Exploring the Evolution of Physics Cognition in Video Generation: A Survey

Recent advancements in video generation have witnessed significant progress, especially with the rapid advancement of diffusion models. Despite this, their deficiencies in physical cognition have gradually received widespread attention - generated content often violates the fundamental laws of physics, falling into the dilemma of ''visual realism but physical absurdity". Researchers began to increasingly recognize the importance of physical fidelity in video generation and attempted to integrate heuristic physical cognition such as motion representations and physical knowledge into generative systems to simulate real-world dynamic scenarios. Considering the lack of a systematic overview in this field, this survey aims to provide a comprehensive summary of architecture designs and their applications to fill this gap. Specifically, we discuss and organize the evolutionary process of physical cognition in video generation from a cognitive science perspective, while proposing a three-tier taxonomy: 1) basic schema perception for generation, 2) passive cognition of physical knowledge for generation, and 3) active cognition for world simulation, encompassing state-of-the-art methods, classical paradigms, and benchmarks. Subsequently, we emphasize the inherent key challenges in this domain and delineate potential pathways for future research, contributing to advancing the frontiers of discussion in both academia and industry. Through structured review and interdisciplinary analysis, this survey aims to provide directional guidance for developing interpretable, controllable, and physically consistent video generation paradigms, thereby propelling generative models from the stage of ''visual mimicry'' towards a new phase of ''human-like physical comprehension''.

Towards Unified Latent Space for 3D Molecular Latent Diffusion Modeling

3D molecule generation is crucial for drug discovery and material science, requiring models to process complex multi-modalities, including atom types, chemical bonds, and 3D coordinates. A key challenge is integrating these modalities of different shapes while maintaining SE(3) equivariance for 3D coordinates. To achieve this, existing approaches typically maintain separate latent spaces for invariant and equivariant modalities, reducing efficiency in both training and sampling. In this work, we propose \textbf{U}nified Variational \textbf{A}uto-\textbf{E}ncoder for \textbf{3D} Molecular Latent Diffusion Modeling (\textbf{UAE-3D}), a multi-modal VAE that compresses 3D molecules into latent sequences from a unified latent space, while maintaining near-zero reconstruction error. This unified latent space eliminates the complexities of handling multi-modality and equivariance when performing latent diffusion modeling. We demonstrate this by employing the Diffusion Transformer--a general-purpose diffusion model without any molecular inductive bias--for latent generation. Extensive experiments on GEOM-Drugs and QM9 datasets demonstrate that our method significantly establishes new benchmarks in both \textit{de novo} and conditional 3D molecule generation, achieving leading efficiency and quality.

Multimodal Language Modeling for High-Accuracy Single Cell Transcriptomics Analysis and Generation

Pre-trained language models (PLMs) have revolutionized scientific research, yet their application to single-cell analysis remains limited. Text PLMs cannot process single-cell RNA sequencing data, while cell PLMs lack the ability to handle free text, restricting their use in multimodal tasks. Existing efforts to bridge these modalities often suffer from information loss or inadequate single-modal pre-training, leading to suboptimal performances. To address these challenges, we propose Single-Cell MultiModal Generative Pre-trained Transformer (scMMGPT), a unified PLM for joint cell and text modeling. scMMGPT effectively integrates the state-of-the-art cell and text PLMs, facilitating cross-modal knowledge sharing for improved performance. To bridge the text-cell modality gap, scMMGPT leverages dedicated cross-modal projectors, and undergoes extensive pre-training on 27 million cells -- the largest dataset for multimodal cell-text PLMs to date. This large-scale pre-training enables scMMGPT to excel in joint cell-text tasks, achieving an 84\% relative improvement of textual discrepancy for cell description generation, 20.5\% higher accuracy for cell type annotation, and 4\% improvement in $k$-NN accuracy for text-conditioned pseudo-cell generation, outperforming baselines.

ACE: Concept Editing in Diffusion Models without Performance Degradation

Diffusion-based text-to-image models have demonstrated remarkable capabilities in generating realistic images, but they raise societal and ethical concerns, such as the creation of unsafe content. While concept editing is proposed to address these issues, they often struggle to balance the removal of unsafe concept with maintaining the model's general genera-tive capabilities. In this work, we propose ACE, a new editing method that enhances concept editing in diffusion models. ACE introduces a novel cross null-space projection approach to precisely erase unsafe concept while maintaining the model's ability to generate high-quality, semantically consistent images. Extensive experiments demonstrate that ACE significantly outperforms the advancing baselines,improving semantic consistency by 24.56% and image generation quality by 34.82% on average with only 1% of the time cost. These results highlight the practical utility of concept editing by mitigating its potential risks, paving the way for broader applications in the field. Code is avaliable at https://github.com/littlelittlenine/ACE-zero.git

Route Sparse Autoencoder to Interpret Large Language Models

Mechanistic interpretability of large language models (LLMs) aims to uncover the internal processes of information propagation and reasoning. Sparse autoencoders (SAEs) have demonstrated promise in this domain by extracting interpretable and monosemantic features. However, prior works primarily focus on feature extraction from a single layer, failing to effectively capture activations that span multiple layers. In this paper, we introduce Route Sparse Autoencoder (RouteSAE), a new framework that integrates a routing mechanism with a shared SAE to efficiently extract features from multiple layers. It dynamically assigns weights to activations from different layers, incurring minimal parameter overhead while achieving high interpretability and flexibility for targeted feature manipulation. We evaluate RouteSAE through extensive experiments on Llama-3.2-1B-Instruct. Specifically, under the same sparsity constraint of 64, RouteSAE extracts 22.5% more features than baseline SAEs while achieving a 22.3% higher interpretability score. These results underscore the potential of RouteSAE as a scalable and effective method for LLM interpretability, with applications in feature discovery and model intervention. Our codes are available at https://github.com/swei2001/RouteSAEs.

RePO: ReLU-based Preference Optimization

Aligning large language models (LLMs) with human preferences is critical for real-world deployment, yet existing methods like RLHF face computational and stability challenges. While DPO establishes an offline paradigm with single hyperparameter $\beta$, subsequent methods like SimPO reintroduce complexity through dual parameters ($\beta$, $\gamma$). We propose {ReLU-based Preference Optimization (RePO)}, a streamlined algorithm that eliminates $\beta$ via two advances: (1) retaining SimPO's reference-free margins but removing $\beta$ through gradient analysis, and (2) adopting a ReLU-based max-margin loss that naturally filters trivial pairs. Theoretically, RePO is characterized as SimPO's limiting case ($\beta \to \infty$), where the logistic weighting collapses to binary thresholding, forming a convex envelope of the 0-1 loss. Empirical results on AlpacaEval 2 and Arena-Hard show that RePO outperforms DPO and SimPO across multiple base models, requiring only one hyperparameter to tune.

DreamRelation: Relation-Centric Video Customization

Relational video customization refers to the creation of personalized videos that depict user-specified relations between two subjects, a crucial task for comprehending real-world visual content. While existing methods can personalize subject appearances and motions, they still struggle with complex relational video customization, where precise relational modeling and high generalization across subject categories are essential. The primary challenge arises from the intricate spatial arrangements, layout variations, and nuanced temporal dynamics inherent in relations; consequently, current models tend to overemphasize irrelevant visual details rather than capturing meaningful interactions. To address these challenges, we propose DreamRelation, a novel approach that personalizes relations through a small set of exemplar videos, leveraging two key components: Relational Decoupling Learning and Relational Dynamics Enhancement. First, in Relational Decoupling Learning, we disentangle relations from subject appearances using relation LoRA triplet and hybrid mask training strategy, ensuring better generalization across diverse relationships. Furthermore, we determine the optimal design of relation LoRA triplet by analyzing the distinct roles of the query, key, and value features within MM-DiT's attention mechanism, making DreamRelation the first relational video generation framework with explainable components. Second, in Relational Dynamics Enhancement, we introduce space-time relational contrastive loss, which prioritizes relational dynamics while minimizing the reliance on detailed subject appearances. Extensive experiments demonstrate that DreamRelation outperforms state-of-the-art methods in relational video customization. Code and models will be made publicly available.

START: Self-taught Reasoner with Tools

Large reasoning models (LRMs) like OpenAI-o1 and DeepSeek-R1 have demonstrated remarkable capabilities in complex reasoning tasks through the utilization of long Chain-of-thought (CoT). However, these models often suffer from hallucinations and inefficiencies due to their reliance solely on internal reasoning processes. In this paper, we introduce START (Self-Taught Reasoner with Tools), a novel tool-integrated long CoT reasoning LLM that significantly enhances reasoning capabilities by leveraging external tools. Through code execution, START is capable of performing complex computations, self-checking, exploring diverse methods, and self-debugging, thereby addressing the limitations of LRMs. The core innovation of START lies in its self-learning framework, which comprises two key techniques: 1) Hint-infer: We demonstrate that inserting artificially designed hints (e.g., ``Wait, maybe using Python here is a good idea.'') during the inference process of a LRM effectively stimulates its ability to utilize external tools without the need for any demonstration data. Hint-infer can also serve as a simple and effective sequential test-time scaling method; 2) Hint Rejection Sampling Fine-Tuning (Hint-RFT): Hint-RFT combines Hint-infer and RFT by scoring, filtering, and modifying the reasoning trajectories with tool invocation generated by a LRM via Hint-infer, followed by fine-tuning the LRM. Through this framework, we have fine-tuned the QwQ-32B model to achieve START. On PhD-level science QA (GPQA), competition-level math benchmarks (AMC23, AIME24, AIME25), and the competition-level code benchmark (LiveCodeBench), START achieves accuracy rates of 63.6%, 95.0%, 66.7%, 47.1%, and 47.3%, respectively. It significantly outperforms the base QwQ-32B and achieves performance comparable to the state-of-the-art open-weight model R1-Distill-Qwen-32B and the proprietary model o1-Preview.

NExT-Mol: 3D Diffusion Meets 1D Language Modeling for 3D Molecule Generation

3D molecule generation is crucial for drug discovery and material design. While prior efforts focus on 3D diffusion models for their benefits in modeling continuous 3D conformers, they overlook the advantages of 1D SELFIES-based Language Models (LMs), which can generate 100% valid molecules and leverage the billion-scale 1D molecule datasets. To combine these advantages for 3D molecule generation, we propose a foundation model -- NExT-Mol: 3D Diffusion Meets 1D Language Modeling for 3D Molecule Generation. NExT-Mol uses an extensively pretrained molecule LM for 1D molecule generation, and subsequently predicts the generated molecule's 3D conformers with a 3D diffusion model. We enhance NExT-Mol's performance by scaling up the LM's model size, refining the diffusion neural architecture, and applying 1D to 3D transfer learning. Notably, our 1D molecule LM significantly outperforms baselines in distributional similarity while ensuring validity, and our 3D diffusion model achieves leading performances in conformer prediction. Given these improvements in 1D and 3D modeling, NExT-Mol achieves a 26% relative improvement in 3D FCD for de novo 3D generation on GEOM-DRUGS, and a 13% average relative gain for conditional 3D generation on QM9-2014. Our codes and pretrained checkpoints are available at https://github.com/acharkq/NExT-Mol.

Reinforced Lifelong Editing for Language Models

Large language models (LLMs) acquire information from pre-training corpora, but their stored knowledge can become inaccurate or outdated over time. Model editing addresses this challenge by modifying model parameters without retraining, and prevalent approaches leverage hypernetworks to generate these parameter updates. However, they face significant challenges in lifelong editing due to their incompatibility with LLM parameters that dynamically change during the editing process. To address this, we observed that hypernetwork-based lifelong editing aligns with reinforcement learning modeling and proposed RLEdit, an RL-based editing method. By treating editing losses as rewards and optimizing hypernetwork parameters at the full knowledge sequence level, we enable it to precisely capture LLM changes and generate appropriate parameter updates. Our extensive empirical evaluation across several LLMs demonstrates that RLEdit outperforms existing methods in lifelong editing with superior effectiveness and efficiency, achieving a 59.24% improvement while requiring only 2.11% of the time compared to most approaches. Our code is available at: https://github.com/zhrli324/RLEdit.