From Automated to Autonomous: Hierarchical Agent-native Network Architecture (HANA)

Realizing Level 4/5 Autonomous Networks (AN) demands a shift from static automation to agent-native intelligence. Current operations, reliant on rigid scripts, lack the cognitive agency to handle off-nominal conditions. To address this, this letter proposes a hierarchical multi-agent reference architecture enabling high-level autonomy. The framework features a Dual-Driven Orchestrator that coordinates specialized Executive Agents, supported by a shared Public Memory for unified domain knowledge. A key innovation is the integration of agent self-awareness, which empowers the system to harmonize deliberative strategic governance with reflexive fault recovery. We instantiate and validate this architecture within a 5G Core environment. Case studies demonstrate that the system sustains critical throughput under congestion and reduces Mean Time to Repair (MTTR) by 86%, confirming its efficacy in unifying strategic planning with operational resilience.

Position: Life-Logging Video Streams Make the Privacy-Utility Trade-off Inevitable

With the growing prevalence of always-on hardware such as smart glasses, body cameras, and home security systems, life-logging visual sensing is becoming inevitable, forming the backbone of persistent, always-on AI systems. Meanwhile, recent advances in proactive agents and world models signal a fundamental shift from episodic, prompt-driven tools to next-generation AI systems that continuously perceive and react to the physical world. Although life-logging video streams can substantially improve utility of these promising systems, they also introduce significant privacy risks by revealing sensitive information, such as behavioral patterns, emotional states, and social interactions, beyond what isolated images expose. If unresolved, these risks may undermine public trust and hinder the sustainable development of always-on AI technologies. Existing privacy protections are either attack-specific or incur substantial utility loss, and fail to consider the entire data exploitation pipeline. We therefore posit that the privacy-utility trade-off in life-logging video streams is a foundational challenge for next-generation AI systems that demands further investigation. We call for novel pipeline-aware privacy-preserving designs that jointly optimize utility and privacy for long-horizon life-logging visual data. In parallel, formal privacy leakage metrics and standardized benchmarks remain important open directions for future research.

CUDA Agent: Large-Scale Agentic RL for High-Performance CUDA Kernel Generation

GPU kernel optimization is fundamental to modern deep learning but remains a highly specialized task requiring deep hardware expertise. Despite strong performance in general programming, large language models (LLMs) remain uncompetitive with compiler-based systems such as torch.compile for CUDA kernel generation. Existing CUDA code generation approaches either rely on training-free refinement or fine-tune models within fixed multi-turn execution-feedback loops, but both paradigms fail to fundamentally improve the model's intrinsic CUDA optimization ability, resulting in limited performance gains. We present CUDA Agent, a large-scale agentic reinforcement learning system that develops CUDA kernel expertise through three components: a scalable data synthesis pipeline, a skill-augmented CUDA development environment with automated verification and profiling to provide reliable reward signals, and reinforcement learning algorithmic techniques enabling stable training. CUDA Agent achieves state-of-the-art results on KernelBench, delivering 100\%, 100\%, and 92\% faster rate over torch.compile on KernelBench Level-1, Level-2, and Level-3 splits, outperforming the strongest proprietary models such as Claude Opus 4.5 and Gemini 3 Pro by about 40\% on the hardest Level-3 setting.

RISE: Self-Improving Robot Policy with Compositional World Model

Despite the sustained scaling on model capacity and data acquisition, Vision-Language-Action (VLA) models remain brittle in contact-rich and dynamic manipulation tasks, where minor execution deviations can compound into failures. While reinforcement learning (RL) offers a principled path to robustness, on-policy RL in the physical world is constrained by safety risk, hardware cost, and environment reset. To bridge this gap, we present RISE, a scalable framework of robotic reinforcement learning via imagination. At its core is a Compositional World Model that (i) predicts multi-view future via a controllable dynamics model, and (ii) evaluates imagined outcomes with a progress value model, producing informative advantages for the policy improvement. Such compositional design allows state and value to be tailored by best-suited yet distinct architectures and objectives. These components are integrated into a closed-loop self-improving pipeline that continuously generates imaginary rollouts, estimates advantages, and updates the policy in imaginary space without costly physical interaction. Across three challenging real-world tasks, RISE yields significant improvement over prior art, with more than +35% absolute performance increase in dynamic brick sorting, +45% for backpack packing, and +35% for box closing, respectively.

Enhancing Indoor Occupancy Prediction via Sparse Query-Based Multi-Level Consistent Knowledge Distillation

Occupancy prediction provides critical geometric and semantic understanding for robotics but faces efficiency-accuracy trade-offs. Current dense methods suffer computational waste on empty voxels, while sparse query-based approaches lack robustness in diverse and complex indoor scenes. In this paper, we propose DiScene, a novel sparse query-based framework that leverages multi-level distillation to achieve efficient and robust occupancy prediction. In particular, our method incorporates two key innovations: (1) a Multi-level Consistent Knowledge Distillation strategy, which transfers hierarchical representations from large teacher models to lightweight students through coordinated alignment across four levels, including encoder-level feature alignment, query-level feature matching, prior-level spatial guidance, and anchor-level high-confidence knowledge transfer and (2) a Teacher-Guided Initialization policy, employing optimized parameter warm-up to accelerate model convergence. Validated on the Occ-Scannet benchmark, DiScene achieves 23.2 FPS without depth priors while outperforming our baseline method, OPUS, by 36.1% and even better than the depth-enhanced version, OPUS†. With depth integration, DiScene† attains new SOTA performance, surpassing EmbodiedOcc by 3.7% with 1.62$\times$ faster inference speed. Furthermore, experiments on the Occ3D-nuScenes benchmark and in-the-wild scenarios demonstrate the versatility of our approach in various environments. Code and models can be accessed at https://github.com/getterupper/DiScene.

S$^2$Drug: Bridging Protein Sequence and 3D Structure in Contrastive Representation Learning for Virtual Screening

Virtual screening (VS) is an essential task in drug discovery, focusing on the identification of small-molecule ligands that bind to specific protein pockets. Existing deep learning methods, from early regression models to recent contrastive learning approaches, primarily rely on structural data while overlooking protein sequences, which are more accessible and can enhance generalizability. However, directly integrating protein sequences poses challenges due to the redundancy and noise in large-scale protein-ligand datasets. To address these limitations, we propose \textbf{S$^2$Drug}, a two-stage framework that explicitly incorporates protein \textbf{S}equence information and 3D \textbf{S}tructure context in protein-ligand contrastive representation learning. In the first stage, we perform protein sequence pretraining on ChemBL using an ESM2-based backbone, combined with a tailored data sampling strategy to reduce redundancy and noise on both protein and ligand sides. In the second stage, we fine-tune on PDBBind by fusing sequence and structure information through a residue-level gating module, while introducing an auxiliary binding site prediction task. This auxiliary task guides the model to accurately localize binding residues within the protein sequence and capture their 3D spatial arrangement, thereby refining protein-ligand matching. Across multiple benchmarks, S$^2$Drug consistently improves virtual screening performance and achieves strong results on binding site prediction, demonstrating the value of bridging sequence and structure in contrastive learning.

FLEX: Continuous Agent Evolution via Forward Learning from Experience

Autonomous agents driven by Large Language Models (LLMs) have revolutionized reasoning and problem-solving but remain static after training, unable to grow with experience as intelligent beings do during deployment. We introduce Forward Learning with EXperience (FLEX), a gradient-free learning paradigm that enables LLM agents to continuously evolve through accumulated experience. Specifically, FLEX cultivates scalable and inheritable evolution by constructing a structured experience library through continual reflection on successes and failures during interaction with the environment. FLEX delivers substantial improvements on mathematical reasoning, chemical retrosynthesis, and protein fitness prediction (up to 23% on AIME25, 10% on USPTO50k, and 14% on ProteinGym). We further identify a clear scaling law of experiential growth and the phenomenon of experience inheritance across agents, marking a step toward scalable and inheritable continuous agent evolution. Project Page: https://flex-gensi-thuair.github.io.

Coder as Editor: Code-driven Interpretable Molecular Optimization

Molecular optimization is a central task in drug discovery that requires precise structural reasoning and domain knowledge. While large language models (LLMs) have shown promise in generating high-level editing intentions in natural language, they often struggle to faithfully execute these modifications-particularly when operating on non-intuitive representations like SMILES. We introduce MECo, a framework that bridges reasoning and execution by translating editing actions into executable code. MECo reformulates molecular optimization for LLMs as a cascaded framework: generating human-interpretable editing intentions from a molecule and property goal, followed by translating those intentions into executable structural edits via code generation. Our approach achieves over 98% accuracy in reproducing held-out realistic edits derived from chemical reactions and target-specific compound pairs. On downstream optimization benchmarks spanning physicochemical properties and target activities, MECo substantially improves consistency by 38-86 percentage points to 90%+ and achieves higher success rates over SMILES-based baselines while preserving structural similarity. By aligning intention with execution, MECo enables consistent, controllable and interpretable molecular design, laying the foundation for high-fidelity feedback loops and collaborative human-AI workflows in drug discovery.

Leveraging AI Agents for Autonomous Networks: A Reference Architecture and Empirical Studies

The evolution toward Level 4 (L4) Autonomous Networks (AN) represents a strategic inflection point in telecommunications, where networks must transcend reactive automation to achieve genuine cognitive capabilities--fulfilling TM Forum's vision of self-configuring, self-healing, and self-optimizing systems that deliver zero-wait, zero-touch, and zero-fault services. This work bridges the gap between architectural theory and operational reality by implementing Joseph Sifakis's AN Agent reference architecture in a functional cognitive system, deploying coordinated proactive-reactive runtimes driven by hybrid knowledge representation. Through an empirical case study of a Radio Access Network (RAN) Link Adaptation (LA) Agent, we validate this framework's transformative potential: demonstrating sub-10 ms real-time control in 5G NR sub-6 GHz while achieving 6% higher downlink throughput than Outer Loop Link Adaptation (OLLA) algorithms and 67% Block Error Rate (BLER) reduction for ultra-reliable services through dynamic Modulation and Coding Scheme (MCS) optimization. These improvements confirm the architecture's viability in overcoming traditional autonomy barriers and advancing critical L4-enabling capabilities toward next-generation objectives.

BudgetThinker: Empowering Budget-aware LLM Reasoning with Control Tokens

Recent advancements in Large Language Models (LLMs) have leveraged increased test-time computation to enhance reasoning capabilities, a strategy that, while effective, incurs significant latency and resource costs, limiting their applicability in real-world time-constrained or cost-sensitive scenarios. This paper introduces BudgetThinker, a novel framework designed to empower LLMs with budget-aware reasoning, enabling precise control over the length of their thought processes. We propose a methodology that periodically inserts special control tokens during inference to continuously inform the model of its remaining token budget. This approach is coupled with a comprehensive two-stage training pipeline, beginning with Supervised Fine-Tuning (SFT) to familiarize the model with budget constraints, followed by a curriculum-based Reinforcement Learning (RL) phase that utilizes a length-aware reward function to optimize for both accuracy and budget adherence. We demonstrate that BudgetThinker significantly surpasses strong baselines in maintaining performance across a variety of reasoning budgets on challenging mathematical benchmarks. Our method provides a scalable and effective solution for developing efficient and controllable LLM reasoning, making advanced models more practical for deployment in resource-constrained and real-time environments.