SEW: Self-calibration Enhanced Whole Slide Pathology Image Analysis

Pathology images are considered the "gold standard" for cancer diagnosis and treatment, with gigapixel images providing extensive tissue and cellular information. Existing methods fail to simultaneously extract global structural and local detail f

Efficient and Comprehensive Feature Extraction in Large Vision-Language Model for Clinical Pathology Analysis

Pathological diagnosis is vital for determining disease characteristics, guiding treatment, and assessing prognosis, relying heavily on detailed, multi-scale analysis of high-resolution whole slide images (WSI). However, traditional pure vision models face challenges of redundant feature extraction, whereas existing large vision-language models (LVLMs) are limited by input resolution constraints, hindering their efficiency and accuracy. To overcome these issues, we propose two innovative strategies: the mixed task-guided feature enhancement, which directs feature extraction toward lesion-related details across scales, and the prompt-guided detail feature completion, which integrates coarse- and fine-grained features from WSI based on specific prompts without compromising inference speed. Leveraging a comprehensive dataset of 490,000 samples from diverse pathology tasks-including cancer detection, grading, vascular and neural invasion identification, and so on-we trained the pathology-specialized LVLM, OmniPath. Extensive experiments demonstrate that this model significantly outperforms existing methods in diagnostic accuracy and efficiency, offering an interactive, clinically aligned approach for auxiliary diagnosis in a wide range of pathology applications.

DiffusionRig: Learning Personalized Priors for Facial Appearance Editing

We address the problem of learning person-specific facial priors from a small number (e.g., 20) of portrait photos of the same person. This enables us to edit this specific person's facial appearance, such as expression and lighting, while preserving their identity and high-frequency facial details. Key to our approach, which we dub DiffusionRig, is a diffusion model conditioned on, or "rigged by," crude 3D face models estimated from single in-the-wild images by an off-the-shelf estimator. On a high level, DiffusionRig learns to map simplistic renderings of 3D face models to realistic photos of a given person. Specifically, DiffusionRig is trained in two stages: It first learns generic facial priors from a large-scale face dataset and then person-specific priors from a small portrait photo collection of the person of interest. By learning the CGI-to-photo mapping with such personalized priors, DiffusionRig can "rig" the lighting, facial expression, head pose, etc. of a portrait photo, conditioned only on coarse 3D models while preserving this person's identity and other high-frequency characteristics. Qualitative and quantitative experiments show that DiffusionRig outperforms existing approaches in both identity preservation and photorealism. Please see the project website: https://diffusionrig.github.io for the supplemental material, video, code, and data.

Bone marrow sparing for cervical cancer radiotherapy on multimodality medical images

Cervical cancer threatens the health of women seriously. Radiotherapy is one of the main therapy methods but with high risk of acute hematologic toxicity. Delineating the bone marrow (BM) for sparing using computer tomography (CT) images to plan before radiotherapy can effectively avoid this risk. Comparing with magnetic resonance (MR) images, CT lacks the ability to express the activity of BM. Thus, in current clinical practice, medical practitioners manually delineate the BM on CT images by corresponding to MR images. However, the time?consuming delineating BM by hand cannot guarantee the accuracy due to the inconsistency of the CT-MR multimodal images. In this study, we propose a multimodal image oriented automatic registration method for pelvic BM sparing, which consists of three-dimensional bone point cloud reconstruction, a local spherical system iteration closest point registration for marking BM on CT images. Experiments on patient dataset reveal that our proposed method can enhance the multimodal image registration accuracy and efficiency for medical practitioners in sparing BM of cervical cancer radiotherapy. The method proposed in this contribution might also provide references for similar studies in other clinical application.

SunStage: Portrait Reconstruction and Relighting using the Sun as a Light Stage

Outdoor portrait photographs are often marred by the harsh shadows cast under direct sunlight. To resolve this, one can use post-capture lighting manipulation techniques, but these methods either require complex hardware (e.g., a light stage) to capture each individual, or rely on image-based priors and thus fail to reconstruct many of the subtle facial details that vary from person to person. In this paper, we present SunStage, a system for accurate, individually-tailored, and lightweight reconstruction of facial geometry and reflectance that can be used for general portrait relighting with cast shadows. Our method only requires the user to capture a selfie video outdoors, rotating in place, and uses the varying angles between the sun and the face as constraints in the joint reconstruction of facial geometry, reflectance properties, and lighting parameters. Aside from relighting, we show that our reconstruction can be used for applications like reflectance editing and view synthesis. Results and interactive demos are available at https://grail.cs.washington.edu/projects/sunstage/.

Edge-competing Pathological Liver Vessel Segmentation with Limited Labels

The microvascular invasion (MVI) is a major prognostic factor in hepatocellular carcinoma, which is one of the malignant tumors with the highest mortality rate. The diagnosis of MVI needs discovering the vessels that contain hepatocellular carcinoma cells and counting their number in each vessel, which depends heavily on experiences of the doctor, is largely subjective and time-consuming. However, there is no algorithm as yet tailored for the MVI detection from pathological images. This paper collects the first pathological liver image dataset containing 522 whole slide images with labels of vessels, MVI, and hepatocellular carcinoma grades. The first and essential step for the automatic diagnosis of MVI is the accurate segmentation of vessels. The unique characteristics of pathological liver images, such as super-large size, multi-scale vessel, and blurred vessel edges, make the accurate vessel segmentation challenging. Based on the collected dataset, we propose an Edge-competing Vessel Segmentation Network (EVS-Net), which contains a segmentation network and two edge segmentation discriminators. The segmentation network, combined with an edge-aware self-supervision mechanism, is devised to conduct vessel segmentation with limited labeled patches. Meanwhile, two discriminators are introduced to distinguish whether the segmented vessel and background contain residual features in an adversarial manner. In the training stage, two discriminators are devised tocompete for the predicted position of edges. Exhaustive experiments demonstrate that, with only limited labeled patches, EVS-Net achieves a close performance of fully supervised methods, which provides a convenient tool for the pathological liver vessel segmentation. Code is publicly available at https://github.com/zju-vipa/EVS-Net.

Editing Conditional Radiance Fields

A neural radiance field (NeRF) is a scene model supporting high-quality view synthesis, optimized per scene. In this paper, we explore enabling user editing of a category-level NeRF - also known as a conditional radiance field - trained on a shape category. Specifically, we introduce a method for propagating coarse 2D user scribbles to the 3D space, to modify the color or shape of a local region. First, we propose a conditional radiance field that incorporates new modular network components, including a shape branch that is shared across object instances. Observing multiple instances of the same category, our model learns underlying part semantics without any supervision, thereby allowing the propagation of coarse 2D user scribbles to the entire 3D region (e.g., chair seat). Next, we propose a hybrid network update strategy that targets specific network components, which balances efficiency and accuracy. During user interaction, we formulate an optimization problem that both satisfies the user's constraints and preserves the original object structure. We demonstrate our approach on various editing tasks over three shape datasets and show that it outperforms prior neural editing approaches. Finally, we edit the appearance and shape of a real photograph and show that the edit propagates to extrapolated novel views.

NeRFactor: Neural Factorization of Shape and Reflectance Under an Unknown Illumination

We address the problem of recovering the shape and spatially-varying reflectance of an object from posed multi-view images of the object illuminated by one unknown lighting condition. This enables the rendering of novel views of the object under arbitrary environment lighting and editing of the object's material properties. The key to our approach, which we call Neural Radiance Factorization (NeRFactor), is to distill the volumetric geometry of a Neural Radiance Field (NeRF) [Mildenhall et al. 2020] representation of the object into a surface representation and then jointly refine the geometry while solving for the spatially-varying reflectance and the environment lighting. Specifically, NeRFactor recovers 3D neural fields of surface normals, light visibility, albedo, and Bidirectional Reflectance Distribution Functions (BRDFs) without any supervision, using only a re-rendering loss, simple smoothness priors, and a data-driven BRDF prior learned from real-world BRDF measurements. By explicitly modeling light visibility, NeRFactor is able to separate shadows from albedo and synthesize realistic soft or hard shadows under arbitrary lighting conditions. NeRFactor is able to recover convincing 3D models for free-viewpoint relighting in this challenging and underconstrained capture setup for both synthetic and real scenes. Qualitative and quantitative experiments show that NeRFactor outperforms classic and deep learning-based state of the art across various tasks. Our code and data are available at people.csail.mit.edu/xiuming/projects/nerfactor/.

NeRV: Neural Reflectance and Visibility Fields for Relighting and View Synthesis

We present a method that takes as input a set of images of a scene illuminated by unconstrained known lighting, and produces as output a 3D representation that can be rendered from novel viewpoints under arbitrary lighting conditions. Our method represents the scene as a continuous volumetric function parameterized as MLPs whose inputs are a 3D location and whose outputs are the following scene properties at that input location: volume density, surface normal, material parameters, distance to the first surface intersection in any direction, and visibility of the external environment in any direction. Together, these allow us to render novel views of the object under arbitrary lighting, including indirect illumination effects. The predicted visibility and surface intersection fields are critical to our model's ability to simulate direct and indirect illumination during training, because the brute-force techniques used by prior work are intractable for lighting conditions outside of controlled setups with a single light. Our method outperforms alternative approaches for recovering relightable 3D scene representations, and performs well in complex lighting settings that have posed a significant challenge to prior work.

Multi-Plane Program Induction with 3D Box Priors

We consider two important aspects in understanding and editing images: modeling regular, program-like texture or patterns in 2D planes, and 3D posing of these planes in the scene. Unlike prior work on image-based program synthesis, which assumes the image contains a single visible 2D plane, we present Box Program Induction (BPI), which infers a program-like scene representation that simultaneously models repeated structure on multiple 2D planes, the 3D position and orientation of the planes, and camera parameters, all from a single image. Our model assumes a box prior, i.e., that the image captures either an inner view or an outer view of a box in 3D. It uses neural networks to infer visual cues such as vanishing points, wireframe lines to guide a search-based algorithm to find the program that best explains the image. Such a holistic, structured scene representation enables 3D-aware interactive image editing operations such as inpainting missing pixels, changing camera parameters, and extrapolate the image contents.