MedTrinity-25M: A Large-scale Multimodal Dataset with Multigranular Annotations for Medicine

This paper introduces MedTrinity-25M, a comprehensive, large-scale multimodal dataset for medicine, covering over 25 million images across 10 modalities, with multigranular annotations for more than 65 diseases. These enriched annotations encompass both global textual information, such as disease/lesion type, modality, region-specific descriptions, and inter-regional relationships, as well as detailed local annotations for regions of interest (ROIs), including bounding boxes, segmentation masks. Unlike existing approach which is limited by the availability of image-text pairs, we have developed the first automated pipeline that scales up multimodal data by generating multigranular visual and texual annotations (in the form of image-ROI-description triplets) without the need for any paired text descriptions. Specifically, data from over 90 different sources have been collected, preprocessed, and grounded using domain-specific expert models to identify ROIs related to abnormal regions. We then build a comprehensive knowledge base and prompt multimodal large language models to perform retrieval-augmented generation with the identified ROIs as guidance, resulting in multigranular texual descriptions. Compared to existing datasets, MedTrinity-25M provides the most enriched annotations, supporting a comprehensive range of multimodal tasks such as captioning and report generation, as well as vision-centric tasks like classification and segmentation. Pretraining on MedTrinity-25M, our model achieves state-of-the-art performance on VQA-RAD and PathVQA, surpassing both multimodal large language models and other representative SoTA approaches. This dataset can also be utilized to support large-scale pre-training of multimodal medical AI models, contributing to the development of future foundation models in the medical domain.

DDR: Exploiting Deep Degradation Response as Flexible Image Descriptor

Image deep features extracted by pre-trained networks are known to contain rich and informative representations. In this paper, we present Deep Degradation Response (DDR), a method to quantify changes in image deep features under varying degradation conditions. Specifically, our approach facilitates flexible and adaptive degradation, enabling the controlled synthesis of image degradation through text-driven prompts. Extensive evaluations demonstrate the versatility of DDR as an image descriptor, with strong correlations observed with key image attributes such as complexity, colorfulness, sharpness, and overall quality. Moreover, we demonstrate the efficacy of DDR across a spectrum of applications. It excels as a blind image quality assessment metric, outperforming existing methodologies across multiple datasets. Additionally, DDR serves as an effective unsupervised learning objective in image restoration tasks, yielding notable advancements in image deblurring and single-image super-resolution. Our code will be made available.

Misalignment-Robust Frequency Distribution Loss for Image Transformation

This paper aims to address a common challenge in deep learning-based image transformation methods, such as image enhancement and super-resolution, which heavily rely on precisely aligned paired datasets with pixel-level alignments. However, creating precisely aligned paired images presents significant challenges and hinders the advancement of methods trained on such data. To overcome this challenge, this paper introduces a novel and simple Frequency Distribution Loss (FDL) for computing distribution distance within the frequency domain. Specifically, we transform image features into the frequency domain using Discrete Fourier Transformation (DFT). Subsequently, frequency components (amplitude and phase) are processed separately to form the FDL loss function. Our method is empirically proven effective as a training constraint due to the thoughtful utilization of global information in the frequency domain. Extensive experimental evaluations, focusing on image enhancement and super-resolution tasks, demonstrate that FDL outperforms existing misalignment-robust loss functions. Furthermore, we explore the potential of our FDL for image style transfer that relies solely on completely misaligned data. Our code is available at: https://github.com/eezkni/FDL