Non-Invasive to Invasive: Enhancing FFA Synthesis from CFP with a Benchmark Dataset and a Novel Network

Fundus imaging is a pivotal tool in ophthalmology, and different imaging modalities are characterized by their specific advantages. For example, Fundus Fluorescein Angiography (FFA) uniquely provides detailed insights into retinal vascular dynamics and pathology, surpassing Color Fundus Photographs (CFP) in detecting microvascular abnormalities and perfusion status. However, the conventional invasive FFA involves discomfort and risks due to fluorescein dye injection, and it is meaningful but challenging to synthesize FFA images from non-invasive CFP. Previous studies primarily focused on FFA synthesis in a single disease category. In this work, we explore FFA synthesis in multiple diseases by devising a Diffusion-guided generative adversarial network, which introduces an adaptive and dynamic diffusion forward process into the discriminator and adds a category-aware representation enhancer. Moreover, to facilitate this research, we collect the first multi-disease CFP and FFA paired dataset, named the Multi-disease Paired Ocular Synthesis (MPOS) dataset, with four different fundus diseases. Experimental results show that our FFA synthesis network can generate better FFA images compared to state-of-the-art methods. Furthermore, we introduce a paired-modal diagnostic network to validate the effectiveness of synthetic FFA images in the diagnosis of multiple fundus diseases, and the results show that our synthesized FFA images with the real CFP images have higher diagnosis accuracy than that of the compared FFA synthesizing methods. Our research bridges the gap between non-invasive imaging and FFA, thereby offering promising prospects to enhance ophthalmic diagnosis and patient care, with a focus on reducing harm to patients through non-invasive procedures. Our dataset and code will be released to support further research in this field (https://github.com/whq-xxh/FFA-Synthesis).

Semi-Supervised Video Desnowing Network via Temporal Decoupling Experts and Distribution-Driven Contrastive Regularization

Snow degradations present formidable challenges to the advancement of computer vision tasks by the undesirable corruption in outdoor scenarios. While current deep learning-based desnowing approaches achieve success on synthetic benchmark datasets, they struggle to restore out-of-distribution real-world snowy videos due to the deficiency of paired real-world training data. To address this bottleneck, we devise a new paradigm for video desnowing in a semi-supervised spirit to involve unlabeled real data for the generalizable snow removal. Specifically, we construct a real-world dataset with 85 snowy videos, and then present a Semi-supervised Video Desnowing Network (SemiVDN) equipped by a novel Distribution-driven Contrastive Regularization. The elaborated contrastive regularization mitigates the distribution gap between the synthetic and real data, and consequently maintains the desired snow-invariant background details. Furthermore, based on the atmospheric scattering model, we introduce a Prior-guided Temporal Decoupling Experts module to decompose the physical components that make up a snowy video in a frame-correlated manner. We evaluate our SemiVDN on benchmark datasets and the collected real snowy data. The experimental results demonstrate the superiority of our approach against state-of-the-art image- and video-level desnowing methods.

WALL-E: World Alignment by Rule Learning Improves World Model-based LLM Agents

Can large language models (LLMs) directly serve as powerful world models for model-based agents? While the gaps between the prior knowledge of LLMs and the specified environment's dynamics do exist, our study reveals that the gaps can be bridged by aligning an LLM with its deployed environment and such "world alignment" can be efficiently achieved by rule learning on LLMs. Given the rich prior knowledge of LLMs, only a few additional rules suffice to align LLM predictions with the specified environment dynamics. To this end, we propose a neurosymbolic approach to learn these rules gradient-free through LLMs, by inducing, updating, and pruning rules based on comparisons of agent-explored trajectories and world model predictions. The resulting world model is composed of the LLM and the learned rules. Our embodied LLM agent "WALL-E" is built upon model-predictive control (MPC). By optimizing look-ahead actions based on the precise world model, MPC significantly improves exploration and learning efficiency. Compared to existing LLM agents, WALL-E's reasoning only requires a few principal rules rather than verbose buffered trajectories being included in the LLM input. On open-world challenges in Minecraft and ALFWorld, WALL-E achieves higher success rates than existing methods, with lower costs on replanning time and the number of tokens used for reasoning. In Minecraft, WALL-E exceeds baselines by 15-30% in success rate while costing 8-20 fewer replanning rounds and only 60-80% of tokens. In ALFWorld, its success rate surges to a new record high of 95% only after 6 iterations.

Cross-conditioned Diffusion Model for Medical Image to Image Translation

Multi-modal magnetic resonance imaging (MRI) provides rich, complementary information for analyzing diseases. However, the practical challenges of acquiring multiple MRI modalities, such as cost, scan time, and safety considerations, often result in incomplete datasets. This affects both the quality of diagnosis and the performance of deep learning models trained on such data. Recent advancements in generative adversarial networks (GANs) and denoising diffusion models have shown promise in natural and medical image-to-image translation tasks. However, the complexity of training GANs and the computational expense associated with diffusion models hinder their development and application in this task. To address these issues, we introduce a Cross-conditioned Diffusion Model (CDM) for medical image-to-image translation. The core idea of CDM is to use the distribution of target modalities as guidance to improve synthesis quality while achieving higher generation efficiency compared to conventional diffusion models. First, we propose a Modality-specific Representation Model (MRM) to model the distribution of target modalities. Then, we design a Modality-decoupled Diffusion Network (MDN) to efficiently and effectively learn the distribution from MRM. Finally, a Cross-conditioned UNet (C-UNet) with a Condition Embedding module is designed to synthesize the target modalities with the source modalities as input and the target distribution for guidance. Extensive experiments conducted on the BraTS2023 and UPenn-GBM benchmark datasets demonstrate the superiority of our method.

Diff-VPS: Video Polyp Segmentation via a Multi-task Diffusion Network with Adversarial Temporal Reasoning

Diffusion Probabilistic Models have recently attracted significant attention in the community of computer vision due to their outstanding performance. However, while a substantial amount of diffusion-based research has focused on generative tasks, no work introduces diffusion models to advance the results of polyp segmentation in videos, which is frequently challenged by polyps' high camouflage and redundant temporal cues.In this paper, we present a novel diffusion-based network for video polyp segmentation task, dubbed as Diff-VPS. We incorporate multi-task supervision into diffusion models to promote the discrimination of diffusion models on pixel-by-pixel segmentation. This integrates the contextual high-level information achieved by the joint classification and detection tasks. To explore the temporal dependency, Temporal Reasoning Module (TRM) is devised via reasoning and reconstructing the target frame from the previous frames. We further equip TRM with a generative adversarial self-supervised strategy to produce more realistic frames and thus capture better dynamic cues. Extensive experiments are conducted on SUN-SEG, and the results indicate that our proposed Diff-VPS significantly achieves state-of-the-art performance. Code is available at https://github.com/lydia-yllu/Diff-VPS.

RainMamba: Enhanced Locality Learning with State Space Models for Video Deraining

The outdoor vision systems are frequently contaminated by rain streaks and raindrops, which significantly degenerate the performance of visual tasks and multimedia applications. The nature of videos exhibits redundant temporal cues for rain removal with higher stability. Traditional video deraining methods heavily rely on optical flow estimation and kernel-based manners, which have a limited receptive field. Yet, transformer architectures, while enabling long-term dependencies, bring about a significant increase in computational complexity. Recently, the linear-complexity operator of the state space models (SSMs) has contrarily facilitated efficient long-term temporal modeling, which is crucial for rain streaks and raindrops removal in videos. Unexpectedly, its uni-dimensional sequential process on videos destroys the local correlations across the spatio-temporal dimension by distancing adjacent pixels. To address this, we present an improved SSMs-based video deraining network (RainMamba) with a novel Hilbert scanning mechanism to better capture sequence-level local information. We also introduce a difference-guided dynamic contrastive locality learning strategy to enhance the patch-level self-similarity learning ability of the proposed network. Extensive experiments on four synthesized video deraining datasets and real-world rainy videos demonstrate the superiority of our network in the removal of rain streaks and raindrops.

LGRNet: Local-Global Reciprocal Network for Uterine Fibroid Segmentation in Ultrasound Videos

Regular screening and early discovery of uterine fibroid are crucial for preventing potential malignant transformations and ensuring timely, life-saving interventions. To this end, we collect and annotate the first ultrasound video dataset with 100 videos for uterine fibroid segmentation (UFUV). We also present Local-Global Reciprocal Network (LGRNet) to efficiently and effectively propagate the long-term temporal context which is crucial to help distinguish between uninformative noisy surrounding tissues and target lesion regions. Specifically, the Cyclic Neighborhood Propagation (CNP) is introduced to propagate the inter-frame local temporal context in a cyclic manner. Moreover, to aggregate global temporal context, we first condense each frame into a set of frame bottleneck queries and devise Hilbert Selective Scan (HilbertSS) to both efficiently path connect each frame and preserve the locality bias. A distribute layer is then utilized to disseminate back the global context for reciprocal refinement. Extensive experiments on UFUV and three public Video Polyp Segmentation (VPS) datasets demonstrate consistent improvements compared to state-of-the-art segmentation methods, indicating the effectiveness and versatility of LGRNet. Code, checkpoints, and dataset are available at https://github.com/bio-mlhui/LGRNet

Driving-Video Dehazing with Non-Aligned Regularization for Safety Assistance

Real driving-video dehazing poses a significant challenge due to the inherent difficulty in acquiring precisely aligned hazy/clear video pairs for effective model training, especially in dynamic driving scenarios with unpredictable weather conditions. In this paper, we propose a pioneering approach that addresses this challenge through a nonaligned regularization strategy. Our core concept involves identifying clear frames that closely match hazy frames, serving as references to supervise a video dehazing network. Our approach comprises two key components: reference matching and video dehazing. Firstly, we introduce a non-aligned reference frame matching module, leveraging an adaptive sliding window to match high-quality reference frames from clear videos. Video dehazing incorporates flow-guided cosine attention sampler and deformable cosine attention fusion modules to enhance spatial multiframe alignment and fuse their improved information. To validate our approach, we collect a GoProHazy dataset captured effortlessly with GoPro cameras in diverse rural and urban road environments. Extensive experiments demonstrate the superiority of the proposed method over current state-of-the-art methods in the challenging task of real driving-video dehazing. Project page.

CloudFort: Enhancing Robustness of 3D Point Cloud Classification Against Backdoor Attacks via Spatial Partitioning and Ensemble Prediction

The increasing adoption of 3D point cloud data in various applications, such as autonomous vehicles, robotics, and virtual reality, has brought about significant advancements in object recognition and scene understanding. However, this progress is accompanied by new security challenges, particularly in the form of backdoor attacks. These attacks involve inserting malicious information into the training data of machine learning models, potentially compromising the model's behavior. In this paper, we propose CloudFort, a novel defense mechanism designed to enhance the robustness of 3D point cloud classifiers against backdoor attacks. CloudFort leverages spatial partitioning and ensemble prediction techniques to effectively mitigate the impact of backdoor triggers while preserving the model's performance on clean data. We evaluate the effectiveness of CloudFort through extensive experiments, demonstrating its strong resilience against the Point Cloud Backdoor Attack (PCBA). Our results show that CloudFort significantly enhances the security of 3D point cloud classification models without compromising their accuracy on benign samples. Furthermore, we explore the limitations of CloudFort and discuss potential avenues for future research in the field of 3D point cloud security. The proposed defense mechanism represents a significant step towards ensuring the trustworthiness and reliability of point-cloud-based systems in real-world applications.

UniArk: Improving Generalisation and Consistency for Factual Knowledge Extraction through Debiasing

Several recent papers have investigated the potential of language models as knowledge bases as well as the existence of severe biases when extracting factual knowledge. In this work, we focus on the factual probing performance over unseen prompts from tuning, and using a probabilistic view we show the inherent misalignment between pre-training and downstream tuning objectives in language models for probing knowledge. We hypothesize that simultaneously debiasing these objectives can be the key to generalisation over unseen prompts. We propose an adapter-based framework, UniArk, for generalised and consistent factual knowledge extraction through simple methods without introducing extra parameters. Extensive experiments show that UniArk can significantly improve the model's out-of-domain generalisation as well as consistency under various prompts. Additionally, we construct ParaTrex, a large-scale and diverse dataset for measuring the inconsistency and out-of-domain generation of models. Further, ParaTrex offers a reference method for constructing paraphrased datasets using large language models.