EJ
Abstract:Vision impairment affects millions globally, and early detection is critical to preventing irreversible vision loss. Ophthalmology workflows require clinicians to integrate medical images, structured clinical data, and free-text notes to determine disease severity and management, which is time-consuming and burdensome. Recent multimodal large language models (MLLMs) show promise, but existing general and medical MLLMs perform poorly in ophthalmology, and few ophthalmology-specific MLLMs are openly available. We present VOLMO (Versatile and Open Large Models for Ophthalmology), a model-agnostic, data-open framework for developing ophthalmology-specific MLLMs. VOLMO includes three stages: ophthalmology knowledge pretraining on 86,965 image-text pairs from 26,569 articles across 82 journals; domain task fine-tuning on 26,929 annotated instances spanning 12 eye conditions for disease screening and severity classification; and multi-step clinical reasoning on 913 patient case reports for assessment, planning, and follow-up care. Using this framework, we trained a compact 2B-parameter MLLM and compared it with strong baselines, including InternVL-2B, LLaVA-Med-7B, MedGemma-4B, MedGemma-27B, and RETFound. We evaluated these models on image description generation, disease screening and staging classification, and assessment-and-management generation, with additional manual review by two healthcare professionals and external validation on three independent cohorts for age-related macular degeneration and diabetic retinopathy. Across settings, VOLMO-2B consistently outperformed baselines, achieving stronger image description performance, an average F1 of 87.4% across 12 eye conditions, and higher scores in external validation.
Abstract:Despite deep learning's success in chemistry, its impact is hindered by a lack of interpretability and an inability to resolve activity cliffs, where minor structural nuances trigger drastic property shifts. Current representation learning, bound by the similarity principle, often fails to capture these structural-activity discontinuities. To address this, we introduce MolEvolve, an evolutionary framework that reformulates molecular discovery as an autonomous, look-ahead planning problem. Unlike traditional methods that depend on human-engineered features or rigid prior knowledge, MolEvolve leverages a Large Language Model (LLM) to actively explore and evolve a library of executable chemical symbolic operations. By utilizing the LLM to cold start and an Monte Carlo Tree Search (MCTS) engine for test-time planning with external tools (e.g. RDKit), the system self-discovers optimal trajectories autonomously. This process evolves transparent reasoning chains that translate complex structural transformations into actionable, human-readable chemical insights. Experimental results demonstrate that MolEvolve's autonomous search not only evolves transparent, human-readable chemical insights, but also outperforms baselines in both property prediction and molecule optimization tasks.
Abstract:As real-world tasks grow increasingly complex, long-context reasoning has become a core capability for Large Language Models (LLMs). However, few studies explore which data types are effective for long-context reasoning and why. We find that structured table data with periodic structures shows strong potential for long-context reasoning. Motivated by this observation, we mathematically analyze tabular dependency structures using mutual information, revealing periodic non-vanishing dependencies in table data. Furthermore, we systematically analyze the capabilities of structured table data, conduct relevant scaling experiments, and validate its underlying mechanisms for enhancing long-context reasoning, yielding several meaningful insights. Leveraging these insights, we propose a simple yet scalable pipeline(TableLong) for synthesizing high-quality, diverse, and verifiable structured table data to boost long-context reasoning via RL. Extensive experimental results demonstrate that table data significantly enhances the long-context reasoning capability of LLMs across multiple long-context benchmarks (+8.24\% on average), and even improves performance on out-of-domain benchmarks (+8.06\% on average). We hope that our insights provide practical guidance for effective post-training data to enhance long-context reasoning in LLMs.
Abstract:Collaborative multi-agent large language models (LLMs) can solve complex reasoning tasks by decomposing roles and aggregating diverse hypotheses. Yet, reinforcement learning (RL) for such systems is often undermined by credit assignment: a shared global reward obscures individual contributions, inflating update variance and encouraging free-riding. We introduce Counterfactual Credit Policy Optimization (CCPO), a framework that assigns agent-specific learning signals by estimating each agent's marginal contribution through counterfactual trajectories. CCPO builds dynamic counterfactual baselines that simulate outcomes with an agent's contribution removed, yielding role-sensitive advantages for policy optimization. To further improve stability under heterogeneous tasks and data distributions, we propose a global-history-aware normalization scheme that calibrates advantages using global rollout statistics. We evaluate CCPO on two collaboration topologies: a sequential Think--Reason dyad and multi-agent voting. Across mathematical and logical reasoning benchmarks, CCPO mitigates free-riding and outperforms strong multi-agent RL baselines, yielding finer-grained and more effective credit assignment for collaborative LLM training. Our code is available at https://github.com/bhai114/ccpo.
Abstract:Large vision-language models (LVLMs) demonstrate strong performance in dermatology; however, evaluating diagnostic reasoning for rare conditions remains largely unexplored. Existing benchmarks focus on common diseases and assess only final accuracy, overlooking the clinical reasoning process, which is critical for complex cases. We address this gap by constructing DermCase, a long-context benchmark derived from peer-reviewed case reports. Our dataset contains 26,030 multi-modal image-text pairs and 6,354 clinically challenging cases, each annotated with comprehensive clinical information and step-by-step reasoning chains. To enable reliable evaluation, we establish DermLIP-based similarity metrics that achieve stronger alignment with dermatologists for assessing differential diagnosis quality. Benchmarking 22 leading LVLMs exposes significant deficiencies across diagnosis accuracy, differential diagnosis, and clinical reasoning. Fine-tuning experiments demonstrate that instruction tuning substantially improves performance while Direct Preference Optimization (DPO) yields minimal gains. Systematic error analysis further reveals critical limitations in current models' reasoning capabilities.
Abstract:Reinforcement learning (RL) for large-scale Vision-Language-Action (VLA) models faces significant challenges in computational efficiency and data acquisition. We propose AcceRL, a fully asynchronous and decoupled RL framework designed to eliminate synchronization barriers by physically isolating training, inference, and rollouts. Crucially, AcceRL is the first to integrate a plug-and-play, trainable world model into a distributed asynchronous RL pipeline to generate virtual experiences. Experiments on the LIBERO benchmark demonstrate that AcceRL achieves state-of-the-art (SOTA) performance. Systematically, it exhibits super-linear scaling in throughput and highly efficient hardware utilization. Algorithmically, the world-model-augmented variant delivers unprecedented sample efficiency and robust training stability in complex control tasks.
Abstract:Accurately estimating task progress is critical for embodied agents to plan and execute long-horizon, multi-step tasks. Despite promising advances, existing Vision-Language Models (VLMs) based methods primarily leverage their video understanding capabilities, while neglecting their complex reasoning potential. Furthermore, processing long video trajectories with VLMs is computationally prohibitive for real-world deployment. To address these challenges, we propose the Recurrent Reasoning Vision-Language Model ($\text{R}^2$VLM). Our model features a recurrent reasoning framework that processes local video snippets iteratively, maintaining a global context through an evolving Chain of Thought (CoT). This CoT explicitly records task decomposition, key steps, and their completion status, enabling the model to reason about complex temporal dependencies. This design avoids the high cost of processing long videos while preserving essential reasoning capabilities. We train $\text{R}^2$VLM on large-scale, automatically generated datasets from ALFRED and Ego4D. Extensive experiments on progress estimation and downstream applications, including progress-enhanced policy learning, reward modeling for reinforcement learning, and proactive assistance, demonstrate that $\text{R}^2$VLM achieves strong performance and generalization, achieving a new state-of-the-art in long-horizon task progress estimation. The models and benchmarks are publicly available at \href{https://huggingface.co/collections/zhangyuelin/r2vlm}{huggingface}.
Abstract:Constraints are essential for stabilizing reinforcement learning fine-tuning (RFT) and preventing degenerate outputs, yet they inherently conflict with the optimization objective because stronger constraints limit the ability of a fine-tuned model to discover better solutions. We propose \textit{dynamic constraints} that resolve this tension by adapting to the evolving capabilities of the fine-tuned model based on the insight that constraints should only intervene when degenerate outputs occur. We implement this by using a reference model as an \textit{online refiner} that takes the response from the fine-tuned model and generates a minimally corrected version which preserves correct content verbatim while fixing errors. A supervised fine-tuning loss then trains the fine-tuned model to produce the refined output. This mechanism yields a constraint that automatically strengthens or relaxes based on output quality. Experiments on dialogue and code generation show that dynamic constraints outperform both KL regularization and unconstrained baselines, achieving substantially higher task rewards while maintaining training stability.
Abstract:Gaussian process (GP) regression is widely used for uncertainty quantification, yet the standard formulation assumes noise-free covariates. When inputs are measured with error, this errors-in-variables (EIV) setting can lead to optimistically narrow posterior intervals and biased decisions. We study GP regression under input measurement uncertainty by representing each noisy input as a probability measure and defining covariance through Wasserstein distances between these measures. Building on this perspective, we instantiate a deterministic projected Wasserstein ARD (PWA) kernel whose one-dimensional components admit closed-form expressions and whose product structure yields a scalable, positive-definite kernel on distributions. Unlike latent-input GP models, PWA-based GPs (\PWAGPs) handle input noise without introducing unobserved covariates or Monte Carlo projections, making uncertainty quantification more transparent and robust.
Abstract:Tennis is one of the most widely followed sports, generating extensive broadcast footage with strong potential for professional analysis, automated coaching, and real-time commentary. However, automatic tennis understanding remains underexplored due to two key challenges: (1) the lack of large-scale benchmarks with fine-grained annotations and expert-level commentary, and (2) the difficulty of building accurate yet efficient multimodal systems suitable for real-time deployment. To address these challenges, we introduce TennisVL, a large-scale tennis benchmark comprising over 200 professional matches (471.9 hours) and 40,000+ rally-level clips. Unlike existing commentary datasets that focus on descriptive play-by-play narration, TennisVL emphasizes expert analytical commentary capturing tactical reasoning, player decisions, and match momentum. Furthermore, we propose TennisExpert, a multimodal tennis understanding framework that integrates a video semantic parser with a memory-augmented model built on Qwen3-VL-8B. The parser extracts key match elements (e.g., scores, shot sequences, ball bounces, and player locations), while hierarchical memory modules capture both short- and long-term temporal context. Experiments show that TennisExpert consistently outperforms strong proprietary baselines, including GPT-5, Gemini, and Claude, and demonstrates improved ability to capture tactical context and match dynamics. Our dataset and code are publicly available at https://github.com/LZYAndy/TennisExpert.