HySurvPred: Multimodal Hyperbolic Embedding with Angle-Aware Hierarchical Contrastive Learning and Uncertainty Constraints for Survival Prediction

Multimodal learning that integrates histopathology images and genomic data holds great promise for cancer survival prediction. However, existing methods face key limitations: 1) They rely on multimodal mapping and metrics in Euclidean space, which cannot fully capture the hierarchical structures in histopathology (among patches from different resolutions) and genomics data (from genes to pathways). 2) They discretize survival time into independent risk intervals, which ignores its continuous and ordinal nature and fails to achieve effective optimization. 3) They treat censorship as a binary indicator, excluding censored samples from model optimization and not making full use of them. To address these challenges, we propose HySurvPred, a novel framework for survival prediction that integrates three key modules: Multimodal Hyperbolic Mapping (MHM), Angle-aware Ranking-based Contrastive Loss (ARCL) and Censor-Conditioned Uncertainty Constraint (CUC). Instead of relying on Euclidean space, we design the MHM module to explore the inherent hierarchical structures within each modality in hyperbolic space. To better integrate multimodal features in hyperbolic space, we introduce the ARCL module, which uses ranking-based contrastive learning to preserve the ordinal nature of survival time, along with the CUC module to fully explore the censored data. Extensive experiments demonstrate that our method outperforms state-of-the-art methods on five benchmark datasets. The source code is to be released.

Unlocking Generalization Power in LiDAR Point Cloud Registration

In real-world environments, a LiDAR point cloud registration method with robust generalization capabilities (across varying distances and datasets) is crucial for ensuring safety in autonomous driving and other LiDAR-based applications. However, current methods fall short in achieving this level of generalization. To address these limitations, we propose UGP, a pruned framework designed to enhance generalization power for LiDAR point cloud registration. The core insight in UGP is the elimination of cross-attention mechanisms to improve generalization, allowing the network to concentrate on intra-frame feature extraction. Additionally, we introduce a progressive self-attention module to reduce ambiguity in large-scale scenes and integrate Bird's Eye View (BEV) features to incorporate semantic information about scene elements. Together, these enhancements significantly boost the network's generalization performance. We validated our approach through various generalization experiments in multiple outdoor scenes. In cross-distance generalization experiments on KITTI and nuScenes, UGP achieved state-of-the-art mean Registration Recall rates of 94.5% and 91.4%, respectively. In cross-dataset generalization from nuScenes to KITTI, UGP achieved a state-of-the-art mean Registration Recall of 90.9%. Code will be available at https://github.com/peakpang/UGP.

Multimodal Language Modeling for High-Accuracy Single Cell Transcriptomics Analysis and Generation

Pre-trained language models (PLMs) have revolutionized scientific research, yet their application to single-cell analysis remains limited. Text PLMs cannot process single-cell RNA sequencing data, while cell PLMs lack the ability to handle free text, restricting their use in multimodal tasks. Existing efforts to bridge these modalities often suffer from information loss or inadequate single-modal pre-training, leading to suboptimal performances. To address these challenges, we propose Single-Cell MultiModal Generative Pre-trained Transformer (scMMGPT), a unified PLM for joint cell and text modeling. scMMGPT effectively integrates the state-of-the-art cell and text PLMs, facilitating cross-modal knowledge sharing for improved performance. To bridge the text-cell modality gap, scMMGPT leverages dedicated cross-modal projectors, and undergoes extensive pre-training on 27 million cells -- the largest dataset for multimodal cell-text PLMs to date. This large-scale pre-training enables scMMGPT to excel in joint cell-text tasks, achieving an 84\% relative improvement of textual discrepancy for cell description generation, 20.5\% higher accuracy for cell type annotation, and 4\% improvement in $k$-NN accuracy for text-conditioned pseudo-cell generation, outperforming baselines.

AxisPose: Model-Free Matching-Free Single-Shot 6D Object Pose Estimation via Axis Generation

Object pose estimation, which plays a vital role in robotics, augmented reality, and autonomous driving, has been of great interest in computer vision. Existing studies either require multi-stage pose regression or rely on 2D-3D feature matching. Though these approaches have shown promising results, they rely heavily on appearance information, requiring complex input (i.e., multi-view reference input, depth, or CAD models) and intricate pipeline (i.e., feature extraction-SfM-2D to 3D matching-PnP). We propose AxisPose, a model-free, matching-free, single-shot solution for robust 6D pose estimation, which fundamentally diverges from the existing paradigm. Unlike existing methods that rely on 2D-3D or 2D-2D matching using 3D techniques, such as SfM and PnP, AxisPose directly infers a robust 6D pose from a single view by leveraging a diffusion model to learn the latent axis distribution of objects without reference views. Specifically, AxisPose constructs an Axis Generation Module (AGM) to capture the latent geometric distribution of object axes through a diffusion model. The diffusion process is guided by injecting the gradient of geometric consistency loss into the noise estimation to maintain the geometric consistency of the generated tri-axis. With the generated tri-axis projection, AxisPose further adopts a Triaxial Back-projection Module (TBM) to recover the 6D pose from the object tri-axis. The proposed AxisPose achieves robust performance at the cross-instance level (i.e., one model for N instances) using only a single view as input without reference images, with great potential for generalization to unseen-object level.

HyperGCT: A Dynamic Hyper-GNN-Learned Geometric Constraint for 3D Registration

Geometric constraints between feature matches are critical in 3D point cloud registration problems. Existing approaches typically model unordered matches as a consistency graph and sample consistent matches to generate hypotheses. However, explicit graph construction introduces noise, posing great challenges for handcrafted geometric constraints to render consistency among matches. To overcome this, we propose HyperGCT, a flexible dynamic Hyper-GNN-learned geometric constraint that leverages high-order consistency among 3D correspondences. To our knowledge, HyperGCT is the first method that mines robust geometric constraints from dynamic hypergraphs for 3D registration. By dynamically optimizing the hypergraph through vertex and edge feature aggregation, HyperGCT effectively captures the correlations among correspondences, leading to accurate hypothesis generation. Extensive experiments on 3DMatch, 3DLoMatch, KITTI-LC, and ETH show that HyperGCT achieves state-of-the-art performance. Furthermore, our method is robust to graph noise, demonstrating a significant advantage in terms of generalization. The code will be released.

SPU-IMR: Self-supervised Arbitrary-scale Point Cloud Upsampling via Iterative Mask-recovery Network

Point cloud upsampling aims to generate dense and uniformly distributed point sets from sparse point clouds. Existing point cloud upsampling methods typically approach the task as an interpolation problem. They achieve upsampling by performing local interpolation between point clouds or in the feature space, then regressing the interpolated points to appropriate positions. By contrast, our proposed method treats point cloud upsampling as a global shape completion problem. Specifically, our method first divides the point cloud into multiple patches. Then, a masking operation is applied to remove some patches, leaving visible point cloud patches. Finally, our custom-designed neural network iterative completes the missing sections of the point cloud through the visible parts. During testing, by selecting different mask sequences, we can restore various complete patches. A sufficiently dense upsampled point cloud can be obtained by merging all the completed patches. We demonstrate the superior performance of our method through both quantitative and qualitative experiments, showing overall superiority against both existing self-supervised and supervised methods.

Dual Classification Head Self-training Network for Cross-scene Hyperspectral Image Classification

Due to the difficulty of obtaining labeled data for hyperspectral images (HSIs), cross-scene classification has emerged as a widely adopted approach in the remote sensing community. It involves training a model using labeled data from a source domain (SD) and unlabeled data from a target domain (TD), followed by inferencing on the TD. However, variations in the reflectance spectrum of the same object between the SD and the TD, as well as differences in the feature distribution of the same land cover class, pose significant challenges to the performance of cross-scene classification. To address this issue, we propose a dual classification head self-training network (DHSNet). This method aligns class-wise features across domains, ensuring that the trained classifier can accurately classify TD data of different classes. We introduce a dual classification head self-training strategy for the first time in the cross-scene HSI classification field. The proposed approach mitigates domain gap while preventing the accumulation of incorrect pseudo-labels in the model. Additionally, we incorporate a novel central feature attention mechanism to enhance the model's capacity to learn scene-invariant features across domains. Experimental results on three cross-scene HSI datasets demonstrate that the proposed DHSNET significantly outperforms other state-of-the-art approaches. The code for DHSNet will be available at https://github.com/liurongwhm.

OmniHuman-1: Rethinking the Scaling-Up of One-Stage Conditioned Human Animation Models

End-to-end human animation, such as audio-driven talking human generation, has undergone notable advancements in the recent few years. However, existing methods still struggle to scale up as large general video generation models, limiting their potential in real applications. In this paper, we propose OmniHuman, a Diffusion Transformer-based framework that scales up data by mixing motion-related conditions into the training phase. To this end, we introduce two training principles for these mixed conditions, along with the corresponding model architecture and inference strategy. These designs enable OmniHuman to fully leverage data-driven motion generation, ultimately achieving highly realistic human video generation. More importantly, OmniHuman supports various portrait contents (face close-up, portrait, half-body, full-body), supports both talking and singing, handles human-object interactions and challenging body poses, and accommodates different image styles. Compared to existing end-to-end audio-driven methods, OmniHuman not only produces more realistic videos, but also offers greater flexibility in inputs. It also supports multiple driving modalities (audio-driven, video-driven and combined driving signals). Video samples are provided on the ttfamily project page (https://omnihuman-lab.github.io)

DFF: Decision-Focused Fine-tuning for Smarter Predict-then-Optimize with Limited Data

Decision-focused learning (DFL) offers an end-to-end approach to the predict-then-optimize (PO) framework by training predictive models directly on decision loss (DL), enhancing decision-making performance within PO contexts. However, the implementation of DFL poses distinct challenges. Primarily, DL can result in deviation from the physical significance of the predictions under limited data. Additionally, some predictive models are non-differentiable or black-box, which cannot be adjusted using gradient-based methods. To tackle the above challenges, we propose a novel framework, Decision-Focused Fine-tuning (DFF), which embeds the DFL module into the PO pipeline via a novel bias correction module. DFF is formulated as a constrained optimization problem that maintains the proximity of the DL-enhanced model to the original predictive model within a defined trust region. We theoretically prove that DFF strictly confines prediction bias within a predetermined upper bound, even with limited datasets, thereby substantially reducing prediction shifts caused by DL under limited data. Furthermore, the bias correction module can be integrated into diverse predictive models, enhancing adaptability to a broad range of PO tasks. Extensive evaluations on synthetic and real-world datasets, including network flow, portfolio optimization, and resource allocation problems with different predictive models, demonstrate that DFF not only improves decision performance but also adheres to fine-tuning constraints, showcasing robust adaptability across various scenarios.

Active Learning with Variational Quantum Circuits for Quantum Process Tomography

Quantum process tomography (QPT), used for reconstruction of an unknown quantum process from measurement data, is a fundamental tool for the diagnostic and full characterization of quantum systems. It relies on querying a set of quantum states as input to the quantum process. Previous works commonly use a straightforward strategy to select a set of quantum states randomly, overlooking differences in informativeness among quantum states. Since querying the quantum system requires multiple experiments that can be prohibitively costly, it is always the case that there are not enough quantum states for high-quality reconstruction. In this paper, we propose a general framework for active learning (AL) to adaptively select a set of informative quantum states that improves the reconstruction most efficiently. In particular, we introduce a learning framework that leverages the widely-used variational quantum circuits (VQCs) to perform the QPT task and integrate our AL algorithms into the query step. We design and evaluate three various types of AL algorithms: committee-based, uncertainty-based, and diversity-based, each exhibiting distinct advantages in terms of performance and computational cost. Additionally, we provide a guideline for selecting algorithms suitable for different scenarios. Numerical results demonstrate that our algorithms achieve significantly improved reconstruction compared to the baseline method that selects a set of quantum states randomly. Moreover, these results suggest that active learning based approaches are applicable to other complicated learning tasks in large-scale quantum information processing.