Slide-based Graph Collaborative Training for Histopathology Whole Slide Image Analysis

The development of computational pathology lies in the consensus that pathological characteristics of tumors are significant guidance for cancer diagnostics. Most existing research focuses on the inner-contextual information within each WSI yet ignores the possible inter-correlations between slides. As the development of tumors is a continuous process involving a series of histological, morphological, and genetic changes that accumulate over time, the similarities and differences between WSIs across various stages, grades, locations and patients should potentially contribute to the representation of WSIs and deserve to be taken into account in WSI modeling. To verify the advancement of introducing the slide inter-correlations into the representation learning of WSIs, we proposed a generic WSI analysis pipeline SlideGCD that can be adapted to any existing Multiple Instance Learning (MIL) frameworks and improve their performance. With the new paradigm, the prior knowledge of cancer development can participate in the end-to-end workflow, which concurrently initializes and refines the slide representation, as a guide for message passing in the slide-based graph. Extensive comparisons and experiments are conducted to validate the effectiveness and robustness of the proposed pipeline across 4 different tasks, including cancer subtyping, cancer staging, survival prediction, and gene mutation prediction, with 7 representative SOTA WSI analysis frameworks as backbones.

HASN: Hybrid Attention Separable Network for Efficient Image Super-resolution

Recently, lightweight methods for single image super-resolution (SISR) have gained significant popularity and achieved impressive performance due to limited hardware resources. These methods demonstrate that adopting residual feature distillation is an effective way to enhance performance. However, we find that using residual connections after each block increases the model's storage and computational cost. Therefore, to simplify the network structure and learn higher-level features and relationships between features, we use depthwise separable convolutions, fully connected layers, and activation functions as the basic feature extraction modules. This significantly reduces computational load and the number of parameters while maintaining strong feature extraction capabilities. To further enhance model performance, we propose the Hybrid Attention Separable Block (HASB), which combines channel attention and spatial attention, thus making use of their complementary advantages. Additionally, we use depthwise separable convolutions instead of standard convolutions, significantly reducing the computational load and the number of parameters while maintaining strong feature extraction capabilities. During the training phase, we also adopt a warm-start retraining strategy to exploit the potential of the model further. Extensive experiments demonstrate the effectiveness of our approach. Our method achieves a smaller model size and reduced computational complexity without compromising performance. Code can be available at https://github.com/nathan66666/HASN.git

EHC-MM: Embodied Holistic Control for Mobile Manipulation

Mobile manipulation typically entails the base for mobility, the arm for accurate manipulation, and the camera for perception. It is necessary to follow the principle of Distant Mobility, Close Grasping(DMCG) in holistic control. We propose Embodied Holistic Control for Mobile Manipulation(EHC-MM) with the embodied function of sig(w): By formulating the DMCG principle as a Quadratic Programming (QP) problem, sig(w) dynamically balances the robot's emphasis between movement and manipulation with the consideration of the robot's state and environment. In addition, we propose the Monitor-Position-Based Servoing (MPBS) with sig(w), enabling the tracking of the target during the operation. This approach allows coordinated control between the robot's base, arm, and camera. Through extensive simulations and real-world experiments, our approach significantly improves both the success rate and efficiency of mobile manipulation tasks, achieving a 95.6% success rate in the real-world scenarios and a 52.8% increase in time efficiency.

Topological GCN for Improving Detection of Hip Landmarks from B-Mode Ultrasound Images

The B-mode ultrasound based computer-aided diagnosis (CAD) has demonstrated its effectiveness for diagnosis of Developmental Dysplasia of the Hip (DDH) in infants. However, due to effect of speckle noise in ultrasound im-ages, it is still a challenge task to accurately detect hip landmarks. In this work, we propose a novel hip landmark detection model by integrating the Topological GCN (TGCN) with an Improved Conformer (TGCN-ICF) into a unified frame-work to improve detection performance. The TGCN-ICF includes two subnet-works: an Improved Conformer (ICF) subnetwork to generate heatmaps and a TGCN subnetwork to additionally refine landmark detection. This TGCN can effectively improve detection accuracy with the guidance of class labels. Moreo-ver, a Mutual Modulation Fusion (MMF) module is developed for deeply ex-changing and fusing the features extracted from the U-Net and Transformer branches in ICF. The experimental results on the real DDH dataset demonstrate that the proposed TGCN-ICF outperforms all the compared algorithms.

SlideGCD: Slide-based Graph Collaborative Training with Knowledge Distillation for Whole Slide Image Classification

Existing WSI analysis methods lie on the consensus that histopathological characteristics of tumors are significant guidance for cancer diagnostics. Particularly, as the evolution of cancers is a continuous process, the correlations and differences across various stages, anatomical locations and patients should be taken into account. However, recent research mainly focuses on the inner-contextual information in a single WSI, ignoring the correlations between slides. To verify whether introducing the slide inter-correlations can bring improvements to WSI representation learning, we propose a generic WSI analysis pipeline SlideGCD that considers the existing multi-instance learning (MIL) methods as the backbone and forge the WSI classification task as a node classification problem. More specifically, SlideGCD declares a node buffer that stores previous slide embeddings for subsequent extensive slide-based graph construction and conducts graph learning to explore the inter-correlations implied in the slide-based graph. Moreover, we frame the MIL classifier and graph learning into two parallel workflows and deploy the knowledge distillation to transfer the differentiable information to the graph neural network. The consistent performance boosting, brought by SlideGCD, of four previous state-of-the-art MIL methods is observed on two TCGA benchmark datasets. The code is available at https://github.com/HFUT-miaLab/SlideGCD.

Lifelong Histopathology Whole Slide Image Retrieval via Distance Consistency Rehearsal

Content-based histopathological image retrieval (CBHIR) has gained attention in recent years, offering the capability to return histopathology images that are content-wise similar to the query one from an established database. However, in clinical practice, the continuously expanding size of WSI databases limits the practical application of the current CBHIR methods. In this paper, we propose a Lifelong Whole Slide Retrieval (LWSR) framework to address the challenges of catastrophic forgetting by progressive model updating on continuously growing retrieval database. Our framework aims to achieve the balance between stability and plasticity during continuous learning. To preserve system plasticity, we utilize local memory bank with reservoir sampling method to save instances, which can comprehensively encompass the feature spaces of both old and new tasks. Furthermore, A distance consistency rehearsal (DCR) module is designed to ensure the retrieval queue's consistency for previous tasks, which is regarded as stability within a lifelong CBHIR system. We evaluated the proposed method on four public WSI datasets from TCGA projects. The experimental results have demonstrated the proposed method is effective and is superior to the state-of-the-art methods.

Pan-cancer Histopathology WSI Pre-training with Position-aware Masked Autoencoder

Large-scale pre-training models have promoted the development of histopathology image analysis. However, existing self-supervised methods for histopathology images focus on learning patch features, while there is still a lack of available pre-training models for WSI-level feature learning. In this paper, we propose a novel self-supervised learning framework for pan-cancer WSI-level representation pre-training with the designed position-aware masked autoencoder (PAMA). Meanwhile, we propose the position-aware cross-attention (PACA) module with a kernel reorientation (KRO) strategy and an anchor dropout (AD) mechanism. The KRO strategy can capture the complete semantic structure and eliminate ambiguity in WSIs, and the AD contributes to enhancing the robustness and generalization of the model. We evaluated our method on 6 large-scale datasets from multiple organs for pan-cancer classification tasks. The results have demonstrated the effectiveness of PAMA in generalized and discriminative WSI representation learning and pan-cancer WSI pre-training. The proposed method was also compared with \R{7} WSI analysis methods. The experimental results have indicated that our proposed PAMA is superior to the state-of-the-art methods.The code and checkpoints are available at https://github.com/WkEEn/PAMA.

ASGrasp: Generalizable Transparent Object Reconstruction and Grasping from RGB-D Active Stereo Camera

In this paper, we tackle the problem of grasping transparent and specular objects. This issue holds importance, yet it remains unsolved within the field of robotics due to failure of recover their accurate geometry by depth cameras. For the first time, we propose ASGrasp, a 6-DoF grasp detection network that uses an RGB-D active stereo camera. ASGrasp utilizes a two-layer learning-based stereo network for the purpose of transparent object reconstruction, enabling material-agnostic object grasping in cluttered environments. In contrast to existing RGB-D based grasp detection methods, which heavily depend on depth restoration networks and the quality of depth maps generated by depth cameras, our system distinguishes itself by its ability to directly utilize raw IR and RGB images for transparent object geometry reconstruction. We create an extensive synthetic dataset through domain randomization, which is based on GraspNet-1Billion. Our experiments demonstrate that ASGrasp can achieve over 90% success rate for generalizable transparent object grasping in both simulation and the real via seamless sim-to-real transfer. Our method significantly outperforms SOTA networks and even surpasses the performance upper bound set by perfect visible point cloud inputs.Project page: https://pku-epic.github.io/ASGrasp

Predictive Accuracy-Based Active Learning for Medical Image Segmentation

Active learning is considered a viable solution to alleviate the contradiction between the high dependency of deep learning-based segmentation methods on annotated data and the expensive pixel-level annotation cost of medical images. However, most existing methods suffer from unreliable uncertainty assessment and the struggle to balance diversity and informativeness, leading to poor performance in segmentation tasks. In response, we propose an efficient Predictive Accuracy-based Active Learning (PAAL) method for medical image segmentation, first introducing predictive accuracy to define uncertainty. Specifically, PAAL mainly consists of an Accuracy Predictor (AP) and a Weighted Polling Strategy (WPS). The former is an attached learnable module that can accurately predict the segmentation accuracy of unlabeled samples relative to the target model with the predicted posterior probability. The latter provides an efficient hybrid querying scheme by combining predicted accuracy and feature representation, aiming to ensure the uncertainty and diversity of the acquired samples. Extensive experiment results on multiple datasets demonstrate the superiority of PAAL. PAAL achieves comparable accuracy to fully annotated data while reducing annotation costs by approximately 50% to 80%, showcasing significant potential in clinical applications. The code is available at https://github.com/shijun18/PAAL-MedSeg.

What Foundation Models can Bring for Robot Learning in Manipulation : A Survey

The realization of universal robots is an ultimate goal of researchers. However, a key hurdle in achieving this goal lies in the robots' ability to manipulate objects in their unstructured surrounding environments according to different tasks. The learning-based approach is considered an effective way to address generalization. The impressive performance of foundation models in the fields of computer vision and natural language suggests the potential of embedding foundation models into manipulation tasks as a viable path toward achieving general manipulation capability. However, we believe achieving general manipulation capability requires an overarching framework akin to auto driving. This framework should encompass multiple functional modules, with different foundation models assuming distinct roles in facilitating general manipulation capability. This survey focuses on the contributions of foundation models to robot learning for manipulation. We propose a comprehensive framework and detail how foundation models can address challenges in each module of the framework. What's more, we examine current approaches, outline challenges, suggest future research directions, and identify potential risks associated with integrating foundation models into this domain.