HisynSeg: Weakly-Supervised Histopathological Image Segmentation via Image-Mixing Synthesis and Consistency Regularization

Tissue semantic segmentation is one of the key tasks in computational pathology. To avoid the expensive and laborious acquisition of pixel-level annotations, a wide range of studies attempt to adopt the class activation map (CAM), a weakly-supervised learning scheme, to achieve pixel-level tissue segmentation. However, CAM-based methods are prone to suffer from under-activation and over-activation issues, leading to poor segmentation performance. To address this problem, we propose a novel weakly-supervised semantic segmentation framework for histopathological images based on image-mixing synthesis and consistency regularization, dubbed HisynSeg. Specifically, synthesized histopathological images with pixel-level masks are generated for fully-supervised model training, where two synthesis strategies are proposed based on Mosaic transformation and B\'ezier mask generation. Besides, an image filtering module is developed to guarantee the authenticity of the synthesized images. In order to further avoid the model overfitting to the occasional synthesis artifacts, we additionally propose a novel self-supervised consistency regularization, which enables the real images without segmentation masks to supervise the training of the segmentation model. By integrating the proposed techniques, the HisynSeg framework successfully transforms the weakly-supervised semantic segmentation problem into a fully-supervised one, greatly improving the segmentation accuracy. Experimental results on three datasets prove that the proposed method achieves a state-of-the-art performance. Code is available at https://github.com/Vison307/HisynSeg.

Efficient Self-Supervised Video Hashing with Selective State Spaces

Self-supervised video hashing (SSVH) is a practical task in video indexing and retrieval. Although Transformers are predominant in SSVH for their impressive temporal modeling capabilities, they often suffer from computational and memory inefficiencies. Drawing inspiration from Mamba, an advanced state-space model, we explore its potential in SSVH to achieve a better balance between efficacy and efficiency. We introduce S5VH, a Mamba-based video hashing model with an improved self-supervised learning paradigm. Specifically, we design bidirectional Mamba layers for both the encoder and decoder, which are effective and efficient in capturing temporal relationships thanks to the data-dependent selective scanning mechanism with linear complexity. In our learning strategy, we transform global semantics in the feature space into semantically consistent and discriminative hash centers, followed by a center alignment loss as a global learning signal. Our self-local-global (SLG) paradigm significantly improves learning efficiency, leading to faster and better convergence. Extensive experiments demonstrate S5VH's improvements over state-of-the-art methods, superior transferability, and scalable advantages in inference efficiency. Code is available at https://github.com/gimpong/AAAI25-S5VH.

A Mixed-Language Multi-Document News Summarization Dataset and a Graphs-Based Extract-Generate Model

Existing research on news summarization primarily focuses on single-language single-document (SLSD), single-language multi-document (SLMD) or cross-language single-document (CLSD). However, in real-world scenarios, news about a international event often involves multiple documents in different languages, i.e., mixed-language multi-document (MLMD). Therefore, summarizing MLMD news is of great significance. However, the lack of datasets for MLMD news summarization has constrained the development of research in this area. To fill this gap, we construct a mixed-language multi-document news summarization dataset (MLMD-news), which contains four different languages and 10,992 source document cluster and target summary pairs. Additionally, we propose a graph-based extract-generate model and benchmark various methods on the MLMD-news dataset and publicly release our dataset and code\footnote[1]{https://github.com/Southnf9/MLMD-news}, aiming to advance research in summarization within MLMD scenarios.

Multimodal Cross-Task Interaction for Survival Analysis in Whole Slide Pathological Images

Survival prediction, utilizing pathological images and genomic profiles, is increasingly important in cancer analysis and prognosis. Despite significant progress, precise survival analysis still faces two main challenges: (1) The massive pixels contained in whole slide images (WSIs) complicate the process of pathological images, making it difficult to generate an effective representation of the tumor microenvironment (TME). (2) Existing multimodal methods often rely on alignment strategies to integrate complementary information, which may lead to information loss due to the inherent heterogeneity between pathology and genes. In this paper, we propose a Multimodal Cross-Task Interaction (MCTI) framework to explore the intrinsic correlations between subtype classification and survival analysis tasks. Specifically, to capture TME-related features in WSIs, we leverage the subtype classification task to mine tumor regions. Simultaneously, multi-head attention mechanisms are applied in genomic feature extraction, adaptively performing genes grouping to obtain task-related genomic embedding. With the joint representation of pathological images and genomic data, we further introduce a Transport-Guided Attention (TGA) module that uses optimal transport theory to model the correlation between subtype classification and survival analysis tasks, effectively transferring potential information. Extensive experiments demonstrate the superiority of our approaches, with MCTI outperforming state-of-the-art frameworks on three public benchmarks. \href{https://github.com/jsh0792/MCTI}{https://github.com/jsh0792/MCTI}.

Dynamic Pseudo Label Optimization in Point-Supervised Nuclei Segmentation

Deep learning has achieved impressive results in nuclei segmentation, but the massive requirement for pixel-wise labels remains a significant challenge. To alleviate the annotation burden, existing methods generate pseudo masks for model training using point labels. However, the generated masks are inevitably different from the ground truth, and these dissimilarities are not handled reasonably during the network training, resulting in the subpar performance of the segmentation model. To tackle this issue, we propose a framework named DoNuSeg, enabling \textbf{D}ynamic pseudo label \textbf{O}ptimization in point-supervised \textbf{Nu}clei \textbf{Seg}mentation. Specifically, DoNuSeg takes advantage of class activation maps (CAMs) to adaptively capture regions with semantics similar to annotated points. To leverage semantic diversity in the hierarchical feature levels, we design a dynamic selection module to choose the optimal one among CAMs from different encoder blocks as pseudo masks. Meanwhile, a CAM-guided contrastive module is proposed to further enhance the accuracy of pseudo masks. In addition to exploiting the semantic information provided by CAMs, we consider location priors inherent to point labels, developing a task-decoupled structure for effectively differentiating nuclei. Extensive experiments demonstrate that DoNuSeg outperforms state-of-the-art point-supervised methods. The code is available at https://github.com/shinning0821/MICCAI24-DoNuSeg.

Protect-Your-IP: Scalable Source-Tracing and Attribution against Personalized Generation

With the advent of personalized generation models, users can more readily create images resembling existing content, heightening the risk of violating portrait rights and intellectual property (IP). Traditional post-hoc detection and source-tracing methods for AI-generated content (AIGC) employ proactive watermark approaches; however, these are less effective against personalized generation models. Moreover, attribution techniques for AIGC rely on passive detection but often struggle to differentiate AIGC from authentic images, presenting a substantial challenge. Integrating these two processes into a cohesive framework not only meets the practical demands for protection and forensics but also improves the effectiveness of attribution tasks. Inspired by this insight, we propose a unified approach for image copyright source-tracing and attribution, introducing an innovative watermarking-attribution method that blends proactive and passive strategies. We embed copyright watermarks into protected images and train a watermark decoder to retrieve copyright information from the outputs of personalized models, using this watermark as an initial step for confirming if an image is AIGC-generated. To pinpoint specific generation techniques, we utilize powerful visual backbone networks for classification. Additionally, we implement an incremental learning strategy to adeptly attribute new personalized models without losing prior knowledge, thereby enhancing the model's adaptability to novel generation methods. We have conducted experiments using various celebrity portrait series sourced online, and the results affirm the efficacy of our method in source-tracing and attribution tasks, as well as its robustness against knowledge forgetting.

GS-Hider: Hiding Messages into 3D Gaussian Splatting

3D Gaussian Splatting (3DGS) has already become the emerging research focus in the fields of 3D scene reconstruction and novel view synthesis. Given that training a 3DGS requires a significant amount of time and computational cost, it is crucial to protect the copyright, integrity, and privacy of such 3D assets. Steganography, as a crucial technique for encrypted transmission and copyright protection, has been extensively studied. However, it still lacks profound exploration targeted at 3DGS. Unlike its predecessor NeRF, 3DGS possesses two distinct features: 1) explicit 3D representation; and 2) real-time rendering speeds. These characteristics result in the 3DGS point cloud files being public and transparent, with each Gaussian point having a clear physical significance. Therefore, ensuring the security and fidelity of the original 3D scene while embedding information into the 3DGS point cloud files is an extremely challenging task. To solve the above-mentioned issue, we first propose a steganography framework for 3DGS, dubbed GS-Hider, which can embed 3D scenes and images into original GS point clouds in an invisible manner and accurately extract the hidden messages. Specifically, we design a coupled secured feature attribute to replace the original 3DGS's spherical harmonics coefficients and then use a scene decoder and a message decoder to disentangle the original RGB scene and the hidden message. Extensive experiments demonstrated that the proposed GS-Hider can effectively conceal multimodal messages without compromising rendering quality and possesses exceptional security, robustness, capacity, and flexibility. Our project is available at: https://xuanyuzhang21.github.io/project/gshider.

DAWN: Domain-Adaptive Weakly Supervised Nuclei Segmentation via Cross-Task Interactions

Weakly supervised segmentation methods have gained significant attention due to their ability to reduce the reliance on costly pixel-level annotations during model training. However, the current weakly supervised nuclei segmentation approaches typically follow a two-stage pseudo-label generation and network training process. The performance of the nuclei segmentation heavily relies on the quality of the generated pseudo-labels, thereby limiting its effectiveness. This paper introduces a novel domain-adaptive weakly supervised nuclei segmentation framework using cross-task interaction strategies to overcome the challenge of pseudo-label generation. Specifically, we utilize weakly annotated data to train an auxiliary detection task, which assists the domain adaptation of the segmentation network. To enhance the efficiency of domain adaptation, we design a consistent feature constraint module integrating prior knowledge from the source domain. Furthermore, we develop pseudo-label optimization and interactive training methods to improve the domain transfer capability. To validate the effectiveness of our proposed method, we conduct extensive comparative and ablation experiments on six datasets. The results demonstrate the superiority of our approach over existing weakly supervised approaches. Remarkably, our method achieves comparable or even better performance than fully supervised methods. Our code will be released in https://github.com/zhangye-zoe/DAWN.

Rethinking Attention-Based Multiple Instance Learning for Whole-Slide Pathological Image Classification: An Instance Attribute Viewpoint

Multiple instance learning (MIL) is a robust paradigm for whole-slide pathological image (WSI) analysis, processing gigapixel-resolution images with slide-level labels. As pioneering efforts, attention-based MIL (ABMIL) and its variants are increasingly becoming popular due to the characteristics of simultaneously handling clinical diagnosis and tumor localization. However, the attention mechanism exhibits limitations in discriminating between instances, which often misclassifies tissues and potentially impairs MIL performance. This paper proposes an Attribute-Driven MIL (AttriMIL) framework to address these issues. Concretely, we dissect the calculation process of ABMIL and present an attribute scoring mechanism that measures the contribution of each instance to bag prediction effectively, quantifying instance attributes. Based on attribute quantification, we develop a spatial attribute constraint and an attribute ranking constraint to model instance correlations within and across slides, respectively. These constraints encourage the network to capture the spatial correlation and semantic similarity of instances, improving the ability of AttriMIL to distinguish tissue types and identify challenging instances. Additionally, AttriMIL employs a histopathology adaptive backbone that maximizes the pre-trained model's feature extraction capability for collecting pathological features. Extensive experiments on three public benchmarks demonstrate that our AttriMIL outperforms existing state-of-the-art frameworks across multiple evaluation metrics. The implementation code is available at https://github.com/MedCAI/AttriMIL.

H2ASeg: Hierarchical Adaptive Interaction and Weighting Network for Tumor Segmentation in PET/CT Images

Positron emission tomography (PET) combined with computed tomography (CT) imaging is routinely used in cancer diagnosis and prognosis by providing complementary information. Automatically segmenting tumors in PET/CT images can significantly improve examination efficiency. Traditional multi-modal segmentation solutions mainly rely on concatenation operations for modality fusion, which fail to effectively model the non-linear dependencies between PET and CT modalities. Recent studies have investigated various approaches to optimize the fusion of modality-specific features for enhancing joint representations. However, modality-specific encoders used in these methods operate independently, inadequately leveraging the synergistic relationships inherent in PET and CT modalities, for example, the complementarity between semantics and structure. To address these issues, we propose a Hierarchical Adaptive Interaction and Weighting Network termed H2ASeg to explore the intrinsic cross-modal correlations and transfer potential complementary information. Specifically, we design a Modality-Cooperative Spatial Attention (MCSA) module that performs intra- and inter-modal interactions globally and locally. Additionally, a Target-Aware Modality Weighting (TAMW) module is developed to highlight tumor-related features within multi-modal features, thereby refining tumor segmentation. By embedding these modules across different layers, H2ASeg can hierarchically model cross-modal correlations, enabling a nuanced understanding of both semantic and structural tumor features. Extensive experiments demonstrate the superiority of H2ASeg, outperforming state-of-the-art methods on AutoPet-II and Hecktor2022 benchmarks. The code is released at https://github.com/JinPLu/H2ASeg.