Blend the Separated: Mixture of Synergistic Experts for Data-Scarcity Drug-Target Interaction Prediction

Drug-target interaction prediction (DTI) is essential in various applications including drug discovery and clinical application. There are two perspectives of input data widely used in DTI prediction: Intrinsic data represents how drugs or targets are constructed, and extrinsic data represents how drugs or targets are related to other biological entities. However, any of the two perspectives of input data can be scarce for some drugs or targets, especially for those unpopular or newly discovered. Furthermore, ground-truth labels for specific interaction types can also be scarce. Therefore, we propose the first method to tackle DTI prediction under input data and/or label scarcity. To make our model functional when only one perspective of input data is available, we design two separate experts to process intrinsic and extrinsic data respectively and fuse them adaptively according to different samples. Furthermore, to make the two perspectives complement each other and remedy label scarcity, two experts synergize with each other in a mutually supervised way to exploit the enormous unlabeled data. Extensive experiments on 3 real-world datasets under different extents of input data scarcity and/or label scarcity demonstrate our model outperforms states of the art significantly and steadily, with a maximum improvement of 53.53%. We also test our model without any data scarcity and it still outperforms current methods.

Oasis: One Image is All You Need for Multimodal Instruction Data Synthesis

The success of multi-modal large language models (MLLMs) has been largely attributed to the large-scale training data. However, the training data of many MLLMs is unavailable due to privacy concerns. The expensive and labor-intensive process of collecting multi-modal data further exacerbates the problem. Is it possible to synthesize multi-modal training data automatically without compromising diversity and quality? In this paper, we propose a new method, Oasis, to synthesize high-quality multi-modal data with only images. Oasis breaks through traditional methods by prompting only images to the MLLMs, thus extending the data diversity by a large margin. Our method features a delicate quality control method which ensures the data quality. We collected over 500k data and conducted incremental experiments on LLaVA-NeXT. Extensive experiments demonstrate that our method can significantly improve the performance of MLLMs. The image-based synthesis also allows us to focus on the specific-domain ability of MLLMs. Code and data will be publicly available.

Intrinsic and Extrinsic Factor Disentanglement for Recommendation in Various Context Scenarios

In recommender systems, the patterns of user behaviors (e.g., purchase, click) may vary greatly in different contexts (e.g., time and location). This is because user behavior is jointly determined by two types of factors: intrinsic factors, which reflect consistent user preference, and extrinsic factors, which reflect external incentives that may vary in different contexts. Differentiating between intrinsic and extrinsic factors helps learn user behaviors better. However, existing studies have only considered differentiating them from a single, pre-defined context (e.g., time or location), ignoring the fact that a user's extrinsic factors may be influenced by the interplay of various contexts at the same time. In this paper, we propose the Intrinsic-Extrinsic Disentangled Recommendation (IEDR) model, a generic framework that differentiates intrinsic from extrinsic factors considering various contexts simultaneously, enabling more accurate differentiation of factors and hence the improvement of recommendation accuracy. IEDR contains a context-invariant contrastive learning component to capture intrinsic factors, and a disentanglement component to extract extrinsic factors under the interplay of various contexts. The two components work together to achieve effective factor learning. Extensive experiments on real-world datasets demonstrate IEDR's effectiveness in learning disentangled factors and significantly improving recommendation accuracy by up to 4% in NDCG.

SrSv: Integrating Sequential Rollouts with Sequential Value Estimation for Multi-agent Reinforcement Learning

Although multi-agent reinforcement learning (MARL) has shown its success across diverse domains, extending its application to large-scale real-world systems still faces significant challenges. Primarily, the high complexity of real-world environments exacerbates the credit assignment problem, substantially reducing training efficiency. Moreover, the variability of agent populations in large-scale scenarios necessitates scalable decision-making mechanisms. To address these challenges, we propose a novel framework: Sequential rollout with Sequential value estimation (SrSv). This framework aims to capture agent interdependence and provide a scalable solution for cooperative MARL. Specifically, SrSv leverages the autoregressive property of the Transformer model to handle varying populations through sequential action rollout. Furthermore, to capture the interdependence of policy distributions and value functions among multiple agents, we introduce an innovative sequential value estimation methodology and integrates the value approximation into an attention-based sequential model. We evaluate SrSv on three benchmarks: Multi-Agent MuJoCo, StarCraft Multi-Agent Challenge, and DubinsCars. Experimental results demonstrate that SrSv significantly outperforms baseline methods in terms of training efficiency without compromising convergence performance. Moreover, when implemented in a large-scale DubinsCar system with 1,024 agents, our framework surpasses existing benchmarks, highlighting the excellent scalability of SrSv.

Judge as A Judge: Improving the Evaluation of Retrieval-Augmented Generation through the Judge-Consistency of Large Language Models

Retrieval-Augmented Generation (RAG) has proven its effectiveness in alleviating hallucinations for Large Language Models (LLMs). However, existing automated evaluation metrics cannot fairly evaluate the outputs generated by RAG models during training and evaluation. LLM-based judgment models provide the potential to produce high-quality judgments, but they are highly sensitive to evaluation prompts, leading to inconsistencies when judging the output of RAG models. This paper introduces the Judge-Consistency (ConsJudge) method, which aims to enhance LLMs to generate more accurate evaluations for RAG models. Specifically, ConsJudge prompts LLMs to generate different judgments based on various combinations of judgment dimensions, utilize the judge-consistency to evaluate these judgments and select the accepted and rejected judgments for DPO training. Our experiments show that ConsJudge can effectively provide more accurate judgments for optimizing RAG models across various RAG models and datasets. Further analysis reveals that judgments generated by ConsJudge have a high agreement with the superior LLM. All codes are available at https://github.com/OpenBMB/ConsJudge.

PathRAG: Pruning Graph-based Retrieval Augmented Generation with Relational Paths

Retrieval-augmented generation (RAG) improves the response quality of large language models (LLMs) by retrieving knowledge from external databases. Typical RAG approaches split the text database into chunks, organizing them in a flat structure for efficient searches. To better capture the inherent dependencies and structured relationships across the text database, researchers propose to organize textual information into an indexing graph, known asgraph-based RAG. However, we argue that the limitation of current graph-based RAG methods lies in the redundancy of the retrieved information, rather than its insufficiency. Moreover, previous methods use a flat structure to organize retrieved information within the prompts, leading to suboptimal performance. To overcome these limitations, we propose PathRAG, which retrieves key relational paths from the indexing graph, and converts these paths into textual form for prompting LLMs. Specifically, PathRAG effectively reduces redundant information with flow-based pruning, while guiding LLMs to generate more logical and coherent responses with path-based prompting. Experimental results show that PathRAG consistently outperforms state-of-the-art baselines across six datasets and five evaluation dimensions. The code is available at the following link: https://github.com/BUPT-GAMMA/PathRAG

Graph Foundation Models for Recommendation: A Comprehensive Survey

Recommender systems (RS) serve as a fundamental tool for navigating the vast expanse of online information, with deep learning advancements playing an increasingly important role in improving ranking accuracy. Among these, graph neural networks (GNNs) excel at extracting higher-order structural information, while large language models (LLMs) are designed to process and comprehend natural language, making both approaches highly effective and widely adopted. Recent research has focused on graph foundation models (GFMs), which integrate the strengths of GNNs and LLMs to model complex RS problems more efficiently by leveraging the graph-based structure of user-item relationships alongside textual understanding. In this survey, we provide a comprehensive overview of GFM-based RS technologies by introducing a clear taxonomy of current approaches, diving into methodological details, and highlighting key challenges and future directions. By synthesizing recent advancements, we aim to offer valuable insights into the evolving landscape of GFM-based recommender systems.

SymAgent: A Neural-Symbolic Self-Learning Agent Framework for Complex Reasoning over Knowledge Graphs

Recent advancements have highlighted that Large Language Models (LLMs) are prone to hallucinations when solving complex reasoning problems, leading to erroneous results. To tackle this issue, researchers incorporate Knowledge Graphs (KGs) to improve the reasoning ability of LLMs. However, existing methods face two limitations: 1) they typically assume that all answers to the questions are contained in KGs, neglecting the incompleteness issue of KGs, and 2) they treat the KG as a static repository and overlook the implicit logical reasoning structures inherent in KGs. In this paper, we introduce SymAgent, an innovative neural-symbolic agent framework that achieves collaborative augmentation between KGs and LLMs. We conceptualize KGs as dynamic environments and transform complex reasoning tasks into a multi-step interactive process, enabling KGs to participate deeply in the reasoning process. SymAgent consists of two modules: Agent-Planner and Agent-Executor. The Agent-Planner leverages LLM's inductive reasoning capability to extract symbolic rules from KGs, guiding efficient question decomposition. The Agent-Executor autonomously invokes predefined action tools to integrate information from KGs and external documents, addressing the issues of KG incompleteness. Furthermore, we design a self-learning framework comprising online exploration and offline iterative policy updating phases, enabling the agent to automatically synthesize reasoning trajectories and improve performance. Experimental results demonstrate that SymAgent with weak LLM backbones (i.e., 7B series) yields better or comparable performance compared to various strong baselines. Further analysis reveals that our agent can identify missing triples, facilitating automatic KG updates.

LLM2: Let Large Language Models Harness System 2 Reasoning

Large language models (LLMs) have exhibited impressive capabilities across a myriad of tasks, yet they occasionally yield undesirable outputs. We posit that these limitations are rooted in the foundational autoregressive architecture of LLMs, which inherently lacks mechanisms for differentiating between desirable and undesirable results. Drawing inspiration from the dual-process theory of human cognition, we introduce LLM2, a novel framework that combines an LLM (System 1) with a process-based verifier (System 2). Within LLM2, the LLM is responsible for generating plausible candidates, while the verifier provides timely process-based feedback to distinguish desirable and undesirable outputs. The verifier is trained with a pairwise comparison loss on synthetic process-supervision data generated through our token quality exploration strategy. Empirical results on mathematical reasoning benchmarks substantiate the efficacy of LLM2, exemplified by an accuracy enhancement from 50.3 to 57.8 (+7.5) for Llama3-1B on GSM8K. Furthermore, when combined with self-consistency, LLM2 achieves additional improvements, boosting major@20 accuracy from 56.2 to 70.2 (+14.0).

Invariant debiasing learning for recommendation via biased imputation

Previous debiasing studies utilize unbiased data to make supervision of model training. They suffer from the high trial risks and experimental costs to obtain unbiased data. Recent research attempts to use invariant learning to detach the invariant preference of users for unbiased recommendations in an unsupervised way. However, it faces the drawbacks of low model accuracy and unstable prediction performance due to the losing cooperation with variant preference. In this paper, we experimentally demonstrate that invariant learning causes information loss by directly discarding the variant information, which reduces the generalization ability and results in the degradation of model performance in unbiased recommendations. Based on this consideration, we propose a novel lightweight knowledge distillation framework (KDDebias) to automatically learn the unbiased preference of users from both invariant and variant information. Specifically, the variant information is imputed to the invariant user preference in the distance-aware knowledge distillation process. Extensive experiments on three public datasets, i.e., Yahoo!R3, Coat, and MIND, show that with the biased imputation from the variant preference of users, our proposed method achieves significant improvements with less than 50% learning parameters compared to the SOTA unsupervised debiasing model in recommender systems. Our code are publicly available at https://github.com/BAI-LAB/KD-Debias.