Cognition Chain for Explainable Psychological Stress Detection on Social Media

Stress is a pervasive global health issue that can lead to severe mental health problems. Early detection offers timely intervention and prevention of stress-related disorders. The current early detection models perform "black box" inference suffering from limited explainability and trust which blocks the real-world clinical application. Thanks to the generative properties introduced by the Large Language Models (LLMs), the decision and the prediction from such models are semi-interpretable through the corresponding description. However, the existing LLMs are mostly trained for general purposes without the guidance of psychological cognitive theory. To this end, we first highlight the importance of prior theory with the observation of performance boosted by the chain-of-thoughts tailored for stress detection. This method termed Cognition Chain explicates the generation of stress through a step-by-step cognitive perspective based on cognitive appraisal theory with a progress pipeline: Stimulus $\rightarrow$ Evaluation $\rightarrow$ Reaction $\rightarrow$ Stress State, guiding LLMs to provide comprehensive reasoning explanations. We further study the benefits brought by the proposed Cognition Chain format by utilising it as a synthetic dataset generation template for LLMs instruction-tuning and introduce CogInstruct, an instruction-tuning dataset for stress detection. This dataset is developed using a three-stage self-reflective annotation pipeline that enables LLMs to autonomously generate and refine instructional data. By instruction-tuning Llama3 with CogInstruct, we develop CogLLM, an explainable stress detection model. Evaluations demonstrate that CogLLM achieves outstanding performance while enhancing explainability. Our work contributes a novel approach by integrating cognitive theories into LLM reasoning processes, offering a promising direction for future explainable AI research.

F$^3$OCUS -- Federated Finetuning of Vision-Language Foundation Models with Optimal Client Layer Updating Strategy via Multi-objective Meta-Heuristics

Effective training of large Vision-Language Models (VLMs) on resource-constrained client devices in Federated Learning (FL) requires the usage of parameter-efficient fine-tuning (PEFT) strategies. To this end, we demonstrate the impact of two factors \textit{viz.}, client-specific layer importance score that selects the most important VLM layers for fine-tuning and inter-client layer diversity score that encourages diverse layer selection across clients for optimal VLM layer selection. We first theoretically motivate and leverage the principal eigenvalue magnitude of layerwise Neural Tangent Kernels and show its effectiveness as client-specific layer importance score. Next, we propose a novel layer updating strategy dubbed F$^3$OCUS that jointly optimizes the layer importance and diversity factors by employing a data-free, multi-objective, meta-heuristic optimization on the server. We explore 5 different meta-heuristic algorithms and compare their effectiveness for selecting model layers and adapter layers towards PEFT-FL. Furthermore, we release a new MedVQA-FL dataset involving overall 707,962 VQA triplets and 9 modality-specific clients and utilize it to train and evaluate our method. Overall, we conduct more than 10,000 client-level experiments on 6 Vision-Language FL task settings involving 58 medical image datasets and 4 different VLM architectures of varying sizes to demonstrate the effectiveness of the proposed method.

Applying and Evaluating Large Language Models in Mental Health Care: A Scoping Review of Human-Assessed Generative Tasks

Large language models (LLMs) are emerging as promising tools for mental health care, offering scalable support through their ability to generate human-like responses. However, the effectiveness of these models in clinical settings remains unclear. This scoping review aimed to assess the current generative applications of LLMs in mental health care, focusing on studies where these models were tested with human participants in real-world scenarios. A systematic search across APA PsycNet, Scopus, PubMed, and Web of Science identified 726 unique articles, of which 17 met the inclusion criteria. These studies encompassed applications such as clinical assistance, counseling, therapy, and emotional support. However, the evaluation methods were often non-standardized, with most studies relying on ad hoc scales that limit comparability and robustness. Privacy, safety, and fairness were also frequently underexplored. Moreover, reliance on proprietary models, such as OpenAI's GPT series, raises concerns about transparency and reproducibility. While LLMs show potential in expanding mental health care access, especially in underserved areas, the current evidence does not fully support their use as standalone interventions. More rigorous, standardized evaluations and ethical oversight are needed to ensure these tools can be safely and effectively integrated into clinical practice.

Voice EHR: Introducing Multimodal Audio Data for Health

Large AI models trained on audio data may have the potential to rapidly classify patients, enhancing medical decision-making and potentially improving outcomes through early detection. Existing technologies depend on limited datasets using expensive recording equipment in high-income, English-speaking countries. This challenges deployment in resource-constrained, high-volume settings where audio data may have a profound impact. This report introduces a novel data type and a corresponding collection system that captures health data through guided questions using only a mobile/web application. This application ultimately results in an audio electronic health record (voice EHR) which may contain complex biomarkers of health from conventional voice/respiratory features, speech patterns, and language with semantic meaning - compensating for the typical limitations of unimodal clinical datasets. This report introduces a consortium of partners for global work, presents the application used for data collection, and showcases the potential of informative voice EHR to advance the scalability and diversity of audio AI.

Efficiency at Scale: Investigating the Performance of Diminutive Language Models in Clinical Tasks

The entry of large language models (LLMs) into research and commercial spaces has led to a trend of ever-larger models, with initial promises of generalisability, followed by a widespread desire to downsize and create specialised models without the need for complete fine-tuning, using Parameter Efficient Fine-tuning (PEFT) methods. We present an investigation into the suitability of different PEFT methods to clinical decision-making tasks, across a range of model sizes, including extremely small models with as few as $25$ million parameters. Our analysis shows that the performance of most PEFT approaches varies significantly from one task to another, with the exception of LoRA, which maintains relatively high performance across all model sizes and tasks, typically approaching or matching full fine-tuned performance. The effectiveness of PEFT methods in the clinical domain is evident, particularly for specialised models which can operate on low-cost, in-house computing infrastructure. The advantages of these models, in terms of speed and reduced training costs, dramatically outweighs any performance gain from large foundation LLMs. Furthermore, we highlight how domain-specific pre-training interacts with PEFT methods and model size, and discuss how these factors interplay to provide the best efficiency-performance trade-off. Full code available at: tbd.

All models are local: time to replace external validation with recurrent local validation

External validation is often recommended to ensure the generalizability of ML models. However, it neither guarantees generalizability nor equates to a model's clinical usefulness (the ultimate goal of any clinical decision-support tool). External validation is misaligned with current healthcare ML needs. First, patient data changes across time, geography, and facilities. These changes create significant volatility in the performance of a single fixed model (especially for deep learning models, which dominate clinical ML). Second, newer ML techniques, current market forces, and updated regulatory frameworks are enabling frequent updating and monitoring of individual deployed model instances. We submit that external validation is insufficient to establish ML models' safety or utility. Proposals to fix the external validation paradigm do not go far enough. Continued reliance on it as the ultimate test is likely to lead us astray. We propose the MLOps-inspired paradigm of recurring local validation as an alternative that ensures the validity of models while protecting against performance-disruptive data variability. This paradigm relies on site-specific reliability tests before every deployment, followed by regular and recurrent checks throughout the life cycle of the deployed algorithm. Initial and recurrent reliability tests protect against performance-disruptive distribution shifts, and concept drifts that jeopardize patient safety.

Is dataset condensation a silver bullet for healthcare data sharing?

Safeguarding personal information is paramount for healthcare data sharing, a challenging issue without any silver bullet thus far. We study the prospect of a recent deep-learning advent, dataset condensation (DC), in sharing healthcare data for AI research, and the results are promising. The condensed data abstracts original records and irreversibly conceals individual-level knowledge to achieve a bona fide de-identification, which permits free sharing. Moreover, the original deep-learning utilities are well preserved in the condensed data with compressed volume and accelerated model convergences. In PhysioNet-2012, a condensed dataset of 20 samples can orient deep models attaining 80.3% test AUC of mortality prediction (versus 85.8% of 5120 original records), an inspiring discovery generalised to MIMIC-III and Coswara datasets. We also interpret the inhere privacy protections of DC through theoretical analysis and empirical evidence. Dataset condensation opens a new gate to sharing healthcare data for AI research with multiple desirable traits.

Adversarial De-confounding in Individualised Treatment Effects Estimation

Observational studies have recently received significant attention from the machine learning community due to the increasingly available non-experimental observational data and the limitations of the experimental studies, such as considerable cost, impracticality, small and less representative sample sizes, etc. In observational studies, de-confounding is a fundamental problem of individualised treatment effects (ITE) estimation. This paper proposes disentangled representations with adversarial training to selectively balance the confounders in the binary treatment setting for the ITE estimation. The adversarial training of treatment policy selectively encourages treatment-agnostic balanced representations for the confounders and helps to estimate the ITE in the observational studies via counterfactual inference. Empirical results on synthetic and real-world datasets, with varying degrees of confounding, prove that our proposed approach improves the state-of-the-art methods in achieving lower error in the ITE estimation.

Using Bottleneck Adapters to Identify Cancer in Clinical Notes under Low-Resource Constraints

Processing information locked within clinical health records is a challenging task that remains an active area of research in biomedical NLP. In this work, we evaluate a broad set of machine learning techniques ranging from simple RNNs to specialised transformers such as BioBERT on a dataset containing clinical notes along with a set of annotations indicating whether a sample is cancer-related or not. Furthermore, we specifically employ efficient fine-tuning methods from NLP, namely, bottleneck adapters and prompt tuning, to adapt the models to our specialised task. Our evaluations suggest that fine-tuning a frozen BERT model pre-trained on natural language and with bottleneck adapters outperforms all other strategies, including full fine-tuning of the specialised BioBERT model. Based on our findings, we suggest that using bottleneck adapters in low-resource situations with limited access to labelled data or processing capacity could be a viable strategy in biomedical text mining. The code used in the experiments are going to be made available at https://github.com/omidrohanian/bottleneck-adapters.

Nowruz at SemEval-2022 Task 7: Tackling Cloze Tests with Transformers and Ordinal Regression

This paper outlines the system using which team Nowruz participated in SemEval 2022 Task 7 Identifying Plausible Clarifications of Implicit and Underspecified Phrases for both subtasks A and B. Using a pre-trained transformer as a backbone, the model targeted the task of multi-task classification and ranking in the context of finding the best fillers for a cloze task related to instructional texts on the website Wikihow. The system employed a combination of two ordinal regression components to tackle this task in a multi-task learning scenario. According to the official leaderboard of the shared task, this system was ranked 5th in the ranking and 7th in the classification subtasks out of 21 participating teams. With additional experiments, the models have since been further optimised.