Efficient MedSAMs: Segment Anything in Medical Images on Laptop

Promptable segmentation foundation models have emerged as a transformative approach to addressing the diverse needs in medical images, but most existing models require expensive computing, posing a big barrier to their adoption in clinical practice. In this work, we organized the first international competition dedicated to promptable medical image segmentation, featuring a large-scale dataset spanning nine common imaging modalities from over 20 different institutions. The top teams developed lightweight segmentation foundation models and implemented an efficient inference pipeline that substantially reduced computational requirements while maintaining state-of-the-art segmentation accuracy. Moreover, the post-challenge phase advanced the algorithms through the design of performance booster and reproducibility tasks, resulting in improved algorithms and validated reproducibility of the winning solution. Furthermore, the best-performing algorithms have been incorporated into the open-source software with a user-friendly interface to facilitate clinical adoption. The data and code are publicly available to foster the further development of medical image segmentation foundation models and pave the way for impactful real-world applications.

A New Federated Learning Framework Against Gradient Inversion Attacks

Federated Learning (FL) aims to protect data privacy by enabling clients to collectively train machine learning models without sharing their raw data. However, recent studies demonstrate that information exchanged during FL is subject to Gradient Inversion Attacks (GIA) and, consequently, a variety of privacy-preserving methods have been integrated into FL to thwart such attacks, such as Secure Multi-party Computing (SMC), Homomorphic Encryption (HE), and Differential Privacy (DP). Despite their ability to protect data privacy, these approaches inherently involve substantial privacy-utility trade-offs. By revisiting the key to privacy exposure in FL under GIA, which lies in the frequent sharing of model gradients that contain private data, we take a new perspective by designing a novel privacy preserve FL framework that effectively ``breaks the direct connection'' between the shared parameters and the local private data to defend against GIA. Specifically, we propose a Hypernetwork Federated Learning (HyperFL) framework that utilizes hypernetworks to generate the parameters of the local model and only the hypernetwork parameters are uploaded to the server for aggregation. Theoretical analyses demonstrate the convergence rate of the proposed HyperFL, while extensive experimental results show the privacy-preserving capability and comparable performance of HyperFL. Code is available at https://github.com/Pengxin-Guo/HyperFL.

Generative Image Layer Decomposition with Visual Effects

Recent advancements in large generative models, particularly diffusion-based methods, have significantly enhanced the capabilities of image editing. However, achieving precise control over image composition tasks remains a challenge. Layered representations, which allow for independent editing of image components, are essential for user-driven content creation, yet existing approaches often struggle to decompose image into plausible layers with accurately retained transparent visual effects such as shadows and reflections. We propose $\textbf{LayerDecomp}$, a generative framework for image layer decomposition which outputs photorealistic clean backgrounds and high-quality transparent foregrounds with faithfully preserved visual effects. To enable effective training, we first introduce a dataset preparation pipeline that automatically scales up simulated multi-layer data with synthesized visual effects. To further enhance real-world applicability, we supplement this simulated dataset with camera-captured images containing natural visual effects. Additionally, we propose a consistency loss which enforces the model to learn accurate representations for the transparent foreground layer when ground-truth annotations are not available. Our method achieves superior quality in layer decomposition, outperforming existing approaches in object removal and spatial editing tasks across several benchmarks and multiple user studies, unlocking various creative possibilities for layer-wise image editing. The project page is https://rayjryang.github.io/LayerDecomp.

Causal Image Modeling for Efficient Visual Understanding

In this work, we present a comprehensive analysis of causal image modeling and introduce the Adventurer series models where we treat images as sequences of patch tokens and employ uni-directional language models to learn visual representations. This modeling paradigm allows us to process images in a recurrent formulation with linear complexity relative to the sequence length, which can effectively address the memory and computation explosion issues posed by high-resolution and fine-grained images. In detail, we introduce two simple designs that seamlessly integrate image inputs into the causal inference framework: a global pooling token placed at the beginning of the sequence and a flipping operation between every two layers. Extensive empirical studies demonstrate the significant efficiency and effectiveness of this causal image modeling paradigm. For example, our base-sized Adventurer model attains a competitive test accuracy of 84.0% on the standard ImageNet-1k benchmark with 216 images/s training throughput, which is 5.3 times more efficient than vision transformers to achieve the same result.

Story-Adapter: A Training-free Iterative Framework for Long Story Visualization

Story visualization, the task of generating coherent images based on a narrative, has seen significant advancements with the emergence of text-to-image models, particularly diffusion models. However, maintaining semantic consistency, generating high-quality fine-grained interactions, and ensuring computational feasibility remain challenging, especially in long story visualization (i.e., up to 100 frames). In this work, we propose a training-free and computationally efficient framework, termed Story-Adapter, to enhance the generative capability of long stories. Specifically, we propose an iterative paradigm to refine each generated image, leveraging both the text prompt and all generated images from the previous iteration. Central to our framework is a training-free global reference cross-attention module, which aggregates all generated images from the previous iteration to preserve semantic consistency across the entire story, while minimizing computational costs with global embeddings. This iterative process progressively optimizes image generation by repeatedly incorporating text constraints, resulting in more precise and fine-grained interactions. Extensive experiments validate the superiority of Story-Adapter in improving both semantic consistency and generative capability for fine-grained interactions, particularly in long story scenarios. The project page and associated code can be accessed via https://jwmao1.github.io/storyadapter .

MedTrinity-25M: A Large-scale Multimodal Dataset with Multigranular Annotations for Medicine

This paper introduces MedTrinity-25M, a comprehensive, large-scale multimodal dataset for medicine, covering over 25 million images across 10 modalities, with multigranular annotations for more than 65 diseases. These enriched annotations encompass both global textual information, such as disease/lesion type, modality, region-specific descriptions, and inter-regional relationships, as well as detailed local annotations for regions of interest (ROIs), including bounding boxes, segmentation masks. Unlike existing approach which is limited by the availability of image-text pairs, we have developed the first automated pipeline that scales up multimodal data by generating multigranular visual and texual annotations (in the form of image-ROI-description triplets) without the need for any paired text descriptions. Specifically, data from over 90 different sources have been collected, preprocessed, and grounded using domain-specific expert models to identify ROIs related to abnormal regions. We then build a comprehensive knowledge base and prompt multimodal large language models to perform retrieval-augmented generation with the identified ROIs as guidance, resulting in multigranular texual descriptions. Compared to existing datasets, MedTrinity-25M provides the most enriched annotations, supporting a comprehensive range of multimodal tasks such as captioning and report generation, as well as vision-centric tasks like classification and segmentation. Pretraining on MedTrinity-25M, our model achieves state-of-the-art performance on VQA-RAD and PathVQA, surpassing both multimodal large language models and other representative SoTA approaches. This dataset can also be utilized to support large-scale pre-training of multimodal medical AI models, contributing to the development of future foundation models in the medical domain.

DDR: Exploiting Deep Degradation Response as Flexible Image Descriptor

Image deep features extracted by pre-trained networks are known to contain rich and informative representations. In this paper, we present Deep Degradation Response (DDR), a method to quantify changes in image deep features under varying degradation conditions. Specifically, our approach facilitates flexible and adaptive degradation, enabling the controlled synthesis of image degradation through text-driven prompts. Extensive evaluations demonstrate the versatility of DDR as an image descriptor, with strong correlations observed with key image attributes such as complexity, colorfulness, sharpness, and overall quality. Moreover, we demonstrate the efficacy of DDR across a spectrum of applications. It excels as a blind image quality assessment metric, outperforming existing methodologies across multiple datasets. Additionally, DDR serves as an effective unsupervised learning objective in image restoration tasks, yielding notable advancements in image deblurring and single-image super-resolution. Our code will be made available.

What If We Recaption Billions of Web Images with LLaMA-3?

Web-crawled image-text pairs are inherently noisy. Prior studies demonstrate that semantically aligning and enriching textual descriptions of these pairs can significantly enhance model training across various vision-language tasks, particularly text-to-image generation. However, large-scale investigations in this area remain predominantly closed-source. Our paper aims to bridge this community effort, leveraging the powerful and \textit{open-sourced} LLaMA-3, a GPT-4 level LLM. Our recaptioning pipeline is simple: first, we fine-tune a LLaMA-3-8B powered LLaVA-1.5 and then employ it to recaption 1.3 billion images from the DataComp-1B dataset. Our empirical results confirm that this enhanced dataset, Recap-DataComp-1B, offers substantial benefits in training advanced vision-language models. For discriminative models like CLIP, we observe enhanced zero-shot performance in cross-modal retrieval tasks. For generative models like text-to-image Diffusion Transformers, the generated images exhibit a significant improvement in alignment with users' text instructions, especially in following complex queries. Our project page is https://www.haqtu.me/Recap-Datacomp-1B/

Medical Vision Generalist: Unifying Medical Imaging Tasks in Context

This study presents Medical Vision Generalist (MVG), the first foundation model capable of handling various medical imaging tasks -- such as cross-modal synthesis, image segmentation, denoising, and inpainting -- within a unified image-to-image generation framework. Specifically, MVG employs an in-context generation strategy that standardizes the handling of inputs and outputs as images. By treating these tasks as an image generation process conditioned on prompt image-label pairs and input images, this approach enables a flexible unification of various tasks, even those spanning different modalities and datasets. To capitalize on both local and global context, we design a hybrid method combining masked image modeling with autoregressive training for conditional image generation. This hybrid approach yields the most robust performance across all involved medical imaging tasks. To rigorously evaluate MVG's capabilities, we curated the first comprehensive generalist medical vision benchmark, comprising 13 datasets and spanning four imaging modalities (CT, MRI, X-ray, and micro-ultrasound). Our results consistently establish MVG's superior performance, outperforming existing vision generalists, such as Painter and LVM. Furthermore, MVG exhibits strong scalability, with its performance demonstrably improving when trained on a more diverse set of tasks, and can be effectively adapted to unseen datasets with only minimal task-specific samples. The code is available at \url{https://github.com/OliverRensu/MVG}.

Scaling White-Box Transformers for Vision

CRATE, a white-box transformer architecture designed to learn compressed and sparse representations, offers an intriguing alternative to standard vision transformers (ViTs) due to its inherent mathematical interpretability. Despite extensive investigations into the scaling behaviors of language and vision transformers, the scalability of CRATE remains an open question which this paper aims to address. Specifically, we propose CRATE-$\alpha$, featuring strategic yet minimal modifications to the sparse coding block in the CRATE architecture design, and a light training recipe designed to improve the scalability of CRATE. Through extensive experiments, we demonstrate that CRATE-$\alpha$ can effectively scale with larger model sizes and datasets. For example, our CRATE-$\alpha$-B substantially outperforms the prior best CRATE-B model accuracy on ImageNet classification by 3.7%, achieving an accuracy of 83.2%. Meanwhile, when scaling further, our CRATE-$\alpha$-L obtains an ImageNet classification accuracy of 85.1%. More notably, these model performance improvements are achieved while preserving, and potentially even enhancing the interpretability of learned CRATE models, as we demonstrate through showing that the learned token representations of increasingly larger trained CRATE-$\alpha$ models yield increasingly higher-quality unsupervised object segmentation of images. The project page is https://rayjryang.github.io/CRATE-alpha/.