ViDTA: Enhanced Drug-Target Affinity Prediction via Virtual Graph Nodes and Attention-based Feature Fusion

Drug-target interaction is fundamental in understanding how drugs affect biological systems, and accurately predicting drug-target affinity (DTA) is vital for drug discovery. Recently, deep learning methods have emerged as a significant approach for estimating the binding strength between drugs and target proteins. However, existing methods simply utilize the drug's local information from molecular topology rather than global information. Additionally, the features of drugs and proteins are usually fused with a simple concatenation operation, limiting their effectiveness. To address these challenges, we proposed ViDTA, an enhanced DTA prediction framework. We introduce virtual nodes into the Graph Neural Network (GNN)-based drug feature extraction network, which acts as a global memory to exchange messages more efficiently. By incorporating virtual graph nodes, we seamlessly integrate local and global features of drug molecular structures, expanding the GNN's receptive field. Additionally, we propose an attention-based linear feature fusion network for better capturing the interaction information between drugs and proteins. Experimental results evaluated on various benchmarks including Davis, Metz, and KIBA demonstrate that our proposed ViDTA outperforms the state-of-the-art baselines.

ProGDF: Progressive Gaussian Differential Field for Controllable and Flexible 3D Editing

3D editing plays a crucial role in editing and reusing existing 3D assets, thereby enhancing productivity. Recently, 3DGS-based methods have gained increasing attention due to their efficient rendering and flexibility. However, achieving desired 3D editing results often requires multiple adjustments in an iterative loop, resulting in tens of minutes of training time cost for each attempt and a cumbersome trial-and-error cycle for users. This in-the-loop training paradigm results in a poor user experience. To address this issue, we introduce the concept of process-oriented modelling for 3D editing and propose the Progressive Gaussian Differential Field (ProGDF), an out-of-loop training approach that requires only a single training session to provide users with controllable editing capability and variable editing results through a user-friendly interface in real-time. ProGDF consists of two key components: Progressive Gaussian Splatting (PGS) and Gaussian Differential Field (GDF). PGS introduces the progressive constraint to extract the diverse intermediate results of the editing process and employs rendering quality regularization to improve the quality of these results. Based on these intermediate results, GDF leverages a lightweight neural network to model the editing process. Extensive results on two novel applications, namely controllable 3D editing and flexible fine-grained 3D manipulation, demonstrate the effectiveness, practicality and flexibility of the proposed ProGDF.

Mastering Collaborative Multi-modal Data Selection: A Focus on Informativeness, Uniqueness, and Representativeness

Instruction tuning fine-tunes pre-trained Multi-modal Large Language Models (MLLMs) to handle real-world tasks. However, the rapid expansion of visual instruction datasets introduces data redundancy, leading to excessive computational costs. We propose a collaborative framework, DataTailor, which leverages three key principles--informativeness, uniqueness, and representativeness--for effective data selection. We argue that a valuable sample should be informative of the task, non-redundant, and represent the sample distribution (i.e., not an outlier). We further propose practical ways to score against each principle, which automatically adapts to a given dataset without tedious hyperparameter tuning. Comprehensive experiments on various benchmarks demonstrate that DataTailor achieves 100.8% of the performance of full-data fine-tuning with only 15% of the data, significantly reducing computational costs while maintaining superior results. This exemplifies the "Less is More" philosophy in MLLM development.

ROSE: A Reward-Oriented Data Selection Framework for LLM Task-Specific Instruction Tuning

Instruction tuning has underscored the significant potential of large language models (LLMs) in producing more human-controllable and effective outputs in various domains. In this work, we focus on the data selection problem for task-specific instruction tuning of LLMs. Prevailing methods primarily rely on the crafted similarity metrics to select training data that aligns with the test data distribution. The goal is to minimize instruction tuning loss on the test data, ultimately improving performance on the target task. However, it has been widely observed that instruction tuning loss (i.e., cross-entropy loss for next token prediction) in LLMs often fails to exhibit a monotonic relationship with actual task performance. This misalignment undermines the effectiveness of current data selection methods for task-specific instruction tuning. To address this issue, we introduce ROSE, a novel Reward-Oriented inStruction data sElection method which leverages pairwise preference loss as a reward signal to optimize data selection for task-specific instruction tuning. Specifically, ROSE adapts an influence formulation to approximate the influence of training data points relative to a few-shot preference validation set to select the most task-related training data points. Experimental results show that by selecting just 5% of the training data using ROSE, our approach can achieve competitive results compared to fine-tuning with the full training dataset, and it surpasses other state-of-the-art data selection methods for task-specific instruction tuning. Our qualitative analysis further confirms the robust generalizability of our method across multiple benchmark datasets and diverse model architectures.

AnyEdit: Mastering Unified High-Quality Image Editing for Any Idea

Instruction-based image editing aims to modify specific image elements with natural language instructions. However, current models in this domain often struggle to accurately execute complex user instructions, as they are trained on low-quality data with limited editing types. We present AnyEdit, a comprehensive multi-modal instruction editing dataset, comprising 2.5 million high-quality editing pairs spanning over 20 editing types and five domains. We ensure the diversity and quality of the AnyEdit collection through three aspects: initial data diversity, adaptive editing process, and automated selection of editing results. Using the dataset, we further train a novel AnyEdit Stable Diffusion with task-aware routing and learnable task embedding for unified image editing. Comprehensive experiments on three benchmark datasets show that AnyEdit consistently boosts the performance of diffusion-based editing models. This presents prospects for developing instruction-driven image editing models that support human creativity.

Attentive Contextual Attention for Cloud Removal

Cloud cover can significantly hinder the use of remote sensing images for Earth observation, prompting urgent advancements in cloud removal technology. Recently, deep learning strategies have shown strong potential in restoring cloud-obscured areas. These methods utilize convolution to extract intricate local features and attention mechanisms to gather long-range information, improving the overall comprehension of the scene. However, a common drawback of these approaches is that the resulting images often suffer from blurriness, artifacts, and inconsistencies. This is partly because attention mechanisms apply weights to all features based on generalized similarity scores, which can inadvertently introduce noise and irrelevant details from cloud-covered areas. To overcome this limitation and better capture relevant distant context, we introduce a novel approach named Attentive Contextual Attention (AC-Attention). This method enhances conventional attention mechanisms by dynamically learning data-driven attentive selection scores, enabling it to filter out noise and irrelevant features effectively. By integrating the AC-Attention module into the DSen2-CR cloud removal framework, we significantly improve the model's ability to capture essential distant information, leading to more effective cloud removal. Our extensive evaluation of various datasets shows that our method outperforms existing ones regarding image reconstruction quality. Additionally, we conducted ablation studies by integrating AC-Attention into multiple existing methods and widely used network architectures. These studies demonstrate the effectiveness and adaptability of AC-Attention and reveal its ability to focus on relevant features, thereby improving the overall performance of the networks. The code is available at \url{https://github.com/huangwenwenlili/ACA-CRNet}.

E.T. Bench: Towards Open-Ended Event-Level Video-Language Understanding

Recent advances in Video Large Language Models (Video-LLMs) have demonstrated their great potential in general-purpose video understanding. To verify the significance of these models, a number of benchmarks have been proposed to diagnose their capabilities in different scenarios. However, existing benchmarks merely evaluate models through video-level question-answering, lacking fine-grained event-level assessment and task diversity. To fill this gap, we introduce E.T. Bench (Event-Level & Time-Sensitive Video Understanding Benchmark), a large-scale and high-quality benchmark for open-ended event-level video understanding. Categorized within a 3-level task taxonomy, E.T. Bench encompasses 7.3K samples under 12 tasks with 7K videos (251.4h total length) under 8 domains, providing comprehensive evaluations. We extensively evaluated 8 Image-LLMs and 12 Video-LLMs on our benchmark, and the results reveal that state-of-the-art models for coarse-level (video-level) understanding struggle to solve our fine-grained tasks, e.g., grounding event-of-interests within videos, largely due to the short video context length, improper time representations, and lack of multi-event training data. Focusing on these issues, we further propose a strong baseline model, E.T. Chat, together with an instruction-tuning dataset E.T. Instruct 164K tailored for fine-grained event-level understanding. Our simple but effective solution demonstrates superior performance in multiple scenarios.

Text2LiDAR: Text-guided LiDAR Point Cloud Generation via Equirectangular Transformer

The complex traffic environment and various weather conditions make the collection of LiDAR data expensive and challenging. Achieving high-quality and controllable LiDAR data generation is urgently needed, controlling with text is a common practice, but there is little research in this field. To this end, we propose Text2LiDAR, the first efficient, diverse, and text-controllable LiDAR data generation model. Specifically, we design an equirectangular transformer architecture, utilizing the designed equirectangular attention to capture LiDAR features in a manner with data characteristics. Then, we design a control-signal embedding injector to efficiently integrate control signals through the global-to-focused attention mechanism. Additionally, we devise a frequency modulator to assist the model in recovering high-frequency details, ensuring the clarity of the generated point cloud. To foster development in the field and optimize text-controlled generation performance, we construct nuLiDARtext which offers diverse text descriptors for 34,149 LiDAR point clouds from 850 scenes. Experiments on uncontrolled and text-controlled generation in various forms on KITTI-360 and nuScenes datasets demonstrate the superiority of our approach.

Large Language Models Meet Text-Centric Multimodal Sentiment Analysis: A Survey

Compared to traditional sentiment analysis, which only considers text, multimodal sentiment analysis needs to consider emotional signals from multimodal sources simultaneously and is therefore more consistent with the way how humans process sentiment in real-world scenarios. It involves processing emotional information from various sources such as natural language, images, videos, audio, physiological signals, etc. However, although other modalities also contain diverse emotional cues, natural language usually contains richer contextual information and therefore always occupies a crucial position in multimodal sentiment analysis. The emergence of ChatGPT has opened up immense potential for applying large language models (LLMs) to text-centric multimodal tasks. However, it is still unclear how existing LLMs can adapt better to text-centric multimodal sentiment analysis tasks. This survey aims to (1) present a comprehensive review of recent research in text-centric multimodal sentiment analysis tasks, (2) examine the potential of LLMs for text-centric multimodal sentiment analysis, outlining their approaches, advantages, and limitations, (3) summarize the application scenarios of LLM-based multimodal sentiment analysis technology, and (4) explore the challenges and potential research directions for multimodal sentiment analysis in the future.

PosterLLaVa: Constructing a Unified Multi-modal Layout Generator with LLM

Layout generation is the keystone in achieving automated graphic design, requiring arranging the position and size of various multi-modal design elements in a visually pleasing and constraint-following manner. Previous approaches are either inefficient for large-scale applications or lack flexibility for varying design requirements. Our research introduces a unified framework for automated graphic layout generation, leveraging the multi-modal large language model (MLLM) to accommodate diverse design tasks. In contrast, our data-driven method employs structured text (JSON format) and visual instruction tuning to generate layouts under specific visual and textual constraints, including user-defined natural language specifications. We conducted extensive experiments and achieved state-of-the-art (SOTA) performance on public multi-modal layout generation benchmarks, demonstrating the effectiveness of our method. Moreover, recognizing existing datasets' limitations in capturing the complexity of real-world graphic designs, we propose two new datasets for much more challenging tasks (user-constrained generation and complicated poster), further validating our model's utility in real-life settings. Marking by its superior accessibility and adaptability, this approach further automates large-scale graphic design tasks. The code and datasets will be publicly available on https://github.com/posterllava/PosterLLaVA.