Be Your Own Teacher: Steering Protein Language Models via Unsupervised Reward Optimization

Protein language models (PLMs) have emerged as powerful tools for controllable biomolecular design, yet their post-training adaptation typically relies on costly wet-lab validation or curated preference datasets. To overcome this supervision bottleneck, we introduce unsupervised reward optimization of PLMs, a comprehensive framework for steerable protein generation without ground-truth labels. Our key insight is that task-agnostic rewards, which combine intrinsic model uncertainty with extrinsic semantic consistency informed by protein representation models, exhibit strong correlation with controllability measures across base models and temperature regimes. Building upon this discovery, we propose two offline algorithms: Soft Reward Optimization (SRO) and Binarized Reward Optimization (BRO), which effectively maximize the classical RLHF objective induced by these proxy rewards. Extensive experiments on compositional out-of-distribution prompts demonstrate that both methods significantly outperform competitive baselines (DPO, KTO), while approaching oracle performance across multiple sampling temperatures, model scales and protein families. Moreover, PLMs fine-tuned with unsupervised rewards can achieve consistently higher coverage compared to their base model in pass@k evaluations. By enabling self-improvement of PLMs through their own generated experience, our framework provides a scalable pathway toward controllable biomolecular design in settings where labeled preferences or experimental feedback are scarce or unavailable.

Native Active Perception as Reasoning for Omni-Modal Understanding

Passive models for long video understanding typically rely on a "watch-it-all" paradigm, processing frames uniformly regardless of query difficulty, causing computational cost to grow with video duration. Although interactive frameworks have emerged, they often rely on global pre-scanning, and their context cost still scales with video length. We propose OmniAgent, the first native omni-modal agent that formulates video understanding as a POMDP-based iterative Observation-Thought-Action cycle. OmniAgent executes on-demand actions to selectively distill audio-visual cues into a persistent textual memory, effectively decoupling reasoning complexity from raw video duration. To operationalize this, we introduce (1) Agentic Supervised Fine-Tuning to bootstrap native active perception via best-of-N trajectory synthesis with dual-stage quality control, and (2) Agentic Reinforcement Learning with TAURA (Turn-aware Adaptive Uncertainty Rescaled Advantage), which leverages turn-level entropy to steer credit assignment toward pivotal discovery turns. Crucially, OmniAgent exhibits positive test-time scaling, where performance improves as the number of reasoning turns increases, validating the efficacy of active perception. Empirical results across ten benchmarks (e.g., VideoMME, LVBench) demonstrate that OmniAgent achieves state-of-the-art performance among open-source models. Notably, on LVBench, our 7B agent outperforms the 10$\times$ larger Qwen2.5-VL-72B (50.5% vs. 47.3%).

Orchestra-o1: Omnimodal Agent Orchestration

The recent success of agent swarms has shifted the paradigm of large language model (LLM)-based agents from single-agent workflows to multi-agent systems, highlighting the importance of agent orchestration for task decomposition and collaboration. However, existing orchestration frameworks are limited to a narrow set of modalities and struggle to generalize to more complex settings where heterogeneous modalities coexist and interact. This limitation becomes particularly pronounced in omnimodal scenarios, where tasks require the unified understanding and coordination of diverse inputs such as text, image, audio, and video. In this work, we propose Orchestra-o1, an omnimodal agent orchestration framework designed to support efficient agent collaboration across multiple modalities. Orchestra-o1 introduces a unified orchestration mechanism that enables modality-aware task decomposition, online sub-agent specialization, and parallel sub-task execution. This scalable design allows agent systems to effectively tackle complex real-world tasks involving heterogeneous information sources, surpassing the second-best approach by 10.3% accuracy on the OmniGAIA benchmark. Furthermore, we introduce decision-aligned group relative policy optimization (DA-GRPO), an efficient agentic reinforcement learning approach for training Orchestra-o1-8B, which also achieves state-of-the-art performance against all existing open-source omnimodal agents.

EPS3D: End-to-End Feed-Forward 3D Panoptic Segmentation

This paper introduces EPS3D, a new end-to-end feed-forward framework for open-vocabulary 3D panoptic segmentation. Unlike existing methods relying on additional preprocessing, we design an end-to-end architecture, with a distillation-based training strategy on diverse 3D scenes to predict 3D-aware semantic and instance features from multi-view images, improving 3D consistency and avoiding error accumulation. We further propose a mutual enhancement module to enforce inherent semantic-instance consistency. By aligning semantics within instances (Ins2Sem) and refining instance features with semantic guidance (Sem2Ins), we achieve more coherent 3D scene understanding. Ultimately, EPS3D outperforms SOTA baselines on two benchmarks (e.g., +13% mIoU for semantics on Replica) with high efficiency (e.g., 1s per scene), supporting tasks like robotic manipulation and 3D scene editing.

Struct-Searcher: Agentic Structural Thinking Advances Multimodal Deep Information Seeking

Deep research agents have attracted increasing attention for their ability to collect large-scale online information to acquire target knowledge, with recent efforts shifting from purely text-based information seeking to multimodal settings. However, existing agentic workflows are largely aligned with evidence accumulation models, which linearly aggregate evidence and lack principled mechanisms for handling contradictory information across heterogeneous modalities. Towards this end, we propose Struct-Searcher, a structural agentic workflow grounded in belief revision theory that explicitly maintains an evolving multimodal structural graph throughout the reasoning process, enabling effective conflict-aware multimodal deep information seeking. Extensive experiments across multiple benchmark datasets and backbone models demonstrate that Struct-Searcher is (1) plug-and-play and model-agnostic, yielding an average relative accuracy improvement of 17.2% on BrowseComp-VL across five different backbones. (2) top-performing, consistently outperforming state-of-the-art vision-language models (VLMs) and deep research agents, with relative accuracy improvements of 3.7% on MM-BrowseComp, 1.5% on HLE-VL, and 0.7% on BrowseComp-VL over the second-best competing approach.

Attenuation-Resilient Alternating Optimization for Laparoscopic Liver Landmark Detection

Liver surface landmark detection is a fundamental prerequisite for anatomical guidance in laparoscopic liver surgery. However, it remains unreliable in practice due to two pervasive challenges: illumination attenuation in underexposed regions and the structural mismatch between pixel-wise localization and continuous curvilinear geometry. To address these limitations, we propose A2ONet, an attenuation-resilient alternating optimization network for robust liver landmark detection. To mitigate illumination attenuation, A2ONet embraces an illumination field compensation (IFC) block that adaptively enhances dark regions while preserving structural consistency. Meanwhile, we introduce a lightweight frequency-orientation selective filter (FOSF) to suppress repetitive texture interference and preserve salient curvilinear cues. Building upon these resilient representations, we design an alternating seg-curve optimization (ASCO) decoder that iteratively couples dense segmentation with explicit curve modeling, enabling mutual guidance to optimize both structural continuity and endpoint localization. Extensive evaluations on L3D-2K, L3D, and P2ILF demonstrate consistent improvements over competitive methods, establishing a more reliable foundation for intraoperative anatomy guidance. Our code will be available at https://github.com/hyperiondk115/A2ONet.

ATLAS: Agentic or Latent Visual Reasoning? One Word is Enough for Both

Visual reasoning, often interleaved with intermediate visual states, has emerged as a promising direction in the field. A straightforward approach is to directly generate images via unified models during reasoning, but this is computationally expensive and architecturally non-trivial. Recent alternatives include agentic reasoning through code or tool calls, and latent reasoning with learnable hidden embeddings. However, agentic methods incur context-switching latency from external execution, while latent methods lack task generalization and are difficult to train with autoregressive parallelization. To combine their strengths while mitigating their limitations, we propose ATLAS, a framework in which a single discrete 'word', termed as a functional token, serves both as an agentic operation and a latent visual reasoning unit. Each functional token is associated with an internalized visual operation, yet requires no visual supervision and remains a standard token in the tokenizer vocabulary, which can be generated via next-token prediction. This design avoids verbose intermediate visual content generation, while preserving compatibility with the vanilla scalable SFT and RL training, without architectural or methodological modifications. To further address the sparsity of functional tokens during RL, we introduce Latent-Anchored GRPO (LA-GRPO), which stabilizes the training by anchoring functional tokens with a statically weighted auxiliary objective, providing stronger gradient updates. Extensive experiments and analyses demonstrate that ATLAS achieves superior performance on challenging benchmarks while maintaining clear interpretability. We hope ATLAS offers a new paradigm inspiring future visual reasoning research.

Does Engram Do Memory Retrieval in Autoregressive Image Generation?

The Engram module -- a hash-keyed, O(1) associative memory injected into Transformer layers -- was recently shown to improve large language model pretraining, with the appealing interpretation that it provides a content-addressed shortcut to recurring local token patterns. We ask whether this interpretation transfers to autoregressive (AR) image generation, or whether the observed gains, if any, come from a different mechanism. We adapt the Engram module to vision with 2D spatial $n$-gram hashing, gated fusion, and KV-cache-compatible incremental inference, and inject it into a class-conditional AR generator trained on ImageNet 256x256. Across a sweep of backbone-to-memory budget ratios $ρ{\in}[0.17, 0.90]$, every Engram-augmented variant trails the pure AR baseline in FID, indicating that the module saves backbone FLOPs but does not, by itself, improve sample quality. We then probe how the module is used. A gate-clamp sweep shows that disabling the Engram pathway entirely is catastrophic, yet a tiny constant gate (g=0.10) matches or beats the learned gate -- inconsistent with a heavily content-addressed recall mechanism. A donor-probe experiment shows that swapping the hash inputs for matched, adversarial, or random same-class exemplars produces statistically indistinguishable next-token distributions, while collapsing or randomising the table degrades them by two to three orders of magnitude. Finally, training a model from scratch with the entire memory table frozen to $\mathcal{N}(0, 1)$ noise costs only $Δ\text{FID}{=}0.10$ and actually raises Inception Score. Together, these findings indicate that the Engram in AR image generation behaves not as a content-addressed retriever but as a gated architectural side-pathway: a hash-keyed residual stream whose benefit is dominated by the pathway itself, with the learned table contributing only a small distributional refinement.

Unifying Physically-Informed Weather Priors in A Single Model for Image Restoration Across Multiple Adverse Weather Conditions

Image restoration under multiple adverse weather conditions aims to develop a single model to recover the underlying scene with high visibility. Weather-related artifacts vary with the particle's distance to the camera according to the established scene visibility analysis, where close and faraway regions are more affected by falling drops and fog effects, respectively. Existing methods fail to consider this weather-specific physical visual process; thus, the restoration performance is limited. In this work, we analyze the common visual factors in adverse weather conditions and present a unified imaging model that considers the individually visible particles and fog-like aggregate scattering effects. Further, we design a novel weather-prior-based network, which leverages the weather-related prior information to help recover the scene by enhancing the features using the estimated occlusion and transmission. Experimental results in multiple adverse scenarios show the superiority of our method against state-of-the-art methods.

Fast Image Super-Resolution via Consistency Rectified Flow

Diffusion models (DMs) have demonstrated remarkable success in real-world image super-resolution (SR), yet their reliance on time-consuming multi-step sampling largely hinders their practical applications. While recent efforts have introduced few- or single-step solutions, existing methods either inefficiently model the process from noisy input or fail to fully exploit iterative generative priors, compromising the fidelity and quality of the reconstructed images. To address this issue, we propose FlowSR, a novel approach that reformulates the SR problem as a rectified flow from low-resolution (LR) to high-resolution (HR) images. Our method leverages an improved consistency learning strategy to enable high-quality SR in a single step. Specifically, we refine the original consistency distillation process by incorporating HR regularization, ensuring that the learned SR flow not only enforces self-consistency but also converges precisely to the ground-truth HR target. Furthermore, we introduce a fast-slow scheduling strategy, where adjacent timesteps for consistency learning are sampled from two distinct schedulers: a fast scheduler with fewer timesteps to improve efficiency, and a slow scheduler with more timesteps to capture fine-grained texture details. Extensive experiments demonstrate that FlowSR achieves outstanding performance in both efficiency and image quality.