From Bench to Bedside: A Review of Clinical Trialsin Drug Discovery and Development

Clinical trials are an indispensable part of the drug development process, bridging the gap between basic research and clinical application. During the development of new drugs, clinical trials are used not only to evaluate the safety and efficacy of the drug but also to explore its dosage, treatment regimens, and potential side effects. This review discusses the various stages of clinical trials, including Phase I (safety assessment), Phase II (preliminary efficacy evaluation), Phase III (large-scale validation), and Phase IV (post-marketing surveillance), highlighting the characteristics of each phase and their interrelationships. Additionally, the paper addresses the major challenges encountered in clinical trials, such as ethical issues, subject recruitment difficulties, diversity and representativeness concerns, and proposes strategies for overcoming these challenges. With the advancement of technology, innovative technologies such as artificial intelligence, big data, and digitalization are gradually transforming clinical trial design and implementation, improving trial efficiency and data quality. The article also looks forward to the future of clinical trials, particularly the impact of emerging therapies such as gene therapy and immunotherapy on trial design, as well as the importance of regulatory reforms and global collaboration. In conclusion, the core role of clinical trials in drug development will continue to drive the progress of innovative drug development and clinical treatment.

Deep Learning Model Security: Threats and Defenses

Deep learning has transformed AI applications but faces critical security challenges, including adversarial attacks, data poisoning, model theft, and privacy leakage. This survey examines these vulnerabilities, detailing their mechanisms and impact on model integrity and confidentiality. Practical implementations, including adversarial examples, label flipping, and backdoor attacks, are explored alongside defenses such as adversarial training, differential privacy, and federated learning, highlighting their strengths and limitations. Advanced methods like contrastive and self-supervised learning are presented for enhancing robustness. The survey concludes with future directions, emphasizing automated defenses, zero-trust architectures, and the security challenges of large AI models. A balanced approach to performance and security is essential for developing reliable deep learning systems.

Deep Learning, Machine Learning, Advancing Big Data Analytics and Management

Advancements in artificial intelligence, machine learning, and deep learning have catalyzed the transformation of big data analytics and management into pivotal domains for research and application. This work explores the theoretical foundations, methodological advancements, and practical implementations of these technologies, emphasizing their role in uncovering actionable insights from massive, high-dimensional datasets. The study presents a systematic overview of data preprocessing techniques, including data cleaning, normalization, integration, and dimensionality reduction, to prepare raw data for analysis. Core analytics methodologies such as classification, clustering, regression, and anomaly detection are examined, with a focus on algorithmic innovation and scalability. Furthermore, the text delves into state-of-the-art frameworks for data mining and predictive modeling, highlighting the role of neural networks, support vector machines, and ensemble methods in tackling complex analytical challenges. Special emphasis is placed on the convergence of big data with distributed computing paradigms, including cloud and edge computing, to address challenges in storage, computation, and real-time analytics. The integration of ethical considerations, including data privacy and compliance with global standards, ensures a holistic perspective on data management. Practical applications across healthcare, finance, marketing, and policy-making illustrate the real-world impact of these technologies. Through comprehensive case studies and Python-based implementations, this work equips researchers, practitioners, and data enthusiasts with the tools to navigate the complexities of modern data analytics. It bridges the gap between theory and practice, fostering the development of innovative solutions for managing and leveraging data in the era of artificial intelligence.

EventGPT: Event Stream Understanding with Multimodal Large Language Models

Event cameras record visual information as asynchronous pixel change streams, excelling at scene perception under unsatisfactory lighting or high-dynamic conditions. Existing multimodal large language models (MLLMs) concentrate on natural RGB images, failing in scenarios where event data fits better. In this paper, we introduce EventGPT, the first MLLM for event stream understanding, to the best of our knowledge, marking a pioneering attempt to integrate large language models (LLMs) with event stream comprehension. To mitigate the huge domain gaps, we develop a three-stage optimization paradigm to gradually equip a pre-trained LLM with the capability of understanding event-based scenes. Our EventGPT comprises an event encoder, followed by a spatio-temporal aggregator, a linear projector, an event-language adapter, and an LLM. Firstly, RGB image-text pairs generated by GPT are leveraged to warm up the linear projector, referring to LLaVA, as the gap between natural image and language modalities is relatively smaller. Secondly, we construct a synthetic yet large dataset, N-ImageNet-Chat, consisting of event frames and corresponding texts to enable the use of the spatio-temporal aggregator and to train the event-language adapter, thereby aligning event features more closely with the language space. Finally, we gather an instruction dataset, Event-Chat, which contains extensive real-world data to fine-tune the entire model, further enhancing its generalization ability. We construct a comprehensive benchmark, and experiments show that EventGPT surpasses previous state-of-the-art MLLMs in generation quality, descriptive accuracy, and reasoning capability.

A Comprehensive Guide to Explainable AI: From Classical Models to LLMs

Explainable Artificial Intelligence (XAI) addresses the growing need for transparency and interpretability in AI systems, enabling trust and accountability in decision-making processes. This book offers a comprehensive guide to XAI, bridging foundational concepts with advanced methodologies. It explores interpretability in traditional models such as Decision Trees, Linear Regression, and Support Vector Machines, alongside the challenges of explaining deep learning architectures like CNNs, RNNs, and Large Language Models (LLMs), including BERT, GPT, and T5. The book presents practical techniques such as SHAP, LIME, Grad-CAM, counterfactual explanations, and causal inference, supported by Python code examples for real-world applications. Case studies illustrate XAI's role in healthcare, finance, and policymaking, demonstrating its impact on fairness and decision support. The book also covers evaluation metrics for explanation quality, an overview of cutting-edge XAI tools and frameworks, and emerging research directions, such as interpretability in federated learning and ethical AI considerations. Designed for a broad audience, this resource equips readers with the theoretical insights and practical skills needed to master XAI. Hands-on examples and additional resources are available at the companion GitHub repository: https://github.com/Echoslayer/XAI_From_Classical_Models_to_LLMs.

EFTViT: Efficient Federated Training of Vision Transformers with Masked Images on Resource-Constrained Edge Devices

Federated learning research has recently shifted from Convolutional Neural Networks (CNNs) to Vision Transformers (ViTs) due to their superior capacity. ViTs training demands higher computational resources due to the lack of 2D inductive biases inherent in CNNs. However, efficient federated training of ViTs on resource-constrained edge devices remains unexplored in the community. In this paper, we propose EFTViT, a hierarchical federated framework that leverages masked images to enable efficient, full-parameter training on resource-constrained edge devices, offering substantial benefits for learning on heterogeneous data. In general, we patchify images and randomly mask a portion of the patches, observing that excluding them from training has minimal impact on performance while substantially reducing computation costs and enhancing data content privacy protection. Specifically, EFTViT comprises a series of lightweight local modules and a larger global module, updated independently on clients and the central server, respectively. The local modules are trained on masked image patches, while the global module is trained on intermediate patch features uploaded from the local client, balanced through a proposed median sampling strategy to erase client data distribution privacy. We analyze the computational complexity and privacy protection of EFTViT. Extensive experiments on popular benchmarks show that EFTViT achieves up to 28.17% accuracy improvement, reduces local training computational cost by up to 2.8$\times$, and cuts local training time by up to 4.4$\times$ compared to existing methods.

Disentangling the Complex Multiplexed DIA Spectra in De Novo Peptide Sequencing

Data-Independent Acquisition (DIA) was introduced to improve sensitivity to cover all peptides in a range rather than only sampling high-intensity peaks as in Data-Dependent Acquisition (DDA) mass spectrometry. However, it is not very clear how useful DIA data is for de novo peptide sequencing as the DIA data are marred with coeluted peptides, high noises, and varying data quality. We present a new deep learning method DIANovo, and address each of these difficulties, and improves the previous established system DeepNovo-DIA by from 25% to 81%, averaging 48%, for amino acid recall, and by from 27% to 89%, averaging 57%, for peptide recall, by equipping the model with a deeper understanding of coeluted DIA spectra. This paper also provides criteria about when DIA data could be used for de novo peptide sequencing and when not to by providing a comparison between DDA and DIA, in both de novo and database search mode. We find that while DIA excels with narrow isolation windows on older-generation instruments, it loses its advantage with wider windows. However, with Orbitrap Astral, DIA consistently outperforms DDA due to narrow window mode enabled. We also provide a theoretical explanation of this phenomenon, emphasizing the critical role of the signal-to-noise profile in the successful application of de novo sequencing.

Sequence-to-Sequence Neural Diarization with Automatic Speaker Detection and Representation

This paper proposes a novel Sequence-to-Sequence Neural Diarization (SSND) framework to perform online and offline speaker diarization. It is developed from the sequence-to-sequence architecture of our previous target-speaker voice activity detection system and then evolves into a new diarization paradigm by addressing two critical problems. 1) Speaker Detection: The proposed approach can utilize incompletely given speaker embeddings to discover the unknown speaker and predict the target voice activities in the audio signal. It does not require a prior diarization system for speaker enrollment in advance. 2) Speaker Representation: The proposed approach can adopt the predicted voice activities as reference information to extract speaker embeddings from the audio signal simultaneously. The representation space of speaker embedding is jointly learned within the whole diarization network without using an extra speaker embedding model. During inference, the SSND framework can process long audio recordings blockwise. The detection module utilizes the previously obtained speaker-embedding buffer to predict both enrolled and unknown speakers' voice activities for each coming audio block. Next, the speaker-embedding buffer is updated according to the predictions of the representation module. Assuming that up to one new speaker may appear in a small block shift, our model iteratively predicts the results of each block and extracts target embeddings for the subsequent blocks until the signal ends. Finally, the last speaker-embedding buffer can re-score the entire audio, achieving highly accurate diarization performance as an offline system. (......)

Script-centric behavior understanding for assisted autism spectrum disorder diagnosis

Observing and analyzing children's social behaviors is crucial for the early diagnosis of Autism Spectrum Disorders (ASD). This work focuses on automatically detecting ASD using computer vision techniques and large language models (LLMs). Existing methods typically rely on supervised learning. However, the scarcity of ASD diagnostic datasets and the lack of interpretability in diagnostic results significantly limits its clinical application. To address these challenges, we introduce a novel unsupervised approach based on script-centric behavior understanding. Our pipeline converts video content into scripts that describe the behavior of characters, leveraging the generalizability of large language models to detect ASD in a zero-shot or few-shot manner. Specifically, we propose a scripts transcription module for multimodal behavior data textualization and a domain prompts module to bridge LLMs. Our method achieves an accuracy of 92.00\% in diagnosing ASD in children with an average age of 24 months, surpassing the performance of supervised learning methods by 3.58\% absolutely. Extensive experiments confirm the effectiveness of our approach and suggest its potential for advancing ASD research through LLMs.

MARM: Unlocking the Future of Recommendation Systems through Memory Augmentation and Scalable Complexity

Scaling-law has guided the language model designing for past years, however, it is worth noting that the scaling laws of NLP cannot be directly applied to RecSys due to the following reasons: (1) The amount of training samples and model parameters is typically not the bottleneck for the model. Our recommendation system can generate over 50 billion user samples daily, and such a massive amount of training data can easily allow our model parameters to exceed 200 billion, surpassing many LLMs (about 100B). (2) To ensure the stability and robustness of the recommendation system, it is essential to control computational complexity FLOPs carefully. Considering the above differences with LLM, we can draw a conclusion that: for a RecSys model, compared to model parameters, the computational complexity FLOPs is a more expensive factor that requires careful control. In this paper, we propose our milestone work, MARM (Memory Augmented Recommendation Model), which explores a new cache scaling-laws successfully.