PLAY2PROMPT: Zero-shot Tool Instruction Optimization for LLM Agents via Tool Play

Large language models (LLMs) are increasingly integrated with specialized external tools, yet many tasks demand zero-shot tool usage with minimal or noisy documentation. Existing solutions rely on manual rewriting or labeled data for validation, making them inapplicable in true zero-shot settings. To address these challenges, we propose PLAY2PROMPT, an automated framework that systematically "plays" with each tool to explore its input-output behaviors. Through this iterative trial-and-error process, PLAY2PROMPT refines tool documentation and generates usage examples without any labeled data. These examples not only guide LLM inference but also serve as validation to further enhance tool utilization. Extensive experiments on real-world tasks demonstrate that PLAY2PROMPT significantly improves zero-shot tool performance across both open and closed models, offering a scalable and effective solution for domain-specific tool integration.

Multimodal Language Modeling for High-Accuracy Single Cell Transcriptomics Analysis and Generation

Pre-trained language models (PLMs) have revolutionized scientific research, yet their application to single-cell analysis remains limited. Text PLMs cannot process single-cell RNA sequencing data, while cell PLMs lack the ability to handle free text, restricting their use in multimodal tasks. Existing efforts to bridge these modalities often suffer from information loss or inadequate single-modal pre-training, leading to suboptimal performances. To address these challenges, we propose Single-Cell MultiModal Generative Pre-trained Transformer (scMMGPT), a unified PLM for joint cell and text modeling. scMMGPT effectively integrates the state-of-the-art cell and text PLMs, facilitating cross-modal knowledge sharing for improved performance. To bridge the text-cell modality gap, scMMGPT leverages dedicated cross-modal projectors, and undergoes extensive pre-training on 27 million cells -- the largest dataset for multimodal cell-text PLMs to date. This large-scale pre-training enables scMMGPT to excel in joint cell-text tasks, achieving an 84\% relative improvement of textual discrepancy for cell description generation, 20.5\% higher accuracy for cell type annotation, and 4\% improvement in $k$-NN accuracy for text-conditioned pseudo-cell generation, outperforming baselines.

The Challenge of Identifying the Origin of Black-Box Large Language Models

The tremendous commercial potential of large language models (LLMs) has heightened concerns about their unauthorized use. Third parties can customize LLMs through fine-tuning and offer only black-box API access, effectively concealing unauthorized usage and complicating external auditing processes. This practice not only exacerbates unfair competition, but also violates licensing agreements. In response, identifying the origin of black-box LLMs is an intrinsic solution to this issue. In this paper, we first reveal the limitations of state-of-the-art passive and proactive identification methods with experiments on 30 LLMs and two real-world black-box APIs. Then, we propose the proactive technique, PlugAE, which optimizes adversarial token embeddings in a continuous space and proactively plugs them into the LLM for tracing and identification. The experiments show that PlugAE can achieve substantial improvement in identifying fine-tuned derivatives. We further advocate for legal frameworks and regulations to better address the challenges posed by the unauthorized use of LLMs.

Measuring What Makes You Unique: Difference-Aware User Modeling for Enhancing LLM Personalization

Personalizing Large Language Models (LLMs) has become a critical step in facilitating their widespread application to enhance individual life experiences. In pursuit of personalization, distilling key preference information from an individual's historical data as instructional preference context to customize LLM generation has emerged as a promising direction. However, these methods face a fundamental limitation by overlooking the inter-user comparative analysis, which is essential for identifying the inter-user differences that truly shape preferences. To address this limitation, we propose Difference-aware Personalization Learning (DPL), a novel approach that emphasizes extracting inter-user differences to enhance LLM personalization. DPL strategically selects representative users for comparison and establishes a structured standard to extract meaningful, task-relevant differences for customizing LLM generation. Extensive experiments on real-world datasets demonstrate that DPL significantly enhances LLM personalization. We release our code at https://github.com/SnowCharmQ/DPL.

Fairness and/or Privacy on Social Graphs

Graph Neural Networks (GNNs) have shown remarkable success in various graph-based learning tasks. However, recent studies have raised concerns about fairness and privacy issues in GNNs, highlighting the potential for biased or discriminatory outcomes and the vulnerability of sensitive information. This paper presents a comprehensive investigation of fairness and privacy in GNNs, exploring the impact of various fairness-preserving measures on model performance. We conduct experiments across diverse datasets and evaluate the effectiveness of different fairness interventions. Our analysis considers the trade-offs between fairness, privacy, and accuracy, providing insights into the challenges and opportunities in achieving both fair and private graph learning. The results highlight the importance of carefully selecting and combining fairness-preserving measures based on the specific characteristics of the data and the desired fairness objectives. This study contributes to a deeper understanding of the complex interplay between fairness, privacy, and accuracy in GNNs, paving the way for the development of more robust and ethical graph learning models.

Code-as-Symbolic-Planner: Foundation Model-Based Robot Planning via Symbolic Code Generation

Recent works have shown great potentials of Large Language Models (LLMs) in robot task and motion planning (TAMP). Current LLM approaches generate text- or code-based reasoning chains with sub-goals and action plans. However, they do not fully leverage LLMs' symbolic computing and code generation capabilities. Many robot TAMP tasks involve complex optimization under multiple constraints, where pure textual reasoning is insufficient. While augmenting LLMs with predefined solvers and planners improves performance, it lacks generalization across tasks. Given LLMs' growing coding proficiency, we enhance their TAMP capabilities by steering them to generate code as symbolic planners for optimization and constraint verification. Unlike prior work that uses code to interface with robot action modules, we steer LLMs to generate code as solvers, planners, and checkers for TAMP tasks requiring symbolic computing, while still leveraging textual reasoning to incorporate common sense. With a multi-round guidance and answer evolution framework, the proposed Code-as-Symbolic-Planner improves success rates by average 24.1\% over best baseline methods across seven typical TAMP tasks and three popular LLMs. Code-as-Symbolic-Planner shows strong effectiveness and generalizability across discrete and continuous environments, 2D/3D simulations and real-world settings, as well as single- and multi-robot tasks with diverse requirements. See our project website https://yongchao98.github.io/Code-Symbol-Planner/ for prompts, videos, and code.

Label-free Prediction of Vascular Connectivity in Perfused Microvascular Networks in vitro

Continuous monitoring and in-situ assessment of microvascular connectivity have significant implications for culturing vascularized organoids and optimizing the therapeutic strategies. However, commonly used methods for vascular connectivity assessment heavily rely on fluorescent labels that may either raise biocompatibility concerns or interrupt the normal cell growth process. To address this issue, a Vessel Connectivity Network (VC-Net) was developed for label-free assessment of vascular connectivity. To validate the VC-Net, microvascular networks (MVNs) were cultured in vitro and their microscopic images were acquired at different culturing conditions as a training dataset. The VC-Net employs a Vessel Queue Contrastive Learning (VQCL) method and a class imbalance algorithm to address the issues of limited sample size, indistinctive class features and imbalanced class distribution in the dataset. The VC-Net successfully evaluated the vascular connectivity with no significant deviation from that by fluorescence imaging. In addition, the proposed VC-Net successfully differentiated the connectivity characteristics between normal and tumor-related MVNs. In comparison with those cultured in the regular microenvironment, the averaged connectivity of MVNs cultured in the tumor-related microenvironment decreased by 30.8%, whereas the non-connected area increased by 37.3%. This study provides a new avenue for label-free and continuous assessment of organoid or tumor vascularization in vitro.

Effective Field Neural Network

In recent years, with the rapid development of machine learning, physicists have been exploring its new applications in solving or alleviating the curse of dimensionality in many-body problems. In order to accurately reflect the underlying physics of the problem, domain knowledge must be encoded into the machine learning algorithms. In this work, inspired by field theory, we propose a new set of machine learning models called effective field neural networks (EFNNs) that can automatically and efficiently capture important many-body interactions through multiple self-refining processes. Taking the classical $3$-spin infinite-range model and the quantum double exchange model as case studies, we explicitly demonstrate that EFNNs significantly outperform fully-connected deep neural networks (DNNs) and the effective model. Furthermore, with the help of convolution operations, the EFNNs learned in a small system can be seamlessly used in a larger system without additional training and the relative errors even decrease, which further demonstrates the efficacy of EFNNs in representing core physical behaviors.

EDocNet: Efficient Datasheet Layout Analysis Based on Focus and Global Knowledge Distillation

When designing circuits, engineers obtain the information of electronic devices by browsing a large number of documents, which is low efficiency and heavy workload. The use of artificial intelligence technology to automatically parse documents can greatly improve the efficiency of engineers. However, the current document layout analysis model is aimed at various types of documents and is not suitable for electronic device documents. This paper proposes to use EDocNet to realize the document layout analysis function for document analysis, and use the electronic device document data set created by myself for training. The training method adopts the focus and global knowledge distillation method, and a model suitable for electronic device documents is obtained, which can divide the contents of electronic device documents into 21 categories. It has better average accuracy and average recall rate. It also greatly improves the speed of model checking.

Advanced Chain-of-Thought Reasoning for Parameter Extraction from Documents Using Large Language Models

Extracting parameters from technical documentation is crucial for ensuring design precision and simulation reliability in electronic design. However, current methods struggle to handle high-dimensional design data and meet the demands of real-time processing. In electronic design automation (EDA), engineers often manually search through extensive documents to retrieve component parameters required for constructing PySpice models, a process that is both labor-intensive and time-consuming. To address this challenge, we propose an innovative framework that leverages large language models (LLMs) to automate the extraction of parameters and the generation of PySpice models directly from datasheets. Our framework introduces three Chain-of-Thought (CoT) based techniques: (1) Targeted Document Retrieval (TDR), which enables the rapid identification of relevant technical sections; (2) Iterative Retrieval Optimization (IRO), which refines the parameter search through iterative improvements; and (3) Preference Optimization (PO), which dynamically prioritizes key document sections based on relevance. Experimental results show that applying all three methods together improves retrieval precision by 47.69% and reduces processing latency by 37.84%. Furthermore, effect size analysis using Cohen's d reveals that PO significantly reduces latency, while IRO contributes most to precision enhancement. These findings underscore the potential of our framework to streamline EDA processes, enhance design accuracy, and shorten development timelines. Additionally, our algorithm has model-agnostic generalization, meaning it can improve parameter search performance across different LLMs.