Applying and Evaluating Large Language Models in Mental Health Care: A Scoping Review of Human-Assessed Generative Tasks

Large language models (LLMs) are emerging as promising tools for mental health care, offering scalable support through their ability to generate human-like responses. However, the effectiveness of these models in clinical settings remains unclear. This scoping review aimed to assess the current generative applications of LLMs in mental health care, focusing on studies where these models were tested with human participants in real-world scenarios. A systematic search across APA PsycNet, Scopus, PubMed, and Web of Science identified 726 unique articles, of which 17 met the inclusion criteria. These studies encompassed applications such as clinical assistance, counseling, therapy, and emotional support. However, the evaluation methods were often non-standardized, with most studies relying on ad hoc scales that limit comparability and robustness. Privacy, safety, and fairness were also frequently underexplored. Moreover, reliance on proprietary models, such as OpenAI's GPT series, raises concerns about transparency and reproducibility. While LLMs show potential in expanding mental health care access, especially in underserved areas, the current evidence does not fully support their use as standalone interventions. More rigorous, standardized evaluations and ethical oversight are needed to ensure these tools can be safely and effectively integrated into clinical practice.

Vision-Language Models Meet Meteorology: Developing Models for Extreme Weather Events Detection with Heatmaps

Real-time detection and prediction of extreme weather protect human lives and infrastructure. Traditional methods rely on numerical threshold setting and manual interpretation of weather heatmaps with Geographic Information Systems (GIS), which can be slow and error-prone. Our research redefines Extreme Weather Events Detection (EWED) by framing it as a Visual Question Answering (VQA) problem, thereby introducing a more precise and automated solution. Leveraging Vision-Language Models (VLM) to simultaneously process visual and textual data, we offer an effective aid to enhance the analysis process of weather heatmaps. Our initial assessment of general-purpose VLMs (e.g., GPT-4-Vision) on EWED revealed poor performance, characterized by low accuracy and frequent hallucinations due to inadequate color differentiation and insufficient meteorological knowledge. To address these challenges, we introduce ClimateIQA, the first meteorological VQA dataset, which includes 8,760 wind gust heatmaps and 254,040 question-answer pairs covering four question types, both generated from the latest climate reanalysis data. We also propose Sparse Position and Outline Tracking (SPOT), an innovative technique that leverages OpenCV and K-Means clustering to capture and depict color contours in heatmaps, providing ClimateIQA with more accurate color spatial location information. Finally, we present Climate-Zoo, the first meteorological VLM collection, which adapts VLMs to meteorological applications using the ClimateIQA dataset. Experiment results demonstrate that models from Climate-Zoo substantially outperform state-of-the-art general VLMs, achieving an accuracy increase from 0% to over 90% in EWED verification. The datasets and models in this study are publicly available for future climate science research: https://github.com/AlexJJJChen/Climate-Zoo.

FinTextQA: A Dataset for Long-form Financial Question Answering

Accurate evaluation of financial question answering (QA) systems necessitates a comprehensive dataset encompassing diverse question types and contexts. However, current financial QA datasets lack scope diversity and question complexity. This work introduces FinTextQA, a novel dataset for long-form question answering (LFQA) in finance. FinTextQA comprises 1,262 high-quality, source-attributed QA pairs extracted and selected from finance textbooks and government agency websites.Moreover, we developed a Retrieval-Augmented Generation (RAG)-based LFQA system, comprising an embedder, retriever, reranker, and generator. A multi-faceted evaluation approach, including human ranking, automatic metrics, and GPT-4 scoring, was employed to benchmark the performance of different LFQA system configurations under heightened noisy conditions. The results indicate that: (1) Among all compared generators, Baichuan2-7B competes closely with GPT-3.5-turbo in accuracy score; (2) The most effective system configuration on our dataset involved setting the embedder, retriever, reranker, and generator as Ada2, Automated Merged Retrieval, Bge-Reranker-Base, and Baichuan2-7B, respectively; (3) models are less susceptible to noise after the length of contexts reaching a specific threshold.

Large Language Models in Healthcare: A Comprehensive Benchmark

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering task with answer options for evaluation. However, in real clinical settings, many clinical decisions, such as treatment recommendations, involve answering open-ended questions without pre-set options. Meanwhile, existing studies mainly use accuracy to assess model performance. In this paper, we comprehensively benchmark diverse LLMs in healthcare, to clearly understand their strengths and weaknesses. Our benchmark contains seven tasks and thirteen datasets across medical language generation, understanding, and reasoning. We conduct a detailed evaluation of the existing sixteen LLMs in healthcare under both zero-shot and few-shot (i.e., 1,3,5-shot) learning settings. We report the results on five metrics (i.e. matching, faithfulness, comprehensiveness, generalizability, and robustness) that are critical in achieving trust from clinical users. We further invite medical experts to conduct human evaluation.

Large Language Models in Mental Health Care: a Scoping Review

Objective: The growing use of large language models (LLMs) stimulates a need for a comprehensive review of their applications and outcomes in mental health care contexts. This scoping review aims to critically analyze the existing development and applications of LLMs in mental health care, highlighting their successes and identifying their challenges and limitations in these specialized fields. Materials and Methods: A broad literature search was conducted in November 2023 using six databases (PubMed, Web of Science, Google Scholar, arXiv, medRxiv, and PsyArXiv) following the 2020 version of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 313 publications were initially identified, and after applying the study inclusion criteria, 34 publications were selected for the final review. Results: We identified diverse applications of LLMs in mental health care, including diagnosis, therapy, patient engagement enhancement, etc. Key challenges include data availability and reliability, nuanced handling of mental states, and effective evaluation methods. Despite successes in accuracy and accessibility improvement, gaps in clinical applicability and ethical considerations were evident, pointing to the need for robust data, standardized evaluations, and interdisciplinary collaboration. Conclusion: LLMs show promising potential in advancing mental health care, with applications in diagnostics, and patient support. Continued advancements depend on collaborative, multidisciplinary efforts focused on framework enhancement, rigorous dataset development, technological refinement, and ethical integration to ensure the effective and safe application of LLMs in mental health care.

A Survey of Large Language Models in Medicine: Progress, Application, and Challenge

Large language models (LLMs), such as ChatGPT, have achieved substantial attention due to their impressive human language understanding and generation capabilities. Therefore, the application of LLMs in medicine to assist physicians and patient care emerges as a promising research direction in both artificial intelligence and clinical medicine. To this end, this survey provides a comprehensive overview of the current progress, applications, and challenges faced by LLMs in medicine. Specifically, we aim to address the following questions: 1) What are LLMs and how can medical LLMs be built? 2) What are the downstream performances of medical LLMs? 3) How can medical LLMs be utilized in real-world clinical practice? 4) What challenges arise from the use of medical LLMs? 5) How can we better construct and utilize medical LLMs? As a result, this survey aims to provide insights into the opportunities and challenges of LLMs in medicine and serve as a valuable resource for constructing practical and effective medical LLMs. A regularly updated list of practical guide resources of medical LLMs can be found at https://github.com/AI-in-Health/MedLLMsPracticalGuide.

Exploring Recommendation Capabilities of GPT-4V(ision): A Preliminary Case Study

Large Multimodal Models (LMMs) have demonstrated impressive performance across various vision and language tasks, yet their potential applications in recommendation tasks with visual assistance remain unexplored. To bridge this gap, we present a preliminary case study investigating the recommendation capabilities of GPT-4V(ison), a recently released LMM by OpenAI. We construct a series of qualitative test samples spanning multiple domains and employ these samples to assess the quality of GPT-4V's responses within recommendation scenarios. Evaluation results on these test samples prove that GPT-4V has remarkable zero-shot recommendation abilities across diverse domains, thanks to its robust visual-text comprehension capabilities and extensive general knowledge. However, we have also identified some limitations in using GPT-4V for recommendations, including a tendency to provide similar responses when given similar inputs. This report concludes with an in-depth discussion of the challenges and research opportunities associated with utilizing GPT-4V in recommendation scenarios. Our objective is to explore the potential of extending LMMs from vision and language tasks to recommendation tasks. We hope to inspire further research into next-generation multimodal generative recommendation models, which can enhance user experiences by offering greater diversity and interactivity. All images and prompts used in this report will be accessible at https://github.com/PALIN2018/Evaluate_GPT-4V_Rec.

Continuous Training and Fine-tuning for Domain-Specific Language Models in Medical Question Answering

Large language models exhibit promising general capabilities but often lack specialized knowledge for domain-specific tasks. Developing domain experts from a base model enables a range of applications without prohibitive training costs. This work demonstrates a method using continuous training and instruction fine-tuning to rapidly adapt Llama 2 base models to the Chinese medical domain. We first conduct continuous training on 1B tokens from Chinese medical references to teach relevant vocabulary and knowledge. The models are then fine-tuned on 54K examples sourced from the Chinese National Medical Licensing Examination. Experiments on Chinese medical data confirm the effectiveness of this approach, producing a model comparable to GPT-3.5-turbo while using way less computational resource. The resulting domain-specific model could be useful for various Chinese medical applications. More broadly, this provides a template for domain-specific training of large language models in areas where pre-trained models lack the required expertise, such as law, science, and engineering.

Qilin-Med-VL: Towards Chinese Large Vision-Language Model for General Healthcare

Large Language Models (LLMs) have introduced a new era of proficiency in comprehending complex healthcare and biomedical topics. However, there is a noticeable lack of models in languages other than English and models that can interpret multi-modal input, which is crucial for global healthcare accessibility. In response, this study introduces Qilin-Med-VL, the first Chinese large vision-language model designed to integrate the analysis of textual and visual data. Qilin-Med-VL combines a pre-trained Vision Transformer (ViT) with a foundational LLM. It undergoes a thorough two-stage curriculum training process that includes feature alignment and instruction tuning. This method enhances the model's ability to generate medical captions and answer complex medical queries. We also release ChiMed-VL, a dataset consisting of more than 1M image-text pairs. This dataset has been carefully curated to enable detailed and comprehensive interpretation of medical data using various types of images.

Qilin-Med: Multi-stage Knowledge Injection Advanced Medical Large Language Model

Integrating large language models (LLMs) into healthcare presents potential but faces challenges. Directly pre-training LLMs for domains like medicine is resource-heavy and sometimes unfeasible. Sole reliance on Supervised Fine-tuning (SFT) can result in overconfident predictions and may not tap into domain specific insights. Addressing these challenges, we present a multi-stage training method combining Domain-specific Continued Pre-training (DCPT), SFT, and Direct Preference Optimization (DPO). A notable contribution of our study is the introduction of a 3Gb Chinese Medicine (ChiMed) dataset, encompassing medical question answering, plain texts, knowledge graphs, and dialogues, segmented into three training stages. The medical LLM trained with our pipeline, Qilin-Med, exhibits significant performance boosts. In the CPT and SFT phases, it achieves 38.4% and 40.0% accuracy on the CMExam, surpassing Baichuan-7B's 33.5%. In the DPO phase, on the Huatuo-26M test set, it scores 16.66 in BLEU-1 and 27.44 in ROUGE1, outperforming the SFT's 12.69 and 24.21. This highlights the strength of our training approach in refining LLMs for medical applications.