ProteinOPD: Towards Effective and Efficient Preference Alignment for Protein Design

Designing proteins with desired functions or properties represents a core goal in synthetic biology and drug discovery. Recent advances in protein language models (PLMs) have enabled the generation of highly designable protein sequences, while preference alignment provides a promising way to steer designs toward desired functions and properties. Nevertheless, they often trigger catastrophic forgetting of pretrained knowledge, degrading basic designability and failing to balance multiple competing objectives. To address these issues, we draw inspiration from On-Policy Distillation (OPD), an advanced post-training method renowned for mitigating catastrophic forgetting through its mode-seeking nature. In this work, we propose ProteinOPD, a multi-objective preference alignment framework that can effectively balance multiple preference objectives while maintaining the inherent designability of PLMs. ProteinOPD adapts a pretrained PLM into preference-specific teachers and distills their knowledge into a shared student via token-level OPD on the student's own trajectories. During this process, the student is aligned to a unique normalized geometric consensus of weighted teachers while ensuring bounded optimization under conflicts. This bridges the gap for OPD in multi-objective/teacher alignment. Extensive experiments show that ProteinOPD achieves substantial gains on target preference objectives without compromising the designability, with an 8x training speedup over RL-based alignment competitors.

Learning the Interaction Prior for Protein-Protein Interaction Prediction: A Model-Agnostic Approach

Protein-protein interactions (PPIs) are fundamental to cellular function and disease mechanisms. Current learning-based PPI predictors focus on learning powerful protein representations but neglect designing specialized classification heads. They mainly rely on generic aggregating methods like concatenation or dot products, which lack biological insight. Motivated by the biological "L3 rule", where multiple length-3 paths between a pair of proteins indicate their interaction likelihood, our study addresses this gap by designing a biologically informed PPI classifier. In this paper, we provide empirical evidence that popular PPI datasets strongly support the L3 rule. We propose an L3-path-regularized graph prompt learning method called L3-PPI, which can generate a prompt graph with virtual L3 paths based on protein representations and controls the number of paths. L3-PPI reformulates the classification of protein embedding pairs into a graph-level classification task over the generated prompt graph. This lightweight module seamlessly integrates with PPI predictors as a plug-and-play component, injecting the interaction prior of complementarity to enhance performance. Extensive experiments show that L3-PPI achieves superior performance enhancements over advanced competitors.

SDTalk: Structured Facial Priors and Dual-Branch Motion Fields for Generalizable Gaussian Talking Head Synthesis

High-quality, real-time talking head synthesis remains a fundamental challenge in computer vision. Existing reconstruction- and rendering-based methods typically rely on identity-specific models, limiting cross-identity generalization. To address this issue, we propose SDTalk, a one-shot 3D Gaussian Splatting (3DGS)-based framework that generalizes to unseen identities without personalized training or fine-tuning. Our framework comprises two modules with a two-stage training strategy. In the first stage, we incorporate structured facial priors into the reconstruction module and separately predict 3DGS parameters for visible and occluded regions, enabling complete head reconstruction from a single image. In the second stage, we introduce a dual-branch motion field to model coarse and fine facial dynamics, improving detail fidelity and lip synchronization. Experiments demonstrate that SDTalk surpasses existing methods in both visual quality and inference efficiency.

PiCA: Pivot-Based Credit Assignment for Search Agentic Reinforcement Learning

Large Language Model (LLM)-based search agents trained with reinforcement learning (RL) have significantly improved the performance of knowledge-intensive tasks. However, existing methods encounter critical challenges in long-horizon credit assignment: (i) Reward Sparsity, where models receive only outcome feedback without step-level guidance to differentiate action quality; (ii) Isolated Credit, where credit is assigned to steps independently, failing to capture sequential dependencies; and (iii) Distributional Shift, where rewards are estimated on templates that deviate from the model's natural generative distribution. To address these issues, we propose Pivot-Based Credit Assignment (PiCA), a novel step reward mechanism that reformulates the search trajectory as a sequential process of cumulative search progress. Unlike prior isolated step rewards, PiCA defines process rewards as success probabilities dependent on the historical context based on Potential-Based Reward Shaping (PBRS). This approach identifies pivot steps, which comprise target golden sub-queries and sub-answers derived from historical trajectories, as information peaks that significantly boost the likelihood of a correct final answer. By anchoring these step rewards to the final task objective, PiCA provides dense, pivot-aware and trajectory-dependent guidance while maintaining distributional consistency. Extensive experiments show that PiCA outperforms existing strong baselines across seven knowledge-intensive QA benchmarks, achieving 15.2% and 2.2% improvements for 3B and 7B models. The consistent performance gains across various models show PiCA's robust generalization. The code is available at https://github.com/novdream/PiCA.

An Empirical Study of Proactive Coding Assistants in Real-World Software Development

Large language model (LLM)-based coding assistants have made substantial progress, yet most systems remain reactive, requiring developers to explicitly formulate their needs. Proactive coding assistants aim to infer latent developer intent from integrated development environment (IDE) interactions and repository context, thereby reducing interaction overhead and supporting more seamless assistance. However, research in this direction is limited by the scarcity of large-scale real-world developer behavior data. Existing studies therefore often rely on LLM-simulated IDE traces, whose fidelity to real development behavior remains unclear. In this paper, we investigate this simulation-to-reality gap through a large-scale empirical study. We collect real IDE interaction traces from 1{,}246 experienced industry developers over three consecutive days using a custom Visual Studio Code extension, and construct paired LLM-simulated traces for controlled comparison. Our analysis shows that simulated traces differ substantially from real traces in behavioral diversity, temporal structure, and exploratory patterns. Based on the collected data, we introduce \textbf{ProCodeBench}, a real-world benchmark for proactive intent prediction. Experiments with representative LLMs, retrieval-augmented methods, and agentic baselines show that current approaches remain far from reliable under real IDE traces, suggesting that simulation-based evaluation can overestimate real-world performance. Finally, our training study shows that simulated data cannot replace real data, but can complement it when used before real-world fine-tuning. These findings highlight the importance of real developer behavior data for evaluating and training proactive coding assistants.

Adaptive Physical-Facial Representation Fusion via Subject-Invariant Cross-Modal Prompt Tuning for Video-Based Emotion Recognition

Emotion recognition from facial videos enables non-contact inference of human emotional states. Although facial expressions are widely used cues, they cannot fully reflect intrinsic affective states. Remote photoplethysmography (rPPG) provides complementary physiological information, but it is highly susceptible to noise and inter-subject variability, limiting generalization to unseen individuals. Existing multimodal methods combine facial and rPPG features, yet their fusion strategies often disrupt pretrained facial representations and lack explicit mechanisms to suppress subject-specific variations. To address these issues, we propose a subject-invariant cross-modal prompt-tuning framework for video-based emotion recognition. Specifically, rPPG waveforms are transformed into noise-robust time-frequency representations (TFRs), from which modality-complementary prompts are generated to modulate facial tokens within a frozen Vision Transformer (ViT). This design enables effective cross-modal interaction while preserving the generalizable facial representations learned by the pretrained backbone. In addition, we introduce a decoupled shared-specific adapter (DSSA) into each ViT layer to explicitly separate subject-shared and subject-specific components, thereby improving cross-subject generalization. Experiments on the MAHNOB-HCI and DEAP benchmarks demonstrate that the proposed method consistently outperforms strong baselines in both recognition accuracy and generalization ability, highlighting its effectiveness for video-based emotion recognition.

To Fuse or to Drop? Dual-Path Learning for Resolving Modality Conflicts in Multimodal Emotion Recognition

Multimodal emotion recognition (MER) benefits from combining text, audio, and vision, yet standard fusion often fails when modalities conflict. Crucially, conflicts differ in resolvability: benign conflicts stem from missing, weak, or ambiguous cues and can be mitigated by cross-modal calibration, while severe conflicts arise from intrinsically contradictory (e.g., sarcasm) or misleading signals, for which forced fusion may amplify errors. Recognizing this, we propose Dual-Path Conflict Resolution (DCR), a unified framework that learns when to fuse and when to drop modalities. Path I (Affective Fusion Distiller, AFD) performs reverse distillation from audio/visual teachers to a textual student using temporally weighted class evidence, thereby enhancing representation-level calibration and improving fusion when alignment is beneficial. Path II (Affective Discernment Agent, ADA) formulates MER as a contextual bandit that selects among fusion and unimodal predictions based on a dual-view state and a calibration-aware reward, enabling decision-level arbitration under irreconcilable conflicts without requiring per-modality reliability labels. By taking into account the full multimodal context and coupling soft calibration with hard arbitration, DCR reconciles conflicts that can be aligned while bypassing misleading modalities when fusion is harmful. Across five benchmarks covering both dialogue-level and clip-level MER, DCR consistently outperforms competitive baselines or achieves highly competitive results. Further ablations, conflict-specific subset evaluation, and modality-selection analysis verify that AFD and ADA are complementary and jointly improve robust conflict-aware emotion recognition.

MEMCoder: Multi-dimensional Evolving Memory for Private-Library-Oriented Code Generation

Large Language Models (LLMs) excel at general code generation, but their performance drops sharply in enterprise settings that rely on internal private libraries absent from public pre-training corpora. While Retrieval-Augmented Generation (RAG) offers a training-free alternative by providing static API documentation, we find that such documentation typically provides only isolated definitions, leaving a fundamental knowledge gap. Specifically, LLMs struggle with a task-level lack of coordination patterns between APIs and an API-level misunderstanding of parameter constraints and boundary conditions. To address this, we propose MEMCoder, a novel framework that enables LLMs to autonomously accumulate and evolve Usage Guidelines across these two dimensions. MEMCoder introduces a Multi-dimensional Evolving Memory that captures distilled lessons from the model's own problem-solving trajectories. During inference, MEMCoder employs a dual-source retrieval mechanism to inject both static documentation and relevant historical guidelines into the context. The framework operates in an automated closed loop by using objective execution feedback to reflect on successes and failures, resolve knowledge conflicts, and dynamically update memory. Extensive evaluations on the NdonnxEval and NumbaEval benchmarks demonstrate that MEMCoder substantially enhances existing RAG systems, yielding an average absolute pass@1 gain of 16.31%. Furthermore, MEMCoder exhibits vastly superior domain-specific adaptation compared to existing memory-based continual learning methods.

LoReC: Rethinking Large Language Models for Graph Data Analysis

The advent of Large Language Models (LLMs) has fundamentally reshaped the way we interact with graphs, giving rise to a new paradigm called GraphLLM. As revealed in recent studies, graph learning can benefit from LLMs. However, we observe limited benefits when we directly utilize LLMs to make predictions for graph-related tasks within GraphLLM paradigm, which even yields suboptimal results compared to conventional GNN-based approaches. Through in-depth analysis, we find this failure can be attributed to LLMs' limited capability for processing graph data and their tendency to overlook graph information. To address this issue, we propose LoReC (Look, Remember, and Contrast), a novel plug-and-play method for GraphLLM paradigm, which enhances LLM's understanding of graph data through three stages: (1) Look: redistributing attention to graph; (2) Remember: re-injecting graph information into the Feed-Forward Network (FFN); (3) Contrast: rectifying the vanilla logits produced in the decoding process. Extensive experiments demonstrate that LoReC brings notable improvements over current GraphLLM methods and outperforms GNN-based approaches across diverse datasets. The implementation is available at https://github.com/Git-King-Zhan/LoReC.

Training LLM Agents for Spontaneous, Reward-Free Self-Evolution via World Knowledge Exploration

Most agents today ``self-evolve'' by following rewards and rules defined by humans. However, this process remains fundamentally dependent on external supervision; without human guidance, the evolution stops. In this work, we train agents to possess an intrinsic meta-evolution capability to spontaneously learn about unseen environments prior to task execution. To instill this ability, we design an outcome-based reward mechanism that measures how much an agent's self-generated world knowledge improves its success rate on downstream tasks. This reward signal is used exclusively during the training phase to teach the model how to explore and summarize effectively. At inference time, the agent requires no external rewards or human instructions. It spontaneously performs native self-evolution to adapt to unknown environments using its internal parameters. When applied to Qwen3-30B and Seed-OSS-36B, this shift to native evolution yields a 20% performance increase on WebVoyager and WebWalker. Most strikingly, the generated world knowledge even enables a compact 14B Qwen3 model to outperform the unassisted Gemini-2.5-Flash, establishing a new paradigm for truly evolving agents.