A Multi-modal Agentic Co-pilot for Evidence Grounded Computational Pathology

Pathology is the cornerstone of modern medicine, where accurate decision-making relies heavily on evidence-based practices. While artificial intelligence (AI) has the potential to transform clinical workflows, the intersection of AI and evidence-based medicine remains under-explored, with primitive attempts restricted to text-only general medicine. In this work, we present PathPocket, a multimodal AI agentic co-pilot designed specifically for evidence grounded pathology. We construct the most comprehensive pathology evidence corpus to date, encompassing approximately 110,472 public and authorized documents structured across a rigorous hierarchy of evidence from clinical guideline to expert opinion. From this meticulously graded foundation, we build a large-scale multimodal pathology hypergraph containing over 4.55 million entities and 7.10 million relations. Serving as a robust knowledge engine, this hypergraph provides traceable evidence for a collaborative multi-agent reasoning framework integrating input understanding, evidence retrieval, filtering, and diagnosis generation. This enables PathPocket to seamlessly resolve a wide spectrum of clinical tasks, ranging from text-only queries to complex multimodal diagnostics involving region-of-interest (ROI) and gigapixel whole-slide images (WSIs). We rigorously evaluate the system on a multidimensional benchmark of over 200,000 real-world cases, where it significantly outperforms existing state-of-the-arts. Crucially, extensive user studies demonstrate that PathPocket substantially improves the diagnostic accuracy and confidence of pathologists. By directly grounding pathology interpretations in verifiable literature, PathPocket offers a practical and scalable solution for the future of evidence grounded computational pathology.

A Pathology Foundation Model for Gastric Cancer with Real-World Validation

Gastric cancer remains a major cause of cancer mortality, yet its histological and molecular heterogeneity complicates diagnosis and risk stratification. General-purpose pathology foundation models (PFMs) often plateau on fine-grained endpoints central to gastric cancer care, and few have undergone rigorous prospective validation or clinical reader studies. We present GRACE, a Gastric-specific foundation model for Real-world Assessment and Clinical dEcision support. GRACE was developed from multicenter gastric pathology datasets totaling 48,364 primarily HE-stained whole-slide images from 37,493 patients. When evaluated on 28 clinically relevant tasks, GRACE consistently outperformed representative pancancer PFMs, achieving a macro-AUC of 0.9188, with strong performance for precancerous lesion diagnosis (macro-AUC 0.9322), tumor histopathological assessment (macro-AUC 0.9119), molecular profiling (macro-AUC 0.8682), and prognostic prediction. Beyond benchmarking, GRACE's translational value was substantiated through a rigorous evidence chain. Under safety-gated criteria requiring 100% NPV for rule-out and 100% PPV for rule-in, GRACE streamlined review for up to 69.6% of malignancy-diagnosis cases and triaged 46.8% of MMR-IHC follow-up requests. This translational feasibility was further strengthened by a randomized crossover reader study of pathologist-AI collaboration. With GRACE assistance, diagnostic accuracy improved from 82.0% to 89.9%, yielding nearly twofold higher adjusted odds of a correct diagnosis (OR 1.987) alongside concurrent gains in sensitivity and specificity. AI assistance also reduced diagnostic time by 14.9%, elevated diagnostic confidence by 9.0%, and markedly improved inter-rater agreement. When calibrated to maintain non-inferior performance to senior pathologists, the AI-assisted workflow could triage 60.7% of atrophy and 82.7% of intestinal metaplasia cases.

GPU-Parallel Multi-Task Reinforcement Learning with Demonstration Guided Policy Optimization

Large scale GPU-parallel reinforcement learning has changed what can be trained in robot simulation, yet most systems still optimize one specialist policy per task. We propose a construction methodology for turning structured manipulation task families into GPU-parallel multi-task RL benchmarks, and instantiate it as MT-Libero using LIBERO assets and task predicates in Isaac Lab. The resulting benchmark supports simultaneous reinforcement learning over heterogeneous task suites with parallel rendering, physics randomization, and state-input or visual-input policies. To make such training practical under sparse success signals and limited prior data, we further propose DGPO, an on-policy demonstration guided method that combines importance weighted PPO with adaptive behavior cloning on matched demonstration actions. DGPO enables a tunable preference toward demonstrated task distributions, outperforming both prior-free RL and existing demonstration-based methods while preserving the stability and online improvement benefits of on-policy PPO.

Spatial Transcriptomics-Guided Alignment Enhances Molecular Profiling in Pathology Foundation Model

Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times. While pathology foundation models (PFMs) have demonstrated potential for inferring molecular phenotypes from routine hematoxylin and eosin (H&E) whole-slide images (WSIs), current architectures primarily rely on vision-centric self-supervised learning or vision-language alignment, lacking the spatially resolved molecular supervision required to connect subtle morphological features with underlying genomic alterations. Spatial transcriptomics (ST) emerges as a transformative technology that enables transcriptomic quantification within intact tissue sections, thereby preserving the precise spatial link between histology and molecular profiles. In this study, we present a Spatial Transcriptomics-guided Alignment framework for Molecular Profiling (STAMP), which endows PFMs with intrinsic molecular awareness. To support this paradigm, we curated HumanST-1k, a human ST dataset spanning diverse anatomical organs and sequencing platforms. This atlas yields 1.8 million pairs of H&E patches and corresponding transcriptomic profiles, providing a corpus that links histological structures with their molecular states. To mitigate the technical noise inherent to raw transcriptomics, STAMP applies a pathway-informed alignment strategy that aggregates transcriptomic data into biologically functional pathways, which are subsequently integrated into PFMs via parameter-efficient fine-tuning. This alignment enriches the representation space of PFMs and unlocks their capacity to resolve sub-visual molecular signatures. The clinical utility of these augmented representations was validated through a multi-tier evaluation framework.

A Clinically Validated Foundation Model for Comprehensive Lung Pathology Interpretation

Pathological assessment guides lung cancer diagnosis, treatment selection, and prognostic evaluation, yet current CPath approaches rely on task-specific models for isolated objectives. Although pan-cancer foundation models offer versatility, they lack subspecialty-level depth and have not been evaluated across clinical workflows or prospectively validated in real-world settings. We introduce PulmoFoundation, a multi-center, prospectively validated, randomized controlled trial (RCT)-evaluated foundation model for comprehensive lung pathology assessment across pre-operative, intra-operative, and post-operative care. Built upon Virchow2 via subspecialty-specific pretraining using ~40,000 diagnostic H&E-stained whole-slide images (WSIs), PulmoFoundation was systematically evaluated on ~26,000 WSIs across 32 clinically relevant tasks. In addition to accurately predicting molecular markers and patient survival, our model achieves clinical-grade performance in core diagnostic tasks across biopsy, frozen section, and surgical resection slides. In a registered prospective study of 1,357 patients across 11 diagnostic tasks, our model achieved an average AUC of 92.3%. Using pre-specified triage thresholds, PulmoFoundation could reduce additional second-review burden for 68.8% of biopsies and 83.0% of frozen sections, and defer 44.5% of IHC stain orders, with PPVs of 1.0, 0.991, and 0.966. Beyond prospective validation, we conducted a crossover RCT with eight pathologists, in which AI assistance improved diagnostic accuracy across 4,928 case-reader pairs (91.7% w/ AI vs. 83.8% w/o AI). AI assistance also reduced median diagnostic time by 19.6%, increased diagnostic confidence by 8.7%, and improved inter-rater agreement from moderate (kappa = 0.56) to substantial (kappa = 0.76). Together, these evaluations support PulmoFoundation as a clinically validated decision-support system for lung pathology.

PointNeRT: A Physics Aware Neural Ray Tracing Surrogate for Propagation Channel Modeling

Ray tracing (RT) has emerged as a key tool for propagation channel modeling and network planning. Conventional RT is based on electromagnetic (EM) wave theory and its application relies on detailed mesh-based environment representations and material properties. In realistic environments, limited environmental geometry and material uncertainties hinder its scalability to complex scenarios. In this paper, we propose a novel physics aware neural RT surrogate named PointNeRT to address these limitations. The proposed model directly takes point clouds as environmental input, and efficiently reconstruct multipath without explicitly constructing mesh models or manually defining EM interaction rules. PointNeRT adopts a hop-by-hop modeling strategy guided by physical interaction constraints. It supports sequential prediction of multipath propagation and power attenuation. Numerical results and experiments demonstrate that the proposed method implicitly captures surface normal characteristics and EM material effects. It further achieves robust generalization in mobility scenarios and provides a physics-guided neural modeling of multipath propagation.

SOLARIS: Speculative Offloading of Latent-bAsed Representation for Inference Scaling

Recent advances in recommendation scaling laws have led to foundation models of unprecedented complexity. While these models offer superior performance, their computational demands make real-time serving impractical, often forcing practitioners to rely on knowledge distillation-compromising serving quality for efficiency. To address this challenge, we present SOLARIS (Speculative Offloading of Latent-bAsed Representation for Inference Scaling), a novel framework inspired by speculative decoding. SOLARIS proactively precomputes user-item interaction embeddings by predicting which user-item pairs are likely to appear in future requests, and asynchronously generating their foundation model representations ahead of time. This approach decouples the costly foundation model inference from the latency-critical serving path, enabling real-time knowledge transfer from models previously considered too expensive for online use. Deployed across Meta's advertising system serving billions of daily requests, SOLARIS achieves 0.67% revenue-driving top-line metrics gain, demonstrating its effectiveness at scale.

Channel Measurements and Modeling based on Composite Environmental Factor for Urban Street-Canyon Intersections

In urban environments, vehicle-to-everything (V2X) communications require accurate wireless channel characterization. This requirement is particularly critical at street-canyon intersections, where building blockage and rich multipath propagation can severely degrade link reliability. Due to its unique environmental layout, the channel characteristics in urban canyon are influenced by building distribution. However, this feature has not been well captured in existing channel models. In this paper, we propose an environment-related statistical channel model based on 5.8~GHz channel measurements. We construct a composite environmental factor to characterize environmental differences in intersections. Then, the factor is incorporated into 3GPP path-loss model and further linked to small-scale channel parameters. Finally, accuracy of the proposed model is validated using second-order channel statistics. The results show that the proposed model can effectively characterize propagation properties of urban street-canyon intersection channels with different building conditions. The proposed model provides a physically interpretable and statistically effective framework for channel simulation and performance evaluation in urban vehicular scenarios.

Deep Learning Based Site-Specific Channel Inference Using Satellite Images

Site-specific channel inference plays a critical role in the design and evaluation of next-generation wireless communication systems by considering the surrounding propagation environment. However, traditional methods are unscalable, while existing AI-based approaches using satellite image are confined to predicting large-scale fading parameters, lacking the capacity to reconstruct the complete channel impulse response (CIR). To address this limitation, we propose a deep learning-based site-specific channel inference framework using satellite images to predict structured Tapped Delay Line (TDL) parameters. We first establish a joint channel-satellite dataset based on measurements. Then, a novel deep learning network is developed to reconstruct the channel parameters. Specifically, a cross-attention-fused dual-branch pipeline extracts macroscopic and microscopic environmental features, while a recurrent tracking module captures the long-term dynamic evolution of multipath components. Experimental results demonstrate that the proposed method achieves high-quality reconstruction of the CIR in unseen scenarios, with a Power Delay Profile (PDP) Average Cosine Similarity exceeding 0.96. This work provides a pathway toward site-specific channel inference for future dynamic wireless networks.

Emergent Dexterity via Diverse Resets and Large-Scale Reinforcement Learning

Reinforcement learning in massively parallel physics simulations has driven major progress in sim-to-real robot learning. However, current approaches remain brittle and task-specific, relying on extensive per-task engineering to design rewards, curricula, and demonstrations. Even with this engineering, they often fail on long-horizon, contact-rich manipulation tasks and do not meaningfully scale with compute, as performance quickly saturates when training revisits the same narrow regions of state space. We introduce \Method, a simple and scalable framework that enables on-policy reinforcement learning to robustly solve a broad class of dexterous manipulation tasks using a single reward function, fixed algorithm hyperparameters, no curricula, and no human demonstrations. Our key insight is that long-horizon exploration can be dramatically simplified by using simulator resets to systematically expose the RL algorithm to the diverse set of robot-object interactions which underlie dexterous manipulation. \Method\ programmatically generates such resets with minimal human input, converting additional compute directly into broader behavioral coverage and continued performance gains. We show that \Method\ gracefully scales to long-horizon dexterous manipulation tasks beyond the capabilities of existing approaches and is able to learn robust policies over significantly wider ranges of initial conditions than baselines. Finally, we distill \Method \ into visuomotor policies which display robust retrying behavior and substantially higher success rates than baselines when transferred to the real world zero-shot. Project webpage: https://omnireset.github.io