VLM- and LLM-Driven Multi-Agent System for PET Image Denoising

Positron emission tomography (PET) imaging suffers from limited spatial resolution and low signal-to-noise ratio, which can compromise quantitative accuracy and lesion detectability. Deep learning-based denoising methods have demonstrated strong potential for improving PET image quality. However, their practical deployment in real-world settings remains challenging, often requiring multiple specialized models and expert interventions, such as identifying motion-induced misregistration artifacts, estimating noise levels to select an appropriate denoiser, and performing lesion-focused quantitative assessment after denoising. Recent advances in vision-language models (VLMs) for image quality understanding and large language models (LLMs) for contextual reasoning provide new opportunities for automated, decision-driven workflows. Inspired by expert workflows for PET image quality enhancement, we propose an VLM- and LLM-driven multi-agent PET denoising framework that dynamically assesses image quality and lesion status, autonomously selects optimal denoising models and parameters, and enables closed-loop feedback with rollback mechanisms. Experiments were conducted on Siemens Biograph Vision Quadra PET/CT data with 1/20 and 1/50 low-dose settings. Individual module evaluations demonstrated the reliability of the agentic components, while the complete framework achieved higher PSNR and SSIM than UNet, GAN, and DDPM baselines at both dose levels. These preliminary results demonstrate the feasibility of using a closed-loop multi-agent framework to adapt PET denoising strategies to different image conditions.

Decompose and Reorganize: Planning with Primitives and Visuomotor Policies Learned from Demonstrations

Successfully automating dexterous, long-horizon robotic manipulation requires frameworks capable of both high-level reasoning and fine-grained execution. Traditional task and motion planning (TAMP), while excellent at symbolic planning, is often brittle in contact-rich operations. Simultaneously, imitation learning (IL), while effective in manipulation tasks with visual feedback, is limited by its low capability in spatial generalization and multi-stage operation. To reconcile their complementary strengths and limitations, we propose DR-LfD (Decomposed and Reorganized Skills Learned from Demonstrations), a framework that seamlessly integrates visuomotor policies into a TAMP-gated decision-making system. Based on contact relationships, DR-LfD decomposes human demonstrations into atomic skills, which are reproduced as visuomotor policies or object-centric primitives. The initiation, termination, and constraints of the visuomotor policies are carefully modeled and implemented in a TAMP-compatible form, enabling reorganization of skills learned from different sources. DR-LfD transforms the learning problem from one requiring exponential demonstration data over possible skill sequences to one whose demonstration burden scales with the number of distinct skill types, with limited data for each skill. Through comprehensive real-world and simulation benchmarking across diverse scenarios, we demonstrate the strong performance of DR-LfD on tasks involving multiple steps, unseen setups, and physical constraints. Project website: https://dr-lfd.github.io/DR-LfD-website.

Rethinking Scientific Discovery in the Agentic Era

Artificial intelligence has advanced scientific discovery, but most AI4Science systems remain fragmented tools that rely on humans to coordinate problem formulation, literature grounding, model use, simulation, validation, and knowledge reuse. This paper presents \textbf{SCION (Scientific Collaborative Innovation with Agentic Organizational Nexus)}, an agentic scientific operating system that acts as an \textbf{organizational nexus}. Through a Science Agent serving as a \textbf{Meta-Harness}, SCION connects scientific tasks, tools, agents, artifacts, and memory, transforming research into an executable, auditable, and reusable operational process. At its core is the \textbf{Research Execution Plan (REP)}, which compiles high-level scientific intent into staged objectives, dependencies, verification checkpoints, tool requirements, expected artifacts, and fallback conditions. SCION further integrates hierarchical multi-agent execution, profile-driven specialization, selective context construction, governed delegation, and layered epistemic memory to support long-horizon scientific work. We formulate discovery under SCION as \textbf{Target-conditioned Inverse Search} and extend it to hidden-target settings through batch active search under finite experimental budgets. Applications in materials analysis, molecule design, and protein or antibody screening, together with experiments on scientific reading, idea generation, molecule generation, and antibody screening, show that SCION outperforms existing autonomous research-agent baselines, especially in decomposition, verification, refinement, and memory reuse. Overall, SCION shifts AI from isolated tools toward a coordinated operational layer for traceable and reusable scientific innovation.

Rethinking Scientific Discovery in an Agentic Era

Artificial intelligence has advanced scientific discovery, but most AI4Science systems remain fragmented tools that rely on humans to coordinate problem formulation, literature grounding, model use, simulation, validation, and knowledge reuse. This paper presents \textbf{SCION (Scientific Collaborative Innovation with Agentic Organizational Nexus)}, an agentic scientific operating system that acts as an \textbf{organizational nexus}. Through a Science Agent serving as a \textbf{Meta-Harness}, SCION connects scientific tasks, tools, agents, artifacts, and memory, transforming research into an executable, auditable, and reusable operational process. At its core is the \textbf{Research Execution Plan (REP)}, which compiles high-level scientific intent into staged objectives, dependencies, verification checkpoints, tool requirements, expected artifacts, and fallback conditions. SCION further integrates hierarchical multi-agent execution, profile-driven specialization, selective context construction, governed delegation, and layered epistemic memory to support long-horizon scientific work. We formulate discovery under SCION as \textbf{Target-conditioned Inverse Search} and extend it to hidden-target settings through batch active search under finite experimental budgets. Applications in materials analysis, molecule design, and protein or antibody screening, together with experiments on scientific reading, idea generation, molecule generation, and antibody screening, show that SCION outperforms existing autonomous research-agent baselines, especially in decomposition, verification, refinement, and memory reuse. Overall, SCION shifts AI from isolated tools toward a coordinated operational layer for traceable and reusable scientific innovation.

Keypose Exploration: Efficient Automatic Trajectory Labelling and Cross-Embodiment Policy Transfer

Keypose-based manipulation decomposes tasks into critical waypoints to simplify policy learning for long-horizon tasks, but existing approaches rely on task-specific heuristics or manual annotation to extract keyposes from demonstrations. We present an automatic trajectory labelling pipeline for grasp-related tasks. This pipeline combines vision-language models (VLMs) for semantic event detection with classical trajectory analysis for precise temporal alignment, requiring VLM inference only on one single demo among repeating ones per task. Using the labelled data, we train a keypose-guided Diffusion Policy (DP) that exploits keypose conditioning to intervene demonstration distributions. We explore the possibility to apply this property for cross-embodiment transfer: candidate keyposes are sampled and filtered via a reachability map, steering the policy toward kinematically feasible keyposes for the target robot. As a preliminary feasibility study, experiments on two robomimic tasks show that the labelled data produces policies matching a standard DP baseline, and that reachability-filtered keypose conditioning may benefit zero-shot transfer on the multimodal insertion task when feasible candidates are available.

Semantically Structured Mixture-of-Experts for Compositional Robotic Manipulation

Diffusion-based policies have established a new standard for precise robotic manipulation but face a critical scalability bottleneck: high-performance models are computationally expensive, while lightweight alternatives often fail to generalize across diverse multi-task environments. Mixture-of-Experts (MoE) architectures offer a promising path to efficiency by activating only a subset of parameters. However, existing MoE routing mechanisms typically rely on low-level noise or latent statistics, ignoring the compositional nature of manipulation tasks. This can fragment reusable behaviors across experts, limiting interpretability and transferability. We introduce Semantically Structured Mixture-of-Experts Diffusion Policy (SMoDP) for compositional robotic manipulation, a framework that grounds expert specialization in semantic task structure. SMoDP leverages a lightweight, inference-time skill predictor, supervised by offline annotations from Vision-Language Models (VLMs), to route action chunks to experts specialized for specific behavioral phases. To ensure robust assignment, we propose a dual contrastive alignment strategy that grounds multi-modal observations in language-defined skill semantics (Inter-modal) while enforcing routing consistency across visually distinct but functionally related behaviors (Intra-modal). Our approach outperforms representative diffusion and MoE-based baselines on multi-task benchmarks with significantly improved parameter efficiency and demonstrates effective compositional transfer to novel tasks through parameter-efficient fine-tuning. Project website: https://deng-cy20.github.io/SMoDP/

HumanSplatHMR: Closing the Loop Between Human Mesh Recovery and Gaussian Splatting Avatar

Accurately recovering human pose and appearance from video is an essential component of scene reconstruction, with applications to motion capture, motion prediction, virtual reality, and digital twinning. Despite significant interest in building realistic human avatars from video, this paper demonstrates that existing methods do not accurately recover the 3D geometry of humans. ViT-based approaches are not consistently reliable and can overfit to 2D views, while NeRF- and Gaussian Splatting-based avatars treat pose and appearance separately, limiting rendering generalization to new poses. To resolve these shortcomings, this paper proposes HumanSplatHMR, a joint optimization framework that refines 3D human poses while simultaneously learning a high-fidelity avatar for novel-view and novel-pose synthesis. Our key insight is to close the loop between geometric pose estimation and differentiable rendering. Unlike prior human avatar methods that rely on accurate human pose obtained through motion capture systems or offline refinement, which are impractical in in-the-wild scenarios, our approach uses only human mesh estimates from a state-of-the-art human pose estimator to better reflect real-world conditions. Therefore, instead of using the human pose only as a deformation prior, HumanSplatHMR backpropagates photometric, segmentation, and depth losses through a differentiable renderer to the pose parameters and global position. This coupling refines the global 3D pose over time, improving accuracy and alignment while producing better renderings from novel views. Experiments show consistent improvements over pose recovery baselines that omit image-level refinement and avatar baselines that decouple pose estimation from avatar reconstruction.

TrackDeform3D: Markerless and Autonomous 3D Keypoint Tracking and Dataset Collection for Deformable Objects

Structured 3D representations such as keypoints and meshes offer compact, expressive descriptions of deformable objects, jointly capturing geometric and topological information useful for downstream tasks such as dynamics modeling and motion planning. However, robustly extracting such representations remains challenging, as current perception methods struggle to handle complex deformations. Moreover, large-scale 3D data collection remains a bottleneck: existing approaches either require prohibitive data collection efforts, such as labor-intensive annotation or expensive motion capture setups, or rely on simplifying assumptions that break down in unstructured environments. As a result, large-scale 3D datasets and benchmarks for deformable objects remain scarce. To address these challenges, this paper presents an affordable and autonomous framework for collecting 3D datasets of deformable objects using only RGB-D cameras. The proposed method identifies 3D keypoints and robustly tracks their trajectories, incorporating motion consistency constraints to produce temporally smooth and geometrically coherent data. TrackDeform3D is evaluated against several state-of-the-art tracking methods across diverse object categories and demonstrates consistent improvements in both geometric and tracking accuracy. Using this framework, this paper presents a high-quality, large-scale dataset consisting of 6 deformable objects, totaling 110 minutes of trajectory data.

TheraAgent: Multi-Agent Framework with Self-Evolving Memory and Evidence-Calibrated Reasoning for PET Theranostics

PET theranostics is transforming precision oncology, yet treatment response varies substantially; many patients receiving 177Lu-PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) fail to respond, demanding reliable pre-therapy prediction. While LLM-based agents have shown remarkable potential in complex medical diagnosis, their application to PET theranostic outcome prediction remains unexplored, which faces three key challenges: (1) data and knowledge scarcity: RLT was only FDA-approved in 2022, yielding few training cases and insufficient domain knowledge in general LLMs; (2) heterogeneous information integration: robust prediction hinges on structured knowledge extraction from PET/CT, laboratory tests, and free-text clinical documentation; (3) evidence-grounded reasoning: clinical decisions must be anchored in trial evidence rather than LLM hallucinations. In this paper, we present TheraAgent, to our knowledge, the first agentic framework for PET theranostics, with three core innovations: (1) Multi-Expert Feature Extraction with Confidence-Weighted Consensus, where three specialized experts process heterogeneous inputs with uncertainty quantification; (2) Self-Evolving Agentic Memory (SEA-Mem), which learns prognostic patterns from accumulated cases, enabling case-based reasoning from limited data; (3) Evidence-Calibrated Reasoning, integrating a curated theranostics knowledge base to ground predictions in VISION/TheraP trial evidence. Evaluated on 35 real patients and 400 synthetic cases, TheraAgent achieves 75.7% overall accuracy on real patients and 87.0% on synthetic cases, outperforming MDAgents and MedAgent-Pro by over 20%. These results highlight a promising blueprint for trustworthy AI agents in PET theranostics, enabling trial-calibrated, multi-source decision support. Code will be released upon acceptance.

Learning Unified Distance Metric for Heterogeneous Attribute Data Clustering

Datasets composed of numerical and categorical attributes (also called mixed data hereinafter) are common in real clustering tasks. Differing from numerical attributes that indicate tendencies between two concepts (e.g., high and low temperature) with their values in well-defined Euclidean distance space, categorical attribute values are different concepts (e.g., different occupations) embedded in an implicit space. Simultaneously exploiting these two very different types of information is an unavoidable but challenging problem, and most advanced attempts either encode the heterogeneous numerical and categorical attributes into one type, or define a unified metric for them for mixed data clustering, leaving their inherent connection unrevealed. This paper, therefore, studies the connection among any-type of attributes and proposes a novel Heterogeneous Attribute Reconstruction and Representation (HARR) learning paradigm accordingly for cluster analysis. The paradigm transforms heterogeneous attributes into a homogeneous status for distance metric learning, and integrates the learning with clustering to automatically adapt the metric to different clustering tasks. Differing from most existing works that directly adopt defined distance metrics or learn attribute weights to search clusters in a subspace. We propose to project the values of each attribute into unified learnable multiple spaces to more finely represent and learn the distance metric for categorical data. HARR is parameter-free, convergence-guaranteed, and can more effectively self-adapt to different sought number of clusters $k$. Extensive experiments illustrate its superiority in terms of accuracy and efficiency.