QUART-Online: Latency-Free Large Multimodal Language Model for Quadruped Robot Learning

This paper addresses the inherent inference latency challenges associated with deploying multimodal large language models (MLLM) in quadruped vision-language-action (QUAR-VLA) tasks. Our investigation reveals that conventional parameter reduction techniques ultimately impair the performance of the language foundation model during the action instruction tuning phase, making them unsuitable for this purpose. We introduce a novel latency-free quadruped MLLM model, dubbed QUART-Online, designed to enhance inference efficiency without degrading the performance of the language foundation model. By incorporating Action Chunk Discretization (ACD), we compress the original action representation space, mapping continuous action values onto a smaller set of discrete representative vectors while preserving critical information. Subsequently, we fine-tune the MLLM to integrate vision, language, and compressed actions into a unified semantic space. Experimental results demonstrate that QUART-Online operates in tandem with the existing MLLM system, achieving real-time inference in sync with the underlying controller frequency, significantly boosting the success rate across various tasks by 65%. Our project page is https://quart-online.github.io.

Score and Distribution Matching Policy: Advanced Accelerated Visuomotor Policies via Matched Distillation

Visual-motor policy learning has advanced with architectures like diffusion-based policies, known for modeling complex robotic trajectories. However, their prolonged inference times hinder high-frequency control tasks requiring real-time feedback. While consistency distillation (CD) accelerates inference, it introduces errors that compromise action quality. To address these limitations, we propose the Score and Distribution Matching Policy (SDM Policy), which transforms diffusion-based policies into single-step generators through a two-stage optimization process: score matching ensures alignment with true action distributions, and distribution matching minimizes KL divergence for consistency. A dual-teacher mechanism integrates a frozen teacher for stability and an unfrozen teacher for adversarial training, enhancing robustness and alignment with target distributions. Evaluated on a 57-task simulation benchmark, SDM Policy achieves a 6x inference speedup while having state-of-the-art action quality, providing an efficient and reliable framework for high-frequency robotic tasks.

Glo-In-One-v2: Holistic Identification of Glomerular Cells, Tissues, and Lesions in Human and Mouse Histopathology

Segmenting glomerular intraglomerular tissue and lesions traditionally depends on detailed morphological evaluations by expert nephropathologists, a labor-intensive process susceptible to interobserver variability. Our group previously developed the Glo-In-One toolkit for integrated detection and segmentation of glomeruli. In this study, we leverage the Glo-In-One toolkit to version 2 with fine-grained segmentation capabilities, curating 14 distinct labels for tissue regions, cells, and lesions across a dataset of 23,529 annotated glomeruli across human and mouse histopathology data. To our knowledge, this dataset is among the largest of its kind to date.In this study, we present a single dynamic head deep learning architecture designed to segment 14 classes within partially labeled images of human and mouse pathology data. Our model was trained using a training set derived from 368 annotated kidney whole-slide images (WSIs) to identify 5 key intraglomerular tissues covering Bowman's capsule, glomerular tuft, mesangium, mesangial cells, and podocytes. Additionally, the network segments 9 glomerular lesion classes including adhesion, capsular drop, global sclerosis, hyalinosis, mesangial lysis, microaneurysm, nodular sclerosis, mesangial expansion, and segmental sclerosis. The glomerulus segmentation model achieved a decent performance compared with baselines, and achieved a 76.5 % average Dice Similarity Coefficient (DSC). Additional, transfer learning from rodent to human for glomerular lesion segmentation model has enhanced the average segmentation accuracy across different types of lesions by more than 3 %, as measured by Dice scores. The Glo-In-One-v2 model and trained weight have been made publicly available at https: //github.com/hrlblab/Glo-In-One_v2.

On-Board Vision-Language Models for Personalized Autonomous Vehicle Motion Control: System Design and Real-World Validation

Personalized driving refers to an autonomous vehicle's ability to adapt its driving behavior or control strategies to match individual users' preferences and driving styles while maintaining safety and comfort standards. However, existing works either fail to capture every individual preference precisely or become computationally inefficient as the user base expands. Vision-Language Models (VLMs) offer promising solutions to this front through their natural language understanding and scene reasoning capabilities. In this work, we propose a lightweight yet effective on-board VLM framework that provides low-latency personalized driving performance while maintaining strong reasoning capabilities. Our solution incorporates a Retrieval-Augmented Generation (RAG)-based memory module that enables continuous learning of individual driving preferences through human feedback. Through comprehensive real-world vehicle deployment and experiments, our system has demonstrated the ability to provide safe, comfortable, and personalized driving experiences across various scenarios and significantly reduce takeover rates by up to 76.9%. To the best of our knowledge, this work represents the first end-to-end VLM-based motion control system in real-world autonomous vehicles.

How Good Are We? Evaluating Cell AI Foundation Models in Kidney Pathology with Human-in-the-Loop Enrichment

Training AI foundation models has emerged as a promising large-scale learning approach for addressing real-world healthcare challenges, including digital pathology. While many of these models have been developed for tasks like disease diagnosis and tissue quantification using extensive and diverse training datasets, their readiness for deployment on some arguably simplest tasks, such as nuclei segmentation within a single organ (e.g., the kidney), remains uncertain. This paper seeks to answer this key question, "How good are we?", by thoroughly evaluating the performance of recent cell foundation models on a curated multi-center, multi-disease, and multi-species external testing dataset. Additionally, we tackle a more challenging question, "How can we improve?", by developing and assessing human-in-the-loop data enrichment strategies aimed at enhancing model performance while minimizing the reliance on pixel-level human annotation. To address the first question, we curated a multicenter, multidisease, and multispecies dataset consisting of 2,542 kidney whole slide images (WSIs). Three state-of-the-art (SOTA) cell foundation models-Cellpose, StarDist, and CellViT-were selected for evaluation. To tackle the second question, we explored data enrichment algorithms by distilling predictions from the different foundation models with a human-in-the-loop framework, aiming to further enhance foundation model performance with minimal human efforts. Our experimental results showed that all three foundation models improved over their baselines with model fine-tuning with enriched data. Interestingly, the baseline model with the highest F1 score does not yield the best segmentation outcomes after fine-tuning. This study establishes a benchmark for the development and deployment of cell vision foundation models tailored for real-world data applications.

Joint Beamforming and Speaker-Attributed ASR for Real Distant-Microphone Meeting Transcription

Distant-microphone meeting transcription is a challenging task. State-of-the-art end-to-end speaker-attributed automatic speech recognition (SA-ASR) architectures lack a multichannel noise and reverberation reduction front-end, which limits their performance. In this paper, we introduce a joint beamforming and SA-ASR approach for real meeting transcription. We first describe a data alignment and augmentation method to pretrain a neural beamformer on real meeting data. We then compare fixed, hybrid, and fully neural beamformers as front-ends to the SA-ASR model. Finally, we jointly optimize the fully neural beamformer and the SA-ASR model. Experiments on the real AMI corpus show that,while state-of-the-art multi-frame cross-channel attention based channel fusion fails to improve ASR performance, fine-tuning SA-ASR on the fixed beamformer's output and jointly fine-tuning SA-ASR with the neural beamformer reduce the word error rate by 8% and 9% relative, respectively.

ProFD: Prompt-Guided Feature Disentangling for Occluded Person Re-Identification

To address the occlusion issues in person Re-Identification (ReID) tasks, many methods have been proposed to extract part features by introducing external spatial information. However, due to missing part appearance information caused by occlusion and noisy spatial information from external model, these purely vision-based approaches fail to correctly learn the features of human body parts from limited training data and struggle in accurately locating body parts, ultimately leading to misaligned part features. To tackle these challenges, we propose a Prompt-guided Feature Disentangling method (ProFD), which leverages the rich pre-trained knowledge in the textual modality facilitate model to generate well-aligned part features. ProFD first designs part-specific prompts and utilizes noisy segmentation mask to preliminarily align visual and textual embedding, enabling the textual prompts to have spatial awareness. Furthermore, to alleviate the noise from external masks, ProFD adopts a hybrid-attention decoder, ensuring spatial and semantic consistency during the decoding process to minimize noise impact. Additionally, to avoid catastrophic forgetting, we employ a self-distillation strategy, retaining pre-trained knowledge of CLIP to mitigate over-fitting. Evaluation results on the Market1501, DukeMTMC-ReID, Occluded-Duke, Occluded-ReID, and P-DukeMTMC datasets demonstrate that ProFD achieves state-of-the-art results. Our project is available at: https://github.com/Cuixxx/ProFD.

Assessment of Cell Nuclei AI Foundation Models in Kidney Pathology

Cell nuclei instance segmentation is a crucial task in digital kidney pathology. Traditional automatic segmentation methods often lack generalizability when applied to unseen datasets. Recently, the success of foundation models (FMs) has provided a more generalizable solution, potentially enabling the segmentation of any cell type. In this study, we perform a large-scale evaluation of three widely used state-of-the-art (SOTA) cell nuclei foundation models (Cellpose, StarDist, and CellViT). Specifically, we created a highly diverse evaluation dataset consisting of 2,542 kidney whole slide images (WSIs) collected from both human and rodent sources, encompassing various tissue types, sizes, and staining methods. To our knowledge, this is the largest-scale evaluation of its kind to date. Our quantitative analysis of the prediction distribution reveals a persistent performance gap in kidney pathology. Among the evaluated models, CellViT demonstrated superior performance in segmenting nuclei in kidney pathology. However, none of the foundation models are perfect; a performance gap remains in general nuclei segmentation for kidney pathology.

Large-scale cervical precancerous screening via AI-assisted cytology whole slide image analysis

Cervical Cancer continues to be the leading gynecological malignancy, posing a persistent threat to women's health on a global scale. Early screening via cytology Whole Slide Image (WSI) diagnosis is critical to prevent this Cancer progression and improve survival rate, but pathologist's single test suffers inevitable false negative due to the immense number of cells that need to be reviewed within a WSI. Though computer-aided automated diagnostic models can serve as strong complement for pathologists, their effectiveness is hampered by the paucity of extensive and detailed annotations, coupled with the limited interpretability and robustness. These factors significantly hinder their practical applicability and reliability in clinical settings. To tackle these challenges, we develop an AI approach, which is a Scalable Technology for Robust and Interpretable Diagnosis built on Extensive data (STRIDE) of cervical cytology. STRIDE addresses the bottleneck of limited annotations by integrating patient-level labels with a small portion of cell-level labels through an end-to-end training strategy, facilitating scalable learning across extensive datasets. To further improve the robustness to real-world domain shifts of cytology slide-making and imaging, STRIDE employs color adversarial samples training that mimic staining and imaging variations. Lastly, to achieve pathologist-level interpretability for the trustworthiness in clinical settings, STRIDE can generate explanatory textual descriptions that simulates pathologists' diagnostic processes by cell image feature and textual description alignment. Conducting extensive experiments and evaluations in 183 medical centers with a dataset of 341,889 WSIs and 0.1 billion cells from cervical cytology patients, STRIDE has demonstrated a remarkable superiority over previous state-of-the-art techniques.

Adapting Mouse Pathological Model to Human Glomerular Lesion Segmentation

Moving from animal models to human applications in preclinical research encompasses a broad spectrum of disciplines in medical science. A fundamental element in the development of new drugs, treatments, diagnostic methods, and in deepening our understanding of disease processes is the accurate measurement of kidney tissues. Past studies have demonstrated the viability of translating glomeruli segmentation techniques from mouse models to human applications. Yet, these investigations tend to neglect the complexities involved in segmenting pathological glomeruli affected by different lesions. Such lesions present a wider range of morphological variations compared to healthy glomerular tissue, which are arguably more valuable than normal glomeruli in clinical practice. Furthermore, data on lesions from animal models can be more readily scaled up from disease models and whole kidney biopsies. This brings up a question: ``\textit{Can a pathological segmentation model trained on mouse models be effectively applied to human patients?}" To answer this question, we introduced GLAM, a deep learning study for fine-grained segmentation of human kidney lesions using a mouse model, addressing mouse-to-human transfer learning, by evaluating different learning strategies for segmenting human pathological lesions using zero-shot transfer learning and hybrid learning by leveraging mouse samples. From the results, the hybrid learning model achieved superior performance.