Free Lunch in Pathology Foundation Model: Task-specific Model Adaptation with Concept-Guided Feature Enhancement

Whole slide image (WSI) analysis is gaining prominence within the medical imaging field. Recent advances in pathology foundation models have shown the potential to extract powerful feature representations from WSIs for downstream tasks. However, these foundation models are usually designed for general-purpose pathology image analysis and may not be optimal for specific downstream tasks or cancer types. In this work, we present Concept Anchor-guided Task-specific Feature Enhancement (CATE), an adaptable paradigm that can boost the expressivity and discriminativeness of pathology foundation models for specific downstream tasks. Based on a set of task-specific concepts derived from the pathology vision-language model with expert-designed prompts, we introduce two interconnected modules to dynamically calibrate the generic image features extracted by foundation models for certain tasks or cancer types. Specifically, we design a Concept-guided Information Bottleneck module to enhance task-relevant characteristics by maximizing the mutual information between image features and concept anchors while suppressing superfluous information. Moreover, a Concept-Feature Interference module is proposed to utilize the similarity between calibrated features and concept anchors to further generate discriminative task-specific features. The extensive experiments on public WSI datasets demonstrate that CATE significantly enhances the performance and generalizability of MIL models. Additionally, heatmap and umap visualization results also reveal the effectiveness and interpretability of CATE. The source code is available at https://github.com/HKU-MedAI/CATE.

Membership Inference Attacks against Large Vision-Language Models

Large vision-language models (VLLMs) exhibit promising capabilities for processing multi-modal tasks across various application scenarios. However, their emergence also raises significant data security concerns, given the potential inclusion of sensitive information, such as private photos and medical records, in their training datasets. Detecting inappropriately used data in VLLMs remains a critical and unresolved issue, mainly due to the lack of standardized datasets and suitable methodologies. In this study, we introduce the first membership inference attack (MIA) benchmark tailored for various VLLMs to facilitate training data detection. Then, we propose a novel MIA pipeline specifically designed for token-level image detection. Lastly, we present a new metric called MaxR\'enyi-K%, which is based on the confidence of the model output and applies to both text and image data. We believe that our work can deepen the understanding and methodology of MIAs in the context of VLLMs. Our code and datasets are available at https://github.com/LIONS-EPFL/VL-MIA.

Fast Feedforward 3D Gaussian Splatting Compression

With 3D Gaussian Splatting (3DGS) advancing real-time and high-fidelity rendering for novel view synthesis, storage requirements pose challenges for their widespread adoption. Although various compression techniques have been proposed, previous art suffers from a common limitation: for any existing 3DGS, per-scene optimization is needed to achieve compression, making the compression sluggish and slow. To address this issue, we introduce Fast Compression of 3D Gaussian Splatting (FCGS), an optimization-free model that can compress 3DGS representations rapidly in a single feed-forward pass, which significantly reduces compression time from minutes to seconds. To enhance compression efficiency, we propose a multi-path entropy module that assigns Gaussian attributes to different entropy constraint paths for balance between size and fidelity. We also carefully design both inter- and intra-Gaussian context models to remove redundancies among the unstructured Gaussian blobs. Overall, FCGS achieves a compression ratio of over 20X while maintaining fidelity, surpassing most per-scene SOTA optimization-based methods. Our code is available at: https://github.com/YihangChen-ee/FCGS.

MECD: Unlocking Multi-Event Causal Discovery in Video Reasoning

Video causal reasoning aims to achieve a high-level understanding of video content from a causal perspective. However, current video reasoning tasks are limited in scope, primarily executed in a question-answering paradigm and focusing on short videos containing only a single event and simple causal relationships, lacking comprehensive and structured causality analysis for videos with multiple events. To fill this gap, we introduce a new task and dataset, Multi-Event Causal Discovery (MECD). It aims to uncover the causal relationships between events distributed chronologically across long videos. Given visual segments and textual descriptions of events, MECD requires identifying the causal associations between these events to derive a comprehensive, structured event-level video causal diagram explaining why and how the final result event occurred. To address MECD, we devise a novel framework inspired by the Granger Causality method, using an efficient mask-based event prediction model to perform an Event Granger Test, which estimates causality by comparing the predicted result event when premise events are masked versus unmasked. Furthermore, we integrate causal inference techniques such as front-door adjustment and counterfactual inference to address challenges in MECD like causality confounding and illusory causality. Experiments validate the effectiveness of our framework in providing causal relationships in multi-event videos, outperforming GPT-4o and VideoLLaVA by 5.7% and 4.1%, respectively.

cDP-MIL: Robust Multiple Instance Learning via Cascaded Dirichlet Process

Multiple instance learning (MIL) has been extensively applied to whole slide histopathology image (WSI) analysis. The existing aggregation strategy in MIL, which primarily relies on the first-order distance (e.g., mean difference) between instances, fails to accurately approximate the true feature distribution of each instance, leading to biased slide-level representations. Moreover, the scarcity of WSI observations easily leads to model overfitting, resulting in unstable testing performance and limited generalizability. To tackle these challenges, we propose a new Bayesian nonparametric framework for multiple instance learning, which adopts a cascade of Dirichlet processes (cDP) to incorporate the instance-to-bag characteristic of the WSIs. We perform feature aggregation based on the latent clusters formed by the Dirichlet process, which incorporates the covariances of the patch features and forms more representative clusters. We then perform bag-level prediction with another Dirichlet process model on the bags, which imposes a natural regularization on learning to prevent overfitting and enhance generalizability. Moreover, as a Bayesian nonparametric method, the cDP model can accurately generate posterior uncertainty, which allows for the detection of outlier samples and tumor localization. Extensive experiments on five WSI benchmarks validate the superior performance of our method, as well as its generalizability and ability to estimate uncertainties. Codes are available at https://github.com/HKU-MedAI/cDPMIL.

How Far Can We Compress Instant-NGP-Based NeRF?

In recent years, Neural Radiance Field (NeRF) has demonstrated remarkable capabilities in representing 3D scenes. To expedite the rendering process, learnable explicit representations have been introduced for combination with implicit NeRF representation, which however results in a large storage space requirement. In this paper, we introduce the Context-based NeRF Compression (CNC) framework, which leverages highly efficient context models to provide a storage-friendly NeRF representation. Specifically, we excavate both level-wise and dimension-wise context dependencies to enable probability prediction for information entropy reduction. Additionally, we exploit hash collision and occupancy grids as strong prior knowledge for better context modeling. To the best of our knowledge, we are the first to construct and exploit context models for NeRF compression. We achieve a size reduction of 100$\times$ and 70$\times$ with improved fidelity against the baseline Instant-NGP on Synthesic-NeRF and Tanks and Temples datasets, respectively. Additionally, we attain 86.7\% and 82.3\% storage size reduction against the SOTA NeRF compression method BiRF. Our code is available here: https://github.com/YihangChen-ee/CNC.

High-Dimensional Kernel Methods under Covariate Shift: Data-Dependent Implicit Regularization

This paper studies kernel ridge regression in high dimensions under covariate shifts and analyzes the role of importance re-weighting. We first derive the asymptotic expansion of high dimensional kernels under covariate shifts. By a bias-variance decomposition, we theoretically demonstrate that the re-weighting strategy allows for decreasing the variance. For bias, we analyze the regularization of the arbitrary or well-chosen scale, showing that the bias can behave very differently under different regularization scales. In our analysis, the bias and variance can be characterized by the spectral decay of a data-dependent regularized kernel: the original kernel matrix associated with an additional re-weighting matrix, and thus the re-weighting strategy can be regarded as a data-dependent regularization for better understanding. Besides, our analysis provides asymptotic expansion of kernel functions/vectors under covariate shift, which has its own interest.

RapVerse: Coherent Vocals and Whole-Body Motions Generations from Text

In this work, we introduce a challenging task for simultaneously generating 3D holistic body motions and singing vocals directly from textual lyrics inputs, advancing beyond existing works that typically address these two modalities in isolation. To facilitate this, we first collect the RapVerse dataset, a large dataset containing synchronous rapping vocals, lyrics, and high-quality 3D holistic body meshes. With the RapVerse dataset, we investigate the extent to which scaling autoregressive multimodal transformers across language, audio, and motion can enhance the coherent and realistic generation of vocals and whole-body human motions. For modality unification, a vector-quantized variational autoencoder is employed to encode whole-body motion sequences into discrete motion tokens, while a vocal-to-unit model is leveraged to obtain quantized audio tokens preserving content, prosodic information, and singer identity. By jointly performing transformer modeling on these three modalities in a unified way, our framework ensures a seamless and realistic blend of vocals and human motions. Extensive experiments demonstrate that our unified generation framework not only produces coherent and realistic singing vocals alongside human motions directly from textual inputs but also rivals the performance of specialized single-modality generation systems, establishing new benchmarks for joint vocal-motion generation. The project page is available for research purposes at https://vis-www.cs.umass.edu/RapVerse.

HAC: Hash-grid Assisted Context for 3D Gaussian Splatting Compression

3D Gaussian Splatting (3DGS) has emerged as a promising framework for novel view synthesis, boasting rapid rendering speed with high fidelity. However, the substantial Gaussians and their associated attributes necessitate effective compression techniques. Nevertheless, the sparse and unorganized nature of the point cloud of Gaussians (or anchors in our paper) presents challenges for compression. To address this, we make use of the relations between the unorganized anchors and the structured hash grid, leveraging their mutual information for context modeling, and propose a Hash-grid Assisted Context (HAC) framework for highly compact 3DGS representation. Our approach introduces a binary hash grid to establish continuous spatial consistencies, allowing us to unveil the inherent spatial relations of anchors through a carefully designed context model. To facilitate entropy coding, we utilize Gaussian distributions to accurately estimate the probability of each quantized attribute, where an adaptive quantization module is proposed to enable high-precision quantization of these attributes for improved fidelity restoration. Additionally, we incorporate an adaptive masking strategy to eliminate invalid Gaussians and anchors. Importantly, our work is the pioneer to explore context-based compression for 3DGS representation, resulting in a remarkable size reduction of over $75\times$ compared to vanilla 3DGS, while simultaneously improving fidelity, and achieving over $11\times$ size reduction over SOTA 3DGS compression approach Scaffold-GS. Our code is available here: https://github.com/YihangChen-ee/HAC

Generalization of Scaled Deep ResNets in the Mean-Field Regime

Despite the widespread empirical success of ResNet, the generalization properties of deep ResNet are rarely explored beyond the lazy training regime. In this work, we investigate \emph{scaled} ResNet in the limit of infinitely deep and wide neural networks, of which the gradient flow is described by a partial differential equation in the large-neural network limit, i.e., the \emph{mean-field} regime. To derive the generalization bounds under this setting, our analysis necessitates a shift from the conventional time-invariant Gram matrix employed in the lazy training regime to a time-variant, distribution-dependent version. To this end, we provide a global lower bound on the minimum eigenvalue of the Gram matrix under the mean-field regime. Besides, for the traceability of the dynamic of Kullback-Leibler (KL) divergence, we establish the linear convergence of the empirical error and estimate the upper bound of the KL divergence over parameters distribution. Finally, we build the uniform convergence for generalization bound via Rademacher complexity. Our results offer new insights into the generalization ability of deep ResNet beyond the lazy training regime and contribute to advancing the understanding of the fundamental properties of deep neural networks.