Towards Next-Generation Medical Agent: How o1 is Reshaping Decision-Making in Medical Scenarios

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context demonstrations and those with specialized medical fine-tuning, have demonstrated strong performance in medical language processing but struggle with real-time adaptability, multi-step reasoning, and handling complex medical tasks. Agent-based AI systems address these limitations by incorporating reasoning traces, tool selection based on context, knowledge retrieval, and both short- and long-term memory. These additional features enable the medical AI agent to handle complex medical scenarios where decision-making should be built on real-time interaction with the environment. Therefore, unlike conventional model-based approaches that treat medical queries as isolated questions, medical AI agents approach them as complex tasks and behave more like human doctors. In this paper, we study the choice of the backbone LLM for medical AI agents, which is the foundation for the agent's overall reasoning and action generation. In particular, we consider the emergent o1 model and examine its impact on agents' reasoning, tool-use adaptability, and real-time information retrieval across diverse clinical scenarios, including high-stakes settings such as intensive care units (ICUs). Our findings demonstrate o1's ability to enhance diagnostic accuracy and consistency, paving the way for smarter, more responsive AI tools that support better patient outcomes and decision-making efficacy in clinical practice.

Legal Evalutions and Challenges of Large Language Models

In this paper, we review legal testing methods based on Large Language Models (LLMs), using the OPENAI o1 model as a case study to evaluate the performance of large models in applying legal provisions. We compare current state-of-the-art LLMs, including open-source, closed-source, and legal-specific models trained specifically for the legal domain. Systematic tests are conducted on English and Chinese legal cases, and the results are analyzed in depth. Through systematic testing of legal cases from common law systems and China, this paper explores the strengths and weaknesses of LLMs in understanding and applying legal texts, reasoning through legal issues, and predicting judgments. The experimental results highlight both the potential and limitations of LLMs in legal applications, particularly in terms of challenges related to the interpretation of legal language and the accuracy of legal reasoning. Finally, the paper provides a comprehensive analysis of the advantages and disadvantages of various types of models, offering valuable insights and references for the future application of AI in the legal field.

3D-CT-GPT: Generating 3D Radiology Reports through Integration of Large Vision-Language Models

Medical image analysis is crucial in modern radiological diagnostics, especially given the exponential growth in medical imaging data. The demand for automated report generation systems has become increasingly urgent. While prior research has mainly focused on using machine learning and multimodal language models for 2D medical images, the generation of reports for 3D medical images has been less explored due to data scarcity and computational complexities. This paper introduces 3D-CT-GPT, a Visual Question Answering (VQA)-based medical visual language model specifically designed for generating radiology reports from 3D CT scans, particularly chest CTs. Extensive experiments on both public and private datasets demonstrate that 3D-CT-GPT significantly outperforms existing methods in terms of report accuracy and quality. Although current methods are few, including the partially open-source CT2Rep and the open-source M3D, we ensured fair comparison through appropriate data conversion and evaluation methodologies. Experimental results indicate that 3D-CT-GPT enhances diagnostic accuracy and report coherence, establishing itself as a robust solution for clinical radiology report generation. Future work will focus on expanding the dataset and further optimizing the model to enhance its performance and applicability.

HARP: Human-Assisted Regrouping with Permutation Invariant Critic for Multi-Agent Reinforcement Learning

Human-in-the-loop reinforcement learning integrates human expertise to accelerate agent learning and provide critical guidance and feedback in complex fields. However, many existing approaches focus on single-agent tasks and require continuous human involvement during the training process, significantly increasing the human workload and limiting scalability. In this paper, we propose HARP (Human-Assisted Regrouping with Permutation Invariant Critic), a multi-agent reinforcement learning framework designed for group-oriented tasks. HARP integrates automatic agent regrouping with strategic human assistance during deployment, enabling and allowing non-experts to offer effective guidance with minimal intervention. During training, agents dynamically adjust their groupings to optimize collaborative task completion. When deployed, they actively seek human assistance and utilize the Permutation Invariant Group Critic to evaluate and refine human-proposed groupings, allowing non-expert users to contribute valuable suggestions. In multiple collaboration scenarios, our approach is able to leverage limited guidance from non-experts and enhance performance. The project can be found at https://github.com/huawen-hu/HARP.

Identifying Influential nodes in Brain Networks via Self-Supervised Graph-Transformer

Studying influential nodes (I-nodes) in brain networks is of great significance in the field of brain imaging. Most existing studies consider brain connectivity hubs as I-nodes. However, this approach relies heavily on prior knowledge from graph theory, which may overlook the intrinsic characteristics of the brain network, especially when its architecture is not fully understood. In contrast, self-supervised deep learning can learn meaningful representations directly from the data. This approach enables the exploration of I-nodes for brain networks, which is also lacking in current studies. This paper proposes a Self-Supervised Graph Reconstruction framework based on Graph-Transformer (SSGR-GT) to identify I-nodes, which has three main characteristics. First, as a self-supervised model, SSGR-GT extracts the importance of brain nodes to the reconstruction. Second, SSGR-GT uses Graph-Transformer, which is well-suited for extracting features from brain graphs, combining both local and global characteristics. Third, multimodal analysis of I-nodes uses graph-based fusion technology, combining functional and structural brain information. The I-nodes we obtained are distributed in critical areas such as the superior frontal lobe, lateral parietal lobe, and lateral occipital lobe, with a total of 56 identified across different experiments. These I-nodes are involved in more brain networks than other regions, have longer fiber connections, and occupy more central positions in structural connectivity. They also exhibit strong connectivity and high node efficiency in both functional and structural networks. Furthermore, there is a significant overlap between the I-nodes and both the structural and functional rich-club. These findings enhance our understanding of the I-nodes within the brain network, and provide new insights for future research in further understanding the brain working mechanisms.

A Survey of Foundation Models for Music Understanding

Music is essential in daily life, fulfilling emotional and entertainment needs, and connecting us personally, socially, and culturally. A better understanding of music can enhance our emotions, cognitive skills, and cultural connections. The rapid advancement of artificial intelligence (AI) has introduced new ways to analyze music, aiming to replicate human understanding of music and provide related services. While the traditional models focused on audio features and simple tasks, the recent development of large language models (LLMs) and foundation models (FMs), which excel in various fields by integrating semantic information and demonstrating strong reasoning abilities, could capture complex musical features and patterns, integrate music with language and incorporate rich musical, emotional and psychological knowledge. Therefore, they have the potential in handling complex music understanding tasks from a semantic perspective, producing outputs closer to human perception. This work, to our best knowledge, is one of the early reviews of the intersection of AI techniques and music understanding. We investigated, analyzed, and tested recent large-scale music foundation models in respect of their music comprehension abilities. We also discussed their limitations and proposed possible future directions, offering insights for researchers in this field.

ModalityMirror: Improving Audio Classification in Modality Heterogeneity Federated Learning with Multimodal Distillation

Multimodal Federated Learning frequently encounters challenges of client modality heterogeneity, leading to undesired performances for secondary modality in multimodal learning. It is particularly prevalent in audiovisual learning, with audio is often assumed to be the weaker modality in recognition tasks. To address this challenge, we introduce ModalityMirror to improve audio model performance by leveraging knowledge distillation from an audiovisual federated learning model. ModalityMirror involves two phases: a modality-wise FL stage to aggregate uni-modal encoders; and a federated knowledge distillation stage on multi-modality clients to train an unimodal student model. Our results demonstrate that ModalityMirror significantly improves the audio classification compared to the state-of-the-art FL methods such as Harmony, particularly in audiovisual FL facing video missing. Our approach unlocks the potential for exploiting the diverse modality spectrum inherent in multi-modal FL.

A Comprehensive Review of Multimodal Large Language Models: Performance and Challenges Across Different Tasks

In an era defined by the explosive growth of data and rapid technological advancements, Multimodal Large Language Models (MLLMs) stand at the forefront of artificial intelligence (AI) systems. Designed to seamlessly integrate diverse data types-including text, images, videos, audio, and physiological sequences-MLLMs address the complexities of real-world applications far beyond the capabilities of single-modality systems. In this paper, we systematically sort out the applications of MLLM in multimodal tasks such as natural language, vision, and audio. We also provide a comparative analysis of the focus of different MLLMs in the tasks, and provide insights into the shortcomings of current MLLMs, and suggest potential directions for future research. Through these discussions, this paper hopes to provide valuable insights for the further development and application of MLLM.

Potential of Multimodal Large Language Models for Data Mining of Medical Images and Free-text Reports

Medical images and radiology reports are crucial for diagnosing medical conditions, highlighting the importance of quantitative analysis for clinical decision-making. However, the diversity and cross-source heterogeneity of these data challenge the generalizability of current data-mining methods. Multimodal large language models (MLLMs) have recently transformed many domains, significantly affecting the medical field. Notably, Gemini-Vision-series (Gemini) and GPT-4-series (GPT-4) models have epitomized a paradigm shift in Artificial General Intelligence (AGI) for computer vision, showcasing their potential in the biomedical domain. In this study, we evaluated the performance of the Gemini, GPT-4, and 4 popular large models for an exhaustive evaluation across 14 medical imaging datasets, including 5 medical imaging categories (dermatology, radiology, dentistry, ophthalmology, and endoscopy), and 3 radiology report datasets. The investigated tasks encompass disease classification, lesion segmentation, anatomical localization, disease diagnosis, report generation, and lesion detection. Our experimental results demonstrated that Gemini-series models excelled in report generation and lesion detection but faces challenges in disease classification and anatomical localization. Conversely, GPT-series models exhibited proficiency in lesion segmentation and anatomical localization but encountered difficulties in disease diagnosis and lesion detection. Additionally, both the Gemini series and GPT series contain models that have demonstrated commendable generation efficiency. While both models hold promise in reducing physician workload, alleviating pressure on limited healthcare resources, and fostering collaboration between clinical practitioners and artificial intelligence technologies, substantial enhancements and comprehensive validations remain imperative before clinical deployment.

Embracing Federated Learning: Enabling Weak Client Participation via Partial Model Training

In Federated Learning (FL), clients may have weak devices that cannot train the full model or even hold it in their memory space. To implement large-scale FL applications, thus, it is crucial to develop a distributed learning method that enables the participation of such weak clients. We propose EmbracingFL, a general FL framework that allows all available clients to join the distributed training regardless of their system resource capacity. The framework is built upon a novel form of partial model training method in which each client trains as many consecutive output-side layers as its system resources allow. Our study demonstrates that EmbracingFL encourages each layer to have similar data representations across clients, improving FL efficiency. The proposed partial model training method guarantees convergence to a neighbor of stationary points for non-convex and smooth problems. We evaluate the efficacy of EmbracingFL under a variety of settings with a mixed number of strong, moderate (~40% memory), and weak (~15% memory) clients, datasets (CIFAR-10, FEMNIST, and IMDB), and models (ResNet20, CNN, and LSTM). Our empirical study shows that EmbracingFL consistently achieves high accuracy as like all clients are strong, outperforming the state-of-the-art width reduction methods (i.e. HeteroFL and FjORD).