A Pathology Foundation Model for Gastric Cancer with Real-World Validation

Gastric cancer remains a major cause of cancer mortality, yet its histological and molecular heterogeneity complicates diagnosis and risk stratification. General-purpose pathology foundation models (PFMs) often plateau on fine-grained endpoints central to gastric cancer care, and few have undergone rigorous prospective validation or clinical reader studies. We present GRACE, a Gastric-specific foundation model for Real-world Assessment and Clinical dEcision support. GRACE was developed from multicenter gastric pathology datasets totaling 48,364 primarily HE-stained whole-slide images from 37,493 patients. When evaluated on 28 clinically relevant tasks, GRACE consistently outperformed representative pancancer PFMs, achieving a macro-AUC of 0.9188, with strong performance for precancerous lesion diagnosis (macro-AUC 0.9322), tumor histopathological assessment (macro-AUC 0.9119), molecular profiling (macro-AUC 0.8682), and prognostic prediction. Beyond benchmarking, GRACE's translational value was substantiated through a rigorous evidence chain. Under safety-gated criteria requiring 100% NPV for rule-out and 100% PPV for rule-in, GRACE streamlined review for up to 69.6% of malignancy-diagnosis cases and triaged 46.8% of MMR-IHC follow-up requests. This translational feasibility was further strengthened by a randomized crossover reader study of pathologist-AI collaboration. With GRACE assistance, diagnostic accuracy improved from 82.0% to 89.9%, yielding nearly twofold higher adjusted odds of a correct diagnosis (OR 1.987) alongside concurrent gains in sensitivity and specificity. AI assistance also reduced diagnostic time by 14.9%, elevated diagnostic confidence by 9.0%, and markedly improved inter-rater agreement. When calibrated to maintain non-inferior performance to senior pathologists, the AI-assisted workflow could triage 60.7% of atrophy and 82.7% of intestinal metaplasia cases.

SC-TauPath: A Structural Connectivity Attribution Framework for Mapping Tau Propagation Pathways in Alzheimer's Disease

Understanding how structural connections are associated with tau propagation in Alzheimer's disease (AD) remains a central open question, yet existing computational models either rely heavily on biophysical assumptions or lack neurobiologically interpretable pathway maps. We present SC-TauPath, a structural connectivity (SC) attribution framework that maps tau propagation pathways from in vivo neuroimaging data. SC-TauPath combines a Network Diffusion Model (NDM)-augmented multilayer perceptron with gradient $\times$ input attribution to score each SC edge's contribution to tau prediction, then translates these attribution scores into multi-scale pathway maps (backbone edges, high-traffic routes, and hub ROIs), which validates established Braak staging anatomy. Applied to 234 ADNI participants with paired DTI SC and 18F-Flortaucipir PET, SC-TauPath achieves strong cross-validated tau prediction and yields attribution-based pathway maps consistent with established Braak staging anatomy, demonstrating that SC encode spatially specific information about regional tau distribution in AD.

Cosmos 3: Omnimodal World Models for Physical AI

We introduce Cosmos 3, a family of omnimodal world models designed to jointly process and generate language, image, video, audio, and action sequences within a unified mixture-of-transformers architecture. By supporting highly flexible input-output configurations, Cosmos 3 seamlessly unifies critical modalities for Physical AI -- effectively subsuming vision-language models, video generators, world simulators, and world-action models into a single framework. Our evaluation demonstrates that Cosmos 3 establishes a new state-of-the-art across a diverse suite of understanding and generation tasks, demonstrating omnimodal world models as scalable, general-purpose backbones for embodied agents. Our post-trained Cosmos 3 models were ranked as the best open-source Text-to-Image and Image-to-Video models by Artificial Analysis, and the best policy model by RoboArena at the time the technical report was written. To accelerate open research and deployment in Physical AI, we make our code, model checkpoints, curated synthetic datasets, and evaluation benchmark available under the Linux Foundation's OpenMDW-1.1 https://openmdw.ai/license/1-1/ License at https://github.com/nvidia/cosmos}{github.com/nvidia/cosmos and https://huggingface.co/collections/nvidia/cosmos3 . The project website is available at https://research.nvidia.com/labs/cosmos-lab/cosmos3 .

Compass: Navigating Global Marine Lead Data Integration through Expert-Guided LLM Agent

Marine lead (Pb) and its isotopes are critical tracers for ocean circulation and anthropogenic pollution, yet in-situ observations remain costly and sparse. While vast historical records exist, they lie buried within the unstructured content of academic papers, creating "data silos" inaccessible to comprehensive analysis. Manual extraction is unscalable, while general-purpose Large Language Models (LLMs) lack the necessary domain-specific knowledge, leading to hallucinations and scientifically invalid outputs. To address this, we introduce an expert-guided adaptation approach that enables LLMs to perform rigorous scientific data extraction without fine-tuning. We operationalize this approach through Compass, an LLM agent framework enhanced by a Knowledge Tree co-designed with marine scientists, which decomposes complex tasks into verifiable steps, guiding the agent's reasoning to ensure scientific validity. Deploying Compass across a corpus of over 230,000 relevant open-access papers, we successfully extract 3,751 previously unincorporated Pb records. This effort establishes the largest integrated marine Pb database to date. Beyond standard metrics, Compass demonstrates superior reliability through multi-layered validation, achieving 92% accuracy as confirmed through expert manual verification. The newly integrated data expand coverage in previously under-sampled regions such as the East China Sea and the Southern Ocean, providing an enriched data foundation for future scientific discoveries. We release an interactive visualization platform to facilitate open scientific access. Our work demonstrates that expert-guided agents can effectively bridge the gap between general-purpose LLMs and high-stakes scientific domains, enabling scalable data discovery in geosciences.

World Models: A Comprehensive Survey of Architectures, Methodologies, Reasoning Paradigms, and Applications

World models, internal simulators that learn the structure and dynamics of an environment, have emerged as a central paradigm in the pursuit of artificial general intelligence, enabling agents to predict, plan, and reason within learned representations. Despite rapid progress across reinforcement learning, robotics, autonomous driving, and video generation, the field lacks a unified framework integrating its diverse architectural choices, training methods, reasoning mechanisms, and application settings. This survey addresses that gap with a multi-axis taxonomy organized along four dimensions: (i) architecture, encompassing representation format, dynamics formulation, input modality, learning paradigm, and downstream application; (ii) methodological family, including state-space and recurrent approaches, transformer-based models, diffusion-based generators, physics-informed networks, and language-augmented multimodal systems; (iii) reasoning strategy, covering imagination-based planning, latent policy learning, counterfactual reasoning, and planning under uncertainty; and (iv) application domain, spanning robotics, autonomous driving, video prediction, multimodal agents, reinforcement learning, scientific modeling, medical imaging, educational measurement, and business and finance. Tracing the field from early cognitive-science foundations to milestone systems such as PlaNet, the Dreamer family, MuZero, Sora, Cosmos, and Genie, we examine how these dimensions interact and highlight the recent convergence of chain-of-thought reasoning with world-model imagination. We review evaluation protocols and benchmarks, identify persistent challenges such as compounding prediction errors, sim-to-real transfer, and fragmented evaluation, and outline future directions toward unified multimodal world models, foundation-scale interactive simulators, and safe deployment in safety-critical domains.

Low-Overhead Receiver Design for Data-Dependent Superimposed Training via Deep Learning

Superimposed pilot (SIP) transmission improves spectral efficiency by eliminating the dedicated pilot overhead required in orthogonal pilot (OP)-based schemes. However, SIP suffers from severe pilot-data coupling, which leads to a critical performance-complexity bottleneck at the receiver. To address this issue, this paper proposes a low-overhead transmission framework that revitalizes data-dependent superimposed training (DDST) with enhanced interference mitigation strategies. First, for quasi-static block-fading channels, an enhanced DDST receiver is developed to achieve non-iterative pilot-data decoupling by exploiting data-dependent algebraic structures. Second, to overcome the sensitivity of conventional DDST to channel variations and symbol misidentification in fast time-varying environments, a mix transmission scheme is developed. By strategically applying DDST to a subset of resource elements, the proposed scheme combines the interference-free transmission property of OP with the zero-pilot-overhead advantage of SIP, thereby improving demapping reliability and interference suppression. Furthermore, under the proposed mix scheme, a Vision Transformer-based neural receiver is designed to capture the orthogonal structure between pilots and perturbation-bearing data, as well as the underlying channel correlations, thereby relaxing the stringent quasi-static assumption required for interference disentanglement. Simulation results demonstrate that the proposed framework achieves significant performance gains in the low-to-medium SNR regime under time-varying channels while providing superior computational efficiency compared with state-of-the-art SIP receivers.

Structural Energy Guidance for View-Consistent Text-to-3D Generation

Text-to-3D generation based on diffusion models often suffers from the Janus problem, leading to inconsistent geometry across viewpoints. This work identifies viewpoint bias in 2D diffusion priors as the main cause and proposes Structural Energy-Guided Sampling (SEGS), a training-free and plug-and-play framework to improve multi-view consistency. SEGS constructs a structural energy in the PCA subspace of U-Net features and injects its gradient into the denoising process. It can be easily integrated into SDS/VSD pipelines without retraining. Experiments show that SEGS reduces the Janus Rate by about 10% on average and improves View-CS scores across multiple baselines, including DreamFusion, Magic3D, and LucidDreamer. This method effectively alleviates viewpoint artifacts while preserving appearance fidelity, providing a flexible solution for high-quality text-to-3D content generation.

Seirênes: Adversarial Self-Play with Evolving Distractions for LLM Reasoning

We present Seirênes, a self-play RL framework that transforms contextual interference from a failure mode of LLM reasoning into an internal training signal for co-evolving more resilient reasoners. While RL with verifiable rewards has significantly advanced reasoning capabilities, models can still exhibit fragility when encountering non-idealized contexts: scenarios characterized by superfluous information, tangential instructions, or incidental correlations that differ from the clean distributions typical of standard benchmarks. Seirênes harnesses this vulnerability through a parameter-shared and adversarial self-play loop. Within this framework, a single model is trained to both construct plausible yet distracting contexts that expose its own reasoning blind spots, and solve problems by discerning the essential task from these perturbations to recover the core underlying logic. By pitting these competing objectives against each other, Seirênes compels the model to move beyond superficial pattern matching and anchors its capabilities in robust underlying reasoning. This continuous interaction sustains an informative co-evolutionary curriculum as the model improves. Across seven mathematical reasoning benchmarks and model scales from 4B to 30B, Seirênes achieves average gains of +10.2, +9.1, and +7.2 points. Besides, distracting contexts produced by the 4B Seirênes model reduce the accuracy of top-tier closed-source models (GPT and Gemini) by roughly 4--5 points, revealing Seirênes' general ability to uncover reasoning models' blind spots.

UHR-Micro: Diagnosing and Mitigating the Resolution Illusion in Earth Observation VLMs

Vision-Language Models (VLMs) increasingly operate on ultra-high-resolution (UHR) Earth observation imagery, yet they remain vulnerable to a severe scale mismatch between large-scale scene context and micro-scale targets. We refer to this empirical gap as a "resolution illusion": higher input resolution provides the appearance of richer visual detail, but does not necessarily yield reliable perception of spatially small, task-relevant evidence. To benchmark this challenge, we introduce UHR-Micro, a benchmark comprising 11,253 instructions grounded in 1,212 UHR images, designed to evaluate VLMs at the spatial limits of native Earth observation imagery. UHR-Micro spans diverse micro-target scales, context requirements, task families, and visual conditions, and provides diagnostic annotations that support controlled evaluation and fine-grained error attribution. Experiments with representative high-resolution VLMs show substantial failures in spatial grounding and evidence parsing, despite access to high-resolution inputs. Further analysis suggests that these failures are not fully resolved by increasing model capacity, but are closely tied to insufficient guidance in locating and using task-relevant micro-evidence. Motivated by this finding, we propose Micro-evidence Active Perception (MAP), a reference agent that decomposes queries into evidence-seeking steps, actively inspects candidate regions, and grounds its answers in localized observations. MAP-Agent improves micro-level perception by making high-resolution reasoning evidence-centered rather than image-centered. Together, UHR-Micro and MAP-Agent provide a diagnostic platform for evaluating, understanding, and advancing high-resolution reasoning in Earth observation VLMs. Datasets and source code were released at https://github.com/MiliLab/UHR-Micro.

MAGS-SLAM: Monocular Multi-Agent Gaussian Splatting SLAM for Geometrically and Photometrically Consistent Reconstruction

Collaborative photorealistic 3D reconstruction from multiple agents enables rapid large-scale scene capture for virtual production and cooperative multi-robot exploration. While recent 3D Gaussian Splatting (3DGS) SLAM algorithms can generate high-fidelity real-time mapping, most of the existing multi-agent Gaussian SLAM methods still rely on RGB-D sensors to obtain metric depth and simplify cross-agent alignment, which limits the deployment on lightweight, low-cost, or power-constrained robotic platforms. To address this challenge, we propose MAGS-SLAM, the first RGB-only multi-agent 3DGS SLAM framework for collaborative scene reconstruction. Each agent independently builds local monocular Gaussian submaps and transmits compact submap summaries rather than raw observations or dense maps. To facilitate robust collaboration in the presence of monocular scale ambiguity, our framework integrates compact submap communication, geometry- and appearance-aware loop verification, and occupancy-aware Gaussian fusion, enabling coherent global reconstruction without active depth sensors. We further introduce ReplicaMultiagent Plus benchmark for evaluating collaborative Gaussian SLAM. Intensive experiments on synthetic and real-world datasets show that MAGS-SLAM achieves competitive tracking accuracy and comparable or superior rendering quality to state-of-the-art RGB-D collaborative Gaussian SLAM methods while relying only RGB images.