An AI-native experimental laboratory for autonomous biomolecular engineering

Autonomous scientific research, capable of independently conducting complex experiments and serving non-specialists, represents a long-held aspiration. Achieving it requires a fundamental paradigm shift driven by artificial intelligence (AI). While autonomous experimental systems are emerging, they remain confined to areas featuring singular objectives and well-defined, simple experimental workflows, such as chemical synthesis and catalysis. We present an AI-native autonomous laboratory, targeting highly complex scientific experiments for applications like autonomous biomolecular engineering. This system autonomously manages instrumentation, formulates experiment-specific procedures and optimization heuristics, and concurrently serves multiple user requests. Founded on a co-design philosophy of models, experiments, and instruments, the platform supports the co-evolution of AI models and the automation system. This establishes an end-to-end, multi-user autonomous laboratory that handles complex, multi-objective experiments across diverse instrumentation. Our autonomous laboratory supports fundamental nucleic acid functions-including synthesis, transcription, amplification, and sequencing. It also enables applications in fields such as disease diagnostics, drug development, and information storage. Without human intervention, it autonomously optimizes experimental performance to match state-of-the-art results achieved by human scientists. In multi-user scenarios, the platform significantly improves instrument utilization and experimental efficiency. This platform paves the way for advanced biomaterials research to overcome dependencies on experts and resource barriers, establishing a blueprint for science-as-a-service at scale.

Linearly Solving Robust Rotation Estimation

Rotation estimation plays a fundamental role in computer vision and robot tasks, and extremely robust rotation estimation is significantly useful for safety-critical applications. Typically, estimating a rotation is considered a non-linear and non-convex optimization problem that requires careful design. However, in this paper, we provide some new perspectives that solving a rotation estimation problem can be reformulated as solving a linear model fitting problem without dropping any constraints and without introducing any singularities. In addition, we explore the dual structure of a rotation motion, revealing that it can be represented as a great circle on a quaternion sphere surface. Accordingly, we propose an easily understandable voting-based method to solve rotation estimation. The proposed method exhibits exceptional robustness to noise and outliers and can be computed in parallel with graphics processing units (GPUs) effortlessly. Particularly, leveraging the power of GPUs, the proposed method can obtain a satisfactory rotation solution for large-scale($10^6$) and severely corrupted (99$\%$ outlier ratio) rotation estimation problems under 0.5 seconds. Furthermore, to validate our theoretical framework and demonstrate the superiority of our proposed method, we conduct controlled experiments and real-world dataset experiments. These experiments provide compelling evidence supporting the effectiveness and robustness of our approach in solving rotation estimation problems.

Voyager: Long-Range and World-Consistent Video Diffusion for Explorable 3D Scene Generation

Real-world applications like video gaming and virtual reality often demand the ability to model 3D scenes that users can explore along custom camera trajectories. While significant progress has been made in generating 3D objects from text or images, creating long-range, 3D-consistent, explorable 3D scenes remains a complex and challenging problem. In this work, we present Voyager, a novel video diffusion framework that generates world-consistent 3D point-cloud sequences from a single image with user-defined camera path. Unlike existing approaches, Voyager achieves end-to-end scene generation and reconstruction with inherent consistency across frames, eliminating the need for 3D reconstruction pipelines (e.g., structure-from-motion or multi-view stereo). Our method integrates three key components: 1) World-Consistent Video Diffusion: A unified architecture that jointly generates aligned RGB and depth video sequences, conditioned on existing world observation to ensure global coherence 2) Long-Range World Exploration: An efficient world cache with point culling and an auto-regressive inference with smooth video sampling for iterative scene extension with context-aware consistency, and 3) Scalable Data Engine: A video reconstruction pipeline that automates camera pose estimation and metric depth prediction for arbitrary videos, enabling large-scale, diverse training data curation without manual 3D annotations. Collectively, these designs result in a clear improvement over existing methods in visual quality and geometric accuracy, with versatile applications.

Large Language Models Enhanced Hyperbolic Space Recommender Systems

Large Language Models (LLMs) have attracted significant attention in recommender systems for their excellent world knowledge capabilities. However, existing methods that rely on Euclidean space struggle to capture the rich hierarchical information inherent in textual and semantic data, which is essential for capturing user preferences. The geometric properties of hyperbolic space offer a promising solution to address this issue. Nevertheless, integrating LLMs-based methods with hyperbolic space to effectively extract and incorporate diverse hierarchical information is non-trivial. To this end, we propose a model-agnostic framework, named HyperLLM, which extracts and integrates hierarchical information from both structural and semantic perspectives. Structurally, HyperLLM uses LLMs to generate multi-level classification tags with hierarchical parent-child relationships for each item. Then, tag-item and user-item interactions are jointly learned and aligned through contrastive learning, thereby providing the model with clear hierarchical information. Semantically, HyperLLM introduces a novel meta-optimized strategy to extract hierarchical information from semantic embeddings and bridge the gap between the semantic and collaborative spaces for seamless integration. Extensive experiments show that HyperLLM significantly outperforms recommender systems based on hyperbolic space and LLMs, achieving performance improvements of over 40%. Furthermore, HyperLLM not only improves recommender performance but also enhances training stability, highlighting the critical role of hierarchical information in recommender systems.

Endo3R: Unified Online Reconstruction from Dynamic Monocular Endoscopic Video

Reconstructing 3D scenes from monocular surgical videos can enhance surgeon's perception and therefore plays a vital role in various computer-assisted surgery tasks. However, achieving scale-consistent reconstruction remains an open challenge due to inherent issues in endoscopic videos, such as dynamic deformations and textureless surfaces. Despite recent advances, current methods either rely on calibration or instrument priors to estimate scale, or employ SfM-like multi-stage pipelines, leading to error accumulation and requiring offline optimization. In this paper, we present Endo3R, a unified 3D foundation model for online scale-consistent reconstruction from monocular surgical video, without any priors or extra optimization. Our model unifies the tasks by predicting globally aligned pointmaps, scale-consistent video depths, and camera parameters without any offline optimization. The core contribution of our method is expanding the capability of the recent pairwise reconstruction model to long-term incremental dynamic reconstruction by an uncertainty-aware dual memory mechanism. The mechanism maintains history tokens of both short-term dynamics and long-term spatial consistency. Notably, to tackle the highly dynamic nature of surgical scenes, we measure the uncertainty of tokens via Sampson distance and filter out tokens with high uncertainty. Regarding the scarcity of endoscopic datasets with ground-truth depth and camera poses, we further devise a self-supervised mechanism with a novel dynamics-aware flow loss. Abundant experiments on SCARED and Hamlyn datasets demonstrate our superior performance in zero-shot surgical video depth prediction and camera pose estimation with online efficiency. Project page: https://wrld.github.io/Endo3R/.

Hunyuan3D 2.0: Scaling Diffusion Models for High Resolution Textured 3D Assets Generation

We present Hunyuan3D 2.0, an advanced large-scale 3D synthesis system for generating high-resolution textured 3D assets. This system includes two foundation components: a large-scale shape generation model -- Hunyuan3D-DiT, and a large-scale texture synthesis model -- Hunyuan3D-Paint. The shape generative model, built on a scalable flow-based diffusion transformer, aims to create geometry that properly aligns with a given condition image, laying a solid foundation for downstream applications. The texture synthesis model, benefiting from strong geometric and diffusion priors, produces high-resolution and vibrant texture maps for either generated or hand-crafted meshes. Furthermore, we build Hunyuan3D-Studio -- a versatile, user-friendly production platform that simplifies the re-creation process of 3D assets. It allows both professional and amateur users to manipulate or even animate their meshes efficiently. We systematically evaluate our models, showing that Hunyuan3D 2.0 outperforms previous state-of-the-art models, including the open-source models and closed-source models in geometry details, condition alignment, texture quality, and etc. Hunyuan3D 2.0 is publicly released in order to fill the gaps in the open-source 3D community for large-scale foundation generative models. The code and pre-trained weights of our models are available at: https://github.com/Tencent/Hunyuan3D-2

Align3R: Aligned Monocular Depth Estimation for Dynamic Videos

Recent developments in monocular depth estimation methods enable high-quality depth estimation of single-view images but fail to estimate consistent video depth across different frames. Recent works address this problem by applying a video diffusion model to generate video depth conditioned on the input video, which is training-expensive and can only produce scale-invariant depth values without camera poses. In this paper, we propose a novel video-depth estimation method called Align3R to estimate temporal consistent depth maps for a dynamic video. Our key idea is to utilize the recent DUSt3R model to align estimated monocular depth maps of different timesteps. First, we fine-tune the DUSt3R model with additional estimated monocular depth as inputs for the dynamic scenes. Then, we apply optimization to reconstruct both depth maps and camera poses. Extensive experiments demonstrate that Align3R estimates consistent video depth and camera poses for a monocular video with superior performance than baseline methods.

Physically-Based Photometric Bundle Adjustment in Non-Lambertian Environments

Photometric bundle adjustment (PBA) is widely used in estimating the camera pose and 3D geometry by assuming a Lambertian world. However, the assumption of photometric consistency is often violated since the non-diffuse reflection is common in real-world environments. The photometric inconsistency significantly affects the reliability of existing PBA methods. To solve this problem, we propose a novel physically-based PBA method. Specifically, we introduce the physically-based weights regarding material, illumination, and light path. These weights distinguish the pixel pairs with different levels of photometric inconsistency. We also design corresponding models for material estimation based on sequential images and illumination estimation based on point clouds. In addition, we establish the first SLAM-related dataset of non-Lambertian scenes with complete ground truth of illumination and material. Extensive experiments demonstrated that our PBA method outperforms existing approaches in accuracy.

2DGH: 2D Gaussian-Hermite Splatting for High-quality Rendering and Better Geometry Reconstruction

2D Gaussian Splatting has recently emerged as a significant method in 3D reconstruction, enabling novel view synthesis and geometry reconstruction simultaneously. While the well-known Gaussian kernel is broadly used, its lack of anisotropy and deformation ability leads to dim and vague edges at object silhouettes, limiting the reconstruction quality of current Gaussian splatting methods. To enhance the representation power, we draw inspiration from quantum physics and propose to use the Gaussian-Hermite kernel as the new primitive in Gaussian splatting. The new kernel takes a unified mathematical form and extends the Gaussian function, which serves as the zero-rank term in the updated formulation. Our experiments demonstrate the extraordinary performance of Gaussian-Hermite kernel in both geometry reconstruction and novel-view synthesis tasks. The proposed kernel outperforms traditional Gaussian Splatting kernels, showcasing its potential for high-quality 3D reconstruction and rendering.

DreamPhysics: Learning Physical Properties of Dynamic 3D Gaussians with Video Diffusion Priors

Dynamic 3D interaction has witnessed great interest in recent works, while creating such 4D content remains challenging. One solution is to animate 3D scenes with physics-based simulation, and the other is to learn the deformation of static 3D objects with the distillation of video generative models. The former one requires assigning precise physical properties to the target object, otherwise the simulated results would become unnatural. The latter tends to formulate the video with minor motions and discontinuous frames, due to the absence of physical constraints in deformation learning. We think that video generative models are trained with real-world captured data, capable of judging physical phenomenon in simulation environments. To this end, we propose DreamPhysics in this work, which estimates physical properties of 3D Gaussian Splatting with video diffusion priors. DreamPhysics supports both image- and text-conditioned guidance, optimizing physical parameters via score distillation sampling with frame interpolation and log gradient. Based on a material point method simulator with proper physical parameters, our method can generate 4D content with realistic motions. Experimental results demonstrate that, by distilling the prior knowledge of video diffusion models, inaccurate physical properties can be gradually refined for high-quality simulation. Codes are released at: https://github.com/tyhuang0428/DreamPhysics.