Assessment of Cell Nuclei AI Foundation Models in Kidney Pathology

Cell nuclei instance segmentation is a crucial task in digital kidney pathology. Traditional automatic segmentation methods often lack generalizability when applied to unseen datasets. Recently, the success of foundation models (FMs) has provided a more generalizable solution, potentially enabling the segmentation of any cell type. In this study, we perform a large-scale evaluation of three widely used state-of-the-art (SOTA) cell nuclei foundation models (Cellpose, StarDist, and CellViT). Specifically, we created a highly diverse evaluation dataset consisting of 2,542 kidney whole slide images (WSIs) collected from both human and rodent sources, encompassing various tissue types, sizes, and staining methods. To our knowledge, this is the largest-scale evaluation of its kind to date. Our quantitative analysis of the prediction distribution reveals a persistent performance gap in kidney pathology. Among the evaluated models, CellViT demonstrated superior performance in segmenting nuclei in kidney pathology. However, none of the foundation models are perfect; a performance gap remains in general nuclei segmentation for kidney pathology.

AI Foundation Models in Remote Sensing: A Survey

Artificial Intelligence (AI) technologies have profoundly transformed the field of remote sensing, revolutionizing data collection, processing, and analysis. Traditionally reliant on manual interpretation and task-specific models, remote sensing has been significantly enhanced by the advent of foundation models--large-scale, pre-trained AI models capable of performing a wide array of tasks with unprecedented accuracy and efficiency. This paper provides a comprehensive survey of foundation models in the remote sensing domain, covering models released between June 2021 and June 2024. We categorize these models based on their applications in computer vision and domain-specific tasks, offering insights into their architectures, pre-training datasets, and methodologies. Through detailed performance comparisons, we highlight emerging trends and the significant advancements achieved by these foundation models. Additionally, we discuss the technical challenges, practical implications, and future research directions, addressing the need for high-quality data, computational resources, and improved model generalization. Our research also finds that pre-training methods, particularly self-supervised learning techniques like contrastive learning and masked autoencoders, significantly enhance the performance and robustness of foundation models in remote sensing tasks such as scene classification, object detection, and other applications. This survey aims to serve as a resource for researchers and practitioners by providing a panorama of advances and promising pathways for continued development and application of foundation models in remote sensing.