Anatomically and Metabolically Informed Diffusion for Unified Denoising and Segmentation in Low-Count PET Imaging

Positron emission tomography (PET) image denoising, along with lesion and organ segmentation, are critical steps in PET-aided diagnosis. However, existing methods typically treat these tasks independently, overlooking inherent synergies between them as correlated steps in the analysis pipeline. In this work, we present the anatomically and metabolically informed diffusion (AMDiff) model, a unified framework for denoising and lesion/organ segmentation in low-count PET imaging. By integrating multi-task functionality and exploiting the mutual benefits of these tasks, AMDiff enables direct quantification of clinical metrics, such as total lesion glycolysis (TLG), from low-count inputs. The AMDiff model incorporates a semantic-informed denoiser based on diffusion strategy and a denoising-informed segmenter utilizing nnMamba architecture. The segmenter constrains denoised outputs via a lesion-organ-specific regularizer, while the denoiser enhances the segmenter by providing enriched image information through a denoising revision module. These components are connected via a warming-up mechanism to optimize multitask interactions. Experiments on multi-vendor, multi-center, and multi-noise-level datasets demonstrate the superior performance of AMDiff. For test cases below 20% of the clinical count levels from participating sites, AMDiff achieves TLG quantification biases of -26.98%, outperforming its ablated versions which yield biases of -35.85% (without the lesion-organ-specific regularizer) and -40.79% (without the denoising revision module).

Step-Video-TI2V Technical Report: A State-of-the-Art Text-Driven Image-to-Video Generation Model

We present Step-Video-TI2V, a state-of-the-art text-driven image-to-video generation model with 30B parameters, capable of generating videos up to 102 frames based on both text and image inputs. We build Step-Video-TI2V-Eval as a new benchmark for the text-driven image-to-video task and compare Step-Video-TI2V with open-source and commercial TI2V engines using this dataset. Experimental results demonstrate the state-of-the-art performance of Step-Video-TI2V in the image-to-video generation task. Both Step-Video-TI2V and Step-Video-TI2V-Eval are available at https://github.com/stepfun-ai/Step-Video-TI2V.

TAIL: Text-Audio Incremental Learning

Many studies combine text and audio to capture multi-modal information but they overlook the model's generalization ability on new datasets. Introducing new datasets may affect the feature space of the original dataset, leading to catastrophic forgetting. Meanwhile, large model parameters can significantly impact training performance. To address these limitations, we introduce a novel task called Text-Audio Incremental Learning (TAIL) task for text-audio retrieval, and propose a new method, PTAT, Prompt Tuning for Audio-Text incremental learning. This method utilizes prompt tuning to optimize the model parameters while incorporating an audio-text similarity and feature distillation module to effectively mitigate catastrophic forgetting. We benchmark our method and previous incremental learning methods on AudioCaps, Clotho, BBC Sound Effects and Audioset datasets, and our method outperforms previous methods significantly, particularly demonstrating stronger resistance to forgetting on older datasets. Compared to the full-parameters Finetune (Sequential) method, our model only requires 2.42\% of its parameters, achieving 4.46\% higher performance.

Step-Audio: Unified Understanding and Generation in Intelligent Speech Interaction

Real-time speech interaction, serving as a fundamental interface for human-machine collaboration, holds immense potential. However, current open-source models face limitations such as high costs in voice data collection, weakness in dynamic control, and limited intelligence. To address these challenges, this paper introduces Step-Audio, the first production-ready open-source solution. Key contributions include: 1) a 130B-parameter unified speech-text multi-modal model that achieves unified understanding and generation, with the Step-Audio-Chat version open-sourced; 2) a generative speech data engine that establishes an affordable voice cloning framework and produces the open-sourced lightweight Step-Audio-TTS-3B model through distillation; 3) an instruction-driven fine control system enabling dynamic adjustments across dialects, emotions, singing, and RAP; 4) an enhanced cognitive architecture augmented with tool calling and role-playing abilities to manage complex tasks effectively. Based on our new StepEval-Audio-360 evaluation benchmark, Step-Audio achieves state-of-the-art performance in human evaluations, especially in terms of instruction following. On open-source benchmarks like LLaMA Question, shows 9.3% average performance improvement, demonstrating our commitment to advancing the development of open-source multi-modal language technologies. Our code and models are available at https://github.com/stepfun-ai/Step-Audio.

A Generalizable 3D Diffusion Framework for Low-Dose and Few-View Cardiac SPECT

Myocardial perfusion imaging using SPECT is widely utilized to diagnose coronary artery diseases, but image quality can be negatively affected in low-dose and few-view acquisition settings. Although various deep learning methods have been introduced to improve image quality from low-dose or few-view SPECT data, previous approaches often fail to generalize across different acquisition settings, limiting their applicability in reality. This work introduced DiffSPECT-3D, a diffusion framework for 3D cardiac SPECT imaging that effectively adapts to different acquisition settings without requiring further network re-training or fine-tuning. Using both image and projection data, a consistency strategy is proposed to ensure that diffusion sampling at each step aligns with the low-dose/few-view projection measurements, the image data, and the scanner geometry, thus enabling generalization to different low-dose/few-view settings. Incorporating anatomical spatial information from CT and total variation constraint, we proposed a 2.5D conditional strategy to allow the DiffSPECT-3D to observe 3D contextual information from the entire image volume, addressing the 3D memory issues in diffusion model. We extensively evaluated the proposed method on 1,325 clinical 99mTc tetrofosmin stress/rest studies from 795 patients. Each study was reconstructed into 5 different low-count and 5 different few-view levels for model evaluations, ranging from 1% to 50% and from 1 view to 9 view, respectively. Validated against cardiac catheterization results and diagnostic comments from nuclear cardiologists, the presented results show the potential to achieve low-dose and few-view SPECT imaging without compromising clinical performance. Additionally, DiffSPECT-3D could be directly applied to full-dose SPECT images to further improve image quality, especially in a low-dose stress-first cardiac SPECT imaging protocol.

MoTe: Learning Motion-Text Diffusion Model for Multiple Generation Tasks

Recently, human motion analysis has experienced great improvement due to inspiring generative models such as the denoising diffusion model and large language model. While the existing approaches mainly focus on generating motions with textual descriptions and overlook the reciprocal task. In this paper, we present~\textbf{MoTe}, a unified multi-modal model that could handle diverse tasks by learning the marginal, conditional, and joint distributions of motion and text simultaneously. MoTe enables us to handle the paired text-motion generation, motion captioning, and text-driven motion generation by simply modifying the input context. Specifically, MoTe is composed of three components: Motion Encoder-Decoder (MED), Text Encoder-Decoder (TED), and Moti-on-Text Diffusion Model (MTDM). In particular, MED and TED are trained for extracting latent embeddings, and subsequently reconstructing the motion sequences and textual descriptions from the extracted embeddings, respectively. MTDM, on the other hand, performs an iterative denoising process on the input context to handle diverse tasks. Experimental results on the benchmark datasets demonstrate the superior performance of our proposed method on text-to-motion generation and competitive performance on motion captioning.

Differentiable Gaussian Representation for Incomplete CT Reconstruction

Incomplete Computed Tomography (CT) benefits patients by reducing radiation exposure. However, reconstructing high-fidelity images from limited views or angles remains challenging due to the ill-posed nature of the problem. Deep Learning Reconstruction (DLR) methods have shown promise in enhancing image quality, but the paradox between training data diversity and high generalization ability remains unsolved. In this paper, we propose a novel Gaussian Representation for Incomplete CT Reconstruction (GRCT) without the usage of any neural networks or full-dose CT data. Specifically, we model the 3D volume as a set of learnable Gaussians, which are optimized directly from the incomplete sinogram. Our method can be applied to multiple views and angles without changing the architecture. Additionally, we propose a differentiable Fast CT Reconstruction method for efficient clinical usage. Extensive experiments on multiple datasets and settings demonstrate significant improvements in reconstruction quality metrics and high efficiency. We plan to release our code as open-source.

Towards Small Object Editing: A Benchmark Dataset and A Training-Free Approach

A plethora of text-guided image editing methods has recently been developed by leveraging the impressive capabilities of large-scale diffusion-based generative models especially Stable Diffusion. Despite the success of diffusion models in producing high-quality images, their application to small object generation has been limited due to difficulties in aligning cross-modal attention maps between text and these objects. Our approach offers a training-free method that significantly mitigates this alignment issue with local and global attention guidance , enhancing the model's ability to accurately render small objects in accordance with textual descriptions. We detail the methodology in our approach, emphasizing its divergence from traditional generation techniques and highlighting its advantages. What's more important is that we also provide~\textit{SOEBench} (Small Object Editing), a standardized benchmark for quantitatively evaluating text-based small object generation collected from \textit{MSCOCO} and \textit{OpenImage}. Preliminary results demonstrate the effectiveness of our method, showing marked improvements in the fidelity and accuracy of small object generation compared to existing models. This advancement not only contributes to the field of AI and computer vision but also opens up new possibilities for applications in various industries where precise image generation is critical. We will release our dataset on our project page: \href{https://soebench.github.io/}{https://soebench.github.io/}.

Grounding is All You Need? Dual Temporal Grounding for Video Dialog

In the realm of video dialog response generation, the understanding of video content and the temporal nuances of conversation history are paramount. While a segment of current research leans heavily on large-scale pretrained visual-language models and often overlooks temporal dynamics, another delves deep into spatial-temporal relationships within videos but demands intricate object trajectory pre-extractions and sidelines dialog temporal dynamics. This paper introduces the Dual Temporal Grounding-enhanced Video Dialog model (DTGVD), strategically designed to merge the strengths of both dominant approaches. It emphasizes dual temporal relationships by predicting dialog turn-specific temporal regions, filtering video content accordingly, and grounding responses in both video and dialog contexts. One standout feature of DTGVD is its heightened attention to chronological interplay. By recognizing and acting upon the dependencies between different dialog turns, it captures more nuanced conversational dynamics. To further bolster the alignment between video and dialog temporal dynamics, we've implemented a list-wise contrastive learning strategy. Within this framework, accurately grounded turn-clip pairings are designated as positive samples, while less precise pairings are categorized as negative. This refined classification is then funneled into our holistic end-to-end response generation mechanism. Evaluations using AVSD@DSTC-7 and AVSD@DSTC-8 datasets underscore the superiority of our methodology.

Personalized Knowledge Tracing through Student Representation Reconstruction and Class Imbalance Mitigation

Knowledge tracing is a technique that predicts students' future performance by analyzing their learning process through historical interactions with intelligent educational platforms, enabling a precise evaluation of their knowledge mastery. Recent studies have achieved significant progress by leveraging powerful deep neural networks. These models construct complex input representations using questions, skills, and other auxiliary information but overlook individual student characteristics, which limits the capability for personalized assessment. Additionally, the available datasets in the field exhibit class imbalance issues. The models that simply predict all responses as correct without substantial effort can yield impressive accuracy. In this paper, we propose PKT, a novel approach for personalized knowledge tracing. PKT reconstructs representations from sequences of interactions with a tutoring platform to capture latent information about the students. Moreover, PKT incorporates focal loss to improve prioritize minority classes, thereby achieving more balanced predictions. Extensive experimental results on four publicly available educational datasets demonstrate the advanced predictive performance of PKT in comparison with 16 state-of-the-art models. To ensure the reproducibility of our research, the code is publicly available at https://anonymous.4open.science/r/PKT.