VidTok: A Versatile and Open-Source Video Tokenizer

Encoding video content into compact latent tokens has become a fundamental step in video generation and understanding, driven by the need to address the inherent redundancy in pixel-level representations. Consequently, there is a growing demand for high-performance, open-source video tokenizers as video-centric research gains prominence. We introduce VidTok, a versatile video tokenizer that delivers state-of-the-art performance in both continuous and discrete tokenizations. VidTok incorporates several key advancements over existing approaches: 1) model architecture such as convolutional layers and up/downsampling modules; 2) to address the training instability and codebook collapse commonly associated with conventional Vector Quantization (VQ), we integrate Finite Scalar Quantization (FSQ) into discrete video tokenization; 3) improved training strategies, including a two-stage training process and the use of reduced frame rates. By integrating these advancements, VidTok achieves substantial improvements over existing methods, demonstrating superior performance across multiple metrics, including PSNR, SSIM, LPIPS, and FVD, under standardized evaluation settings.

InvDiff: Invariant Guidance for Bias Mitigation in Diffusion Models

As one of the most successful generative models, diffusion models have demonstrated remarkable efficacy in synthesizing high-quality images. These models learn the underlying high-dimensional data distribution in an unsupervised manner. Despite their success, diffusion models are highly data-driven and prone to inheriting the imbalances and biases present in real-world data. Some studies have attempted to address these issues by designing text prompts for known biases or using bias labels to construct unbiased data. While these methods have shown improved results, real-world scenarios often contain various unknown biases, and obtaining bias labels is particularly challenging. In this paper, we emphasize the necessity of mitigating bias in pre-trained diffusion models without relying on auxiliary bias annotations. To tackle this problem, we propose a framework, InvDiff, which aims to learn invariant semantic information for diffusion guidance. Specifically, we propose identifying underlying biases in the training data and designing a novel debiasing training objective. Then, we employ a lightweight trainable module that automatically preserves invariant semantic information and uses it to guide the diffusion model's sampling process toward unbiased outcomes simultaneously. Notably, we only need to learn a small number of parameters in the lightweight learnable module without altering the pre-trained diffusion model. Furthermore, we provide a theoretical guarantee that the implementation of InvDiff is equivalent to reducing the error upper bound of generalization. Extensive experimental results on three publicly available benchmarks demonstrate that InvDiff effectively reduces biases while maintaining the quality of image generation. Our code is available at https://github.com/Hundredl/InvDiff.

BPQP: A Differentiable Convex Optimization Framework for Efficient End-to-End Learning

Data-driven decision-making processes increasingly utilize end-to-end learnable deep neural networks to render final decisions. Sometimes, the output of the forward functions in certain layers is determined by the solutions to mathematical optimization problems, leading to the emergence of differentiable optimization layers that permit gradient back-propagation. However, real-world scenarios often involve large-scale datasets and numerous constraints, presenting significant challenges. Current methods for differentiating optimization problems typically rely on implicit differentiation, which necessitates costly computations on the Jacobian matrices, resulting in low efficiency. In this paper, we introduce BPQP, a differentiable convex optimization framework designed for efficient end-to-end learning. To enhance efficiency, we reformulate the backward pass as a simplified and decoupled quadratic programming problem by leveraging the structural properties of the KKT matrix. This reformulation enables the use of first-order optimization algorithms in calculating the backward pass gradients, allowing our framework to potentially utilize any state-of-the-art solver. As solver technologies evolve, BPQP can continuously adapt and improve its efficiency. Extensive experiments on both simulated and real-world datasets demonstrate that BPQP achieves a significant improvement in efficiency--typically an order of magnitude faster in overall execution time compared to other differentiable optimization layers. Our results not only highlight the efficiency gains of BPQP but also underscore its superiority over differentiable optimization layer baselines.

Identifying and Decomposing Compound Ingredients in Meal Plans Using Large Language Models

This study explores the effectiveness of Large Language Models in meal planning, focusing on their ability to identify and decompose compound ingredients. We evaluated three models-GPT-4o, Llama-3 (70b), and Mixtral (8x7b)-to assess their proficiency in recognizing and breaking down complex ingredient combinations. Preliminary results indicate that while Llama-3 (70b) and GPT-4o excels in accurate decomposition, all models encounter difficulties with identifying essential elements like seasonings and oils. Despite strong overall performance, variations in accuracy and completeness were observed across models. These findings underscore LLMs' potential to enhance personalized nutrition but highlight the need for further refinement in ingredient decomposition. Future research should address these limitations to improve nutritional recommendations and health outcomes.

ElasTST: Towards Robust Varied-Horizon Forecasting with Elastic Time-Series Transformer

Numerous industrial sectors necessitate models capable of providing robust forecasts across various horizons. Despite the recent strides in crafting specific architectures for time-series forecasting and developing pre-trained universal models, a comprehensive examination of their capability in accommodating varied-horizon forecasting during inference is still lacking. This paper bridges this gap through the design and evaluation of the Elastic Time-Series Transformer (ElasTST). The ElasTST model incorporates a non-autoregressive design with placeholders and structured self-attention masks, warranting future outputs that are invariant to adjustments in inference horizons. A tunable version of rotary position embedding is also integrated into ElasTST to capture time-series-specific periods and enhance adaptability to different horizons. Additionally, ElasTST employs a multi-scale patch design, effectively integrating both fine-grained and coarse-grained information. During the training phase, ElasTST uses a horizon reweighting strategy that approximates the effect of random sampling across multiple horizons with a single fixed horizon setting. Through comprehensive experiments and comparisons with state-of-the-art time-series architectures and contemporary foundation models, we demonstrate the efficacy of ElasTST's unique design elements. Our findings position ElasTST as a robust solution for the practical necessity of varied-horizon forecasting.

Pre-trained Molecular Language Models with Random Functional Group Masking

Recent advancements in computational chemistry have leveraged the power of trans-former-based language models, such as MoLFormer, pre-trained using a vast amount of simplified molecular-input line-entry system (SMILES) sequences, to understand and predict molecular properties and activities, a critical step in fields like drug discovery and materials science. To further improve performance, researchers have introduced graph neural networks with graph-based molecular representations, such as GEM, incorporating the topology, geometry, 2D or even 3D structures of molecules into pre-training. While most of molecular graphs in existing studies were automatically converted from SMILES sequences, it is to assume that transformer-based language models might be able to implicitly learn structure-aware representations from SMILES sequences. In this paper, we propose \ours{} -- a SMILES-based \underline{\em M}olecular \underline{\em L}anguage \underline{\em M}odel, which randomly masking SMILES subsequences corresponding to specific molecular \underline{\em F}unctional \underline{\em G}roups to incorporate structure information of atoms during the pre-training phase. This technique aims to compel the model to better infer molecular structures and properties, thus enhancing its predictive capabilities. Extensive experimental evaluations across 11 benchmark classification and regression tasks in the chemical domain demonstrate the robustness and superiority of \ours{}. Our findings reveal that \ours{} outperforms existing pre-training models, either based on SMILES or graphs, in 9 out of the 11 downstream tasks, ranking as a close second in the remaining ones.

Generative AI in Health Economics and Outcomes Research: A Taxonomy of Key Definitions and Emerging Applications, an ISPOR Working Group Report

Objective: This article offers a taxonomy of generative artificial intelligence (AI) for health economics and outcomes research (HEOR), explores its emerging applications, and outlines methods to enhance the accuracy and reliability of AI-generated outputs. Methods: The review defines foundational generative AI concepts and highlights current HEOR applications, including systematic literature reviews, health economic modeling, real-world evidence generation, and dossier development. Approaches such as prompt engineering (zero-shot, few-shot, chain-of-thought, persona pattern prompting), retrieval-augmented generation, model fine-tuning, and the use of domain-specific models are introduced to improve AI accuracy and reliability. Results: Generative AI shows significant potential in HEOR, enhancing efficiency, productivity, and offering novel solutions to complex challenges. Foundation models are promising in automating complex tasks, though challenges remain in scientific reliability, bias, interpretability, and workflow integration. The article discusses strategies to improve the accuracy of these AI tools. Conclusion: Generative AI could transform HEOR by increasing efficiency and accuracy across various applications. However, its full potential can only be realized by building HEOR expertise and addressing the limitations of current AI technologies. As AI evolves, ongoing research and innovation will shape its future role in the field.

C-MORL: Multi-Objective Reinforcement Learning through Efficient Discovery of Pareto Front

Multi-objective reinforcement learning (MORL) excels at handling rapidly changing preferences in tasks that involve multiple criteria, even for unseen preferences. However, previous dominating MORL methods typically generate a fixed policy set or preference-conditioned policy through multiple training iterations exclusively for sampled preference vectors, and cannot ensure the efficient discovery of the Pareto front. Furthermore, integrating preferences into the input of policy or value functions presents scalability challenges, in particular as the dimension of the state and preference space grow, which can complicate the learning process and hinder the algorithm's performance on more complex tasks. To address these issues, we propose a two-stage Pareto front discovery algorithm called Constrained MORL (C-MORL), which serves as a seamless bridge between constrained policy optimization and MORL. Concretely, a set of policies is trained in parallel in the initialization stage, with each optimized towards its individual preference over the multiple objectives. Then, to fill the remaining vacancies in the Pareto front, the constrained optimization steps are employed to maximize one objective while constraining the other objectives to exceed a predefined threshold. Empirically, compared to recent advancements in MORL methods, our algorithm achieves more consistent and superior performances in terms of hypervolume, expected utility, and sparsity on both discrete and continuous control tasks, especially with numerous objectives (up to nine objectives in our experiments).

FlashMask: Efficient and Rich Mask Extension of FlashAttention

The computational and memory demands of vanilla attention scale quadratically with the sequence length $N$, posing significant challenges for processing long sequences in Transformer models. FlashAttention alleviates these challenges by eliminating the $O(N^2)$ memory dependency and reducing attention latency through IO-aware memory optimizations. However, its native support for certain attention mask types is limited, and it does not inherently accommodate more complex masking requirements. Previous approaches resort to using dense masks with $O(N^2)$ memory complexity, leading to inefficiencies. In this paper, we propose FlashMask, an extension of FlashAttention that introduces a column-wise sparse representation of attention masks. This approach efficiently represents a wide range of mask types and facilitates the development of optimized kernel implementations. By adopting this novel representation, FlashMask achieves linear memory complexity $O(N)$, suitable for modeling long-context sequences. Moreover, this representation enables kernel optimizations that eliminate unnecessary computations by leveraging sparsity in the attention mask, without sacrificing computational accuracy, resulting in higher computational efficiency. We evaluate FlashMask's performance in fine-tuning and alignment training of LLMs such as SFT, LoRA, DPO, and RM. FlashMask achieves significant throughput improvements, with end-to-end speedups ranging from 1.65x to 3.22x compared to existing FlashAttention dense method. Additionally, our kernel-level comparisons demonstrate that FlashMask surpasses the latest counterpart, FlexAttention, by 12.1% to 60.7% in terms of kernel TFLOPs/s, achieving 37.8% to 62.3% of the theoretical maximum FLOPs/s on the A100 GPU. The code is open-sourced on PaddlePaddle and integrated into PaddleNLP, supporting models with over 100 billion parameters for contexts up to 128K tokens.

Generative Pre-trained Ranking Model with Over-parameterization at Web-Scale (Extended Abstract)

Learning to rank (LTR) is widely employed in web searches to prioritize pertinent webpages from retrieved content based on input queries. However, traditional LTR models encounter two principal obstacles that lead to suboptimal performance: (1) the lack of well-annotated query-webpage pairs with ranking scores covering a diverse range of search query popularities, which hampers their ability to address queries across the popularity spectrum, and (2) inadequately trained models that fail to induce generalized representations for LTR, resulting in overfitting. To address these challenges, we propose a \emph{\uline{G}enerative \uline{S}emi-\uline{S}upervised \uline{P}re-trained} (GS2P) LTR model. We conduct extensive offline experiments on both a publicly available dataset and a real-world dataset collected from a large-scale search engine. Furthermore, we deploy GS2P in a large-scale web search engine with realistic traffic, where we observe significant improvements in the real-world application.