Resolving the bias-precision paradox with stochastic causal representation learning for personalized medicine

Estimating individualized treatment effects from longitudinal observational data is central to data-driven medicine, yet existing methods face a fundamental limitation: reducing confounding bias often suppresses clinically informative heterogeneity, degrading patient-specific predictions. Here, we identify this tension as a bias-precision paradox in causal representation learning and introduce sampling-based maximum mean discrepancy (sMMD), a stochastic alignment strategy that replaces global adversarial balancing with subset-level matching. We instantiate this approach in a framework for counterfactual outcome prediction with attribution-grounded interpretability. Across two large-scale ICU cohorts (n = 27,783), our framework improves accuracy under distribution shift, reducing error by up to 11.5% and substantially increasing recall in high-risk tasks. Mechanistic analyses show that sMMD selectively preserves clinically decisive variables. In human-AI evaluation, our method outperforms clinicians-in-training and large language models, and improves clinician accuracy by 14.7% while reducing decision time, enabling interpretable, real-time clinical decision support.

Triple Spectral Fusion for Sensor-based Human Activity Recognition

The field of sensor-based human activity recognition (HAR) mainly uses posture, motion and context data of Inertial Measurement Units (IMUs) to identify daily activities. Despite the advancements in learning-based methods, it is challenging to perform information fusion from the temporal perspective due to the complexities in fusing heterogeneous sensor data and establishing long-term context correlations. This paper proposes a novel triple spectral fusion framework tailored for HAR. First, we develop an adaptive complementary filtering technique for noise suppression and organize each IMU's sensors into posture and motion modality nodes. Given that IMU nodes form a dynamic heterogeneous graph, we then apply adaptive filtering within the graph Fourier domain to merge both homogeneous and heterogeneous node information. Furthermore, an adaptive wavelet frequency selection approach is implemented to suppress context redundancy and shorten the length of features. This approach enhances both timestamp-based graph aggregation and the correlation of long-term contexts. Our framework uses adaptive filtering in the Fourier, graph Fourier, and wavelet domains, enabling effective multi-sensor fusion and context correlation. Extensive experiments on ten benchmark datasets demonstrate the superior performance of our framework. Project page: https://github.com/crocodilegogogo/TSF-TPAMI2026.

DoseRAD2026 Challenge dataset: AI accelerated photon and proton dose calculation for radiotherapy

Purpose: Accurate dose calculation is essential in radiotherapy for precise tumor irradiation while sparing healthy tissue. With the growing adoption of MRI-guided and real-time adaptive radiotherapy, fast and accurate dose calculation on CT and MRI is increasingly needed. The DoseRAD2026 dataset and challenge provide a public benchmark of paired CT and MRI data with beam-level photon and proton Monte Carlo dose distributions for developing and evaluating advanced dose calculation methods. Acquisition and validation methods: The dataset comprises paired CT and MRI from 115 patients (75 training, 40 testing) treated on an MRI-linac for thoracic or abdominal lesions, derived from the SynthRAD2025 dataset. Pre-processing included deformable image registration, air-cavity correction, and resampling. Ground-truth photon (6 MV) and proton dose distributions were computed using open-source Monte Carlo algorithms, yielding 40,500 photon beams and 81,000 proton beamlets. Data format and usage notes: Data are organized into photon and proton subsets with paired CT-MRI images, beam-level dose distributions, and JSON beam configuration files. Files are provided in compressed MetaImage (.mha) format. The dataset is released under CC BY-NC 4.0, with training data available from April 2026 and the test set withheld until March 2030. Potential applications: The dataset supports benchmarking of fast dose calculation methods, including beam-level dose estimation for photon and proton therapy, MRI-based dose calculation in MRI-guided workflows, and real-time adaptive radiotherapy.

LoD Sketch Extraction from Architectural Models Using Generative AI: Dataset Construction for Multi-Level Architectural Design Generation

For architectural design, representation across multiple Levels of Details (LoD) is essential for achieving a smooth transition from conceptual massing to detailed modeling. However, traditional LoD modeling processes rely on manual operations that are time-consuming, labor-intensive, and prone to geometric inconsistencies. While the rapid advancement of generative artificial intelligence (AI) has opened new possibilities for generating multi-level architectural models from sketch inputs, its application remains limited by the lack of high-quality paired LoD training data. To address this issue, we propose an automatic LoD sketch extraction framework using generative AI models, which progressively simplifies high-detail architectural models to automatically generate geometrically consistent and hierarchically coherent multi-LoD representations. The proposed framework integrates computer vision techniques with generative AI methods to establish a progressive extraction pipeline that transitions from detailed representations to volumetric abstractions. Experimental results demonstrate that the method maintains strong geometric consistency across LoD levels, achieving SSIM values of 0.7319 and 0.7532 for the transitions from LoD3 to LoD2 and from LoD2 to LoD1, respectively, with corresponding normalized Hausdorff distances of 25.1% and 61.0% of the image diagonal, reflecting controlled geometric deviation during abstraction. These results verify that the proposed framework effectively preserves global structure while achieving progressive semantic simplification across different LoD levels, providing reliable data and technical support for AI-driven multi-level architectural generation and hierarchical modeling.

AI-generated data contamination erodes pathological variability and diagnostic reliability

Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are increasingly at risk of training on uncurated AI-generated data. However, the clinical consequences of this AI-generated data contamination remain unexplored. Here, we show that in the absence of mandatory human verification, this self-referential cycle drives a rapid erosion of pathological variability and diagnostic reliability. By analysing more than 800,000 synthetic data points across clinical text generation, vision-language reporting, and medical image synthesis, we find that models progressively converge toward generic phenotypes regardless of the model architecture. Specifically, rare but critical findings, including pneumothorax and effusions, vanish from the synthetic content generated by AI models, while demographic representations skew heavily toward middle-aged male phenotypes. Crucially, this degradation is masked by false diagnostic confidence; models continue to issue reassuring reports while failing to detect life-threatening pathology, with false reassurance rates tripling to 40%. Blinded physician evaluation confirms that this decoupling of confidence and accuracy renders AI-generated documentation clinically useless after just two generations. We systematically evaluate three mitigation strategies, finding that while synthetic volume scaling fails to prevent collapse, mixing real data with quality-aware filtering effectively preserves diversity. Ultimately, our results suggest that without policy-mandated human oversight, the deployment of generative AI threatens to degrade the very healthcare data ecosystems it relies upon.

Sketch-Based Facade Renovation With Generative AI: A Streamlined Framework for Bypassing As-Built Modelling in Industrial Adaptive Reuse

Facade renovation offers a more sustainable alternative to full demolition, yet producing design proposals that preserve existing structures while expressing new intent remains challenging. Current workflows typically require detailed as-built modelling before design, which is time-consuming, labour-intensive, and often involves repeated revisions. To solve this issue, we propose a three-stage framework combining generative artificial intelligence (AI) and vision-language models (VLM) that directly processes rough structural sketch and textual descriptions to produce consistent renovation proposals. First, the input sketch is used by a fine-tuned VLM model to predict bounding boxes specifying where modifications are needed and which components should be added. Next, a stable diffusion model generates detailed sketches of new elements, which are merged with the original outline through a generative inpainting pipeline. Finally, ControlNet is employed to refine the result into a photorealistic image. Experiments on datasets and real industrial buildings indicate that the proposed framework can generate renovation proposals that preserve the original structure while improving facade detail quality. This approach effectively bypasses the need for detailed as-built modelling, enabling architects to rapidly explore design alternatives, iterate on early-stage concepts, and communicate renovation intentions with greater clarity.

Causality-Aware Temporal Projection for Video Understanding in Video-LLMs

Recent Video Large Language Models (Video-LLMs) have shown strong multimodal reasoning capabilities, yet remain challenged by video understanding tasks that require consistent temporal ordering and causal coherence. Many parameter-efficient Video-LLMs rely on unconstrained bidirectional projectors to model inter-frame interactions, which can blur temporal ordering by allowing later frames to influence earlier representations, without explicit architectural mechanisms to respect the directional nature of video reasoning. To address this limitation, we propose V-CORE, a parameter-efficient framework that introduces explicit temporal ordering constraints for video understanding. V-CORE consists of two key components: (1) Learnable Spatial Aggregation (LSA), which adaptively selects salient spatial tokens to reduce redundancy, and (2) a Causality-Aware Temporal Projector (CATP), which enforces structured unidirectional information flow via block-causal attention and a terminal dynamic summary token acting as a causal sink. This design preserves intra-frame spatial interactions while ensuring that temporal information is aggregated in a strictly ordered manner. With 4-bit QLoRA and a frozen LLM backbone, V-CORE can be trained efficiently on a single consumer GPU. Experiments show that V-CORE achieves strong performance on the challenging NExT-QA benchmark, reaching 61.2% accuracy, and remains competitive across MSVD-QA, MSRVTT-QA, and TGIF-QA, with gains concentrated in temporal and causal reasoning subcategories (+3.5% and +5.2% respectively), directly validating the importance of explicit temporal ordering constraints.

Toward Auditable Neuro-Symbolic Reasoning in Pathology: SQL as an Explicit Trace of Evidence

Automated pathology image analysis is central to clinical diagnosis, but clinicians still ask which slide features drive a model's decision and why. Vision-language models can produce natural language explanations, but these are often correlational and lack verifiable evidence. In this paper, we introduce an SQL-centered agentic framework that enables both feature measurement and reasoning to be auditable. Specifically, after extracting human-interpretable cellular features, Feature Reasoning Agents compose and execute SQL queries over feature tables to aggregate visual evidence into quantitative findings. A Knowledge Comparison Agent then evaluates these findings against established pathological knowledge, mirroring how pathologists justify diagnoses from measurable observations. Extensive experiments evaluated on two pathology visual question answering datasets demonstrate our method improves interpretability and decision traceability while producing executable SQL traces that link cellular measurements to diagnostic conclusions.

Route-DETR: Pairwise Query Routing in Transformers for Object Detection

Detection Transformer (DETR) offers an end-to-end solution for object detection by eliminating hand-crafted components like non-maximum suppression. However, DETR suffers from inefficient query competition where multiple queries converge to similar positions, leading to redundant computations. We present Route-DETR, which addresses these issues through adaptive pairwise routing in decoder self-attention layers. Our key insight is distinguishing between competing queries (targeting the same object) versus complementary queries (targeting different objects) using inter-query similarity, confidence scores, and geometry. We introduce dual routing mechanisms: suppressor routes that modulate attention between competing queries to reduce duplication, and delegator routes that encourage exploration of different regions. These are implemented via learnable low-rank attention biases enabling asymmetric query interactions. A dual-branch training strategy incorporates routing biases only during training while preserving standard attention for inference, ensuring no additional computational cost. Experiments on COCO and Cityscapes demonstrate consistent improvements across multiple DETR baselines, achieving +1.7% mAP gain over DINO on ResNet-50 and reaching 57.6% mAP on Swin-L, surpassing prior state-of-the-art models.

Dual-Stage Safe Herding Framework for Adversarial Attacker in Dynamic Environment

Recent advances in robotics have enabled the widespread deployment of autonomous robotic systems in complex operational environments, presenting both unprecedented opportunities and significant security problems. Traditional shepherding approaches based on fixed formations are often ineffective or risky in urban and obstacle-rich scenarios, especially when facing adversarial agents with unknown and adaptive behaviors. This paper addresses this challenge as an extended herding problem, where defensive robotic systems must safely guide adversarial agents with unknown strategies away from protected areas and into predetermined safe regions, while maintaining collision-free navigation in dynamic environments. We propose a hierarchical hybrid framework based on reach-avoid game theory and local motion planning, incorporating a virtual containment boundary and event-triggered pursuit mechanisms to enable scalable and robust multi-agent coordination. Simulation results demonstrate that the proposed approach achieves safe and efficient guidance of adversarial agents to designated regions.