SlideChat: A Large Vision-Language Assistant for Whole-Slide Pathology Image Understanding

Despite the progress made by multimodal large language models (MLLMs) in computational pathology, they remain limited by a predominant focus on patch-level analysis, missing essential contextual information at the whole-slide level. The lack of large-scale instruction datasets and the gigapixel scale of whole slide images (WSIs) pose significant developmental challenges. In this paper, we present SlideChat, the first vision-language assistant capable of understanding gigapixel whole-slide images, exhibiting excellent multimodal conversational capability and response complex instruction across diverse pathology scenarios. To support its development, we created SlideInstruction, the largest instruction-following dataset for WSIs consisting of 4.2K WSI captions and 176K VQA pairs with multiple categories. Furthermore, we propose SlideBench, a multimodal benchmark that incorporates captioning and VQA tasks to assess SlideChat's capabilities in varied clinical settings such as microscopy, diagnosis. Compared to both general and specialized MLLMs, SlideChat exhibits exceptional capabilities achieving state-of-the-art performance on 18 of 22 tasks. For example, it achieved an overall accuracy of 81.17% on SlideBench-VQA (TCGA), and 54.15% on SlideBench-VQA (BCNB). We will fully release SlideChat, SlideInstruction and SlideBench as open-source resources to facilitate research and development in computational pathology.

Art and Science of Quantizing Large-Scale Models: A Comprehensive Overview

This paper provides a comprehensive overview of the principles, challenges, and methodologies associated with quantizing large-scale neural network models. As neural networks have evolved towards larger and more complex architectures to address increasingly sophisticated tasks, the computational and energy costs have escalated significantly. We explore the necessity and impact of model size growth, highlighting the performance benefits as well as the computational challenges and environmental considerations. The core focus is on model quantization as a fundamental approach to mitigate these challenges by reducing model size and improving efficiency without substantially compromising accuracy. We delve into various quantization techniques, including both post-training quantization (PTQ) and quantization-aware training (QAT), and analyze several state-of-the-art algorithms such as LLM-QAT, PEQA(L4Q), ZeroQuant, SmoothQuant, and others. Through comparative analysis, we examine how these methods address issues like outliers, importance weighting, and activation quantization, ultimately contributing to more sustainable and accessible deployment of large-scale models.

GMAI-MMBench: A Comprehensive Multimodal Evaluation Benchmark Towards General Medical AI

Large Vision-Language Models (LVLMs) are capable of handling diverse data types such as imaging, text, and physiological signals, and can be applied in various fields. In the medical field, LVLMs have a high potential to offer substantial assistance for diagnosis and treatment. Before that, it is crucial to develop benchmarks to evaluate LVLMs' effectiveness in various medical applications. Current benchmarks are often built upon specific academic literature, mainly focusing on a single domain, and lacking varying perceptual granularities. Thus, they face specific challenges, including limited clinical relevance, incomplete evaluations, and insufficient guidance for interactive LVLMs. To address these limitations, we developed the GMAI-MMBench, the most comprehensive general medical AI benchmark with well-categorized data structure and multi-perceptual granularity to date. It is constructed from 285 datasets across 39 medical image modalities, 18 clinical-related tasks, 18 departments, and 4 perceptual granularities in a Visual Question Answering (VQA) format. Additionally, we implemented a lexical tree structure that allows users to customize evaluation tasks, accommodating various assessment needs and substantially supporting medical AI research and applications. We evaluated 50 LVLMs, and the results show that even the advanced GPT-4o only achieves an accuracy of 52\%, indicating significant room for improvement. Moreover, we identified five key insufficiencies in current cutting-edge LVLMs that need to be addressed to advance the development of better medical applications. We believe that GMAI-MMBench will stimulate the community to build the next generation of LVLMs toward GMAI.

KiGRAS: Kinematic-Driven Generative Model for Realistic Agent Simulation

Trajectory generation is a pivotal task in autonomous driving. Recent studies have introduced the autoregressive paradigm, leveraging the state transition model to approximate future trajectory distributions. This paradigm closely mirrors the real-world trajectory generation process and has achieved notable success. However, its potential is limited by the ineffective representation of realistic trajectories within the redundant state space. To address this limitation, we propose the Kinematic-Driven Generative Model for Realistic Agent Simulation (KiGRAS). Instead of modeling in the state space, KiGRAS factorizes the driving scene into action probability distributions at each time step, providing a compact space to represent realistic driving patterns. By establishing physical causality from actions (cause) to trajectories (effect) through the kinematic model, KiGRAS eliminates massive redundant trajectories. All states derived from actions in the cause space are constrained to be physically feasible. Furthermore, redundant trajectories representing identical action sequences are mapped to the same representation, reflecting their underlying actions. This approach significantly reduces task complexity and ensures physical feasibility. KiGRAS achieves state-of-the-art performance in Waymo's SimAgents Challenge, ranking first on the WOMD leaderboard with significantly fewer parameters than other models. The video documentation is available at \url{https://kigras-mach.github.io/KiGRAS/}.

SAM-Med3D-MoE: Towards a Non-Forgetting Segment Anything Model via Mixture of Experts for 3D Medical Image Segmentation

Volumetric medical image segmentation is pivotal in enhancing disease diagnosis, treatment planning, and advancing medical research. While existing volumetric foundation models for medical image segmentation, such as SAM-Med3D and SegVol, have shown remarkable performance on general organs and tumors, their ability to segment certain categories in clinical downstream tasks remains limited. Supervised Finetuning (SFT) serves as an effective way to adapt such foundation models for task-specific downstream tasks but at the cost of degrading the general knowledge previously stored in the original foundation model.To address this, we propose SAM-Med3D-MoE, a novel framework that seamlessly integrates task-specific finetuned models with the foundational model, creating a unified model at minimal additional training expense for an extra gating network. This gating network, in conjunction with a selection strategy, allows the unified model to achieve comparable performance of the original models in their respective tasks both general and specialized without updating any parameters of them.Our comprehensive experiments demonstrate the efficacy of SAM-Med3D-MoE, with an average Dice performance increase from 53 to 56.4 on 15 specific classes. It especially gets remarkable gains of 29.6, 8.5, 11.2 on the spinal cord, esophagus, and right hip, respectively. Additionally, it achieves 48.9 Dice on the challenging SPPIN2023 Challenge, significantly surpassing the general expert's performance of 32.3. We anticipate that SAM-Med3D-MoE can serve as a new framework for adapting the foundation model to specific areas in medical image analysis. Codes and datasets will be publicly available.

StreamMOTP: Streaming and Unified Framework for Joint 3D Multi-Object Tracking and Trajectory Prediction

3D multi-object tracking and trajectory prediction are two crucial modules in autonomous driving systems. Generally, the two tasks are handled separately in traditional paradigms and a few methods have started to explore modeling these two tasks in a joint manner recently. However, these approaches suffer from the limitations of single-frame training and inconsistent coordinate representations between tracking and prediction tasks. In this paper, we propose a streaming and unified framework for joint 3D Multi-Object Tracking and trajectory Prediction (StreamMOTP) to address the above challenges. Firstly, we construct the model in a streaming manner and exploit a memory bank to preserve and leverage the long-term latent features for tracked objects more effectively. Secondly, a relative spatio-temporal positional encoding strategy is introduced to bridge the gap of coordinate representations between the two tasks and maintain the pose-invariance for trajectory prediction. Thirdly, we further improve the quality and consistency of predicted trajectories with a dual-stream predictor. We conduct extensive experiments on popular nuSences dataset and the experimental results demonstrate the effectiveness and superiority of StreamMOTP, which outperforms previous methods significantly on both tasks. Furthermore, we also prove that the proposed framework has great potential and advantages in actual applications of autonomous driving.

SparseAD: Sparse Query-Centric Paradigm for Efficient End-to-End Autonomous Driving

End-to-End paradigms use a unified framework to implement multi-tasks in an autonomous driving system. Despite simplicity and clarity, the performance of end-to-end autonomous driving methods on sub-tasks is still far behind the single-task methods. Meanwhile, the widely used dense BEV features in previous end-to-end methods make it costly to extend to more modalities or tasks. In this paper, we propose a Sparse query-centric paradigm for end-to-end Autonomous Driving (SparseAD), where the sparse queries completely represent the whole driving scenario across space, time and tasks without any dense BEV representation. Concretely, we design a unified sparse architecture for perception tasks including detection, tracking, and online mapping. Moreover, we revisit motion prediction and planning, and devise a more justifiable motion planner framework. On the challenging nuScenes dataset, SparseAD achieves SOTA full-task performance among end-to-end methods and significantly narrows the performance gap between end-to-end paradigms and single-task methods. Codes will be released soon.