Mario: Multimodal Graph Reasoning with Large Language Models

Recent advances in large language models (LLMs) have opened new avenues for multimodal reasoning. Yet, most existing methods still rely on pretrained vision-language models (VLMs) to encode image-text pairs in isolation, ignoring the relational structure that real-world multimodal data naturally form. This motivates reasoning on multimodal graphs (MMGs), where each node has textual and visual attributes and edges provide structural cues. Enabling LLM-based reasoning on such heterogeneous multimodal signals while preserving graph topology introduces two key challenges: resolving weak cross-modal consistency and handling heterogeneous modality preference. To address this, we propose Mario, a unified framework that simultaneously resolves the two above challenges and enables effective LLM-based reasoning over MMGs. Mario consists of two innovative stages. Firstly, a graph-conditioned VLM design that jointly refines textual and visual features through fine-grained cross-modal contrastive learning guided by graph topology. Secondly, a modality-adaptive graph instruction tuning mechanism that organizes aligned multimodal features into graph-aware instruction views and employs a learnable router to surface, for each node and its neighborhood, the most informative modality configuration to the LLM. Extensive experiments across diverse MMG benchmarks demonstrate that Mario consistently outperforms state-of-the-art graph models in both supervised and zero-shot scenarios for node classification and link prediction. The code will be made available at https://github.com/sunyuanfu/Mario.

SaFeR-ToolKit: Structured Reasoning via Virtual Tool Calling for Multimodal Safety

Vision-language models remain susceptible to multimodal jailbreaks and over-refusal because safety hinges on both visual evidence and user intent, while many alignment pipelines supervise only the final response. To address this, we present SaFeR-ToolKit, which formalizes safety decision-making as a checkable protocol. Concretely, a planner specifies a persona, a Perception $\to$ Reasoning $\to$ Decision tool set, and a constrained transition graph, while a responder outputs a typed key-value tool trace before the final answer. To make the protocol reliably followed in practice, we train a single policy with a three-stage curriculum (SFT $\to$ DPO $\to$ GRPO), where GRPO directly supervises tool usage beyond answer-level feedback. Our contributions are two-fold: I. Dataset. The first tool-based safety reasoning dataset, comprising 31,654 examples (SFT 6k, DPO 18.6k, GRPO 6k) plus 1k held-out evaluation. II. Experiments. On Qwen2.5-VL, SaFeR-ToolKit significantly improves Safety/Helpfulness/Reasoning Rigor on 3B (29.39/45.04/4.98 $\to$ 84.40/71.13/78.87) and 7B (53.21/52.92/19.26 $\to$ 86.34/80.79/85.34), while preserving general capabilities (3B: 58.67 $\to$ 59.21; 7B: 66.39 $\to$ 66.81). Codes are available at https://github.com/Duebassx/SaFeR_ToolKit.

StoryTailor:A Zero-Shot Pipeline for Action-Rich Multi-Subject Visual Narratives

Generating multi-frame, action-rich visual narratives without fine-tuning faces a threefold tension: action text faithfulness, subject identity fidelity, and cross-frame background continuity. We propose StoryTailor, a zero-shot pipeline that runs on a single RTX 4090 (24 GB) and produces temporally coherent, identity-preserving image sequences from a long narrative prompt, per-subject references, and grounding boxes. Three synergistic modules drive the system: Gaussian-Centered Attention (GCA) to dynamically focus on each subject core and ease grounding-box overlaps; Action-Boost Singular Value Reweighting (AB-SVR) to amplify action-related directions in the text embedding space; and Selective Forgetting Cache (SFC) that retains transferable background cues, forgets nonessential history, and selectively surfaces retained cues to build cross-scene semantic ties. Compared with baseline methods, experiments show that CLIP-T improves by up to 10-15%, with DreamSim lower than strong baselines, while CLIP-I stays in a visually acceptable, competitive range. With matched resolution and steps on a 24 GB GPU, inference is faster than FluxKontext. Qualitatively, StoryTailor delivers expressive interactions and evolving yet stable scenes.

SAM4Dcap: Training-free Biomechanical Twin System from Monocular Video

Quantitative biomechanical analysis is essential for clinical diagnosis and injury prevention but is often restricted to laboratories due to the high cost of optical motion capture systems. While multi-view video approaches have lowered barriers, they remain impractical for home-based scenarios requiring monocular capture. This paper presents SAM4Dcap, an open-source, end-to-end framework for estimating biomechanical metrics from monocular video without additional training. SAM4Dcap integrates the temporally consistent 4D human mesh recovery of SAM-Body4D with the OpenSim biomechanical solver. The pipeline converts reconstructed meshes into trajectory files compatible with diverse musculoskeletal models. We introduce automated prompting strategies and a Linux-native build for processing. Preliminary evaluations on walking and drop-jump tasks indicate that SAM4Dcap has the potential to achieve knee kinematic predictions comparable to multi-view systems, although some discrepancies in hip flexion and residual jitter remain. By bridging advanced computer vision with established biomechanical simulation, SAM4Dcap provides a flexible, accessible foundation for non-laboratory motion analysis.

Multi-function Robotized Surgical Dissector for Endoscopic Pulmonary Thromboendarterectomy: Preclinical Study and Evaluation

Patients suffering chronic severe pulmonary thromboembolism need Pulmonary Thromboendarterectomy (PTE) to remove the thromb and intima located inside pulmonary artery (PA). During the surgery, a surgeon holds tweezers and a dissector to delicately strip the blockage, but available tools for this surgery are rigid and straight, lacking distal dexterity to access into thin branches of PA. Therefore, this work presents a novel robotized dissector based on concentric push/pull robot (CPPR) structure, enabling entering deep thin branch of tortuous PA. Compared with conventional rigid dissectors, our design characterizes slenderness and dual-segment-bending dexterity. Owing to the hollow and thin-walled structure of the CPPR-based dissector as it has a slender body of 3.5mm in diameter, the central lumen accommodates two channels for irrigation and tip tool, and space for endoscopic camera's signal wire. To provide accurate surgical manipulation, optimization-based kinematics model was established, realizing a 2mm accuracy in positioning the tip tool (60mm length) under open-loop control strategy. As such, with the endoscopic camera, traditional PTE is possible to be upgraded as endoscopic PTE. Basic physic performance of the robotized dissector including stiffness, motion accuracy and maneuverability was evaluated through experiments. Surgery simulation on ex vivo porcine lung also demonstrates its dexterity and notable advantages in PTE.

TRACER: Texture-Robust Affordance Chain-of-Thought for Deformable-Object Refinement

The central challenge in robotic manipulation of deformable objects lies in aligning high-level semantic instructions with physical interaction points under complex appearance and texture variations. Due to near-infinite degrees of freedom, complex dynamics, and heterogeneous patterns, existing vision-based affordance prediction methods often suffer from boundary overflow and fragmented functional regions. To address these issues, we propose TRACER, a Texture-Robust Affordance Chain-of-thought with dEformable-object Refinement framework, which establishes a cross-hierarchical mapping from hierarchical semantic reasoning to appearance-robust and physically consistent functional region refinement. Specifically, a Tree-structured Affordance Chain-of-Thought (TA-CoT) is formulated to decompose high-level task intentions into hierarchical sub-task semantics, providing consistent guidance across various execution stages. To ensure spatial integrity, a Spatial-Constrained Boundary Refinement (SCBR) mechanism is introduced to suppress prediction spillover, guiding the perceptual response to converge toward authentic interaction manifolds. Furthermore, an Interactive Convergence Refinement Flow (ICRF) is developed to aggregate discrete pixels corrupted by appearance noise, significantly enhancing the spatial continuity and physical plausibility of the identified functional regions. Extensive experiments conducted on the Fine-AGDDO15 dataset and a real-world robotic platform demonstrate that TRACER significantly improves affordance grounding precision across diverse textures and patterns inherent to deformable objects. More importantly, it enhances the success rate of long-horizon tasks, effectively bridging the gap between high-level semantic reasoning and low-level physical execution. The source code and dataset will be made publicly available at https://github.com/Dikay1/TRACER.

RareAlert: Aligning heterogeneous large language model reasoning for early rare disease risk screening

Missed and delayed diagnosis remains a major challenge in rare disease care. At the initial clinical encounters, physicians assess rare disease risk using only limited information under high uncertainty. When high-risk patients are not recognised at this stage, targeted diagnostic testing is often not initiated, resulting in missed diagnosis. Existing primary care triage processes are structurally insufficient to reliably identify patients with rare diseases at initial clinical presentation and universal screening is needed to reduce diagnostic delay. Here we present RareAlert, an early screening system which predict patient-level rare disease risk from routinely available primary-visit information. RareAlert integrates reasoning generated by ten LLMs, calibrates and weights these signals using machine learning, and distils the aligned reasoning into a single locally deployable model. To develop and evaluate RareAlert, we curated RareBench, a real-world dataset of 158,666 cases covering 33 Orphanet disease categories and more than 7,000 rare conditions, including both rare and non-rare presentations. The results showed that rare disease identification can be reconceptualised as a universal uncertainty resolution process applied to the general patient population. On an independent test set, RareAlert, a Qwen3-4B based model trained with calibrated reasoning signals, achieved an AUC of 0.917, outperforming the best machine learning ensemble and all evaluated LLMs, including GPT-5, DeepSeek-R1, Claude-3.7-Sonnet, o3-mini, Gemini-2.5-Pro, and Qwen3-235B. These findings demonstrate the diversity in LLM medical reasoning and the effectiveness of aligning such reasoning in highly uncertain clinical tasks. By incorporating calibrated reasoning into a single model, RareAlert enables accurate, privacy-preserving, and scalable rare disease risk screening suitable for large-scale local deployment.

Orchestrating Specialized Agents for Trustworthy Enterprise RAG

Retrieval-Augmented Generation (RAG) shows promise for enterprise knowledge work, yet it often underperforms in high-stakes decision settings that require deep synthesis, strict traceability, and recovery from underspecified prompts. One-pass retrieval-and-write pipelines frequently yield shallow summaries, inconsistent grounding, and weak mechanisms for completeness verification. We introduce ADORE (Adaptive Deep Orchestration for Research in Enterprise), an agentic framework that replaces linear retrieval with iterative, user-steered investigation coordinated by a central orchestrator and a set of specialized agents. ADORE's key insight is that a structured Memory Bank (a curated evidence store with explicit claim-evidence linkage and section-level admissible evidence) enables traceable report generation and systematic checks for evidence completeness. Our contributions are threefold: (1) Memory-locked synthesis - report generation is constrained to a structured Memory Bank (Claim-Evidence Graph) with section-level admissible evidence, enabling traceable claims and grounded citations; (2) Evidence-coverage-guided execution - a retrieval-reflection loop audits section-level evidence coverage to trigger targeted follow-up retrieval and terminates via an evidence-driven stopping criterion; (3) Section-packed long-context grounding - section-level packing, pruning, and citation-preserving compression make long-form synthesis feasible under context limits. Across our evaluation suite, ADORE ranks first on DeepResearch Bench (52.65) and achieves the highest head-to-head preference win rate on DeepConsult (77.2%) against commercial systems.

Evaluating the Diagnostic Classification Ability of Multimodal Large Language Models: Insights from the Osteoarthritis Initiative

Multimodal large language models (MLLMs) show promising performance on medical visual question answering (VQA) and report generation, but these generation and explanation abilities do not reliably transfer to disease-specific classification. We evaluated MLLM architectures on knee osteoarthritis (OA) radiograph classification, which remains underrepresented in existing medical MLLM benchmarks, even though knee OA affects an estimated 300 to 400 million people worldwide. Through systematic ablation studies manipulating the vision encoder, the connector, and the large language model (LLM) across diverse training strategies, we measured each component's contribution to diagnostic accuracy. In our classification task, a trained vision encoder alone could outperform full MLLM pipelines in classification accuracy and fine-tuning the LLM provided no meaningful improvement over prompt-based guidance. And LoRA fine-tuning on a small, class-balanced dataset (500 images) gave better results than training on a much larger but class-imbalanced set (5,778 images), indicating that data balance and quality can matter more than raw scale for this task. These findings suggest that for domain-specific medical classification, LLMs are more effective as interpreters and report generators rather than as primary classifiers. Therefore, the MLLM architecture appears less suitable for medical image diagnostic classification tasks that demand high certainty. We recommend prioritizing vision encoder optimization and careful dataset curation when developing clinically applicable systems.

SaFeR-VLM: Toward Safety-aware Fine-grained Reasoning in Multimodal Models

Multimodal Large Reasoning Models (MLRMs) demonstrate impressive cross-modal reasoning but often amplify safety risks under adversarial or unsafe prompts, a phenomenon we call the \textit{Reasoning Tax}. Existing defenses mainly act at the output level and do not constrain the reasoning process, leaving models exposed to implicit risks. In this paper, we propose SaFeR-VLM, a safety-aligned reinforcement learning framework that embeds safety directly into multimodal reasoning. The framework integrates four components: (I) QI-Safe-10K, a curated dataset emphasizing safety-critical and reasoning-sensitive cases; (II) safety-aware rollout, where unsafe generations undergo reflection and correction instead of being discarded; (III) structured reward modeling with multi-dimensional weighted criteria and explicit penalties for hallucinations and contradictions; and (IV) GRPO optimization, which reinforces both safe and corrected trajectories. This unified design shifts safety from a passive safeguard to an active driver of reasoning, enabling scalable and generalizable safety-aware reasoning. SaFeR-VLM further demonstrates robustness against both explicit and implicit risks, supporting dynamic and interpretable safety decisions beyond surface-level filtering. SaFeR-VLM-3B achieves average performance $70.13$ and $78.97$ on safety and helpfulness across six benchmarks, surpassing both same-scale and $>10\times$ larger models such as Skywork-R1V3-38B, Qwen2.5VL-72B, and GLM4.5V-106B. Remarkably, SaFeR-VLM-7B benefits from its increased scale to surpass GPT-5-mini and Gemini-2.5-Flash by \num{6.47} and \num{16.76} points respectively on safety metrics, achieving this improvement without any degradation in helpfulness performance. Our codes are available at https://github.com/HarveyYi/SaFeR-VLM.