introduce InterleavedBench, the first benchmark carefully curated for the evaluation of interleaved text-and-image generation. InterleavedBench features a rich array of tasks to cover diverse real-world use cases. In addition, we present InterleavedEval, a strong reference-free metric powered by GPT-4o to deliver accurate and explainable evaluation. We carefully define five essential evaluation aspects for InterleavedEval, including text quality, perceptual quality, image coherence, text-image coherence, and helpfulness, to ensure a comprehensive and fine-grained assessment. Through extensive experiments and rigorous human evaluation, we show that our benchmark and metric can effectively evaluate the existing models with a strong correlation with human judgments surpassing previous reference-based metrics. We also provide substantial findings and insights to foster future research in interleaved generation and its evaluation.

InternalInspector $I^2$: Robust Confidence Estimation in LLMs through Internal States

Despite their vast capabilities, Large Language Models (LLMs) often struggle with generating reliable outputs, frequently producing high-confidence inaccuracies known as hallucinations. Addressing this challenge, our research introduces InternalInspector, a novel framework designed to enhance confidence estimation in LLMs by leveraging contrastive learning on internal states including attention states, feed-forward states, and activation states of all layers. Unlike existing methods that primarily focus on the final activation state, InternalInspector conducts a comprehensive analysis across all internal states of every layer to accurately identify both correct and incorrect prediction processes. By benchmarking InternalInspector against existing confidence estimation methods across various natural language understanding and generation tasks, including factual question answering, commonsense reasoning, and reading comprehension, InternalInspector achieves significantly higher accuracy in aligning the estimated confidence scores with the correctness of the LLM's predictions and lower calibration error. Furthermore, InternalInspector excels at HaluEval, a hallucination detection benchmark, outperforming other internal-based confidence estimation methods in this task.

Navigating the Dual Facets: A Comprehensive Evaluation of Sequential Memory Editing in Large Language Models

Memory Editing (ME) has emerged as an efficient method to modify erroneous facts or inject new facts into Large Language Models (LLMs). Two mainstream ME methods exist: parameter-modifying ME and parameter-preserving ME (integrating extra modules while preserving original parameters). Regrettably, previous studies on ME evaluation have two critical limitations: (i) evaluating LLMs with single edit only, neglecting the need for continuous editing, and (ii) evaluations focusing solely on basic factual triples, overlooking broader LLM capabilities like logical reasoning and reading understanding. This study addresses these limitations with contributions threefold: (i) We explore how ME affects a wide range of fundamental capabilities of LLMs under sequential editing. Experimental results reveal an intriguing phenomenon: Most parameter-modifying ME consistently degrade performance across all tasks after a few sequential edits. In contrast, parameter-preserving ME effectively maintains LLMs' fundamental capabilities but struggles to accurately recall edited knowledge presented in a different format. (ii) We extend our evaluation to different editing settings, such as layers to edit, model size, instruction tuning, etc. Experimental findings indicate several strategies that can potentially mitigate the adverse effects of ME. (iii) We further explain why parameter-modifying ME damages LLMs from three dimensions: parameter changes after editing, language modeling capability, and the in-context learning capability. Our in-depth study advocates more careful use of ME in real-world scenarios.

Efficient Federated Prompt Tuning for Black-box Large Pre-trained Models

With the blowout development of pre-trained models (PTMs), the efficient tuning of these models for diverse downstream applications has emerged as a pivotal research concern. Although recent investigations into prompt tuning have provided promising avenues, three salient challenges persist: (1) memory constraint: the continuous growth in the size of open-source PTMs renders fine-tuning, even a fraction of their parameters, challenging for many practitioners. (2) model privacy: existing PTMs often function as public API services, with their parameters inaccessible for effective or tailored fine-tuning. (3) data privacy: the fine-tuning of PTMs necessitates high-quality datasets, which are typically localized and not shared to public. To optimally harness each local dataset while navigating memory constraints and preserving privacy, we propose Federated Black-Box Prompt Tuning (Fed-BBPT). This innovative approach eschews reliance on parameter architectures and private dataset access, instead capitalizing on a central server that aids local users in collaboratively training a prompt generator through regular aggregation. Local users leverage API-driven learning via a zero-order optimizer, obviating the need for PTM deployment. Relative to extensive fine-tuning, Fed-BBPT proficiently sidesteps memory challenges tied to PTM storage and fine-tuning on local machines, tapping into comprehensive, high-quality, yet private training datasets. A thorough evaluation across 40 datasets spanning CV and NLP tasks underscores the robustness of our proposed model.

Rethinking Medical Report Generation: Disease Revealing Enhancement with Knowledge Graph

Knowledge Graph (KG) plays a crucial role in Medical Report Generation (MRG) because it reveals the relations among diseases and thus can be utilized to guide the generation process. However, constructing a comprehensive KG is labor-intensive and its applications on the MRG process are under-explored. In this study, we establish a complete KG on chest X-ray imaging that includes 137 types of diseases and abnormalities. Based on this KG, we find that the current MRG data sets exhibit a long-tailed problem in disease distribution. To mitigate this problem, we introduce a novel augmentation strategy that enhances the representation of disease types in the tail-end of the distribution. We further design a two-stage MRG approach, where a classifier is first trained to detect whether the input images exhibit any abnormalities. The classified images are then independently fed into two transformer-based generators, namely, ``disease-specific generator" and ``disease-free generator" to generate the corresponding reports. To enhance the clinical evaluation of whether the generated reports correctly describe the diseases appearing in the input image, we propose diverse sensitivity (DS), a new metric that checks whether generated diseases match ground truth and measures the diversity of all generated diseases. Results show that the proposed two-stage generation framework and augmentation strategies improve DS by a considerable margin, indicating a notable reduction in the long-tailed problem associated with under-represented diseases.

Towards More Suitable Personalization in Federated Learning via Decentralized Partial Model Training

Personalized federated learning (PFL) aims to produce the greatest personalized model for each client to face an insurmountable problem--data heterogeneity in real FL systems. However, almost all existing works have to face large communication burdens and the risk of disruption if the central server fails. Only limited efforts have been used in a decentralized way but still suffers from inferior representation ability due to sharing the full model with its neighbors. Therefore, in this paper, we propose a personalized FL framework with a decentralized partial model training called DFedAlt. It personalizes the "right" components in the modern deep models by alternately updating the shared and personal parameters to train partially personalized models in a peer-to-peer manner. To further promote the shared parameters aggregation process, we propose DFedSalt integrating the local Sharpness Aware Minimization (SAM) optimizer to update the shared parameters. It adds proper perturbation in the direction of the gradient to overcome the shared model inconsistency across clients. Theoretically, we provide convergence analysis of both algorithms in the general non-convex setting for decentralized partial model training in PFL. Our experiments on several real-world data with various data partition settings demonstrate that (i) decentralized training is more suitable for partial personalization, which results in state-of-the-art (SOTA) accuracy compared with the SOTA PFL baselines; (ii) the shared parameters with proper perturbation make partial personalized FL more suitable for decentralized training, where DFedSalt achieves most competitive performance.

Prompt Tuning based Adapter for Vision-Language Model Adaption

Large pre-trained vision-language (VL) models have shown significant promise in adapting to various downstream tasks. However, fine-tuning the entire network is challenging due to the massive number of model parameters. To address this issue, efficient adaptation methods such as prompt tuning have been proposed. We explore the idea of prompt tuning with multi-task pre-trained initialization and find it can significantly improve model performance. Based on our findings, we introduce a new model, termed Prompt-Adapter, that combines pre-trained prompt tunning with an efficient adaptation network. Our approach beat the state-of-the-art methods in few-shot image classification on the public 11 datasets, especially in settings with limited data instances such as 1 shot, 2 shots, 4 shots, and 8 shots images. Our proposed method demonstrates the promise of combining prompt tuning and parameter-efficient networks for efficient vision-language model adaptation. The code is publicly available at: https://github.com/Jingchensun/prompt_adapter.