BS-LDM: Effective Bone Suppression in High-Resolution Chest X-Ray Images with Conditional Latent Diffusion Models

The interference of overlapping bones and pulmonary structures can reduce the effectiveness of Chest X-ray (CXR) examinations. Bone suppression techniques have been developed to improve diagnostic accuracy. Dual-energy subtraction (DES) imaging, a common method for bone suppression, is costly and exposes patients to higher radiation levels. Deep learning-based image generation methods have been proposed as alternatives, however, they often fail to produce high-quality and high-resolution images, resulting in the loss of critical lesion information and texture details. To address these issues, in this paper, we introduce an end-to-end framework for bone suppression in high-resolution CXR images, termed BS-LDM. This framework employs a conditional latent diffusion model to generate high-resolution soft tissue images with fine detail and critical lung pathology by performing bone suppression in the latent space. We implement offset noise during the noise addition phase of the training process to better render low-frequency information in soft tissue images. Additionally, we introduce a dynamic clipping strategy during the sampling process to refine pixel intensity in the generated soft tissue images. We compiled a substantial and high-quality bone suppression dataset, SZCH-X-Rays, including high-resolution paired CXR and DES soft tissue images from 818 patients, collected from our partner hospitals. Moreover, we pre-processed 241 pairs of CXR and DES soft tissue images from the JSRT dataset, the largest publicly available dataset. Comprehensive experimental and clinical evaluations demonstrate that BS-LDM exhibits superior bone suppression capabilities, highlighting its significant clinical potential.

ICH-SCNet: Intracerebral Hemorrhage Segmentation and Prognosis Classification Network Using CLIP-guided SAM mechanism

Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke and is characterized by a high incidence of disability. Accurate segmentation of the ICH region and prognosis prediction are critically important for developing and refining treatment plans for post-ICH patients. However, existing approaches address these two tasks independently and predominantly focus on imaging data alone, thereby neglecting the intrinsic correlation between the tasks and modalities. This paper introduces a multi-task network, ICH-SCNet, designed for both ICH segmentation and prognosis classification. Specifically, we integrate a SAM-CLIP cross-modal interaction mechanism that combines medical text and segmentation auxiliary information with neuroimaging data to enhance cross-modal feature recognition. Additionally, we develop an effective feature fusion module and a multi-task loss function to improve performance further. Extensive experiments on an ICH dataset reveal that our approach surpasses other state-of-the-art methods. It excels in the overall performance of classification tasks and outperforms competing models in all segmentation task metrics.

LPUWF-LDM: Enhanced Latent Diffusion Model for Precise Late-phase UWF-FA Generation on Limited Dataset

Ultra-Wide-Field Fluorescein Angiography (UWF-FA) enables precise identification of ocular diseases using sodium fluorescein, which can be potentially harmful. Existing research has developed methods to generate UWF-FA from Ultra-Wide-Field Scanning Laser Ophthalmoscopy (UWF-SLO) to reduce the adverse reactions associated with injections. However, these methods have been less effective in producing high-quality late-phase UWF-FA, particularly in lesion areas and fine details. Two primary challenges hinder the generation of high-quality late-phase UWF-FA: the scarcity of paired UWF-SLO and early/late-phase UWF-FA datasets, and the need for realistic generation at lesion sites and potential blood leakage regions. This study introduces an improved latent diffusion model framework to generate high-quality late-phase UWF-FA from limited paired UWF images. To address the challenges as mentioned earlier, our approach employs a module utilizing Cross-temporal Regional Difference Loss, which encourages the model to focus on the differences between early and late phases. Additionally, we introduce a low-frequency enhanced noise strategy in the diffusion forward process to improve the realism of medical images. To further enhance the mapping capability of the variational autoencoder module, especially with limited datasets, we implement a Gated Convolutional Encoder to extract additional information from conditional images. Our Latent Diffusion Model for Ultra-Wide-Field Late-Phase Fluorescein Angiography (LPUWF-LDM) effectively reconstructs fine details in late-phase UWF-FA and achieves state-of-the-art results compared to other existing methods when working with limited datasets. Our source code is available at: https://github.com/Tinysqua/****.

TC-KANRecon: High-Quality and Accelerated MRI Reconstruction via Adaptive KAN Mechanisms and Intelligent Feature Scaling

Magnetic Resonance Imaging (MRI) has become essential in clinical diagnosis due to its high resolution and multiple contrast mechanisms. However, the relatively long acquisition time limits its broader application. To address this issue, this study presents an innovative conditional guided diffusion model, named as TC-KANRecon, which incorporates the Multi-Free U-KAN (MF-UKAN) module and a dynamic clipping strategy. TC-KANRecon model aims to accelerate the MRI reconstruction process through deep learning methods while maintaining the quality of the reconstructed images. The MF-UKAN module can effectively balance the tradeoff between image denoising and structure preservation. Specifically, it presents the multi-head attention mechanisms and scalar modulation factors, which significantly enhances the model's robustness and structure preservation capabilities in complex noise environments. Moreover, the dynamic clipping strategy in TC-KANRecon adjusts the cropping interval according to the sampling steps, thereby mitigating image detail loss typically caused by traditional cropping methods and enriching the visual features of the images. Furthermore, the MC-Model module incorporates full-sampling k-space information, realizing efficient fusion of conditional information, enhancing the model's ability to process complex data, and improving the realism and detail richness of reconstructed images. Experimental results demonstrate that the proposed method outperforms other MRI reconstruction methods in both qualitative and quantitative evaluations. Notably, TC-KANRecon method exhibits excellent reconstruction results when processing high-noise, low-sampling-rate MRI data. Our source code is available at https://github.com/lcbkmm/TC-KANRecon.

UWAFA-GAN: Ultra-Wide-Angle Fluorescein Angiography Transformation via Multi-scale Generation and Registration Enhancement

Fundus photography, in combination with the ultra-wide-angle fundus (UWF) techniques, becomes an indispensable diagnostic tool in clinical settings by offering a more comprehensive view of the retina. Nonetheless, UWF fluorescein angiography (UWF-FA) necessitates the administration of a fluorescent dye via injection into the patient's hand or elbow unlike UWF scanning laser ophthalmoscopy (UWF-SLO). To mitigate potential adverse effects associated with injections, researchers have proposed the development of cross-modality medical image generation algorithms capable of converting UWF-SLO images into their UWF-FA counterparts. Current image generation techniques applied to fundus photography encounter difficulties in producing high-resolution retinal images, particularly in capturing minute vascular lesions. To address these issues, we introduce a novel conditional generative adversarial network (UWAFA-GAN) to synthesize UWF-FA from UWF-SLO. This approach employs multi-scale generators and an attention transmit module to efficiently extract both global structures and local lesions. Additionally, to counteract the image blurriness issue that arises from training with misaligned data, a registration module is integrated within this framework. Our method performs non-trivially on inception scores and details generation. Clinical user studies further indicate that the UWF-FA images generated by UWAFA-GAN are clinically comparable to authentic images in terms of diagnostic reliability. Empirical evaluations on our proprietary UWF image datasets elucidate that UWAFA-GAN outperforms extant methodologies. The code is accessible at https://github.com/Tinysqua/UWAFA-GAN.

VQ-NeRV: A Vector Quantized Neural Representation for Videos

Implicit neural representations (INR) excel in encoding videos within neural networks, showcasing promise in computer vision tasks like video compression and denoising. INR-based approaches reconstruct video frames from content-agnostic embeddings, which hampers their efficacy in video frame regression and restricts their generalization ability for video interpolation. To address these deficiencies, Hybrid Neural Representation for Videos (HNeRV) was introduced with content-adaptive embeddings. Nevertheless, HNeRV's compression ratios remain relatively low, attributable to an oversight in leveraging the network's shallow features and inter-frame residual information. In this work, we introduce an advanced U-shaped architecture, Vector Quantized-NeRV (VQ-NeRV), which integrates a novel component--the VQ-NeRV Block. This block incorporates a codebook mechanism to discretize the network's shallow residual features and inter-frame residual information effectively. This approach proves particularly advantageous in video compression, as it results in smaller size compared to quantized features. Furthermore, we introduce an original codebook optimization technique, termed shallow codebook optimization, designed to refine the utility and efficiency of the codebook. The experimental evaluations indicate that VQ-NeRV outperforms HNeRV on video regression tasks, delivering superior reconstruction quality (with an increase of 1-2 dB in Peak Signal-to-Noise Ratio (PSNR)), better bit per pixel (bpp) efficiency, and improved video inpainting outcomes.

PE-MVCNet: Multi-view and Cross-modal Fusion Network for Pulmonary Embolism Prediction

The early detection of a pulmonary embolism (PE) is critical for enhancing patient survival rates. Both image-based and non-image-based features are of utmost importance in medical classification tasks. In a clinical setting, physicians tend to rely on the contextual information provided by Electronic Medical Records (EMR) to interpret medical imaging. However, very few models effectively integrate clinical information with imaging data. To address this shortcoming, we suggest a multimodal fusion methodology, termed PE-MVCNet, which capitalizes on Computed Tomography Pulmonary Angiography imaging and EMR data. This method comprises the Image-only module with an integrated multi-view block, the EMR-only module, and the Cross-modal Attention Fusion (CMAF) module. These modules cooperate to extract comprehensive features that subsequently generate predictions for PE. We conducted experiments using the publicly accessible Stanford University Medical Center dataset, achieving an AUROC of 94.1%, an accuracy rate of 90.2%, and an F1 score of 90.6%. Our proposed model outperforms existing methodologies, corroborating that our multimodal fusion model excels compared to models that use a single data modality. Our source code is available at https://github.com/LeavingStarW/PE-MVCNET.

TC-DiffRecon: Texture coordination MRI reconstruction method based on diffusion model and modified MF-UNet method

Recently, diffusion models have gained significant attention as a novel set of deep learning-based generative methods. These models attempt to sample data from a Gaussian distribution that adheres to a target distribution, and have been successfully adapted to the reconstruction of MRI data. However, as an unconditional generative model, the diffusion model typically disrupts image coordination because of the consistent projection of data introduced by conditional bootstrap. This often results in image fragmentation and incoherence. Furthermore, the inherent limitations of the diffusion model often lead to excessive smoothing of the generated images. In the same vein, some deep learning-based models often suffer from poor generalization performance, meaning their effectiveness is greatly affected by different acceleration factors. To address these challenges, we propose a novel diffusion model-based MRI reconstruction method, named TC-DiffRecon, which does not rely on a specific acceleration factor for training. We also suggest the incorporation of the MF-UNet module, designed to enhance the quality of MRI images generated by the model while mitigating the over-smoothing issue to a certain extent. During the image generation sampling process, we employ a novel TCKG module and a Coarse-to-Fine sampling scheme. These additions aim to harmonize image texture, expedite the sampling process, while achieving data consistency. Our source code is available at https://github.com/JustlfC03/TC-DiffRecon.

ICHPro: Intracerebral Hemorrhage Prognosis Classification Via Joint-attention Fusion-based 3d Cross-modal Network

Intracerebral Hemorrhage (ICH) is the deadliest subtype of stroke, necessitating timely and accurate prognostic evaluation to reduce mortality and disability. However, the multi-factorial nature and complexity of ICH make methods based solely on computed tomography (CT) image features inadequate. Despite the capacity of cross-modal networks to fuse additional information, the effective combination of different modal features remains a significant challenge. In this study, we propose a joint-attention fusion-based 3D cross-modal network termed ICHPro that simulates the ICH prognosis interpretation process utilized by neurosurgeons. ICHPro includes a joint-attention fusion module to fuse features from CT images with demographic and clinical textual data. To enhance the representation of cross-modal features, we introduce a joint loss function. ICHPro facilitates the extraction of richer cross-modal features, thereby improving classification performance. Upon testing our method using a five-fold cross-validation, we achieved an accuracy of 89.11%, an F1 score of 0.8767, and an AUC value of 0.9429. These results outperform those obtained from other advanced methods based on the test dataset, thereby demonstrating the superior efficacy of ICHPro. The code is available at our Github: https://github.com/YU-deep/ICH.

LKFormer: Large Kernel Transformer for Infrared Image Super-Resolution

Given the broad application of infrared technology across diverse fields, there is an increasing emphasis on investigating super-resolution techniques for infrared images within the realm of deep learning. Despite the impressive results of current Transformer-based methods in image super-resolution tasks, their reliance on the self-attentive mechanism intrinsic to the Transformer architecture results in images being treated as one-dimensional sequences, thereby neglecting their inherent two-dimensional structure. Moreover, infrared images exhibit a uniform pixel distribution and a limited gradient range, posing challenges for the model to capture effective feature information. Consequently, we suggest a potent Transformer model, termed Large Kernel Transformer (LKFormer), to address this issue. Specifically, we have designed a Large Kernel Residual Attention (LKRA) module with linear complexity. This mainly employs depth-wise convolution with large kernels to execute non-local feature modeling, thereby substituting the standard self-attentive layer. Additionally, we have devised a novel feed-forward network structure called Gated-Pixel Feed-Forward Network (GPFN) to augment the LKFormer's capacity to manage the information flow within the network. Comprehensive experimental results reveal that our method surpasses the most advanced techniques available, using fewer parameters and yielding considerably superior performance.The source code will be available at https://github.com/sad192/large-kernel-Transformer.