Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial

Addressing the unavoidable bias inherent in supervised aging clocks, we introduce Sundial, a novel framework that models molecular dynamics through a diffusion field, capturing both the population-level aging process and the individual-level relative aging order. Sundial enables unbiasedestimation of biological age and the forecast of aging roadmap. Fasteraging individuals from Sundial exhibit a higher disease risk compared to those identified from supervised aging clocks. This framework opens new avenues for exploring key topics, including age- and sex-specific aging dynamics and faster yet healthy aging paths.

ProtCLIP: Function-Informed Protein Multi-Modal Learning

Multi-modality pre-training paradigm that aligns protein sequences and biological descriptions has learned general protein representations and achieved promising performance in various downstream applications. However, these works were still unable to replicate the extraordinary success of language-supervised visual foundation models due to the ineffective usage of aligned protein-text paired data and the lack of an effective function-informed pre-training paradigm. To address these issues, this paper curates a large-scale protein-text paired dataset called ProtAnno with a property-driven sampling strategy, and introduces a novel function-informed protein pre-training paradigm. Specifically, the sampling strategy determines selecting probability based on the sample confidence and property coverage, balancing the data quality and data quantity in face of large-scale noisy data. Furthermore, motivated by significance of the protein specific functional mechanism, the proposed paradigm explicitly model protein static and dynamic functional segments by two segment-wise pre-training objectives, injecting fine-grained information in a function-informed manner. Leveraging all these innovations, we develop ProtCLIP, a multi-modality foundation model that comprehensively represents function-aware protein embeddings. On 22 different protein benchmarks within 5 types, including protein functionality classification, mutation effect prediction, cross-modal transformation, semantic similarity inference and protein-protein interaction prediction, our ProtCLIP consistently achieves SOTA performance, with remarkable improvements of 75% on average in five cross-modal transformation benchmarks, 59.9% in GO-CC and 39.7% in GO-BP protein function prediction. The experimental results verify the extraordinary potential of ProtCLIP serving as the protein multi-modality foundation model.

Physical Informed Driving World Model

Autonomous driving requires robust perception models trained on high-quality, large-scale multi-view driving videos for tasks like 3D object detection, segmentation and trajectory prediction. While world models provide a cost-effective solution for generating realistic driving videos, challenges remain in ensuring these videos adhere to fundamental physical principles, such as relative and absolute motion, spatial relationship like occlusion and spatial consistency, and temporal consistency. To address these, we propose DrivePhysica, an innovative model designed to generate realistic multi-view driving videos that accurately adhere to essential physical principles through three key advancements: (1) a Coordinate System Aligner module that integrates relative and absolute motion features to enhance motion interpretation, (2) an Instance Flow Guidance module that ensures precise temporal consistency via efficient 3D flow extraction, and (3) a Box Coordinate Guidance module that improves spatial relationship understanding and accurately resolves occlusion hierarchies. Grounded in physical principles, we achieve state-of-the-art performance in driving video generation quality (3.96 FID and 38.06 FVD on the Nuscenes dataset) and downstream perception tasks. Our project homepage: https://metadrivescape.github.io/papers_project/DrivePhysica/page.html

Benchmarking Large Vision-Language Models via Directed Scene Graph for Comprehensive Image Captioning

Generating detailed captions comprehending text-rich visual content in images has received growing attention for Large Vision-Language Models (LVLMs). However, few studies have developed benchmarks specifically tailored for detailed captions to measure their accuracy and comprehensiveness. In this paper, we introduce a detailed caption benchmark, termed as CompreCap, to evaluate the visual context from a directed scene graph view. Concretely, we first manually segment the image into semantically meaningful regions (i.e., semantic segmentation mask) according to common-object vocabulary, while also distinguishing attributes of objects within all those regions. Then directional relation labels of these objects are annotated to compose a directed scene graph that can well encode rich compositional information of the image. Based on our directed scene graph, we develop a pipeline to assess the generated detailed captions from LVLMs on multiple levels, including the object-level coverage, the accuracy of attribute descriptions, the score of key relationships, etc. Experimental results on the CompreCap dataset confirm that our evaluation method aligns closely with human evaluation scores across LVLMs.

Pysical Informed Driving World Model

Autonomous driving requires robust perception models trained on high-quality, large-scale multi-view driving videos for tasks like 3D object detection, segmentation and trajectory prediction. While world models provide a cost-effective solution for generating realistic driving videos, challenges remain in ensuring these videos adhere to fundamental physical principles, such as relative and absolute motion, spatial relationship like occlusion and spatial consistency, and temporal consistency. To address these, we propose DrivePhysica, an innovative model designed to generate realistic multi-view driving videos that accurately adhere to essential physical principles through three key advancements: (1) a Coordinate System Aligner module that integrates relative and absolute motion features to enhance motion interpretation, (2) an Instance Flow Guidance module that ensures precise temporal consistency via efficient 3D flow extraction, and (3) a Box Coordinate Guidance module that improves spatial relationship understanding and accurately resolves occlusion hierarchies. Grounded in physical principles, we achieve state-of-the-art performance in driving video generation quality (3.96 FID and 38.06 FVD on the Nuscenes dataset) and downstream perception tasks. Our project homepage: https://metadrivescape.github.io/papers_project/DrivePhysica/page.html

Learning Visual Generative Priors without Text

Although text-to-image (T2I) models have recently thrived as visual generative priors, their reliance on high-quality text-image pairs makes scaling up expensive. We argue that grasping the cross-modality alignment is not a necessity for a sound visual generative prior, whose focus should be on texture modeling. Such a philosophy inspires us to study image-to-image (I2I) generation, where models can learn from in-the-wild images in a self-supervised manner. We first develop a pure vision-based training framework, Lumos, and confirm the feasibility and the scalability of learning I2I models. We then find that, as an upstream task of T2I, our I2I model serves as a more foundational visual prior and achieves on-par or better performance than existing T2I models using only 1/10 text-image pairs for fine-tuning. We further demonstrate the superiority of I2I priors over T2I priors on some text-irrelevant visual generative tasks, like image-to-3D and image-to-video.

Flash Communication: Reducing Tensor Parallelization Bottleneck for Fast Large Language Model Inference

The ever-increasing sizes of large language models necessitate distributed solutions for fast inference that exploit multi-dimensional parallelism, where computational loads are split across various accelerators such as GPU clusters. However, this approach often introduces significant communication overhead, especially on devices with limited bandwidth. In this paper, we introduce \emph{Flash Communication}, a novel low-bit compression technique designed to alleviate the tensor-parallelism communication bottleneck during inference. Our method substantially boosts intra-node communication speed by more than 3x and reduces the \emph{time-to-first-token} by 2x, with nearly no sacrifice in model accuracy. Extensive experiments on various up-to-date LLMs demonstrate the effectiveness of our approach.

InfinityDrive: Breaking Time Limits in Driving World Models

Autonomous driving systems struggle with complex scenarios due to limited access to diverse, extensive, and out-of-distribution driving data which are critical for safe navigation. World models offer a promising solution to this challenge; however, current driving world models are constrained by short time windows and limited scenario diversity. To bridge this gap, we introduce InfinityDrive, the first driving world model with exceptional generalization capabilities, delivering state-of-the-art performance in high fidelity, consistency, and diversity with minute-scale video generation. InfinityDrive introduces an efficient spatio-temporal co-modeling module paired with an extended temporal training strategy, enabling high-resolution (576$\times$1024) video generation with consistent spatial and temporal coherence. By incorporating memory injection and retention mechanisms alongside an adaptive memory curve loss to minimize cumulative errors, achieving consistent video generation lasting over 1500 frames (approximately 2 minutes). Comprehensive experiments in multiple datasets validate InfinityDrive's ability to generate complex and varied scenarios, highlighting its potential as a next-generation driving world model built for the evolving demands of autonomous driving. Our project homepage: https://metadrivescape.github.io/papers_project/InfinityDrive/page.html

TokenSelect: Efficient Long-Context Inference and Length Extrapolation for LLMs via Dynamic Token-Level KV Cache Selection

With the development of large language models (LLMs), the ability to handle longer contexts has become a key capability for Web applications such as cross-document understanding and LLM-powered search systems. However, this progress faces two major challenges: performance degradation due to sequence lengths out-of-distribution, and excessively long inference times caused by the quadratic computational complexity of attention. These issues hinder the application of LLMs in long-context scenarios. In this paper, we propose Dynamic Token-Level KV Cache Selection (TokenSelect), a model-agnostic, training-free method for efficient and accurate long-context inference. TokenSelect builds upon the observation of non-contiguous attention sparsity, using Query-Key dot products to measure per-head KV Cache criticality at token-level. By per-head soft voting mechanism, TokenSelect selectively involves a small number of critical KV cache tokens in the attention calculation without sacrificing accuracy. To further accelerate TokenSelect, we designed the Selection Cache based on observations of consecutive Query similarity and implemented efficient dot product kernel, significantly reducing the overhead of token selection. A comprehensive evaluation of TokenSelect demonstrates up to 23.84x speedup in attention computation and up to 2.28x acceleration in end-to-end latency, while providing superior performance compared to state-of-the-art long-context inference methods.

IRS-Enhanced Secure Semantic Communication Networks: Cross-Layer and Context-Awared Resource Allocation

Learning-task oriented semantic communication is pivotal in optimizing transmission efficiency by extracting and conveying essential semantics tailored to specific tasks, such as image reconstruction and classification. Nevertheless, the challenge of eavesdropping poses a formidable threat to semantic privacy due to the open nature of wireless communications. In this paper, intelligent reflective surface (IRS)-enhanced secure semantic communication (IRS-SSC) is proposed to guarantee the physical layer security from a task-oriented semantic perspective. Specifically, a multi-layer codebook is exploited to discretize continuous semantic features and describe semantics with different numbers of bits, thereby meeting the need for hierarchical semantic representation and further enhancing the transmission efficiency. Novel semantic security metrics, i.e., secure semantic rate (S-SR) and secure semantic spectrum efficiency (S-SSE), are defined to map the task-oriented security requirements at the application layer into the physical layer. To achieve artificial intelligence (AI)-native secure communication, we propose a noise disturbance enhanced hybrid deep reinforcement learning (NdeHDRL)-based resource allocation scheme. This scheme dynamically maximizes the S-SSE by jointly optimizing the bits for semantic representations, reflective coefficients of the IRS, and the subchannel assignment. Moreover, we propose a novel semantic context awared state space (SCA-SS) to fusion the high-dimensional semantic space and the observable system state space, which enables the agent to perceive semantic context and solves the dimensional catastrophe problem. Simulation results demonstrate the efficiency of our proposed schemes in both enhancing the security performance and the S-SSE compared to several benchmark schemes.