A General-Purpose Multimodal Foundation Model for Dermatology

Diagnosing and treating skin diseases require advanced visual skills across multiple domains and the ability to synthesize information from various imaging modalities. Current deep learning models, while effective at specific tasks such as diagnosing skin cancer from dermoscopic images, fall short in addressing the complex, multimodal demands of clinical practice. Here, we introduce PanDerm, a multimodal dermatology foundation model pretrained through self-supervised learning on a dataset of over 2 million real-world images of skin diseases, sourced from 11 clinical institutions across 4 imaging modalities. We evaluated PanDerm on 28 diverse datasets covering a range of clinical tasks, including skin cancer screening, phenotype assessment and risk stratification, diagnosis of neoplastic and inflammatory skin diseases, skin lesion segmentation, change monitoring, and metastasis prediction and prognosis. PanDerm achieved state-of-the-art performance across all evaluated tasks, often outperforming existing models even when using only 5-10% of labeled data. PanDerm's clinical utility was demonstrated through reader studies in real-world clinical settings across multiple imaging modalities. It outperformed clinicians by 10.2% in early-stage melanoma detection accuracy and enhanced clinicians' multiclass skin cancer diagnostic accuracy by 11% in a collaborative human-AI setting. Additionally, PanDerm demonstrated robust performance across diverse demographic factors, including different body locations, age groups, genders, and skin tones. The strong results in benchmark evaluations and real-world clinical scenarios suggest that PanDerm could enhance the management of skin diseases and serve as a model for developing multimodal foundation models in other medical specialties, potentially accelerating the integration of AI support in healthcare.

Federated Graph Learning with Adaptive Importance-based Sampling

For privacy-preserving graph learning tasks involving distributed graph datasets, federated learning (FL)-based GCN (FedGCN) training is required. A key challenge for FedGCN is scaling to large-scale graphs, which typically incurs high computation and communication costs when dealing with the explosively increasing number of neighbors. Existing graph sampling-enhanced FedGCN training approaches ignore graph structural information or dynamics of optimization, resulting in high variance and inaccurate node embeddings. To address this limitation, we propose the Federated Adaptive Importance-based Sampling (FedAIS) approach. It achieves substantial computational cost saving by focusing the limited resources on training important nodes, while reducing communication overhead via adaptive historical embedding synchronization. The proposed adaptive importance-based sampling method jointly considers the graph structural heterogeneity and the optimization dynamics to achieve optimal trade-off between efficiency and accuracy. Extensive evaluations against five state-of-the-art baselines on five real-world graph datasets show that FedAIS achieves comparable or up to 3.23% higher test accuracy, while saving communication and computation costs by 91.77% and 85.59%.

OphNet: A Large-Scale Video Benchmark for Ophthalmic Surgical Workflow Understanding

Surgical scene perception via videos are critical for advancing robotic surgery, telesurgery, and AI-assisted surgery, particularly in ophthalmology. However, the scarcity of diverse and richly annotated video datasets has hindered the development of intelligent systems for surgical workflow analysis. Existing datasets for surgical workflow analysis, which typically face challenges such as small scale, a lack of diversity in surgery and phase categories, and the absence of time-localized annotations, limit the requirements for action understanding and model generalization validation in complex and diverse real-world surgical scenarios. To address this gap, we introduce OphNet, a large-scale, expert-annotated video benchmark for ophthalmic surgical workflow understanding. OphNet features: 1) A diverse collection of 2,278 surgical videos spanning 66 types of cataract, glaucoma, and corneal surgeries, with detailed annotations for 102 unique surgical phases and 150 granular operations; 2) It offers sequential and hierarchical annotations for each surgery, phase, and operation, enabling comprehensive understanding and improved interpretability; 3) Moreover, OphNet provides time-localized annotations, facilitating temporal localization and prediction tasks within surgical workflows. With approximately 205 hours of surgical videos, OphNet is about 20 times larger than the largest existing surgical workflow analysis benchmark. Our dataset and code have been made available at: \url{https://github.com/minghu0830/OphNet-benchmark}.

Texture Re-scalable Universal Adversarial Perturbation

Universal adversarial perturbation (UAP), also known as image-agnostic perturbation, is a fixed perturbation map that can fool the classifier with high probabilities on arbitrary images, making it more practical for attacking deep models in the real world. Previous UAP methods generate a scale-fixed and texture-fixed perturbation map for all images, which ignores the multi-scale objects in images and usually results in a low fooling ratio. Since the widely used convolution neural networks tend to classify objects according to semantic information stored in local textures, it seems a reasonable and intuitive way to improve the UAP from the perspective of utilizing local contents effectively. In this work, we find that the fooling ratios significantly increase when we add a constraint to encourage a small-scale UAP map and repeat it vertically and horizontally to fill the whole image domain. To this end, we propose texture scale-constrained UAP (TSC-UAP), a simple yet effective UAP enhancement method that automatically generates UAPs with category-specific local textures that can fool deep models more easily. Through a low-cost operation that restricts the texture scale, TSC-UAP achieves a considerable improvement in the fooling ratio and attack transferability for both data-dependent and data-free UAP methods. Experiments conducted on two state-of-the-art UAP methods, eight popular CNN models and four classical datasets show the remarkable performance of TSC-UAP.

Diffusion Model Driven Test-Time Image Adaptation for Robust Skin Lesion Classification

Deep learning-based diagnostic systems have demonstrated potential in skin disease diagnosis. However, their performance can easily degrade on test domains due to distribution shifts caused by input-level corruptions, such as imaging equipment variability, brightness changes, and image blur. This will reduce the reliability of model deployment in real-world scenarios. Most existing solutions focus on adapting the source model through retraining on different target domains. Although effective, this retraining process is sensitive to the amount of data and the hyperparameter configuration for optimization. In this paper, we propose a test-time image adaptation method to enhance the accuracy of the model on test data by simultaneously updating and predicting test images. We modify the target test images by projecting them back to the source domain using a diffusion model. Specifically, we design a structure guidance module that adds refinement operations through low-pass filtering during reverse sampling, regularizing the diffusion to preserve structural information. Additionally, we introduce a self-ensembling scheme automatically adjusts the reliance on adapted and unadapted inputs, enhancing adaptation robustness by rejecting inappropriate generative modeling results. To facilitate this study, we constructed the ISIC2019-C and Dermnet-C corruption robustness evaluation benchmarks. Extensive experiments on the proposed benchmarks demonstrate that our method makes the classifier more robust across various corruptions, architectures, and data regimes. Our datasets and code will be available at \url{https://github.com/minghu0830/Skin-TTA_Diffusion}.

KoReA-SFL: Knowledge Replay-based Split Federated Learning Against Catastrophic Forgetting

Although Split Federated Learning (SFL) is good at enabling knowledge sharing among resource-constrained clients, it suffers from the problem of low training accuracy due to the neglect of data heterogeneity and catastrophic forgetting. To address this issue, we propose a novel SFL approach named KoReA-SFL, which adopts a multi-model aggregation mechanism to alleviate gradient divergence caused by heterogeneous data and a knowledge replay strategy to deal with catastrophic forgetting. Specifically, in KoReA-SFL cloud servers (i.e., fed server and main server) maintain multiple branch model portions rather than a global portion for local training and an aggregated master-model portion for knowledge sharing among branch portions. To avoid catastrophic forgetting, the main server of KoReA-SFL selects multiple assistant devices for knowledge replay according to the training data distribution of each server-side branch-model portion. Experimental results obtained from non-IID and IID scenarios demonstrate that KoReA-SFL significantly outperforms conventional SFL methods (by up to 23.25\% test accuracy improvement).

CaBaFL: Asynchronous Federated Learning via Hierarchical Cache and Feature Balance

Federated Learning (FL) as a promising distributed machine learning paradigm has been widely adopted in Artificial Intelligence of Things (AIoT) applications. However, the efficiency and inference capability of FL is seriously limited due to the presence of stragglers and data imbalance across massive AIoT devices, respectively. To address the above challenges, we present a novel asynchronous FL approach named CaBaFL, which includes a hierarchical Cache-based aggregation mechanism and a feature Balance-guided device selection strategy. CaBaFL maintains multiple intermediate models simultaneously for local training. The hierarchical cache-based aggregation mechanism enables each intermediate model to be trained on multiple devices to align the training time and mitigate the straggler issue. In specific, each intermediate model is stored in a low-level cache for local training and when it is trained by sufficient local devices, it will be stored in a high-level cache for aggregation. To address the problem of imbalanced data, the feature balance-guided device selection strategy in CaBaFL adopts the activation distribution as a metric, which enables each intermediate model to be trained across devices with totally balanced data distributions before aggregation. Experimental results show that compared with the state-of-the-art FL methods, CaBaFL achieves up to 9.26X training acceleration and 19.71\% accuracy improvements.

Personalized Federated Instruction Tuning via Neural Architecture Search

Federated Instruction Tuning (FIT) has shown the ability to achieve collaborative model instruction tuning among massive data owners without sharing private data. However, it still faces two key challenges, i.e., data and resource heterogeneity. Due to the varying data distribution and preferences among data owners, FIT cannot adapt to the personalized data of individual owners. Moreover, clients with superior computational abilities are constrained since they need to maintain the same fine-tuning architecture as the weaker clients. To address these issues, we propose a novel Personalized Federated Instruction Tuning (PerFIT) framework based on architecture search. Specifically, PerFIT allows each client to search for a personalized architecture by expanding the trainable parameter space of the global model followed by pruning the parameters to the original state. This procedure allows personalized instruction fine-tuning within expanded parameter spaces, concurrently preserving the same number of trainable parameters. Furthermore, to release the abilities of heterogeneous computational resources and enhance the performance of personalization on local data, we exploit personalized parameter-wise aggregation. The evaluation with multiple LLMs non-IID scenarios demonstrates that compared to the state-of-the-art FIT methods, our approach can achieve up to a 23% decrease in perplexity.

Structure-based out-of-distribution (OOD) materials property prediction: a benchmark study

In real-world material research, machine learning (ML) models are usually expected to predict and discover novel exceptional materials that deviate from the known materials. It is thus a pressing question to provide an objective evaluation of ML model performances in property prediction of out-of-distribution (OOD) materials that are different from the training set distribution. Traditional performance evaluation of materials property prediction models through random splitting of the dataset frequently results in artificially high performance assessments due to the inherent redundancy of typical material datasets. Here we present a comprehensive benchmark study of structure-based graph neural networks (GNNs) for extrapolative OOD materials property prediction. We formulate five different categories of OOD ML problems for three benchmark datasets from the MatBench study. Our extensive experiments show that current state-of-the-art GNN algorithms significantly underperform for the OOD property prediction tasks on average compared to their baselines in the MatBench study, demonstrating a crucial generalization gap in realistic material prediction tasks. We further examine the latent physical spaces of these GNN models and identify the sources of CGCNN, ALIGNN, and DeeperGATGNN's significantly more robust OOD performance than those of the current best models in the MatBench study (coGN and coNGN), and provide insights to improve their performance.

HGCLIP: Exploring Vision-Language Models with Graph Representations for Hierarchical Understanding

Object categories are typically organized into a multi-granularity taxonomic hierarchy. When classifying categories at different hierarchy levels, traditional uni-modal approaches focus primarily on image features, revealing limitations in complex scenarios. Recent studies integrating Vision-Language Models (VLMs) with class hierarchies have shown promise, yet they fall short of fully exploiting the hierarchical relationships. These efforts are constrained by their inability to perform effectively across varied granularity of categories. To tackle this issue, we propose a novel framework (HGCLIP) that effectively combines CLIP with a deeper exploitation of the Hierarchical class structure via Graph representation learning. We explore constructing the class hierarchy into a graph, with its nodes representing the textual or image features of each category. After passing through a graph encoder, the textual features incorporate hierarchical structure information, while the image features emphasize class-aware features derived from prototypes through the attention mechanism. Our approach demonstrates significant improvements on both generic and fine-grained visual recognition benchmarks. Our codes are fully available at https://github.com/richard-peng-xia/HGCLIP.