A Language Vision Model Approach for Automated Tumor Contouring in Radiation Oncology

Background: Lung cancer ranks as the leading cause of cancer-related mortality worldwide. The complexity of tumor delineation, crucial for radiation therapy, requires expertise often unavailable in resource-limited settings. Artificial Intelligence(AI), particularly with advancements in deep learning (DL) and natural language processing (NLP), offers potential solutions yet is challenged by high false positive rates. Purpose: The Oncology Contouring Copilot (OCC) system is developed to leverage oncologist expertise for precise tumor contouring using textual descriptions, aiming to increase the efficiency of oncological workflows by combining the strengths of AI with human oversight. Methods: Our OCC system initially identifies nodule candidates from CT scans. Employing Language Vision Models (LVMs) like GPT-4V, OCC then effectively reduces false positives with clinical descriptive texts, merging textual and visual data to automate tumor delineation, designed to elevate the quality of oncology care by incorporating knowledge from experienced domain experts. Results: Deployments of the OCC system resulted in a significant reduction in the false discovery rate by 35.0%, a 72.4% decrease in false positives per scan, and an F1-score of 0.652 across our dataset for unbiased evaluation. Conclusions: OCC represents a significant advance in oncology care, particularly through the use of the latest LVMs to improve contouring results by (1) streamlining oncology treatment workflows by optimizing tumor delineation, reducing manual processes; (2) offering a scalable and intuitive framework to reduce false positives in radiotherapy planning using LVMs; (3) introducing novel medical language vision prompt techniques to minimize LVMs hallucinations with ablation study, and (4) conducting a comparative analysis of LVMs, highlighting their potential in addressing medical language vision challenges.

FedOSAA: Improving Federated Learning with One-Step Anderson Acceleration

Federated learning (FL) is a distributed machine learning approach that enables multiple local clients and a central server to collaboratively train a model while keeping the data on their own devices. First-order methods, particularly those incorporating variance reduction techniques, are the most widely used FL algorithms due to their simple implementation and stable performance. However, these methods tend to be slow and require a large number of communication rounds to reach the global minimizer. We propose FedOSAA, a novel approach that preserves the simplicity of first-order methods while achieving the rapid convergence typically associated with second-order methods. Our approach applies one Anderson acceleration (AA) step following classical local updates based on first-order methods with variance reduction, such as FedSVRG and SCAFFOLD, during local training. This AA step is able to leverage curvature information from the history points and gives a new update that approximates the Newton-GMRES direction, thereby significantly improving the convergence. We establish a local linear convergence rate to the global minimizer of FedOSAA for smooth and strongly convex loss functions. Numerical comparisons show that FedOSAA substantially improves the communication and computation efficiency of the original first-order methods, achieving performance comparable to second-order methods like GIANT.

ValuePilot: A Two-Phase Framework for Value-Driven Decision-Making

Despite recent advances in artificial intelligence (AI), it poses challenges to ensure personalized decision-making in tasks that are not considered in training datasets. To address this issue, we propose ValuePilot, a two-phase value-driven decision-making framework comprising a dataset generation toolkit DGT and a decision-making module DMM trained on the generated data. DGT is capable of generating scenarios based on value dimensions and closely mirroring real-world tasks, with automated filtering techniques and human curation to ensure the validity of the dataset. In the generated dataset, DMM learns to recognize the inherent values of scenarios, computes action feasibility and navigates the trade-offs between multiple value dimensions to make personalized decisions. Extensive experiments demonstrate that, given human value preferences, our DMM most closely aligns with human decisions, outperforming Claude-3.5-Sonnet, Gemini-2-flash, Llama-3.1-405b and GPT-4o. This research is a preliminary exploration of value-driven decision-making. We hope it will stimulate interest in value-driven decision-making and personalized decision-making within the community.

Personalized Interpolation: An Efficient Method to Tame Flexible Optimization Window Estimation

In the realm of online advertising, optimizing conversions is crucial for delivering relevant products to users and enhancing business outcomes. Predicting conversion events is challenging due to variable delays between user interactions, such as impressions or clicks, and the actual conversions. These delays differ significantly across various advertisers and products, necessitating distinct optimization time windows for targeted conversions. To address this, we introduce a novel approach named the \textit{Personalized Interpolation} method, which innovatively builds upon existing fixed conversion window models to estimate flexible conversion windows. This method allows for the accurate estimation of conversions across a variety of delay ranges, thus meeting the diverse needs of advertisers without increasing system complexity. To validate the efficacy of our proposed method, we conducted comprehensive experiments using ads conversion model. Our experiments demonstrate that this method not only achieves high prediction accuracy but also does so more efficiently than other existing solutions. This validation underscores the potential of our Personalized Interpolation method to significantly enhance conversion optimization in real-world online advertising systems, promising improved targeting and effectiveness in advertising strategies.

Causal Graph Guided Steering of LLM Values via Prompts and Sparse Autoencoders

As large language models (LLMs) become increasingly integrated into critical applications, aligning their behavior with human values presents significant challenges. Current methods, such as Reinforcement Learning from Human Feedback (RLHF), often focus on a limited set of values and can be resource-intensive. Furthermore, the correlation between values has been largely overlooked and remains underutilized. Our framework addresses this limitation by mining a causal graph that elucidates the implicit relationships among various values within the LLMs. Leveraging the causal graph, we implement two lightweight mechanisms for value steering: prompt template steering and Sparse Autoencoder feature steering, and analyze the effects of altering one value dimension on others. Extensive experiments conducted on Gemma-2B-IT and Llama3-8B-IT demonstrate the effectiveness and controllability of our steering methods.

Preference Discerning with LLM-Enhanced Generative Retrieval

Sequential recommendation systems aim to provide personalized recommendations for users based on their interaction history. To achieve this, they often incorporate auxiliary information, such as textual descriptions of items and auxiliary tasks, like predicting user preferences and intent. Despite numerous efforts to enhance these models, they still suffer from limited personalization. To address this issue, we propose a new paradigm, which we term preference discerning. In preference dscerning, we explicitly condition a generative sequential recommendation system on user preferences within its context. To this end, we generate user preferences using Large Language Models (LLMs) based on user reviews and item-specific data. To evaluate preference discerning capabilities of sequential recommendation systems, we introduce a novel benchmark that provides a holistic evaluation across various scenarios, including preference steering and sentiment following. We assess current state-of-the-art methods using our benchmark and show that they struggle to accurately discern user preferences. Therefore, we propose a new method named Mender ($\textbf{M}$ultimodal Prefer$\textbf{en}$ce $\textbf{d}$iscern$\textbf{er}$), which improves upon existing methods and achieves state-of-the-art performance on our benchmark. Our results show that Mender can be effectively guided by human preferences even though they have not been observed during training, paving the way toward more personalized sequential recommendation systems. We will open-source the code and benchmarks upon publication.

Unifying Generative and Dense Retrieval for Sequential Recommendation

Sequential dense retrieval models utilize advanced sequence learning techniques to compute item and user representations, which are then used to rank relevant items for a user through inner product computation between the user and all item representations. However, this approach requires storing a unique representation for each item, resulting in significant memory requirements as the number of items grow. In contrast, the recently proposed generative retrieval paradigm offers a promising alternative by directly predicting item indices using a generative model trained on semantic IDs that encapsulate items' semantic information. Despite its potential for large-scale applications, a comprehensive comparison between generative retrieval and sequential dense retrieval under fair conditions is still lacking, leaving open questions regarding performance, and computation trade-offs. To address this, we compare these two approaches under controlled conditions on academic benchmarks and propose LIGER (LeveragIng dense retrieval for GEnerative Retrieval), a hybrid model that combines the strengths of these two widely used methods. LIGER integrates sequential dense retrieval into generative retrieval, mitigating performance differences and enhancing cold-start item recommendation in the datasets evaluated. This hybrid approach provides insights into the trade-offs between these approaches and demonstrates improvements in efficiency and effectiveness for recommendation systems in small-scale benchmarks.

AdaSociety: An Adaptive Environment with Social Structures for Multi-Agent Decision-Making

Traditional interactive environments limit agents' intelligence growth with fixed tasks. Recently, single-agent environments address this by generating new tasks based on agent actions, enhancing task diversity. We consider the decision-making problem in multi-agent settings, where tasks are further influenced by social connections, affecting rewards and information access. However, existing multi-agent environments lack a combination of adaptive physical surroundings and social connections, hindering the learning of intelligent behaviors. To address this, we introduce AdaSociety, a customizable multi-agent environment featuring expanding state and action spaces, alongside explicit and alterable social structures. As agents progress, the environment adaptively generates new tasks with social structures for agents to undertake. In AdaSociety, we develop three mini-games showcasing distinct social structures and tasks. Initial results demonstrate that specific social structures can promote both individual and collective benefits, though current reinforcement learning and LLM-based algorithms show limited effectiveness in leveraging social structures to enhance performance. Overall, AdaSociety serves as a valuable research platform for exploring intelligence in diverse physical and social settings. The code is available at https://github.com/bigai-ai/AdaSociety.

Learning to Balance Altruism and Self-interest Based on Empathy in Mixed-Motive Games

Real-world multi-agent scenarios often involve mixed motives, demanding altruistic agents capable of self-protection against potential exploitation. However, existing approaches often struggle to achieve both objectives. In this paper, based on that empathic responses are modulated by inferred social relationships between agents, we propose LASE Learning to balance Altruism and Self-interest based on Empathy), a distributed multi-agent reinforcement learning algorithm that fosters altruistic cooperation through gifting while avoiding exploitation by other agents in mixed-motive games. LASE allocates a portion of its rewards to co-players as gifts, with this allocation adapting dynamically based on the social relationship -- a metric evaluating the friendliness of co-players estimated by counterfactual reasoning. In particular, social relationship measures each co-player by comparing the estimated $Q$-function of current joint action to a counterfactual baseline which marginalizes the co-player's action, with its action distribution inferred by a perspective-taking module. Comprehensive experiments are performed in spatially and temporally extended mixed-motive games, demonstrating LASE's ability to promote group collaboration without compromising fairness and its capacity to adapt policies to various types of interactive co-players.

Efficient Adaptation in Mixed-Motive Environments via Hierarchical Opponent Modeling and Planning

Despite the recent successes of multi-agent reinforcement learning (MARL) algorithms, efficiently adapting to co-players in mixed-motive environments remains a significant challenge. One feasible approach is to hierarchically model co-players' behavior based on inferring their characteristics. However, these methods often encounter difficulties in efficient reasoning and utilization of inferred information. To address these issues, we propose Hierarchical Opponent modeling and Planning (HOP), a novel multi-agent decision-making algorithm that enables few-shot adaptation to unseen policies in mixed-motive environments. HOP is hierarchically composed of two modules: an opponent modeling module that infers others' goals and learns corresponding goal-conditioned policies, and a planning module that employs Monte Carlo Tree Search (MCTS) to identify the best response. Our approach improves efficiency by updating beliefs about others' goals both across and within episodes and by using information from the opponent modeling module to guide planning. Experimental results demonstrate that in mixed-motive environments, HOP exhibits superior few-shot adaptation capabilities when interacting with various unseen agents, and excels in self-play scenarios. Furthermore, the emergence of social intelligence during our experiments underscores the potential of our approach in complex multi-agent environments.