BrainVista: Modeling Naturalistic Brain Dynamics as Multimodal Next-Token Prediction

Naturalistic fMRI characterizes the brain as a dynamic predictive engine driven by continuous sensory streams. However, modeling the causal forward evolution in realistic neural simulation is impeded by the timescale mismatch between multimodal inputs and the complex topology of cortical networks. To address these challenges, we introduce BrainVista, a multimodal autoregressive framework designed to model the causal evolution of brain states. BrainVista incorporates Network-wise Tokenizers to disentangle system-specific dynamics and a Spatial Mixer Head that captures inter-network information flow without compromising functional boundaries. Furthermore, we propose a novel Stimulus-to-Brain (S2B) masking mechanism to synchronize high-frequency sensory stimuli with hemodynamically filtered signals, enabling strict, history-only causal conditioning. We validate our framework on Algonauts 2025, CineBrain, and HAD, achieving state-of-the-art fMRI encoding performance. In long-horizon rollout settings, our model yields substantial improvements over baselines, increasing pattern correlation by 36.0\% and 33.3\% on relative to the strongest baseline Algonauts 2025 and CineBrain, respectively.

Learning Topology-Aware Implicit Field for Unified Pulmonary Tree Modeling with Incomplete Topological Supervision

Pulmonary trees extracted from CT images frequently exhibit topological incompleteness, such as missing or disconnected branches, which substantially degrades downstream anatomical analysis and limits the applicability of existing pulmonary tree modeling pipelines. Current approaches typically rely on dense volumetric processing or explicit graph reasoning, leading to limited efficiency and reduced robustness under realistic structural corruption. We propose TopoField, a topology-aware implicit modeling framework that treats topology repair as a first-class modeling problem and enables unified multi-task inference for pulmonary tree analysis. TopoField represents pulmonary anatomy using sparse surface and skeleton point clouds and learns a continuous implicit field that supports topology repair without relying on complete or explicit disconnection annotations, by training on synthetically introduced structural disruptions over \textit{already} incomplete trees. Building upon the repaired implicit representation, anatomical labeling and lung segment reconstruction are jointly inferred through task-specific implicit functions within a single forward pass.Extensive experiments on the Lung3D+ dataset demonstrate that TopoField consistently improves topological completeness and achieves accurate anatomical labeling and lung segment reconstruction under challenging incomplete scenarios. Owing to its implicit formulation, TopoField attains high computational efficiency, completing all tasks in just over one second per case, highlighting its practicality for large-scale and time-sensitive clinical applications. Code and data will be available at https://github.com/HINTLab/TopoField.

FUGC: Benchmarking Semi-Supervised Learning Methods for Cervical Segmentation

Accurate segmentation of cervical structures in transvaginal ultrasound (TVS) is critical for assessing the risk of spontaneous preterm birth (PTB), yet the scarcity of labeled data limits the performance of supervised learning approaches. This paper introduces the Fetal Ultrasound Grand Challenge (FUGC), the first benchmark for semi-supervised learning in cervical segmentation, hosted at ISBI 2025. FUGC provides a dataset of 890 TVS images, including 500 training images, 90 validation images, and 300 test images. Methods were evaluated using the Dice Similarity Coefficient (DSC), Hausdorff Distance (HD), and runtime (RT), with a weighted combination of 0.4/0.4/0.2. The challenge attracted 10 teams with 82 participants submitting innovative solutions. The best-performing methods for each individual metric achieved 90.26\% mDSC, 38.88 mHD, and 32.85 ms RT, respectively. FUGC establishes a standardized benchmark for cervical segmentation, demonstrates the efficacy of semi-supervised methods with limited labeled data, and provides a foundation for AI-assisted clinical PTB risk assessment.

DanQing: An Up-to-Date Large-Scale Chinese Vision-Language Pre-training Dataset

Vision-Language Pre-training (VLP) models demonstrate strong performance across various downstream tasks by learning from large-scale image-text pairs through contrastive pretraining. The release of extensive English image-text datasets (e.g., COYO-700M and LAION-400M) has enabled widespread adoption of models such as CLIP and SigLIP in tasks including cross-modal retrieval and image captioning. However, the advancement of Chinese vision-language pretraining has substantially lagged behind, due to the scarcity of high-quality Chinese image-text data. To address this gap, we develop a comprehensive pipeline for constructing a high-quality Chinese cross-modal dataset. As a result, we propose DanQing, which contains 100 million image-text pairs collected from Common Crawl. Different from existing datasets, DanQing is curated through a more rigorous selection process, yielding superior data quality. Moreover, DanQing is primarily built from 2024-2025 web data, enabling models to better capture evolving semantic trends and thus offering greater practical utility. We compare DanQing with existing datasets by continual pre-training of the SigLIP2 model. Experimental results show that DanQing consistently achieves superior performance across a range of Chinese downstream tasks, including zero-shot classification, cross-modal retrieval, and LMM-based evaluations. To facilitate further research in Chinese vision-language pre-training, we will open-source the DanQing dataset under the Creative Common CC-BY 4.0 license.

HiFusion: Hierarchical Intra-Spot Alignment and Regional Context Fusion for Spatial Gene Expression Prediction from Histopathology

Spatial transcriptomics (ST) bridges gene expression and tissue morphology but faces clinical adoption barriers due to technical complexity and prohibitive costs. While computational methods predict gene expression from H&E-stained whole-slide images (WSIs), existing approaches often fail to capture the intricate biological heterogeneity within spots and are susceptible to morphological noise when integrating contextual information from surrounding tissue. To overcome these limitations, we propose HiFusion, a novel deep learning framework that integrates two complementary components. First, we introduce the Hierarchical Intra-Spot Modeling module that extracts fine-grained morphological representations through multi-resolution sub-patch decomposition, guided by a feature alignment loss to ensure semantic consistency across scales. Concurrently, we present the Context-aware Cross-scale Fusion module, which employs cross-attention to selectively incorporate biologically relevant regional context, thereby enhancing representational capacity. This architecture enables comprehensive modeling of both cellular-level features and tissue microenvironmental cues, which are essential for accurate gene expression prediction. Extensive experiments on two benchmark ST datasets demonstrate that HiFusion achieves state-of-the-art performance across both 2D slide-wise cross-validation and more challenging 3D sample-specific scenarios. These results underscore HiFusion's potential as a robust, accurate, and scalable solution for ST inference from routine histopathology.

SurgiATM: A Physics-Guided Plug-and-Play Model for Deep Learning-Based Smoke Removal in Laparoscopic Surgery

During laparoscopic surgery, smoke generated by tissue cauterization can significantly degrade the visual quality of endoscopic frames, increasing the risk of surgical errors and hindering both clinical decision-making and computer-assisted visual analysis. Consequently, removing surgical smoke is critical to ensuring patient safety and maintaining operative efficiency. In this study, we propose the Surgical Atmospheric Model (SurgiATM) for surgical smoke removal. SurgiATM statistically bridges a physics-based atmospheric model and data-driven deep learning models, combining the superior generalizability of the former with the high accuracy of the latter. Furthermore, SurgiATM is designed as a lightweight, plug-and-play module that can be seamlessly integrated into diverse surgical desmoking architectures to enhance their accuracy and stability, better meeting clinical requirements. It introduces only two hyperparameters and no additional trainable weights, preserving the original network architecture with minimal computational and modification overhead. We conduct extensive experiments on three public surgical datasets with ten desmoking methods, involving multiple network architectures and covering diverse procedures, including cholecystectomy, partial nephrectomy, and diaphragm dissection. The results demonstrate that incorporating SurgiATM commonly reduces the restoration errors of existing models and relatively enhances their generalizability, without adding any trainable layers or weights. This highlights the convenience, low cost, effectiveness, and generalizability of the proposed method. The code for SurgiATM is released at https://github.com/MingyuShengSMY/SurgiATM.

Improving Multimodal Brain Encoding Model with Dynamic Subject-awareness Routing

Naturalistic fMRI encoding must handle multimodal inputs, shifting fusion styles, and pronounced inter-subject variability. We introduce AFIRE (Agnostic Framework for Multimodal fMRI Response Encoding), an agnostic interface that standardizes time-aligned post-fusion tokens from varied encoders, and MIND, a plug-and-play Mixture-of-Experts decoder with a subject-aware dynamic gating. Trained end-to-end for whole-brain prediction, AFIRE decouples the decoder from upstream fusion, while MIND combines token-dependent Top-K sparse routing with a subject prior to personalize expert usage without sacrificing generality. Experiments across multiple multimodal backbones and subjects show consistent improvements over strong baselines, enhanced cross-subject generalization, and interpretable expert patterns that correlate with content type. The framework offers a simple attachment point for new encoders and datasets, enabling robust, plug-and-improve performance for naturalistic neuroimaging studies.

Beyond Random Masking: A Dual-Stream Approach for Rotation-Invariant Point Cloud Masked Autoencoders

Existing rotation-invariant point cloud masked autoencoders (MAE) rely on random masking strategies that overlook geometric structure and semantic coherence. Random masking treats patches independently, failing to capture spatial relationships consistent across orientations and overlooking semantic object parts that maintain identity regardless of rotation. We propose a dual-stream masking approach combining 3D Spatial Grid Masking and Progressive Semantic Masking to address these fundamental limitations. Grid masking creates structured patterns through coordinate sorting to capture geometric relationships that persist across different orientations, while semantic masking uses attention-driven clustering to discover semantically meaningful parts and maintain their coherence during masking. These complementary streams are orchestrated via curriculum learning with dynamic weighting, progressing from geometric understanding to semantic discovery. Designed as plug-and-play components, our strategies integrate into existing rotation-invariant frameworks without architectural changes, ensuring broad compatibility across different approaches. Comprehensive experiments on ModelNet40, ScanObjectNN, and OmniObject3D demonstrate consistent improvements across various rotation scenarios, showing substantial performance gains over the baseline rotation-invariant methods.

ScSAM: Debiasing Morphology and Distributional Variability in Subcellular Semantic Segmentation

The significant morphological and distributional variability among subcellular components poses a long-standing challenge for learning-based organelle segmentation models, significantly increasing the risk of biased feature learning. Existing methods often rely on single mapping relationships, overlooking feature diversity and thereby inducing biased training. Although the Segment Anything Model (SAM) provides rich feature representations, its application to subcellular scenarios is hindered by two key challenges: (1) The variability in subcellular morphology and distribution creates gaps in the label space, leading the model to learn spurious or biased features. (2) SAM focuses on global contextual understanding and often ignores fine-grained spatial details, making it challenging to capture subtle structural alterations and cope with skewed data distributions. To address these challenges, we introduce ScSAM, a method that enhances feature robustness by fusing pre-trained SAM with Masked Autoencoder (MAE)-guided cellular prior knowledge to alleviate training bias from data imbalance. Specifically, we design a feature alignment and fusion module to align pre-trained embeddings to the same feature space and efficiently combine different representations. Moreover, we present a cosine similarity matrix-based class prompt encoder to activate class-specific features to recognize subcellular categories. Extensive experiments on diverse subcellular image datasets demonstrate that ScSAM outperforms state-of-the-art methods.

LLM-Enhanced Rapid-Reflex Async-Reflect Embodied Agent for Real-Time Decision-Making in Dynamically Changing Environments

In the realm of embodied intelligence, the evolution of large language models (LLMs) has markedly enhanced agent decision making. Consequently, researchers have begun exploring agent performance in dynamically changing high-risk scenarios, i.e., fire, flood, and wind scenarios in the HAZARD benchmark. Under these extreme conditions, the delay in decision making emerges as a crucial yet insufficiently studied issue. We propose a Time Conversion Mechanism (TCM) that translates inference delays in decision-making into equivalent simulation frames, thus aligning cognitive and physical costs under a single FPS-based metric. By extending HAZARD with Respond Latency (RL) and Latency-to-Action Ratio (LAR), we deliver a fully latency-aware evaluation protocol. Moreover, we present the Rapid-Reflex Async-Reflect Agent (RRARA), which couples a lightweight LLM-guided feedback module with a rule-based agent to enable immediate reactive behaviors and asynchronous reflective refinements in situ. Experiments on HAZARD show that RRARA substantially outperforms existing baselines in latency-sensitive scenarios.