CrownGen: Patient-customized Crown Generation via Point Diffusion Model

Digital crown design remains a labor-intensive bottleneck in restorative dentistry. We present \textbf{CrownGen}, a generative framework that automates patient-customized crown design using a denoising diffusion model on a novel tooth-level point cloud representation. The system employs two core components: a boundary prediction module to establish spatial priors and a diffusion-based generative module to synthesize high-fidelity morphology for multiple teeth in a single inference pass. We validated CrownGen through a quantitative benchmark on 496 external scans and a clinical study of 26 restoration cases. Results demonstrate that CrownGen surpasses state-of-the-art models in geometric fidelity and significantly reduces active design time. Clinical assessments by trained dentists confirmed that CrownGen-assisted crowns are statistically non-inferior in quality to those produced by expert technicians using manual workflows. By automating complex prosthetic modeling, CrownGen offers a scalable solution to lower costs, shorten turnaround times, and enhance patient access to high-quality dental care.

TableGPT-R1: Advancing Tabular Reasoning Through Reinforcement Learning

Tabular data serves as the backbone of modern data analysis and scientific research. While Large Language Models (LLMs) fine-tuned via Supervised Fine-Tuning (SFT) have significantly improved natural language interaction with such structured data, they often fall short in handling the complex, multi-step reasoning and robust code execution required for real-world table tasks. Reinforcement Learning (RL) offers a promising avenue to enhance these capabilities, yet its application in the tabular domain faces three critical hurdles: the scarcity of high-quality agentic trajectories with closed-loop code execution and environment feedback on diverse table structures, the extreme heterogeneity of feedback signals ranging from rigid SQL execution to open-ended data interpretation, and the risk of catastrophic forgetting of general knowledge during vertical specialization. To overcome these challenges and unlock advanced reasoning on complex tables, we introduce \textbf{TableGPT-R1}, a specialized tabular model built on a systematic RL framework. Our approach integrates a comprehensive data engineering pipeline that synthesizes difficulty-stratified agentic trajectories for both supervised alignment and RL rollouts, a task-adaptive reward system that combines rule-based verification with a criteria-injected reward model and incorporates process-level step reward shaping with behavioral regularization, and a multi-stage training framework that progressively stabilizes reasoning before specializing in table-specific tasks. Extensive evaluations demonstrate that TableGPT-R1 achieves state-of-the-art performance on authoritative benchmarks, significantly outperforming baseline models while retaining robust general capabilities. Our model is available at https://huggingface.co/tablegpt/TableGPT-R1.

Dynamic Stream Network for Combinatorial Explosion Problem in Deformable Medical Image Registration

Combinatorial explosion problem caused by dual inputs presents a critical challenge in Deformable Medical Image Registration (DMIR). Since DMIR processes two images simultaneously as input, the combination relationships between features has grown exponentially, ultimately the model considers more interfering features during the feature modeling process. Introducing dynamics in the receptive fields and weights of the network enable the model to eliminate the interfering features combination and model the potential feature combination relationships. In this paper, we propose the Dynamic Stream Network (DySNet), which enables the receptive fields and weights to be dynamically adjusted. This ultimately enables the model to ignore interfering feature combinations and model the potential feature relationships. With two key innovations: 1) Adaptive Stream Basin (AdSB) module dynamically adjusts the shape of the receptive field, thereby enabling the model to focus on the feature relationships with greater correlation. 2) Dynamic Stream Attention (DySA) mechanism generates dynamic weights to search for more valuable feature relationships. Extensive experiments have shown that DySNet consistently outperforms the most advanced DMIR methods, highlighting its outstanding generalization ability. Our code will be released on the website: https://github.com/ShaochenBi/DySNet.

MambaMIL+: Modeling Long-Term Contextual Patterns for Gigapixel Whole Slide Image

Whole-slide images (WSIs) are an important data modality in computational pathology, yet their gigapixel resolution and lack of fine-grained annotations challenge conventional deep learning models. Multiple instance learning (MIL) offers a solution by treating each WSI as a bag of patch-level instances, but effectively modeling ultra-long sequences with rich spatial context remains difficult. Recently, Mamba has emerged as a promising alternative for long sequence learning, scaling linearly to thousands of tokens. However, despite its efficiency, it still suffers from limited spatial context modeling and memory decay, constraining its effectiveness to WSI analysis. To address these limitations, we propose MambaMIL+, a new MIL framework that explicitly integrates spatial context while maintaining long-range dependency modeling without memory forgetting. Specifically, MambaMIL+ introduces 1) overlapping scanning, which restructures the patch sequence to embed spatial continuity and instance correlations; 2) a selective stripe position encoder (S2PE) that encodes positional information while mitigating the biases of fixed scanning orders; and 3) a contextual token selection (CTS) mechanism, which leverages supervisory knowledge to dynamically enlarge the contextual memory for stable long-range modeling. Extensive experiments on 20 benchmarks across diagnostic classification, molecular prediction, and survival analysis demonstrate that MambaMIL+ consistently achieves state-of-the-art performance under three feature extractors (ResNet-50, PLIP, and CONCH), highlighting its effectiveness and robustness for large-scale computational pathology

ToolForge: A Data Synthesis Pipeline for Multi-Hop Search without Real-World APIs

Training LLMs to invoke tools and leverage retrieved information necessitates high-quality, diverse data. However, existing pipelines for synthetic data generation often rely on tens of thousands of real API calls to enhance generalization, incurring prohibitive costs while lacking multi-hop reasoning and self-reflection. To address these limitations, we introduce ToolForge, an automated synthesis framework that achieves strong real-world tool-calling performance by constructing only a small number of virtual tools, eliminating the need for real API calls. ToolForge leverages a (question, golden context, answer) triple to synthesize large-scale tool-learning data specifically designed for multi-hop search scenarios, further enriching the generated data through multi-hop reasoning and self-reflection mechanisms. To ensure data fidelity, we employ a Multi-Layer Validation Framework that integrates both rule-based and model-based assessments. Empirical results show that a model with only 8B parameters, when trained on our synthesized data, outperforms GPT-4o on multiple benchmarks. Our code and dataset are publicly available at https://github.com/Buycar-arb/ToolForge .

Probing Scientific General Intelligence of LLMs with Scientist-Aligned Workflows

Despite advances in scientific AI, a coherent framework for Scientific General Intelligence (SGI)-the ability to autonomously conceive, investigate, and reason across scientific domains-remains lacking. We present an operational SGI definition grounded in the Practical Inquiry Model (PIM: Deliberation, Conception, Action, Perception) and operationalize it via four scientist-aligned tasks: deep research, idea generation, dry/wet experiments, and experimental reasoning. SGI-Bench comprises over 1,000 expert-curated, cross-disciplinary samples inspired by Science's 125 Big Questions, enabling systematic evaluation of state-of-the-art LLMs. Results reveal gaps: low exact match (10--20%) in deep research despite step-level alignment; ideas lacking feasibility and detail; high code executability but low execution result accuracy in dry experiments; low sequence fidelity in wet protocols; and persistent multimodal comparative-reasoning challenges. We further introduce Test-Time Reinforcement Learning (TTRL), which optimizes retrieval-augmented novelty rewards at inference, enhancing hypothesis novelty without reference answer. Together, our PIM-grounded definition, workflow-centric benchmark, and empirical insights establish a foundation for AI systems that genuinely participate in scientific discovery.

Bridging Fidelity-Reality with Controllable One-Step Diffusion for Image Super-Resolution

Recent diffusion-based one-step methods have shown remarkable progress in the field of image super-resolution, yet they remain constrained by three critical limitations: (1) inferior fidelity performance caused by the information loss from compression encoding of low-quality (LQ) inputs; (2) insufficient region-discriminative activation of generative priors; (3) misalignment between text prompts and their corresponding semantic regions. To address these limitations, we propose CODSR, a controllable one-step diffusion network for image super-resolution. First, we propose an LQ-guided feature modulation module that leverages original uncompressed information from LQ inputs to provide high-fidelity conditioning for the diffusion process. We then develop a region-adaptive generative prior activation method to effectively enhance perceptual richness without sacrificing local structural fidelity. Finally, we employ a text-matching guidance strategy to fully harness the conditioning potential of text prompts. Extensive experiments demonstrate that CODSR achieves superior perceptual quality and competitive fidelity compared with state-of-the-art methods with efficient one-step inference.

Bi-Erasing: A Bidirectional Framework for Concept Removal in Diffusion Models

Concept erasure, which fine-tunes diffusion models to remove undesired or harmful visual concepts, has become a mainstream approach to mitigating unsafe or illegal image generation in text-to-image models.However, existing removal methods typically adopt a unidirectional erasure strategy by either suppressing the target concept or reinforcing safe alternatives, making it difficult to achieve a balanced trade-off between concept removal and generation quality. To address this limitation, we propose a novel Bidirectional Image-Guided Concept Erasure (Bi-Erasing) framework that performs concept suppression and safety enhancement simultaneously. Specifically, based on the joint representation of text prompts and corresponding images, Bi-Erasing introduces two decoupled image branches: a negative branch responsible for suppressing harmful semantics and a positive branch providing visual guidance for safe alternatives. By jointly optimizing these complementary directions, our approach achieves a balance between erasure efficacy and generation usability. In addition, we apply mask-based filtering to the image branches to prevent interference from irrelevant content during the erasure process. Across extensive experiment evaluations, the proposed Bi-Erasing outperforms baseline methods in balancing concept removal effectiveness and visual fidelity.

LLM-driven Knowledge Enhancement for Multimodal Cancer Survival Prediction

Current multimodal survival prediction methods typically rely on pathology images (WSIs) and genomic data, both of which are high-dimensional and redundant, making it difficult to extract discriminative features from them and align different modalities. Moreover, using a simple survival follow-up label is insufficient to supervise such a complex task. To address these challenges, we propose KEMM, an LLM-driven Knowledge-Enhanced Multimodal Model for cancer survival prediction, which integrates expert reports and prognostic background knowledge. 1) Expert reports, provided by pathologists on a case-by-case basis and refined by large language model (LLM), offer succinct and clinically focused diagnostic statements. This information may typically suggest different survival outcomes. 2) Prognostic background knowledge (PBK), generated concisely by LLM, provides valuable prognostic background knowledge on different cancer types, which also enhances survival prediction. To leverage these knowledge, we introduce the knowledge-enhanced cross-modal (KECM) attention module. KECM can effectively guide the network to focus on discriminative and survival-relevant features from highly redundant modalities. Extensive experiments on five datasets demonstrate that KEMM achieves state-of-the-art performance. The code will be released upon acceptance.

DynaGen: Unifying Temporal Knowledge Graph Reasoning with Dynamic Subgraphs and Generative Regularization

Temporal Knowledge Graph Reasoning (TKGR) aims to complete missing factual elements along the timeline. Depending on the temporal position of the query, the task is categorized into interpolation and extrapolation. Existing interpolation methods typically embed temporal information into individual facts to complete missing historical knowledge, while extrapolation techniques often leverage sequence models over graph snapshots to identify recurring patterns for future event prediction. These methods face two critical challenges: limited contextual modeling in interpolation and cognitive generalization bias in extrapolation. To address these, we propose a unified method for TKGR, dubbed DynaGen. For interpolation, DynaGen dynamically constructs entity-centric subgraphs and processes them with a synergistic dual-branch GNN encoder to capture evolving structural context. For extrapolation, it applies a conditional diffusion process, which forces the model to learn underlying evolutionary principles rather than just superficial patterns, enhancing its ability to predict unseen future events. Extensive experiments on six benchmark datasets show DynaGen achieves state-of-the-art performance. On average, compared to the second-best models, DynaGen improves the Mean Reciprocal Rank (MRR) score by 2.61 points for interpolation and 1.45 points for extrapolation.