ViDTA: Enhanced Drug-Target Affinity Prediction via Virtual Graph Nodes and Attention-based Feature Fusion

Drug-target interaction is fundamental in understanding how drugs affect biological systems, and accurately predicting drug-target affinity (DTA) is vital for drug discovery. Recently, deep learning methods have emerged as a significant approach for estimating the binding strength between drugs and target proteins. However, existing methods simply utilize the drug's local information from molecular topology rather than global information. Additionally, the features of drugs and proteins are usually fused with a simple concatenation operation, limiting their effectiveness. To address these challenges, we proposed ViDTA, an enhanced DTA prediction framework. We introduce virtual nodes into the Graph Neural Network (GNN)-based drug feature extraction network, which acts as a global memory to exchange messages more efficiently. By incorporating virtual graph nodes, we seamlessly integrate local and global features of drug molecular structures, expanding the GNN's receptive field. Additionally, we propose an attention-based linear feature fusion network for better capturing the interaction information between drugs and proteins. Experimental results evaluated on various benchmarks including Davis, Metz, and KIBA demonstrate that our proposed ViDTA outperforms the state-of-the-art baselines.

NumbOD: A Spatial-Frequency Fusion Attack Against Object Detectors

With the advancement of deep learning, object detectors (ODs) with various architectures have achieved significant success in complex scenarios like autonomous driving. Previous adversarial attacks against ODs have been focused on designing customized attacks targeting their specific structures (e.g., NMS and RPN), yielding some results but simultaneously constraining their scalability. Moreover, most efforts against ODs stem from image-level attacks originally designed for classification tasks, resulting in redundant computations and disturbances in object-irrelevant areas (e.g., background). Consequently, how to design a model-agnostic efficient attack to comprehensively evaluate the vulnerabilities of ODs remains challenging and unresolved. In this paper, we propose NumbOD, a brand-new spatial-frequency fusion attack against various ODs, aimed at disrupting object detection within images. We directly leverage the features output by the OD without relying on its internal structures to craft adversarial examples. Specifically, we first design a dual-track attack target selection strategy to select high-quality bounding boxes from OD outputs for targeting. Subsequently, we employ directional perturbations to shift and compress predicted boxes and change classification results to deceive ODs. Additionally, we focus on manipulating the high-frequency components of images to confuse ODs' attention on critical objects, thereby enhancing the attack efficiency. Our extensive experiments on nine ODs and two datasets show that NumbOD achieves powerful attack performance and high stealthiness.

Breaking Barriers in Physical-World Adversarial Examples: Improving Robustness and Transferability via Robust Feature

As deep neural networks (DNNs) are widely applied in the physical world, many researches are focusing on physical-world adversarial examples (PAEs), which introduce perturbations to inputs and cause the model's incorrect outputs. However, existing PAEs face two challenges: unsatisfactory attack performance (i.e., poor transferability and insufficient robustness to environment conditions), and difficulty in balancing attack effectiveness with stealthiness, where better attack effectiveness often makes PAEs more perceptible. In this paper, we explore a novel perturbation-based method to overcome the challenges. For the first challenge, we introduce a strategy Deceptive RF injection based on robust features (RFs) that are predictive, robust to perturbations, and consistent across different models. Specifically, it improves the transferability and robustness of PAEs by covering RFs of other classes onto the predictive features in clean images. For the second challenge, we introduce another strategy Adversarial Semantic Pattern Minimization, which removes most perturbations and retains only essential adversarial patterns in AEsBased on the two strategies, we design our method Robust Feature Coverage Attack (RFCoA), comprising Robust Feature Disentanglement and Adversarial Feature Fusion. In the first stage, we extract target class RFs in feature space. In the second stage, we use attention-based feature fusion to overlay these RFs onto predictive features of clean images and remove unnecessary perturbations. Experiments show our method's superior transferability, robustness, and stealthiness compared to existing state-of-the-art methods. Additionally, our method's effectiveness can extend to Large Vision-Language Models (LVLMs), indicating its potential applicability to more complex tasks.

PB-UAP: Hybrid Universal Adversarial Attack For Image Segmentation

With the rapid advancement of deep learning, the model robustness has become a significant research hotspot, \ie, adversarial attacks on deep neural networks. Existing works primarily focus on image classification tasks, aiming to alter the model's predicted labels. Due to the output complexity and deeper network architectures, research on adversarial examples for segmentation models is still limited, particularly for universal adversarial perturbations. In this paper, we propose a novel universal adversarial attack method designed for segmentation models, which includes dual feature separation and low-frequency scattering modules. The two modules guide the training of adversarial examples in the pixel and frequency space, respectively. Experiments demonstrate that our method achieves high attack success rates surpassing the state-of-the-art methods, and exhibits strong transferability across different models.

Visual Adversarial Attack on Vision-Language Models for Autonomous Driving

Vision-language models (VLMs) have significantly advanced autonomous driving (AD) by enhancing reasoning capabilities. However, these models remain highly vulnerable to adversarial attacks. While existing research has primarily focused on general VLM attacks, the development of attacks tailored to the safety-critical AD context has been largely overlooked. In this paper, we take the first step toward designing adversarial attacks specifically targeting VLMs in AD, exposing the substantial risks these attacks pose within this critical domain. We identify two unique challenges for effective adversarial attacks on AD VLMs: the variability of textual instructions and the time-series nature of visual scenarios. To this end, we propose ADvLM, the first visual adversarial attack framework specifically designed for VLMs in AD. Our framework introduces Semantic-Invariant Induction, which uses a large language model to create a diverse prompt library of textual instructions with consistent semantic content, guided by semantic entropy. Building on this, we introduce Scenario-Associated Enhancement, an approach where attention mechanisms select key frames and perspectives within driving scenarios to optimize adversarial perturbations that generalize across the entire scenario. Extensive experiments on several AD VLMs over multiple benchmarks show that ADvLM achieves state-of-the-art attack effectiveness. Moreover, real-world attack studies further validate its applicability and potential in practice.

TrojanRobot: Backdoor Attacks Against Robotic Manipulation in the Physical World

Robotic manipulation refers to the autonomous handling and interaction of robots with objects using advanced techniques in robotics and artificial intelligence. The advent of powerful tools such as large language models (LLMs) and large vision-language models (LVLMs) has significantly enhanced the capabilities of these robots in environmental perception and decision-making. However, the introduction of these intelligent agents has led to security threats such as jailbreak attacks and adversarial attacks. In this research, we take a further step by proposing a backdoor attack specifically targeting robotic manipulation and, for the first time, implementing backdoor attack in the physical world. By embedding a backdoor visual language model into the visual perception module within the robotic system, we successfully mislead the robotic arm's operation in the physical world, given the presence of common items as triggers. Experimental evaluations in the physical world demonstrate the effectiveness of the proposed backdoor attack.

Unlearnable 3D Point Clouds: Class-wise Transformation Is All You Need

Traditional unlearnable strategies have been proposed to prevent unauthorized users from training on the 2D image data. With more 3D point cloud data containing sensitivity information, unauthorized usage of this new type data has also become a serious concern. To address this, we propose the first integral unlearnable framework for 3D point clouds including two processes: (i) we propose an unlearnable data protection scheme, involving a class-wise setting established by a category-adaptive allocation strategy and multi-transformations assigned to samples; (ii) we propose a data restoration scheme that utilizes class-wise inverse matrix transformation, thus enabling authorized-only training for unlearnable data. This restoration process is a practical issue overlooked in most existing unlearnable literature, \ie, even authorized users struggle to gain knowledge from 3D unlearnable data. Both theoretical and empirical results (including 6 datasets, 16 models, and 2 tasks) demonstrate the effectiveness of our proposed unlearnable framework. Our code is available at \url{https://github.com/CGCL-codes/UnlearnablePC}

DarkSAM: Fooling Segment Anything Model to Segment Nothing

Segment Anything Model (SAM) has recently gained much attention for its outstanding generalization to unseen data and tasks. Despite its promising prospect, the vulnerabilities of SAM, especially to universal adversarial perturbation (UAP) have not been thoroughly investigated yet. In this paper, we propose DarkSAM, the first prompt-free universal attack framework against SAM, including a semantic decoupling-based spatial attack and a texture distortion-based frequency attack. We first divide the output of SAM into foreground and background. Then, we design a shadow target strategy to obtain the semantic blueprint of the image as the attack target. DarkSAM is dedicated to fooling SAM by extracting and destroying crucial object features from images in both spatial and frequency domains. In the spatial domain, we disrupt the semantics of both the foreground and background in the image to confuse SAM. In the frequency domain, we further enhance the attack effectiveness by distorting the high-frequency components (i.e., texture information) of the image. Consequently, with a single UAP, DarkSAM renders SAM incapable of segmenting objects across diverse images with varying prompts. Experimental results on four datasets for SAM and its two variant models demonstrate the powerful attack capability and transferability of DarkSAM.

ECLIPSE: Expunging Clean-label Indiscriminate Poisons via Sparse Diffusion Purification

Clean-label indiscriminate poisoning attacks add invisible perturbations to correctly labeled training images, thus dramatically reducing the generalization capability of the victim models. Recently, some defense mechanisms have been proposed such as adversarial training, image transformation techniques, and image purification. However, these schemes are either susceptible to adaptive attacks, built on unrealistic assumptions, or only effective against specific poison types, limiting their universal applicability. In this research, we propose a more universally effective, practical, and robust defense scheme called ECLIPSE. We first investigate the impact of Gaussian noise on the poisons and theoretically prove that any kind of poison will be largely assimilated when imposing sufficient random noise. In light of this, we assume the victim has access to an extremely limited number of clean images (a more practical scene) and subsequently enlarge this sparse set for training a denoising probabilistic model (a universal denoising tool). We then begin by introducing Gaussian noise to absorb the poisons and then apply the model for denoising, resulting in a roughly purified dataset. Finally, to address the trade-off of the inconsistency in the assimilation sensitivity of different poisons by Gaussian noise, we propose a lightweight corruption compensation module to effectively eliminate residual poisons, providing a more universal defense approach. Extensive experiments demonstrate that our defense approach outperforms 10 state-of-the-art defenses. We also propose an adaptive attack against ECLIPSE and verify the robustness of our defense scheme. Our code is available at https://github.com/CGCL-codes/ECLIPSE.

Large Language Model Watermark Stealing With Mixed Integer Programming

The Large Language Model (LLM) watermark is a newly emerging technique that shows promise in addressing concerns surrounding LLM copyright, monitoring AI-generated text, and preventing its misuse. The LLM watermark scheme commonly includes generating secret keys to partition the vocabulary into green and red lists, applying a perturbation to the logits of tokens in the green list to increase their sampling likelihood, thus facilitating watermark detection to identify AI-generated text if the proportion of green tokens exceeds a threshold. However, recent research indicates that watermarking methods using numerous keys are susceptible to removal attacks, such as token editing, synonym substitution, and paraphrasing, with robustness declining as the number of keys increases. Therefore, the state-of-the-art watermark schemes that employ fewer or single keys have been demonstrated to be more robust against text editing and paraphrasing. In this paper, we propose a novel green list stealing attack against the state-of-the-art LLM watermark scheme and systematically examine its vulnerability to this attack. We formalize the attack as a mixed integer programming problem with constraints. We evaluate our attack under a comprehensive threat model, including an extreme scenario where the attacker has no prior knowledge, lacks access to the watermark detector API, and possesses no information about the LLM's parameter settings or watermark injection/detection scheme. Extensive experiments on LLMs, such as OPT and LLaMA, demonstrate that our attack can successfully steal the green list and remove the watermark across all settings.