AMA-SAM: Adversarial Multi-Domain Alignment of Segment Anything Model for High-Fidelity Histology Nuclei Segmentation

Accurate segmentation of cell nuclei in histopathology images is essential for numerous biomedical research and clinical applications. However, existing cell nucleus segmentation methods only consider a single dataset (i.e., primary domain), while neglecting to leverage supplementary data from diverse sources (i.e., auxiliary domains) to reduce overfitting and enhance the performance. Although incorporating multiple datasets could alleviate overfitting, it often exacerbates performance drops caused by domain shifts. In this work, we introduce Adversarial Multi-domain Alignment of Segment Anything Model (AMA-SAM) that extends the Segment Anything Model (SAM) to overcome these obstacles through two key innovations. First, we propose a Conditional Gradient Reversal Layer (CGRL), a multi-domain alignment module that harmonizes features from diverse domains to promote domain-invariant representation learning while preserving crucial discriminative features for the primary dataset. Second, we address SAM's inherent low-resolution output by designing a High-Resolution Decoder (HR-Decoder), which directly produces fine-grained segmentation maps in order to capture intricate nuclei boundaries in high-resolution histology images. To the best of our knowledge, this is the first attempt to adapt SAM for multi-dataset learning with application to histology nuclei segmentation. We validate our method on several publicly available datasets, demonstrating consistent and significant improvements over state-of-the-art approaches.

Dual-domain Multi-path Self-supervised Diffusion Model for Accelerated MRI Reconstruction

Magnetic resonance imaging (MRI) is a vital diagnostic tool, but its inherently long acquisition times reduce clinical efficiency and patient comfort. Recent advancements in deep learning, particularly diffusion models, have improved accelerated MRI reconstruction. However, existing diffusion models' training often relies on fully sampled data, models incur high computational costs, and often lack uncertainty estimation, limiting their clinical applicability. To overcome these challenges, we propose a novel framework, called Dual-domain Multi-path Self-supervised Diffusion Model (DMSM), that integrates a self-supervised dual-domain diffusion model training scheme, a lightweight hybrid attention network for the reconstruction diffusion model, and a multi-path inference strategy, to enhance reconstruction accuracy, efficiency, and explainability. Unlike traditional diffusion-based models, DMSM eliminates the dependency on training from fully sampled data, making it more practical for real-world clinical settings. We evaluated DMSM on two human MRI datasets, demonstrating that it achieves favorable performance over several supervised and self-supervised baselines, particularly in preserving fine anatomical structures and suppressing artifacts under high acceleration factors. Additionally, our model generates uncertainty maps that correlate reasonably well with reconstruction errors, offering valuable clinically interpretable guidance and potentially enhancing diagnostic confidence.

Fed-NDIF: A Noise-Embedded Federated Diffusion Model For Low-Count Whole-Body PET Denoising

Low-count positron emission tomography (LCPET) imaging can reduce patients' exposure to radiation but often suffers from increased image noise and reduced lesion detectability, necessitating effective denoising techniques. Diffusion models have shown promise in LCPET denoising for recovering degraded image quality. However, training such models requires large and diverse datasets, which are challenging to obtain in the medical domain. To address data scarcity and privacy concerns, we combine diffusion models with federated learning -- a decentralized training approach where models are trained individually at different sites, and their parameters are aggregated on a central server over multiple iterations. The variation in scanner types and image noise levels within and across institutions poses additional challenges for federated learning in LCPET denoising. In this study, we propose a novel noise-embedded federated learning diffusion model (Fed-NDIF) to address these challenges, leveraging a multicenter dataset and varying count levels. Our approach incorporates liver normalized standard deviation (NSTD) noise embedding into a 2.5D diffusion model and utilizes the Federated Averaging (FedAvg) algorithm to aggregate locally trained models into a global model, which is subsequently fine-tuned on local datasets to optimize performance and obtain personalized models. Extensive validation on datasets from the University of Bern, Ruijin Hospital in Shanghai, and Yale-New Haven Hospital demonstrates the superior performance of our method in enhancing image quality and improving lesion quantification. The Fed-NDIF model shows significant improvements in PSNR, SSIM, and NMSE of the entire 3D volume, as well as enhanced lesion detectability and quantification, compared to local diffusion models and federated UNet-based models.

VMTS: Vision-Assisted Teacher-Student Reinforcement Learning for Multi-Terrain Locomotion in Bipedal Robots

Bipedal robots, due to their anthropomorphic design, offer substantial potential across various applications, yet their control is hindered by the complexity of their structure. Currently, most research focuses on proprioception-based methods, which lack the capability to overcome complex terrain. While visual perception is vital for operation in human-centric environments, its integration complicates control further. Recent reinforcement learning (RL) approaches have shown promise in enhancing legged robot locomotion, particularly with proprioception-based methods. However, terrain adaptability, especially for bipedal robots, remains a significant challenge, with most research focusing on flat-terrain scenarios. In this paper, we introduce a novel mixture of experts teacher-student network RL strategy, which enhances the performance of teacher-student policies based on visual inputs through a simple yet effective approach. Our method combines terrain selection strategies with the teacher policy, resulting in superior performance compared to traditional models. Additionally, we introduce an alignment loss between the teacher and student networks, rather than enforcing strict similarity, to improve the student's ability to navigate diverse terrains. We validate our approach experimentally on the Limx Dynamic P1 bipedal robot, demonstrating its feasibility and robustness across multiple terrain types.

Efficient 4D fMRI ASD Classification using Spatial-Temporal-Omics-based Learning Framework

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder impacting social and behavioral development. Resting-state fMRI, a non-invasive tool for capturing brain connectivity patterns, aids in early ASD diagnosis and differentiation from typical controls (TC). However, previous methods, which rely on either mean time series or full 4D data, are limited by a lack of spatial information or by high computational costs. This underscores the need for an efficient solution that preserves both spatial and temporal information. In this paper, we propose a novel, simple, and efficient spatial-temporal-omics learning framework designed to efficiently extract spatio-temporal features from fMRI for ASD classification. Our approach addresses these limitations by utilizing 3D time-domain derivatives as the spatial-temporal inter-voxel omics, which preserve full spatial resolution while capturing diverse statistical characteristics of the time series at each voxel. Meanwhile, functional connectivity features serve as the spatial-temporal inter-regional omics, capturing correlations across brain regions. Extensive experiments and ablation studies on the ABIDE dataset demonstrate that our framework significantly outperforms previous methods while maintaining computational efficiency. We believe our research offers valuable insights that will inform and advance future ASD studies, particularly in the realm of spatial-temporal-omics-based learning.

Survey on Strategic Mining in Blockchain: A Reinforcement Learning Approach

Strategic mining attacks, such as selfish mining, exploit blockchain consensus protocols by deviating from honest behavior to maximize rewards. Markov Decision Process (MDP) analysis faces scalability challenges in modern digital economics, including blockchain. To address these limitations, reinforcement learning (RL) provides a scalable alternative, enabling adaptive strategy optimization in complex dynamic environments. In this survey, we examine RL's role in strategic mining analysis, comparing it to MDP-based approaches. We begin by reviewing foundational MDP models and their limitations, before exploring RL frameworks that can learn near-optimal strategies across various protocols. Building on this analysis, we compare RL techniques and their effectiveness in deriving security thresholds, such as the minimum attacker power required for profitable attacks. Expanding the discussion further, we classify consensus protocols and propose open challenges, such as multi-agent dynamics and real-world validation. This survey highlights the potential of reinforcement learning (RL) to address the challenges of selfish mining, including protocol design, threat detection, and security analysis, while offering a strategic roadmap for researchers in decentralized systems and AI-driven analytics.

Assessing the Impact of Sampling Irregularity in Time Series Data: Human Activity Recognition As A Case Study

Human activity recognition (HAR) ideally relies on data from wearable or environment-instrumented sensors sampled at regular intervals, enabling standard neural network models optimized for consistent time-series data as input. However, real-world sensor data often exhibits irregular sampling due to, for example, hardware constraints, power-saving measures, or communication delays, posing challenges for deployed static HAR models. This study assesses the impact of sampling irregularities on HAR by simulating irregular data through two methods: introducing slight inconsistencies in sampling intervals (timestamp variations) to mimic sensor jitter, and randomly removing data points (random dropout) to simulate missing values due to packet loss or sensor failure. We evaluate both discrete-time neural networks and continuous-time neural networks, which are designed to handle continuous-time data, on three public datasets. We demonstrate that timestamp variations do not significantly affect the performance of discrete-time neural networks, and the continuous-time neural network is also ineffective in addressing the challenges posed by irregular sampling, possibly due to limitations in modeling complex temporal patterns with missing data. Our findings underscore the necessity for new models or approaches that can robustly handle sampling irregularity in time-series data, like the reading in human activity recognition, paving the way for future research in this domain.

Initial Findings on Sensor based Open Vocabulary Activity Recognition via Text Embedding Inversion

Conventional human activity recognition (HAR) relies on classifiers trained to predict discrete activity classes, inherently limiting recognition to activities explicitly present in the training set. Such classifiers would invariably fail, putting zero likelihood, when encountering unseen activities. We propose Open Vocabulary HAR (OV-HAR), a framework that overcomes this limitation by first converting each activity into natural language and breaking it into a sequence of elementary motions. This descriptive text is then encoded into a fixed-size embedding. The model is trained to regress this embedding, which is subsequently decoded back into natural language using a pre-trained embedding inversion model. Unlike other works that rely on auto-regressive large language models (LLMs) at their core, OV-HAR achieves open vocabulary recognition without the computational overhead of such models. The generated text can be transformed into a single activity class using LLM prompt engineering. We have evaluated our approach on different modalities, including vision (pose), IMU, and pressure sensors, demonstrating robust generalization across unseen activities and modalities, offering a fundamentally different paradigm from contemporary classifiers.

OV-HHIR: Open Vocabulary Human Interaction Recognition Using Cross-modal Integration of Large Language Models

Understanding human-to-human interactions, especially in contexts like public security surveillance, is critical for monitoring and maintaining safety. Traditional activity recognition systems are limited by fixed vocabularies, predefined labels, and rigid interaction categories that often rely on choreographed videos and overlook concurrent interactive groups. These limitations make such systems less adaptable to real-world scenarios, where interactions are diverse and unpredictable. In this paper, we propose an open vocabulary human-to-human interaction recognition (OV-HHIR) framework that leverages large language models to generate open-ended textual descriptions of both seen and unseen human interactions in open-world settings without being confined to a fixed vocabulary. Additionally, we create a comprehensive, large-scale human-to-human interaction dataset by standardizing and combining existing public human interaction datasets into a unified benchmark. Extensive experiments demonstrate that our method outperforms traditional fixed-vocabulary classification systems and existing cross-modal language models for video understanding, setting the stage for more intelligent and adaptable visual understanding systems in surveillance and beyond.

A Generalizable 3D Diffusion Framework for Low-Dose and Few-View Cardiac SPECT

Myocardial perfusion imaging using SPECT is widely utilized to diagnose coronary artery diseases, but image quality can be negatively affected in low-dose and few-view acquisition settings. Although various deep learning methods have been introduced to improve image quality from low-dose or few-view SPECT data, previous approaches often fail to generalize across different acquisition settings, limiting their applicability in reality. This work introduced DiffSPECT-3D, a diffusion framework for 3D cardiac SPECT imaging that effectively adapts to different acquisition settings without requiring further network re-training or fine-tuning. Using both image and projection data, a consistency strategy is proposed to ensure that diffusion sampling at each step aligns with the low-dose/few-view projection measurements, the image data, and the scanner geometry, thus enabling generalization to different low-dose/few-view settings. Incorporating anatomical spatial information from CT and total variation constraint, we proposed a 2.5D conditional strategy to allow the DiffSPECT-3D to observe 3D contextual information from the entire image volume, addressing the 3D memory issues in diffusion model. We extensively evaluated the proposed method on 1,325 clinical 99mTc tetrofosmin stress/rest studies from 795 patients. Each study was reconstructed into 5 different low-count and 5 different few-view levels for model evaluations, ranging from 1% to 50% and from 1 view to 9 view, respectively. Validated against cardiac catheterization results and diagnostic comments from nuclear cardiologists, the presented results show the potential to achieve low-dose and few-view SPECT imaging without compromising clinical performance. Additionally, DiffSPECT-3D could be directly applied to full-dose SPECT images to further improve image quality, especially in a low-dose stress-first cardiac SPECT imaging protocol.