Full end-to-end diagnostic workflow automation of 3D OCT via foundation model-driven AI for retinal diseases

Optical coherence tomography (OCT) has revolutionized retinal disease diagnosis with its high-resolution and three-dimensional imaging nature, yet its full diagnostic automation in clinical practices remains constrained by multi-stage workflows and conventional single-slice single-task AI models. We present Full-process OCT-based Clinical Utility System (FOCUS), a foundation model-driven framework enabling end-to-end automation of 3D OCT retinal disease diagnosis. FOCUS sequentially performs image quality assessment with EfficientNetV2-S, followed by abnormality detection and multi-disease classification using a fine-tuned Vision Foundation Model. Crucially, FOCUS leverages a unified adaptive aggregation method to intelligently integrate 2D slices-level predictions into comprehensive 3D patient-level diagnosis. Trained and tested on 3,300 patients (40,672 slices), and externally validated on 1,345 patients (18,498 slices) across four different-tier centers and diverse OCT devices, FOCUS achieved high F1 scores for quality assessment (99.01%), abnormally detection (97.46%), and patient-level diagnosis (94.39%). Real-world validation across centers also showed stable performance (F1: 90.22%-95.24%). In human-machine comparisons, FOCUS matched expert performance in abnormality detection (F1: 95.47% vs 90.91%) and multi-disease diagnosis (F1: 93.49% vs 91.35%), while demonstrating better efficiency. FOCUS automates the image-to-diagnosis pipeline, representing a critical advance towards unmanned ophthalmology with a validated blueprint for autonomous screening to enhance population scale retinal care accessibility and efficiency.

IntraSlice: Towards High-Performance Structural Pruning with Block-Intra PCA for LLMs

Large Language Models (LLMs) achieve strong performance across diverse tasks but face deployment challenges due to their massive size. Structured pruning offers acceleration benefits but leads to significant performance degradation. Recent PCA-based pruning methods have alleviated this issue by retaining key activation components, but are only applied between modules in order to fuse the transformation matrix, which introduces extra parameters and severely disrupts activation distributions due to residual connections. To address these issues, we propose IntraSlice, a framework that applies block-wise module-intra PCA compression pruning. By leveraging the structural characteristics of Transformer modules, we design an approximate PCA method whose transformation matrices can be fully fused into the model without additional parameters. We also introduce a PCA-based global pruning ratio estimator that further considers the distribution of compressed activations, building on conventional module importance. We validate our method on Llama2, Llama3, and Phi series across various language benchmarks. Experimental results demonstrate that our approach achieves superior compression performance compared to recent baselines at the same compression ratio or inference speed.

Attention Sink Forges Native MoE in Attention Layers: Sink-Aware Training to Address Head Collapse

Large Language Models (LLMs) often assign disproportionate attention to the first token, a phenomenon known as the attention sink. Several recent approaches aim to address this issue, including Sink Attention in GPT-OSS and Gated Attention in Qwen3-Next. However, a comprehensive analysis of the relationship among these attention mechanisms is lacking. In this work, we provide both theoretical and empirical evidence demonstrating that the sink in Vanilla Attention and Sink Attention naturally construct a Mixture-of-Experts (MoE) mechanism within attention layers. This insight explains the head collapse phenomenon observed in prior work, where only a fixed subset of attention heads contributes to generation. To mitigate head collapse, we propose a sink-aware training algorithm with an auxiliary load balancing loss designed for attention layers. Extensive experiments show that our method achieves effective head load balancing and improves model performance across Vanilla Attention, Sink Attention, and Gated Attention. We hope this study offers a new perspective on attention mechanisms and encourages further exploration of the inherent MoE structure within attention layers.

Assembling the Mind's Mosaic: Towards EEG Semantic Intent Decoding

Enabling natural communication through brain-computer interfaces (BCIs) remains one of the most profound challenges in neuroscience and neurotechnology. While existing frameworks offer partial solutions, they are constrained by oversimplified semantic representations and a lack of interpretability. To overcome these limitations, we introduce Semantic Intent Decoding (SID), a novel framework that translates neural activity into natural language by modeling meaning as a flexible set of compositional semantic units. SID is built on three core principles: semantic compositionality, continuity and expandability of semantic space, and fidelity in reconstruction. We present BrainMosaic, a deep learning architecture implementing SID. BrainMosaic decodes multiple semantic units from EEG/SEEG signals using set matching and then reconstructs coherent sentences through semantic-guided reconstruction. This approach moves beyond traditional pipelines that rely on fixed-class classification or unconstrained generation, enabling a more interpretable and expressive communication paradigm. Extensive experiments on multilingual EEG and clinical SEEG datasets demonstrate that SID and BrainMosaic offer substantial advantages over existing frameworks, paving the way for natural and effective BCI-mediated communication.

A New Paradigm for Trusted Respiratory Monitoring Via Consumer Electronics-grade Radar Signals

Respiratory monitoring is an extremely important task in modern medical services. Due to its significant advantages, e.g., non-contact, radar-based respiratory monitoring has attracted widespread attention from both academia and industry. Unfortunately, though it can achieve high monitoring accuracy, consumer electronics-grade radar data inevitably contains User-sensitive Identity Information (USI), which may be maliciously used and further lead to privacy leakage. To track these challenges, by variational mode decomposition (VMD) and adversarial loss-based encryption, we propose a novel Trusted Respiratory Monitoring paradigm, Tru-RM, to perform automated respiratory monitoring through radio signals while effectively anonymizing USI. The key enablers of Tru-RM are Attribute Feature Decoupling (AFD), Flexible Perturbation Encryptor (FPE), and robust Perturbation Tolerable Network (PTN) used for attribute decomposition, identity encryption, and perturbed respiratory monitoring, respectively. Specifically, AFD is designed to decompose the raw radar signals into the universal respiratory component, the personal difference component, and other unrelated components. Then, by using large noise to drown out the other unrelated components, and the phase noise algorithm with a learning intensity parameter to eliminate USI in the personal difference component, FPE is designed to achieve complete user identity information encryption without affecting respiratory features. Finally, by designing the transferred generalized domain-independent network, PTN is employed to accurately detect respiration when waveforms change significantly. Extensive experiments based on various detection distances, respiratory patterns, and durations demonstrate the superior performance of Tru-RM on strong anonymity of USI, and high detection accuracy of perturbed respiratory waveforms.

CLEANER: Self-Purified Trajectories Boost Agentic Reinforcement Learning

Agentic Reinforcement Learning (RL) has empowered Large Language Models (LLMs) to utilize tools like Python interpreters for complex problem-solving. However, for parameter-constrained models (e.g., 4B--7B), the exploration phase is often plagued by frequent execution failures, creating noisy trajectories that hinder policy optimization. Under standard outcome-based reward settings, this noise leads to a critical credit assignment issue, where erroneous actions are inadvertently reinforced alongside successful outcomes. Existing mitigations face a dilemma: dense rewards often trigger reward hacking, while supersampling incurs prohibitive computational costs. To address these challenges, we propose CLEANER. Distinct from external filtering methods, CLEANER exploits the model's intrinsic self-correction capabilities to eliminate error-contaminated context directly during data collection. At its core, the Similarity-Aware Adaptive Rollback (SAAR) mechanism autonomously constructs clean, purified trajectories by retrospectively replacing failures with successful self-corrections. Based on semantic similarity, SAAR adaptively regulates replacement granularity from shallow execution repairs to deep reasoning substitutions. By training on these self-purified paths, the model internalizes correct reasoning patterns rather than error-recovery loops. Empirical results on AIME24/25, GPQA, and LiveCodeBench show average accuracy gains of 6%, 3%, and 5% over baselines. Notably, CLEANER matches state-of-the-art performance using only one-third of the training steps, highlighting trajectory purification as a scalable solution for efficient agentic RL. Our models and code are available at GitHub

What Gets Activated: Uncovering Domain and Driver Experts in MoE Language Models

Most interpretability work focuses on layer- or neuron-level mechanisms in Transformers, leaving expert-level behavior in MoE LLMs underexplored. Motivated by functional specialization in the human brain, we analyze expert activation by distinguishing domain and driver experts. In this work, we study expert activation in MoE models across three public domains and address two key questions: (1) which experts are activated, and whether certain expert types exhibit consistent activation patterns; and (2) how tokens are associated with and trigger the activation of specific experts. To answer these questions, we introduce entropy-based and causal-effect metrics to assess whether an expert is strongly favored for a particular domain, and how strongly expert activation contributes causally to the model's output, thus identify domain and driver experts, respectively. Furthermore, we explore how individual tokens are associated with the activation of specific experts. Our analysis reveals that (1) Among the activated experts, some show clear domain preferences, while others exert strong causal influence on model performance, underscoring their decisive roles. (2) tokens occurring earlier in a sentence are more likely to trigger the driver experts, and (3) adjusting the weights of domain and driver experts leads to significant performance gains across all three models and domains. These findings shed light on the internal mechanisms of MoE models and enhance their interpretability.

Beyond Physical Labels: Redefining Domains for Robust WiFi-based Gesture Recognition

In this paper, we propose GesFi, a novel WiFi-based gesture recognition system that introduces WiFi latent domain mining to redefine domains directly from the data itself. GesFi first processes raw sensing data collected from WiFi receivers using CSI-ratio denoising, Short-Time Fast Fourier Transform, and visualization techniques to generate standardized input representations. It then employs class-wise adversarial learning to suppress gesture semantic and leverages unsupervised clustering to automatically uncover latent domain factors responsible for distributional shifts. These latent domains are then aligned through adversarial learning to support robust cross-domain generalization. Finally, the system is applied to the target environment for robust gesture inference. We deployed GesFi under both single-pair and multi-pair settings using commodity WiFi transceivers, and evaluated it across multiple public datasets and real-world environments. Compared to state-of-the-art baselines, GesFi achieves up to 78% and 50% performance improvements over existing adversarial methods, and consistently outperforms prior generalization approaches across most cross-domain tasks.

RoboMIND 2.0: A Multimodal, Bimanual Mobile Manipulation Dataset for Generalizable Embodied Intelligence

While data-driven imitation learning has revolutionized robotic manipulation, current approaches remain constrained by the scarcity of large-scale, diverse real-world demonstrations. Consequently, the ability of existing models to generalize across long-horizon bimanual tasks and mobile manipulation in unstructured environments remains limited. To bridge this gap, we present RoboMIND 2.0, a comprehensive real-world dataset comprising over 310K dual-arm manipulation trajectories collected across six distinct robot embodiments and 739 complex tasks. Crucially, to support research in contact-rich and spatially extended tasks, the dataset incorporates 12K tactile-enhanced episodes and 20K mobile manipulation trajectories. Complementing this physical data, we construct high-fidelity digital twins of our real-world environments, releasing an additional 20K-trajectory simulated dataset to facilitate robust sim-to-real transfer. To fully exploit the potential of RoboMIND 2.0, we propose MIND-2 system, a hierarchical dual-system frame-work optimized via offline reinforcement learning. MIND-2 integrates a high-level semantic planner (MIND-2-VLM) to decompose abstract natural language instructions into grounded subgoals, coupled with a low-level Vision-Language-Action executor (MIND-2-VLA), which generates precise, proprioception-aware motor actions.

ATLAS: A High-Difficulty, Multidisciplinary Benchmark for Frontier Scientific Reasoning

The rapid advancement of Large Language Models (LLMs) has led to performance saturation on many established benchmarks, questioning their ability to distinguish frontier models. Concurrently, existing high-difficulty benchmarks often suffer from narrow disciplinary focus, oversimplified answer formats, and vulnerability to data contamination, creating a fidelity gap with real-world scientific inquiry. To address these challenges, we introduce ATLAS (AGI-Oriented Testbed for Logical Application in Science), a large-scale, high-difficulty, and cross-disciplinary evaluation suite composed of approximately 800 original problems. Developed by domain experts (PhD-level and above), ATLAS spans seven core scientific fields: mathematics, physics, chemistry, biology, computer science, earth science, and materials science. Its key features include: (1) High Originality and Contamination Resistance, with all questions newly created or substantially adapted to prevent test data leakage; (2) Cross-Disciplinary Focus, designed to assess models' ability to integrate knowledge and reason across scientific domains; (3) High-Fidelity Answers, prioritizing complex, open-ended answers involving multi-step reasoning and LaTeX-formatted expressions over simple multiple-choice questions; and (4) Rigorous Quality Control, employing a multi-stage process of expert peer review and adversarial testing to ensure question difficulty, scientific value, and correctness. We also propose a robust evaluation paradigm using a panel of LLM judges for automated, nuanced assessment of complex answers. Preliminary results on leading models demonstrate ATLAS's effectiveness in differentiating their advanced scientific reasoning capabilities. We plan to develop ATLAS into a long-term, open, community-driven platform to provide a reliable "ruler" for progress toward Artificial General Intelligence.