Domain Adaptive Diabetic Retinopathy Grading with Model Absence and Flowing Data

Domain shift (the difference between source and target domains) poses a significant challenge in clinical applications, e.g., Diabetic Retinopathy (DR) grading. Despite considering certain clinical requirements, like source data privacy, conventional transfer methods are predominantly model-centered and often struggle to prevent model-targeted attacks. In this paper, we address a challenging Online Model-aGnostic Domain Adaptation (OMG-DA) setting, driven by the demands of clinical environments. This setting is characterized by the absence of the model and the flow of target data. To tackle the new challenge, we propose a novel approach, Generative Unadversarial ExampleS (GUES), which enables adaptation from a data-centric perspective. Specifically, we first theoretically reformulate conventional perturbation optimization in a generative way--learning a perturbation generation function with a latent input variable. During model instantiation, we leverage a Variational AutoEncoder to express this function. The encoder with the reparameterization trick predicts the latent input, whilst the decoder is responsible for the generation. Furthermore, the saliency map is selected as pseudo-perturbation labels. Because it not only captures potential lesions but also theoretically provides an upper bound on the function input, enabling the identification of the latent variable. Extensive comparative experiments on DR benchmarks with both frozen pre-trained models and trainable models demonstrate the superiority of GUES, showing robustness even with small batch size.

Implicit neural representation for free-breathing MR fingerprinting (INR-MRF): co-registered 3D whole-liver water T1, water T2, proton density fat fraction, and R2* mapping

Purpose: To develop an MRI technique for free-breathing 3D whole-liver quantification of water T1, water T2, proton density fat fraction (PDFF), R2*. Methods: An Eight-echo spoiled gradient echo pulse sequence with spiral readout was developed by interleaving inversion recovery and T2 magnetization preparation. We propose a neural network based on a 4D and a 3D implicit neural representation (INR) which simultaneously learns the motion deformation fields and the static reference frame MRI subspace images respectively. Water and fat singular images were separated during network training, with no need of performing retrospective water-fat separation. T1, T2, R2* and proton density fat fraction (PDFF) produced by the proposed method were validated in vivo on 10 healthy subjects, using quantitative maps generated from conventional scans as reference. Results: Our results showed minimal bias and narrow 95% limits of agreement on T1, T2, R2* and PDFF values in the liver compared to conventional breath-holding scans. Conclusions: INR-MRF enabled co-registered 3D whole liver T1, T2, R2* and PDFF mapping in a single free-breathing scan.

MRI quantification of liver fibrosis using diamagnetic susceptibility: An ex-vivo feasibility study

In chronic liver disease, liver fibrosis develops as excessive deposition of extracellular matrix macromolecules, predominantly collagens, progressively form fibrous scars that disrupt the hepatic architecture, and fibrosis, iron, and fat are interrelated. Fibrosis is the best predictor of morbidity and mortality in chronic liver disease but liver biopsy, the reference method for diagnosis and staging, is invasive and limited by sampling and interobserver variability and risks of complications. The overall objective of this study was to develop a new non-invasive method to quantify fibrosis using diamagnetic susceptibility sources with histology validation in ex vivo liver explants.

Self-Supervised Contrastive Graph Clustering Network via Structural Information Fusion

Graph clustering, a classical task in graph learning, involves partitioning the nodes of a graph into distinct clusters. This task has applications in various real-world scenarios, such as anomaly detection, social network analysis, and community discovery. Current graph clustering methods commonly rely on module pre-training to obtain a reliable prior distribution for the model, which is then used as the optimization objective. However, these methods often overlook deeper supervised signals, leading to sub-optimal reliability of the prior distribution. To address this issue, we propose a novel deep graph clustering method called CGCN. Our approach introduces contrastive signals and deep structural information into the pre-training process. Specifically, CGCN utilizes a contrastive learning mechanism to foster information interoperability among multiple modules and allows the model to adaptively adjust the degree of information aggregation for different order structures. Our CGCN method has been experimentally validated on multiple real-world graph datasets, showcasing its ability to boost the dependability of prior clustering distributions acquired through pre-training. As a result, we observed notable enhancements in the performance of the model.

Deep learning improved autofocus for motion artifact reduction and its application in quantitative susceptibility mapping

Purpose: To develop a pipeline for motion artifact correction in mGRE and quantitative susceptibility mapping (QSM). Methods: Deep learning is integrated with autofocus to improve motion artifact suppression, which is applied QSM of patients with Parkinson's disease (PD). The estimation of affine motion parameters in the autofocus method depends on signal-to-noise ratio and lacks accuracy when data sampling occurs outside the k-space center. A deep learning strategy is employed to remove the residual motion artifacts in autofocus. Results: Results obtained in simulated brain data (n =15) with reference truth show that the proposed autofocus deep learning method significantly improves the image quality of mGRE and QSM (p = 0.001 for SSIM, p < 0.0001 for PSNR and RMSE). Results from 10 PD patients with real motion artifacts in QSM have also been corrected using the proposed method and sent to an experienced radiologist for image quality evaluation, and the average image quality score has increased (p=0.0039). Conclusions: The proposed method enables substantial suppression of motion artifacts in mGRE and QSM.

Feature-Adaptive and Data-Scalable In-Context Learning

In-context learning (ICL), which promotes inference with several demonstrations, has become a widespread paradigm to stimulate LLM capabilities for downstream tasks. Due to context length constraints, it cannot be further improved in spite of more training data, and general features directly from LLMs in ICL are not adaptive to the specific downstream task. In this paper, we propose a feature-adaptive and data-scalable in-context learning framework (FADS-ICL), which can leverage task-adaptive features to promote inference on the downstream task, with the supervision of beyond-context samples. Specifically, it first extracts general features of beyond-context samples via the LLM with ICL input form one by one, and introduces a task-specific modulator to perform feature refinement and prediction after fitting a specific downstream task. We conduct extensive experiments on FADS-ICL under varying data settings (4$\sim$128 shots) and LLM scale (0.8$\sim$70B) settings. Experimental results show that FADS-ICL consistently outperforms previous state-of-the-art methods by a significant margin under all settings, verifying the effectiveness and superiority of FADS-ICL. For example, under the 1.5B and 32 shots setting, FADS-ICL can achieve \textbf{+14.3} average accuracy from feature adaptation over vanilla ICL on 10 datasets, with \textbf{+6.2} average accuracy over the previous state-of-the-art method, and the performance can further improve with increasing training data. Code and data are publicly available at \url{https://github.com/jiahaozhenbang/FADS-ICL}.

Hunyuan-DiT: A Powerful Multi-Resolution Diffusion Transformer with Fine-Grained Chinese Understanding

We present Hunyuan-DiT, a text-to-image diffusion transformer with fine-grained understanding of both English and Chinese. To construct Hunyuan-DiT, we carefully design the transformer structure, text encoder, and positional encoding. We also build from scratch a whole data pipeline to update and evaluate data for iterative model optimization. For fine-grained language understanding, we train a Multimodal Large Language Model to refine the captions of the images. Finally, Hunyuan-DiT can perform multi-turn multimodal dialogue with users, generating and refining images according to the context. Through our holistic human evaluation protocol with more than 50 professional human evaluators, Hunyuan-DiT sets a new state-of-the-art in Chinese-to-image generation compared with other open-source models. Code and pretrained models are publicly available at github.com/Tencent/HunyuanDiT

Iterative Experience Refinement of Software-Developing Agents

Autonomous agents powered by large language models (LLMs) show significant potential for achieving high autonomy in various scenarios such as software development. Recent research has shown that LLM agents can leverage past experiences to reduce errors and enhance efficiency. However, the static experience paradigm, reliant on a fixed collection of past experiences acquired heuristically, lacks iterative refinement and thus hampers agents' adaptability. In this paper, we introduce the Iterative Experience Refinement framework, enabling LLM agents to refine experiences iteratively during task execution. We propose two fundamental patterns: the successive pattern, refining based on nearest experiences within a task batch, and the cumulative pattern, acquiring experiences across all previous task batches. Augmented with our heuristic experience elimination, the method prioritizes high-quality and frequently-used experiences, effectively managing the experience space and enhancing efficiency. Extensive experiments show that while the successive pattern may yield superior results, the cumulative pattern provides more stable performance. Moreover, experience elimination facilitates achieving better performance using just 11.54% of a high-quality subset.

Uncertainty-Aware Deep Video Compression with Ensembles

Deep learning-based video compression is a challenging task, and many previous state-of-the-art learning-based video codecs use optical flows to exploit the temporal correlation between successive frames and then compress the residual error. Although these two-stage models are end-to-end optimized, the epistemic uncertainty in the motion estimation and the aleatoric uncertainty from the quantization operation lead to errors in the intermediate representations and introduce artifacts in the reconstructed frames. This inherent flaw limits the potential for higher bit rate savings. To address this issue, we propose an uncertainty-aware video compression model that can effectively capture the predictive uncertainty with deep ensembles. Additionally, we introduce an ensemble-aware loss to encourage the diversity among ensemble members and investigate the benefits of incorporating adversarial training in the video compression task. Experimental results on 1080p sequences show that our model can effectively save bits by more than 20% compared to DVC Pro.

Neural Video Compression with Feature Modulation

The emerging conditional coding-based neural video codec (NVC) shows superiority over commonly-used residual coding-based codec and the latest NVC already claims to outperform the best traditional codec. However, there still exist critical problems blocking the practicality of NVC. In this paper, we propose a powerful conditional coding-based NVC that solves two critical problems via feature modulation. The first is how to support a wide quality range in a single model. Previous NVC with this capability only supports about 3.8 dB PSNR range on average. To tackle this limitation, we modulate the latent feature of the current frame via the learnable quantization scaler. During the training, we specially design the uniform quantization parameter sampling mechanism to improve the harmonization of encoding and quantization. This results in a better learning of the quantization scaler and helps our NVC support about 11.4 dB PSNR range. The second is how to make NVC still work under a long prediction chain. We expose that the previous SOTA NVC has an obvious quality degradation problem when using a large intra-period setting. To this end, we propose modulating the temporal feature with a periodically refreshing mechanism to boost the quality. %Besides solving the above two problems, we also design a single model that can support both RGB and YUV colorspaces. Notably, under single intra-frame setting, our codec can achieve 29.7\% bitrate saving over previous SOTA NVC with 16\% MACs reduction. Our codec serves as a notable landmark in the journey of NVC evolution. The codes are at https://github.com/microsoft/DCVC.