HMIL: Hierarchical Multi-Instance Learning for Fine-Grained Whole Slide Image Classification

Fine-grained classification of whole slide images (WSIs) is essential in precision oncology, enabling precise cancer diagnosis and personalized treatment strategies. The core of this task involves distinguishing subtle morphological variations within the same broad category of gigapixel-resolution images, which presents a significant challenge. While the multi-instance learning (MIL) paradigm alleviates the computational burden of WSIs, existing MIL methods often overlook hierarchical label correlations, treating fine-grained classification as a flat multi-class classification task. To overcome these limitations, we introduce a novel hierarchical multi-instance learning (HMIL) framework. By facilitating on the hierarchical alignment of inherent relationships between different hierarchy of labels at instance and bag level, our approach provides a more structured and informative learning process. Specifically, HMIL incorporates a class-wise attention mechanism that aligns hierarchical information at both the instance and bag levels. Furthermore, we introduce supervised contrastive learning to enhance the discriminative capability for fine-grained classification and a curriculum-based dynamic weighting module to adaptively balance the hierarchical feature during training. Extensive experiments on our large-scale cytology cervical cancer (CCC) dataset and two public histology datasets, BRACS and PANDA, demonstrate the state-of-the-art class-wise and overall performance of our HMIL framework. Our source code is available at https://github.com/ChengJin-git/HMIL.

2.5D Multi-view Averaging Diffusion Model for 3D Medical Image Translation: Application to Low-count PET Reconstruction with CT-less Attenuation Correction

Positron Emission Tomography (PET) is an important clinical imaging tool but inevitably introduces radiation hazards to patients and healthcare providers. Reducing the tracer injection dose and eliminating the CT acquisition for attenuation correction can reduce the overall radiation dose, but often results in PET with high noise and bias. Thus, it is desirable to develop 3D methods to translate the non-attenuation-corrected low-dose PET (NAC-LDPET) into attenuation-corrected standard-dose PET (AC-SDPET). Recently, diffusion models have emerged as a new state-of-the-art deep learning method for image-to-image translation, better than traditional CNN-based methods. However, due to the high computation cost and memory burden, it is largely limited to 2D applications. To address these challenges, we developed a novel 2.5D Multi-view Averaging Diffusion Model (MADM) for 3D image-to-image translation with application on NAC-LDPET to AC-SDPET translation. Specifically, MADM employs separate diffusion models for axial, coronal, and sagittal views, whose outputs are averaged in each sampling step to ensure the 3D generation quality from multiple views. To accelerate the 3D sampling process, we also proposed a strategy to use the CNN-based 3D generation as a prior for the diffusion model. Our experimental results on human patient studies suggested that MADM can generate high-quality 3D translation images, outperforming previous CNN-based and Diffusion-based baseline methods.

SceneX:Procedural Controllable Large-scale Scene Generation via Large-language Models

Due to its great application potential, large-scale scene generation has drawn extensive attention in academia and industry. Recent research employs powerful generative models to create desired scenes and achieves promising results. However, most of these methods represent the scene using 3D primitives (e.g. point cloud or radiance field) incompatible with the industrial pipeline, which leads to a substantial gap between academic research and industrial deployment. Procedural Controllable Generation (PCG) is an efficient technique for creating scalable and high-quality assets, but it is unfriendly for ordinary users as it demands profound domain expertise. To address these issues, we resort to using the large language model (LLM) to drive the procedural modeling. In this paper, we introduce a large-scale scene generation framework, SceneX, which can automatically produce high-quality procedural models according to designers' textual descriptions.Specifically, the proposed method comprises two components, PCGBench and PCGPlanner. The former encompasses an extensive collection of accessible procedural assets and thousands of hand-craft API documents. The latter aims to generate executable actions for Blender to produce controllable and precise 3D assets guided by the user's instructions. Our SceneX can generate a city spanning 2.5 km times 2.5 km with delicate layout and geometric structures, drastically reducing the time cost from several weeks for professional PCG engineers to just a few hours for an ordinary user. Extensive experiments demonstrated the capability of our method in controllable large-scale scene generation and editing, including asset placement and season translation.

DiPrompT: Disentangled Prompt Tuning for Multiple Latent Domain Generalization in Federated Learning

Federated learning (FL) has emerged as a powerful paradigm for learning from decentralized data, and federated domain generalization further considers the test dataset (target domain) is absent from the decentralized training data (source domains). However, most existing FL methods assume that domain labels are provided during training, and their evaluation imposes explicit constraints on the number of domains, which must strictly match the number of clients. Because of the underutilization of numerous edge devices and additional cross-client domain annotations in the real world, such restrictions may be impractical and involve potential privacy leaks. In this paper, we propose an efficient and novel approach, called Disentangled Prompt Tuning (DiPrompT), a method that tackles the above restrictions by learning adaptive prompts for domain generalization in a distributed manner. Specifically, we first design two types of prompts, i.e., global prompt to capture general knowledge across all clients and domain prompts to capture domain-specific knowledge. They eliminate the restriction on the one-to-one mapping between source domains and local clients. Furthermore, a dynamic query metric is introduced to automatically search the suitable domain label for each sample, which includes two-substep text-image alignments based on prompt tuning without labor-intensive annotation. Extensive experiments on multiple datasets demonstrate that our DiPrompT achieves superior domain generalization performance over state-of-the-art FL methods when domain labels are not provided, and even outperforms many centralized learning methods using domain labels.

POUR-Net: A Population-Prior-Aided Over-Under-Representation Network for Low-Count PET Attenuation Map Generation

Low-dose PET offers a valuable means of minimizing radiation exposure in PET imaging. However, the prevalent practice of employing additional CT scans for generating attenuation maps (u-map) for PET attenuation correction significantly elevates radiation doses. To address this concern and further mitigate radiation exposure in low-dose PET exams, we propose POUR-Net - an innovative population-prior-aided over-under-representation network that aims for high-quality attenuation map generation from low-dose PET. First, POUR-Net incorporates an over-under-representation network (OUR-Net) to facilitate efficient feature extraction, encompassing both low-resolution abstracted and fine-detail features, for assisting deep generation on the full-resolution level. Second, complementing OUR-Net, a population prior generation machine (PPGM) utilizing a comprehensive CT-derived u-map dataset, provides additional prior information to aid OUR-Net generation. The integration of OUR-Net and PPGM within a cascade framework enables iterative refinement of $\mu$-map generation, resulting in the production of high-quality $\mu$-maps. Experimental results underscore the effectiveness of POUR-Net, showing it as a promising solution for accurate CT-free low-count PET attenuation correction, which also surpasses the performance of previous baseline methods.

Combating Data Imbalances in Federated Semi-supervised Learning with Dual Regulators

Federated learning has become a popular method to learn from decentralized heterogeneous data. Federated semi-supervised learning (FSSL) emerges to train models from a small fraction of labeled data due to label scarcity on decentralized clients. Existing FSSL methods assume independent and identically distributed (IID) labeled data across clients and consistent class distribution between labeled and unlabeled data within a client. This work studies a more practical and challenging scenario of FSSL, where data distribution is different not only across clients but also within a client between labeled and unlabeled data. To address this challenge, we propose a novel FSSL framework with dual regulators, FedDure.} FedDure lifts the previous assumption with a coarse-grained regulator (C-reg) and a fine-grained regulator (F-reg): C-reg regularizes the updating of the local model by tracking the learning effect on labeled data distribution; F-reg learns an adaptive weighting scheme tailored for unlabeled instances in each client. We further formulate the client model training as bi-level optimization that adaptively optimizes the model in the client with two regulators. Theoretically, we show the convergence guarantee of the dual regulators. Empirically, we demonstrate that FedDure is superior to the existing methods across a wide range of settings, notably by more than 11% on CIFAR-10 and CINIC-10 datasets.

An Empirical Study of Pseudo-Labeling for Image-based 3D Object Detection

Image-based 3D detection is an indispensable component of the perception system for autonomous driving. However, it still suffers from the unsatisfying performance, one of the main reasons for which is the limited training data. Unfortunately, annotating the objects in the 3D space is extremely time/resource-consuming, which makes it hard to extend the training set arbitrarily. In this work, we focus on the semi-supervised manner and explore the feasibility of a cheaper alternative, i.e. pseudo-labeling, to leverage the unlabeled data. For this purpose, we conduct extensive experiments to investigate whether the pseudo-labels can provide effective supervision for the baseline models under varying settings. The experimental results not only demonstrate the effectiveness of the pseudo-labeling mechanism for image-based 3D detection (e.g. under monocular setting, we achieve 20.23 AP for moderate level on the KITTI-3D testing set without bells and whistles, improving the baseline model by 6.03 AP), but also show several interesting and noteworthy findings (e.g. the models trained with pseudo-labels perform better than that trained with ground-truth annotations based on the same training data). We hope this work can provide insights for the image-based 3D detection community under a semi-supervised setting. The codes, pseudo-labels, and pre-trained models will be publicly available.

StyleFlow For Content-Fixed Image to Image Translation

Image-to-image (I2I) translation is a challenging topic in computer vision. We divide this problem into three tasks: strongly constrained translation, normally constrained translation, and weakly constrained translation. The constraint here indicates the extent to which the content or semantic information in the original image is preserved. Although previous approaches have achieved good performance in weakly constrained tasks, they failed to fully preserve the content in both strongly and normally constrained tasks, including photo-realism synthesis, style transfer, and colorization, etc. To achieve content-preserving transfer in strongly constrained and normally constrained tasks, we propose StyleFlow, a new I2I translation model that consists of normalizing flows and a novel Style-Aware Normalization (SAN) module. With the invertible network structure, StyleFlow first projects input images into deep feature space in the forward pass, while the backward pass utilizes the SAN module to perform content-fixed feature transformation and then projects back to image space. Our model supports both image-guided translation and multi-modal synthesis. We evaluate our model in several I2I translation benchmarks, and the results show that the proposed model has advantages over previous methods in both strongly constrained and normally constrained tasks.

Probing Visual-Audio Representation for Video Highlight Detection via Hard-Pairs Guided Contrastive Learning

Video highlight detection is a crucial yet challenging problem that aims to identify the interesting moments in untrimmed videos. The key to this task lies in effective video representations that jointly pursue two goals, \textit{i.e.}, cross-modal representation learning and fine-grained feature discrimination. In this paper, these two challenges are tackled by not only enriching intra-modality and cross-modality relations for representation modeling but also shaping the features in a discriminative manner. Our proposed method mainly leverages the intra-modality encoding and cross-modality co-occurrence encoding for fully representation modeling. Specifically, intra-modality encoding augments the modality-wise features and dampens irrelevant modality via within-modality relation learning in both audio and visual signals. Meanwhile, cross-modality co-occurrence encoding focuses on the co-occurrence inter-modality relations and selectively captures effective information among multi-modality. The multi-modal representation is further enhanced by the global information abstracted from the local context. In addition, we enlarge the discriminative power of feature embedding with a hard-pairs guided contrastive learning (HPCL) scheme. A hard-pairs sampling strategy is further employed to mine the hard samples for improving feature discrimination in HPCL. Extensive experiments conducted on two benchmarks demonstrate the effectiveness and superiority of our proposed methods compared to other state-of-the-art methods.

Pyramid Region-based Slot Attention Network for Temporal Action Proposal Generation

It has been found that temporal action proposal generation, which aims to discover the temporal action instances within the range of the start and end frames in the untrimmed videos, can largely benefit from proper temporal and semantic context exploitation. The latest efforts were dedicated to considering the temporal context and similarity-based semantic contexts through self-attention modules. However, they still suffer from cluttered background information and limited contextual feature learning. In this paper, we propose a novel Pyramid Region-based Slot Attention (PRSlot) module to address these issues. Instead of using the similarity computation, our PRSlot module directly learns the local relations in an encoder-decoder manner and generates the representation of a local region enhanced based on the attention over input features called \textit{slot}. Specifically, upon the input snippet-level features, PRSlot module takes the target snippet as \textit{query}, its surrounding region as \textit{key} and then generates slot representations for each \textit{query-key} slot by aggregating the local snippet context with a parallel pyramid strategy. Based on PRSlot modules, we present a novel Pyramid Region-based Slot Attention Network termed PRSA-Net to learn a unified visual representation with rich temporal and semantic context for better proposal generation. Extensive experiments are conducted on two widely adopted THUMOS14 and ActivityNet-1.3 benchmarks. Our PRSA-Net outperforms other state-of-the-art methods. In particular, we improve the AR@100 from the previous best 50.67% to 56.12% for proposal generation and raise the mAP under 0.5 tIoU from 51.9\% to 58.7\% for action detection on THUMOS14. \textit{Code is available at} \url{https://github.com/handhand123/PRSA-Net}