CT-Mamba: A Hybrid Convolutional State Space Model for Low-Dose CT Denoising

Low-dose CT (LDCT) significantly reduces the radiation dose received by patients, thereby decreasing potential health risks. However, dose reduction introduces additional noise and artifacts, adversely affecting image quality and clinical diagnosis. Currently, denoising methods based on convolutional neural networks (CNNs) face limitations in long-range modeling capabilities, while Transformer-based denoising methods, although capable of powerful long-range modeling, suffer from high computational complexity. Furthermore, the denoised images predicted by deep learning-based techniques inevitably exhibit differences in noise distribution compared to Normal-dose CT (NDCT) images, which can also impact the final image quality and diagnostic outcomes. In recent years, the feasibility of applying deep learning methods to low-dose CT imaging has been demonstrated, leading to significant achievements. This paper proposes CT-Mamba, a hybrid convolutional State Space Model for LDCT image denoising. The model combines the local feature extraction advantages of CNNs with Mamba's global modeling capability, enabling it to capture both local details and global context. Additionally, a Mamba-driven deep noise power spectrum (NPS) loss function was designed to guide model training, ensuring that the noise texture of the denoised LDCT images closely resembles that of NDCT images, thereby enhancing overall image quality and diagnostic value. Experimental results have demonstrated that CT-Mamba performs excellently in reducing noise in LDCT images, enhancing detail preservation, and optimizing noise texture distribution, while demonstrating statistically similar radiomics features to those of NDCT images (p > 0.05). The proposed CT-Mamba demonstrates outstanding performance in LDCT denoising and holds promise as a representative approach for applying the Mamba framework to LDCT denoising tasks.

TopoTxR: A topology-guided deep convolutional network for breast parenchyma learning on DCE-MRIs

Characterization of breast parenchyma in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a challenging task owing to the complexity of underlying tissue structures. Existing quantitative approaches, like radiomics and deep learning models, lack explicit quantification of intricate and subtle parenchymal structures, including fibroglandular tissue. To address this, we propose a novel topological approach that explicitly extracts multi-scale topological structures to better approximate breast parenchymal structures, and then incorporates these structures into a deep-learning-based prediction model via an attention mechanism. Our topology-informed deep learning model, \emph{TopoTxR}, leverages topology to provide enhanced insights into tissues critical for disease pathophysiology and treatment response. We empirically validate \emph{TopoTxR} using the VICTRE phantom breast dataset, showing that the topological structures extracted by our model effectively approximate the breast parenchymal structures. We further demonstrate \emph{TopoTxR}'s efficacy in predicting response to neoadjuvant chemotherapy. Our qualitative and quantitative analyses suggest differential topological behavior of breast tissue in treatment-na\"ive imaging, in patients who respond favorably to therapy as achieving pathological complete response (pCR) versus those who do not. In a comparative analysis with several baselines on the publicly available I-SPY 1 dataset (N=161, including 47 patients with pCR and 114 without) and the Rutgers proprietary dataset (N=120, with 69 patients achieving pCR and 51 not), \emph{TopoTxR} demonstrates a notable improvement, achieving a 2.6\% increase in accuracy and a 4.6\% enhancement in AUC compared to the state-of-the-art method.

Sensor2Text: Enabling Natural Language Interactions for Daily Activity Tracking Using Wearable Sensors

Visual Question-Answering, a technology that generates textual responses from an image and natural language question, has progressed significantly. Notably, it can aid in tracking and inquiring about daily activities, crucial in healthcare monitoring, especially for elderly patients or those with memory disabilities. However, video poses privacy concerns and has a limited field of view. This paper presents Sensor2Text, a model proficient in tracking daily activities and engaging in conversations using wearable sensors. The approach outlined here tackles several challenges, including low information density in wearable sensor data, insufficiency of single wearable sensors in human activities recognition, and model's limited capacity for Question-Answering and interactive conversations. To resolve these obstacles, transfer learning and student-teacher networks are utilized to leverage knowledge from visual-language models. Additionally, an encoder-decoder neural network model is devised to jointly process language and sensor data for conversational purposes. Furthermore, Large Language Models are also utilized to enable interactive capabilities. The model showcases the ability to identify human activities and engage in Q\&A dialogues using various wearable sensor modalities. It performs comparably to or better than existing visual-language models in both captioning and conversational tasks. To our knowledge, this represents the first model capable of conversing about wearable sensor data, offering an innovative approach to daily activity tracking that addresses privacy and field-of-view limitations associated with current vision-based solutions.

How Good Are LLMs for Literary Translation, Really? Literary Translation Evaluation with Humans and LLMs

Recent research has focused on literary machine translation (MT) as a new challenge in MT. However, the evaluation of literary MT remains an open problem. We contribute to this ongoing discussion by introducing LITEVAL-CORPUS, a paragraph-level parallel corpus comprising multiple verified human translations and outputs from 9 MT systems, which totals over 2k paragraphs and includes 13k annotated sentences across four language pairs, costing 4.5k Euro. This corpus enables us to (i) examine the consistency and adequacy of multiple annotation schemes, (ii) compare evaluations by students and professionals, and (iii) assess the effectiveness of LLM-based metrics. We find that Multidimensional Quality Metrics (MQM), as the de facto standard in non-literary human MT evaluation, is inadequate for literary translation: While Best-Worst Scaling (BWS) with students and Scalar Quality Metric (SQM) with professional translators prefer human translations at rates of ~82% and ~94%, respectively, MQM with student annotators prefers human professional translations over the translations of the best-performing LLMs in only ~42% of cases. While automatic metrics generally show a moderate correlation with human MQM and SQM, they struggle to accurately identify human translations, with rates of at most ~20%. Our overall evaluation indicates that human professional translations consistently outperform LLM translations, where even the most recent LLMs tend to produce more literal and less diverse translations compared to human translations. However, newer LLMs such as GPT-4o perform substantially better than older ones.

Dynamic Evidence Decoupling for Trusted Multi-view Learning

Multi-view learning methods often focus on improving decision accuracy, while neglecting the decision uncertainty, limiting their suitability for safety-critical applications. To mitigate this, researchers propose trusted multi-view learning methods that estimate classification probabilities and uncertainty by learning the class distributions for each instance. However, these methods assume that the data from each view can effectively differentiate all categories, ignoring the semantic vagueness phenomenon in real-world multi-view data. Our findings demonstrate that this phenomenon significantly suppresses the learning of view-specific evidence in existing methods. We propose a Consistent and Complementary-aware trusted Multi-view Learning (CCML) method to solve this problem. We first construct view opinions using evidential deep neural networks, which consist of belief mass vectors and uncertainty estimates. Next, we dynamically decouple the consistent and complementary evidence. The consistent evidence is derived from the shared portions across all views, while the complementary evidence is obtained by averaging the differing portions across all views. We ensure that the opinion constructed from the consistent evidence strictly aligns with the ground-truth category. For the opinion constructed from the complementary evidence, we allow it for potential vagueness in the evidence. We compare CCML with state-of-the-art baselines on one synthetic and six real-world datasets. The results validate the effectiveness of the dynamic evidence decoupling strategy and show that CCML significantly outperforms baselines on accuracy and reliability. The code is released at https://github.com/Lihong-Liu/CCML.

Adversarial Suffixes May Be Features Too!

Despite significant ongoing efforts in safety alignment, large language models (LLMs) such as GPT-4 and LLaMA 3 remain vulnerable to jailbreak attacks that can induce harmful behaviors, including those triggered by adversarial suffixes. Building on prior research, we hypothesize that these adversarial suffixes are not mere bugs but may represent features that can dominate the LLM's behavior. To evaluate this hypothesis, we conduct several experiments. First, we demonstrate that benign features can be effectively made to function as adversarial suffixes, i.e., we develop a feature extraction method to extract sample-agnostic features from benign dataset in the form of suffixes and show that these suffixes may effectively compromise safety alignment. Second, we show that adversarial suffixes generated from jailbreak attacks may contain meaningful features, i.e., appending the same suffix to different prompts results in responses exhibiting specific characteristics. Third, we show that such benign-yet-safety-compromising features can be easily introduced through fine-tuning using only benign datasets, i.e., even in the absence of harmful content. This highlights the critical risk posed by dominating benign features in the training data and calls for further research to reinforce LLM safety alignment. Our code and data is available at \url{https://github.com/anonymous}.

Do Influence Functions Work on Large Language Models?

Influence functions aim to quantify the impact of individual training data points on a model's predictions. While extensive research has been conducted on influence functions in traditional machine learning models, their application to large language models (LLMs) has been limited. In this work, we conduct a systematic study to address a key question: do influence functions work on LLMs? Specifically, we evaluate influence functions across multiple tasks and find that they consistently perform poorly in most settings. Our further investigation reveals that their poor performance can be attributed to: (1) inevitable approximation errors when estimating the iHVP component due to the scale of LLMs, (2) uncertain convergence during fine-tuning, and, more fundamentally, (3) the definition itself, as changes in model parameters do not necessarily correlate with changes in LLM behavior. Our study thus suggests the need for alternative approaches for identifying influential samples. To support future work, our code is made available at https://github.com/plumprc/Failures-of-Influence-Functions-in-LLMs.

3D-CT-GPT: Generating 3D Radiology Reports through Integration of Large Vision-Language Models

Medical image analysis is crucial in modern radiological diagnostics, especially given the exponential growth in medical imaging data. The demand for automated report generation systems has become increasingly urgent. While prior research has mainly focused on using machine learning and multimodal language models for 2D medical images, the generation of reports for 3D medical images has been less explored due to data scarcity and computational complexities. This paper introduces 3D-CT-GPT, a Visual Question Answering (VQA)-based medical visual language model specifically designed for generating radiology reports from 3D CT scans, particularly chest CTs. Extensive experiments on both public and private datasets demonstrate that 3D-CT-GPT significantly outperforms existing methods in terms of report accuracy and quality. Although current methods are few, including the partially open-source CT2Rep and the open-source M3D, we ensured fair comparison through appropriate data conversion and evaluation methodologies. Experimental results indicate that 3D-CT-GPT enhances diagnostic accuracy and report coherence, establishing itself as a robust solution for clinical radiology report generation. Future work will focus on expanding the dataset and further optimizing the model to enhance its performance and applicability.

Evaluation of OpenAI o1: Opportunities and Challenges of AGI

This comprehensive study evaluates the performance of OpenAI's o1-preview large language model across a diverse array of complex reasoning tasks, spanning multiple domains, including computer science, mathematics, natural sciences, medicine, linguistics, and social sciences. Through rigorous testing, o1-preview demonstrated remarkable capabilities, often achieving human-level or superior performance in areas ranging from coding challenges to scientific reasoning and from language processing to creative problem-solving. Key findings include: -83.3% success rate in solving complex competitive programming problems, surpassing many human experts. -Superior ability in generating coherent and accurate radiology reports, outperforming other evaluated models. -100% accuracy in high school-level mathematical reasoning tasks, providing detailed step-by-step solutions. -Advanced natural language inference capabilities across general and specialized domains like medicine. -Impressive performance in chip design tasks, outperforming specialized models in areas such as EDA script generation and bug analysis. -Remarkable proficiency in anthropology and geology, demonstrating deep understanding and reasoning in these specialized fields. -Strong capabilities in quantitative investing. O1 has comprehensive financial knowledge and statistical modeling skills. -Effective performance in social media analysis, including sentiment analysis and emotion recognition. The model excelled particularly in tasks requiring intricate reasoning and knowledge integration across various fields. While some limitations were observed, including occasional errors on simpler problems and challenges with certain highly specialized concepts, the overall results indicate significant progress towards artificial general intelligence.

YOLOO: You Only Learn from Others Once

Multi-modal 3D multi-object tracking (MOT) typically necessitates extensive computational costs of deep neural networks (DNNs) to extract multi-modal representations. In this paper, we propose an intriguing question: May we learn from multiple modalities only during training to avoid multi-modal input in the inference phase? To answer it, we propose \textbf{YOLOO}, a novel multi-modal 3D MOT paradigm: You Only Learn from Others Once. YOLOO empowers the point cloud encoder to learn a unified tri-modal representation (UTR) from point clouds and other modalities, such as images and textual cues, all at once. Leveraging this UTR, YOLOO achieves efficient tracking solely using the point cloud encoder without compromising its performance, fundamentally obviating the need for computationally intensive DNNs. Specifically, YOLOO includes two core components: a unified tri-modal encoder (UTEnc) and a flexible geometric constraint (F-GC) module. UTEnc integrates a point cloud encoder with image and text encoders adapted from pre-trained CLIP. It seamlessly fuses point cloud information with rich visual-textual knowledge from CLIP into the point cloud encoder, yielding highly discriminative UTRs that facilitate the association between trajectories and detections. Additionally, F-GC filters out mismatched associations with similar representations but significant positional discrepancies. It further enhances the robustness of UTRs without requiring any scene-specific tuning, addressing a key limitation of customized geometric constraints (e.g., 3D IoU). Lastly, high-quality 3D trajectories are generated by a traditional data association component. By integrating these advancements into a multi-modal 3D MOT scheme, our YOLOO achieves substantial gains in both robustness and efficiency.